Vimovo® Tablets for Arthritis Pain and Ulcer Risk Reduction

What Vimovo® Is and How It Works

Vimovo combines naproxen and esomeprazole in one tablet. It helps manage signs and symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The naproxen component is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation. Esomeprazole is a proton pump inhibitor (PPI) that lowers stomach acid and lowers the risk of NSAID-associated stomach ulcers. Many shoppers compare Vimovo price and Vimovo cost when purchasing Vimovo online to manage long-term arthritis pain and reduce ulcer risk. Common strengths include Vimovo 500 20 mg and 375 20 mg.

YouDrugstore is a licensed Canadian pharmacy based in Manitoba where licensed pharmacists review prescriptions before dispensing; we offer brand and generic medicines at Canadian prices and also carry OTC health products. We also partner with vetted, licensed international pharmacies to source authentic brand medications across a broad range at affordable pricing.

Each tablet layers immediate-release esomeprazole with enteric-coated naproxen. This design provides acid suppression first, then releases naproxen in the intestine. Patients typically take Vimovo 500 mg 20 mg twice daily before meals. The product is prescription-only and is taken by mouth. It is not designed for fast relief of sudden pain, but for steady control of arthritis symptoms. Your prescriber will select a dose based on condition and risk factors.

Dosage and Usage

• Usual adult dose: one Vimovo 500 20 mg tablet twice daily.
• Some patients may use the 375 mg/20 mg strength twice daily.
• Take at least 30 minutes before meals, with a glass of water.
• Swallow tablets whole; do not split, crush, or chew.
• Use the lowest effective dose for the shortest duration needed.
• If you miss a dose, take it when remembered unless the next dose is due soon. Skip if close to the next dose.
• Do not take two doses at the same time to make up for a missed dose.
• Do not use with other NSAIDs unless directed by your prescriber.
• Avoid excessive alcohol, which can increase stomach bleeding risk.
• Tell your healthcare provider about all medicines and supplements.
• Vimovo dosage 500 mg/20 mg is common for adults with arthritis; follow your prescriber’s plan.
• Vimovo 500 20 mg tablets are for ongoing management, not immediate pain spikes.

• Store tablets at 15–30°C (59–86°F) in the original container with the lid closed.
• Keep the desiccant in the bottle and protect from moisture.
• Do not store in a bathroom or near sinks.
• Keep out of reach of children and pets.
• When you travel, carry your medicine in your hand luggage.
• Keep tablets dry and away from direct heat or freezing.
• Bring enough supply for your trip, plus a few extra days.
• Use a pill organizer only if it keeps tablets dry and intact.

Benefits and Savings

Vimovo offers two-in-one convenience: naproxen addresses pain and stiffness, while esomeprazole helps lower the chance of stomach ulcers in at-risk patients who require an NSAID. Taking a single pill simplifies dosing and may improve adherence compared to taking two separate products. The 500/20 mg strength suits many adults with osteoarthritis or rheumatoid arthritis who need twice-daily anti-inflammatory therapy.

When you compare Vimovo tablets price between pharmacies, Canadian pricing can lower out-of-pocket costs. You may see 60–80% savings versus typical US prices. Multi-month supplies and occasional bulk promotions can reduce the per-month total. You can turn on reorder reminders in your account so you never run short of treatment.

If you are seeking a deal, a Vimovo coupon may be listed on our promotions page when available.

Some regions have a generic for Vimovo (naproxen/esomeprazole). Availability varies by market and strength. If offered, the Vimovo generic cost may be lower than the brand. Check this page for current pack sizes and pricing, including the Vimovo 500 20mg price.

