Komboglyze® saxagliptin/metformin tablets for type 2 diabetes

What Komboglyze® Is and How It Works

Komboglyze is a prescription tablet that combines saxagliptin and metformin hydrochloride for adults with type 2 diabetes. It helps improve blood sugar when diet and exercise are not enough. Many patients compare Komboglyze cost and look for Komboglyze without insurance options to manage ongoing therapy.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing.

We also work with licensed, vetted international partner pharmacies to supply authentic brand medications, offering a wide selection at affordable pricing.

Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It raises active incretin levels, which increases glucose‑dependent insulin release and lowers glucagon. Metformin is a biguanide that reduces hepatic glucose production and improves insulin sensitivity in muscle and fat. Together they target fasting and post‑meal glucose and can reduce A1C meaningfully.

Komboglyze tablets are taken by mouth. Common strengths include 2.5/500 mg, 2.5/850 mg, and 2.5/1000 mg. Typical dosing is twice daily with meals. The saxagliptin daily dose should not exceed 5 mg. The metformin component is usually limited to 2000 mg per day in immediate‑release form. This product is not for type 1 diabetes or diabetic ketoacidosis.

If searching for komboglyze xr, note that the Canadian brand is Komboglyze (immediate‑release). Extended‑release combinations exist in some countries under different brand names.

Dosage and Usage

• Initiation: common starting regimen is 2.5/500 mg twice daily with meals. Titrate metformin gradually to improve gastrointestinal tolerance.
• Prior metformin therapy: select a strength that matches the current metformin dose, while keeping saxagliptin at 2.5 mg twice daily (5 mg/day total).
• Switching from separate agents: use comparable total daily doses of saxagliptin and metformin as previously prescribed.
• Administration: swallow tablets whole with water. Do not crush or split.
• Timing: take with morning and evening meals to reduce stomach upset and improve adherence.
• Missed dose: take when remembered unless the next dose is near. Skip missed doses rather than doubling.
• Renal considerations: metformin is contraindicated in severe renal impairment; saxagliptin requires dose reduction in moderate renal impairment. Fixed‑dose combinations may not fit all renal dosing needs.
• Drug interactions: strong CYP3A4/5 inhibitors can increase saxagliptin exposure; dose adjustments of saxagliptin may be needed.

• Storage: store at 20–25 °C (68–77 °F). Short excursions 15–30 °C (59–86 °F) are acceptable.
• Moisture: keep tablets dry in the original bottle or blister with desiccant.
• Protection: avoid excessive heat, humidity, and direct sunlight. Do not freeze.
• Travel: keep medicine in your carry‑on, with a copy of your prescription. Use your pill organizer only if it stays dry and labeled.
• Safety at home: keep out of reach of children and pets.

The guidance above summarizes common Komboglyze usage. Follow the prescribing clinician’s directions for individual dosing.

Benefits and Savings

Komboglyze provides complementary glucose control from two well‑studied agents in one tablet. Many adults see fasting and post‑meal glucose improvements within weeks, with A1C reductions that often approach 1–2 percentage points over 8–12 weeks, depending on baseline control and adherence. The combination is generally weight‑neutral and has a low risk of hypoglycemia when not used with insulin or a sulfonylurea.

Ordering from Canada can offer meaningful value. Typical savings are 60–80% compared with many US pharmacy prices. This helps patients managing Komboglyze price month after month, including those seeking Komboglyze without insurance solutions or a lower cash price.

For current promotions, see our komboglyze coupon page.

If comparing specific strengths, the popular komboglyze 2.5 1000 mg (often written as 2.5/1000 mg) pairs the full 5 mg daily saxagliptin dose with a higher metformin dose, taken twice daily. Select strength based on tolerability and prescriber guidance.

Shoppers sometimes look for cheap Komboglyze or a komboglyze deal. We provide transparent Canadian pricing and occasional komboglyze promo offers. Multi‑month supplies or komboglyze bulk promotions can reduce the average monthly cost.

Side Effects and Safety

• Diarrhea, nausea, vomiting, or stomach upset
• Gas or abdominal discomfort
• Headache
• Nasopharyngitis, sore throat, or cough
• Urinary tract infection
• Fatigue or mild dizziness

Serious but uncommon risks include lactic acidosis with metformin (higher risk in severe renal impairment, advanced liver disease, hypoxia, dehydration, or heavy alcohol use), pancreatitis, severe joint pain, allergic reactions including angioedema and rash, possible heart failure worsening with saxagliptin in susceptible patients, and vitamin B12 reduction with long‑term metformin. Hypoglycemia can occur when combined with insulin or a sulfonylurea; dose adjustments of those agents may be needed.

Review full Komboglyze side effects and Komboglyze safety information with your prescriber and pharmacist before starting therapy.

Onset Time

Metformin’s effect on fasting glucose often starts within several days, with gastrointestinal symptoms most prominent during the first 1–2 weeks and usually improving as the dose is titrated. Saxagliptin’s post‑meal effect begins quickly as incretin hormones rise. Expect the A1C to reflect the combined effect after 8–12 weeks of stable dosing. Weight tends to remain stable.

Compare With Alternatives

Janumet is another DPP‑4 inhibitor plus metformin combination, using sitagliptin instead of saxagliptin. Some patients respond similarly to both; choice may depend on tolerability, renal considerations, or cost. You can compare features and strengths on Janumet®.

SGLT2 inhibitors offer a different approach by increasing urinary glucose excretion and may support modest weight loss and blood pressure reductions. They can be used alongside metformin or a DPP‑4 inhibitor. See options like Invokana® for a comparison to this class.

Other DPP‑4 plus metformin combinations include Jentadueto (linagliptin/metformin). Individual factors, such as renal function and drug interactions, often guide selection within the class.

Combination Therapy

• With an SGLT2 inhibitor to further reduce A1C and address cardiovascular or renal goals when appropriate.
• With basal insulin if targets are not met; reduce insulin or sulfonylurea dose to lower hypoglycemia risk.
• With a GLP‑1 receptor agonist for additional post‑meal control and potential weight benefit, as tolerated.

Patient Suitability and Cost-Saving Tips

Adults with type 2 diabetes who need dual therapy may be candidates. Avoid use in type 1 diabetes or diabetic ketoacidosis. The metformin component is contraindicated in severe renal impairment. Use caution with significant liver disease, conditions associated with hypoxia, heavy alcohol intake, or a history of pancreatitis. Monitor for heart failure symptoms if there is a cardiac history.

Discuss pregnancy and breastfeeding with a clinician. Long‑term metformin therapy may reduce vitamin B12 levels; periodic monitoring can be considered.

Ways to manage Komboglyze cost include choosing a strength that supports gradual titration, using reorder reminders, and asking about multi‑month fills to lower the per‑month price. Patients paying cash often compare the Komboglyze cash price between pharmacies; Komboglyze without insurance buyers may find the best value through Canadian pricing and periodic sale events.

Authoritative Sources

Review detailed prescribing guidance from the manufacturer and regulators: see the manufacturer’s product page for saxagliptin/metformin, the Health Canada Drug Product Database monograph for Komboglyze (Drug Product Database), and the US FDA labeling for saxagliptin/metformin fixed‑dose combinations where applicable (FDA Labeling).

Order Komboglyze® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This page is educational and does not replace advice from your healthcare professional. Always consult a qualified clinician for diagnosis and treatment decisions.