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Vimovo® Tablets for Arthritis Pain
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Vimovo® is a prescription combination of naproxen and esomeprazole for arthritis pain. It helps manage symptoms while lowering the chance of NSAID-related stomach ulcers. Available with US shipping from Canada, it suits people comparing costs without insurance.
What Vimovo Is and How It Works
This medicine contains naproxen, a nonsteroidal anti-inflammatory drug that reduces prostaglandins involved in pain and swelling. It also contains esomeprazole, a proton pump inhibitor that lowers stomach acid. Together, the treatment manages pain while helping protect the stomach during ongoing NSAID therapy.
YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.
Use is aligned with approved labeling. It may help adults with osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis who need long-term anti-inflammatory therapy and ulcer risk reduction. See the official product information for complete details. Explore related topics in Pain Inflammation and Osteoarthritis.
Who It’s For
This therapy is indicated for adults who require naproxen to relieve arthritis signs and symptoms and who may benefit from lowered risk of NSAID-associated gastric ulcers. It is not for relief of immediate pain. People with a history of serious allergic reactions to aspirin or other NSAIDs should avoid it. Do not use after coronary artery bypass graft surgery. Avoid in the third trimester of pregnancy. Those with active gastrointestinal bleeding, severe liver disease, or significant kidney problems should consult a healthcare professional.
Dosage and Usage
Dosing follows the approved label. The usual schedule is one tablet twice daily. Take each dose at least 30 minutes before meals with a glass of water. Swallow tablets whole; do not split, chew, or crush. Use the lowest effective dose for the shortest duration consistent with goals. Do not take with other naproxen-containing products unless directed. Limit alcohol and discuss tobacco use, as both can increase gastrointestinal risk.
Try to take doses at the same times every day. If sensitive stomach symptoms develop, contact your prescriber. Do not change your dose on your own. Refer to the official prescribing information if anything is unclear.
Strengths and Forms
This combination is supplied as delayed-release tablets for oral use. Commonly published strengths include 375 mg/20 mg and 500 mg/20 mg. Pack sizes vary by market and supplier, such as 30 or 60 tablets. Availability may differ by region.
Missed Dose and Timing
If a dose is missed, take it when remembered unless it is near the next scheduled time. If it is close to the next dose, skip the missed dose and resume the regular schedule. Do not double up. Maintain a steady routine to support symptom control and stomach protection.
Storage and Travel Basics
Store tablets at room temperature in the original container with the lid tightly closed. Keep them dry and away from heat and light. Always keep out of reach of children and pets. For travel, pack the medication in your carry-on with the pharmacy label and your prescription. Use a simple dosing plan that accounts for time zone changes. Do not store tablets in a hot car or near a window. Dispose of outdated medicine according to local guidance.
Benefits
The class combines anti-inflammatory pain relief with acid suppression, which may lower the chance of NSAID-associated stomach ulcers. Combining agents in one tablet can simplify therapy and may improve adherence. Taken consistently, it can help reduce joint pain and stiffness so daily tasks feel more manageable.
Side Effects and Safety
- Stomach symptoms: heartburn, nausea, abdominal pain, diarrhea, gas, or constipation
- Headache or dizziness
- Upper respiratory symptoms
Serious risks include cardiovascular events, gastrointestinal bleeding or ulceration, kidney problems, liver injury, severe skin reactions, and allergic reactions. Acid suppression can, rarely, be associated with low magnesium, vitamin B12 deficiency with long-term use, and increased risk of certain infections. Stop the medicine and seek medical help if you experience chest pain, black stools, vomiting blood, severe rash, facial swelling, trouble breathing, or signs of liver injury.
Drug Interactions and Cautions
Tell your clinician about all medicines and supplements. Notable interactions include anticoagulants and antiplatelets, selective serotonin reuptake inhibitors or SNRIs, corticosteroids, other NSAIDs, lithium, methotrexate, cyclosporine, digoxin, and certain blood pressure medicines such as ACE inhibitors, ARBs, and diuretics. Proton pump inhibitors may interact with clopidogrel by affecting CYP2C19; discuss antiplatelet therapy with your prescriber. Alcohol increases gastrointestinal risk. If you are pregnant, planning to become pregnant, or breastfeeding, ask your healthcare professional for guidance.
What to Expect Over Time
With regular use, pain and stiffness may become more manageable. Stomach protection continues as long as you take the therapy as prescribed. Your clinician may monitor blood pressure, kidney function, and overall tolerability. If your condition changes, your prescriber may adjust your plan or consider alternatives. Good adherence, paired with routine follow-up, supports safer, effective use over the long term. Budget planning helps if your treatment continues for months, especially when considering the Vimovo cash price compared to separate components.
Compare With Alternatives
Alternatives include other NSAIDs or different protective strategies. Some patients use selective COX-2 therapy such as Celecoxib. Others may be managed on a traditional NSAID like Meloxicam. In some cases, a prescriber may pair a standard NSAID with a separate proton pump inhibitor. Discuss the best fit for your medical history and risk factors.