Side Effects and Safety

• Headache
• Heartburn, gas, abdominal pain
• Nausea, vomiting, diarrhea, or constipation
• Dizziness or drowsiness
• Fluid retention or swelling in the legs
• Rash or itching

Serious effects are uncommon but need urgent care: signs of stomach bleeding (black or bloody stools, vomiting blood), chest pain, shortness of breath, weakness on one side, severe abdominal pain, yellowing skin or eyes, little or no urine, severe skin reactions (blistering or peeling), or anaphylaxis. NSAIDs may increase the risk of heart attack and stroke, especially with higher doses and long-term use. Patients with a history of asthma, urticaria, or allergic reactions to aspirin/NSAIDs should not use naproxen-containing products. Esomeprazole used long term may relate to low magnesium, vitamin B12 deficiency, fractures, or Clostridioides difficile–associated diarrhea. Avoid use right before or after coronary artery bypass graft (CABG) surgery.

Ask a healthcare professional before combining with anticoagulants, antiplatelets, SSRIs/SNRIs, systemic steroids, methotrexate, lithium, diuretics, ACE inhibitors/ARBs, or other NSAIDs. Esomeprazole can reduce the effect of clopidogrel; prescribers may choose alternatives or adjust therapy.

Onset Time

Naproxen begins reducing pain and stiffness within hours of the first dose. Many patients notice improvement during the first day or two. Best results often appear after several days of regular use. The esomeprazole component starts suppressing acid quickly, and protection from NSAID-related ulcers builds over days to weeks. For chronic conditions like osteoarthritis, steady twice-daily dosing helps maintain symptom control.

Compare With Alternatives

Celecoxib is a COX-2 selective NSAID that may have a lower rate of upper GI ulcers than nonselective NSAIDs at standard doses. Some patients who cannot take a PPI prefer once- or twice-daily celecoxib monotherapy. You can review options on Celecoxib.

Topical diclofenac helps localized joint or soft-tissue pain with lower systemic exposure. It can be useful for knee, hand, or soft-tissue flares where a topical approach is reasonable. See Voltaren® Emulgel Extra Strength if a topical route is suitable.

Meloxicam is a once-daily NSAID option often used for osteoarthritis and rheumatoid arthritis. It does not include a PPI, so GI protection is considered separately in at-risk patients. Some patients rotate to meloxicam if twice-daily dosing is not preferred.

Combination Therapy

• Can be used with disease-modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis.
• Biologics (e.g., TNF inhibitors) are often continued; monitor for additive GI risks.
• Low-dose aspirin for cardiovascular protection may be used with careful timing and monitoring of bleeding risk.
• Acetaminophen can be combined for breakthrough pain as advised by the prescriber.
• Gastroprotective strategies are part of the Vimovo design; avoid adding other NSAIDs.

Patient Suitability and Cost-Saving Tips

Vimovo is intended for adults with arthritis who need an NSAID and benefit from ulcer risk reduction. It is not approved for use in late pregnancy (third trimester). It should not be used by patients with a history of asthma or allergic-type reactions after aspirin or NSAIDs, active GI bleeding or ulcer, severe kidney disease, or immediately before or after CABG surgery. Older adults and patients with cardiovascular disease, hypertension, kidney or liver impairment, a history of ulcers, or those on anticoagulants need careful risk assessment. Discuss all medicines, including over-the-counter products and supplements, with a healthcare professional.

Vimovo tablets for back pain may help if back pain stems from inflammatory arthritis or spinal osteoarthritis. It is not designed for rapid relief of acute injury pain. For everyday strains, topical NSAIDs or short-term oral NSAIDs may be considered under medical guidance.

To manage costs, compare pack sizes and strengths. Many patients use Vimovo 500 mg 20 mg tablets twice daily; consolidating into a multi-month order can lower shipping cost per month. Watch for bulk promotions on this page. You can set simple reorder reminders in your account so your next fill is on time. A generic for Vimovo (naproxen esomeprazole 500mg 20mg) may be available depending on supply; check current selection on this page.

Authoritative Sources

FDA Prescribing Information for VIMOVO (naproxen and esomeprazole)

Health Canada Drug Product Database: VIMOVO

Order Vimovo® from YouDrugstore.com: add to cart, upload your prescription, and we ship with prompt, express shipping.

This page is educational and does not replace advice from your healthcare professional. Always consult your prescriber or pharmacist about your treatment.