Pricing and Access
Canadian pricing can be competitive, especially for mail-order refills. Check the Vimovo tablets price on the product page to see current options. You can also compare the Generic naproxen esomeprazole cost where available. We offer clear pricing, itemized checkout, and encrypted checkout for security.
Orders include US delivery from Canada for eligible addresses. View availability and timing on the product page before you place an order. If you look for periodic offers, see our Promotions page for current notices.
Availability and Substitutions
Supply can vary by strength and package size. If a specific option is unavailable, a prescriber may recommend a therapeutically suitable alternative, such as an NSAID with a separate acid-reducing agent. For budgeting, some people compare the Vimovo price alongside individual components to decide on the most practical approach.
Patient Suitability and Cost-Saving Tips
This therapy suits adults who need ongoing anti-inflammatory treatment and have risks for NSAID-related ulcers. It may not be appropriate for those with certain cardiovascular, renal, hepatic, or gastrointestinal conditions, or for those in late pregnancy. Ask your prescriber about gastroprotection if you take aspirin for cardiovascular prevention.
To manage expenses, consider longer refill intervals if appropriate, which can lower per-fill fees. Set reminders to avoid missed doses and emergency refills. Patients sometimes compare the Naproxen esomeprazole price with separate agents when discussing options. If paying out of pocket, reviewing the Vimovo cash price versus comparable therapies can inform planning.
Questions to Ask Your Clinician
- Right candidate: Is this combination suitable for my arthritis and risk profile?
- Strength choice: Which strength and schedule fit my condition and medicines?
- Ulcer risk: How will you monitor my gastrointestinal safety over time?
- Heart and kidney: What signs of cardiovascular or renal issues should I watch for?
- Other meds: Are any of my prescriptions or supplements unsafe with this therapy?
- Long-term plan: If I respond well, how long might I continue this treatment?
Authoritative Sources
Health Canada Drug Product Database
Buy Vimovo online to view current options, with prompt US delivery from Canada. Information here is educational and not a substitute for professional medical advice; always follow your prescriber’s guidance and the official label.
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What conditions is Vimovo used to treat?
This combination is indicated to relieve signs and symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis in adults who also need protection from NSAID-associated gastric ulcers. It is not meant for immediate pain relief. A clinician may consider it when anti-inflammatory therapy is required on an ongoing basis and the person has risk factors for stomach ulcers. Always discuss your medical history, including prior ulcer disease or bleeding, before starting treatment.
How should I take this medicine with meals?
Take each dose at least 30 minutes before a meal with a glass of water. Swallow the tablet whole; do not split, crush, or chew it. Keeping a consistent schedule helps the delayed-release design work as intended. If you experience new or worsening stomach symptoms, contact your healthcare professional. Do not change your dose or timing without guidance from the official label and your prescriber.
Can I use low-dose aspirin with this treatment?
Some patients require low-dose aspirin for cardiovascular protection. Combining aspirin with an NSAID can increase gastrointestinal risk. The proton pump inhibitor component may reduce ulcer risk, but it does not eliminate it. Your prescriber will weigh cardiovascular benefits and GI risks and may suggest monitoring or alternatives. Do not start or stop aspirin without medical advice, and report any signs of stomach bleeding or black stools immediately.
What are common side effects and serious warnings?
Common effects include stomach discomfort, heartburn, nausea, diarrhea, gas, constipation, headache, and dizziness. Serious risks can include gastrointestinal bleeding or ulceration, cardiovascular events, kidney problems, liver injury, severe skin reactions, and allergic reactions. Acid suppression may rarely relate to low magnesium, vitamin B12 deficiency with long-term use, or certain infections. Seek medical help if you notice chest pain, black stools, vomiting blood, facial swelling, or a severe rash.
How do I handle missed doses?
If you miss a dose, take it when remembered unless it is close to your next scheduled dose. If it is almost time for the next dose, skip the missed dose and resume your regular schedule. Do not take two doses at once. Consider setting reminders on your phone to improve consistency. Staying on schedule supports both symptom control and gastrointestinal protection. Ask your clinician if you have frequent timing problems.
How should I store tablets during travel?
Keep tablets in the original labeled container at room temperature, away from heat and moisture. When flying, pack them in your carry-on. Bring a copy of your prescription and a current medication list. For longer trips, plan your refills and keep doses accessible for time zone changes. Do not store the medicine in a hot car, and keep it out of reach of children at all times.
Are there important interactions to discuss?
Tell your prescriber about all medicines and supplements. Key interactions include anticoagulants, antiplatelets, SSRIs and SNRIs, corticosteroids, other NSAIDs, lithium, methotrexate, cyclosporine, digoxin, and certain blood pressure medicines. Proton pump inhibitors can affect clopidogrel activation through CYP2C19. Alcohol raises gastrointestinal risk. Share your full history so your clinician can guide safe use and monitoring during therapy.

