Komboglyze® Tablets for Type 2 Diabetes

Komboglyze is a prescription tablet that combines saxagliptin and metformin. It helps adults with type 2 diabetes improve blood sugar control when used with diet and activity. This page explains how it works, how to use it safely, and ways to manage costs without insurance.

What Komboglyze Is and How It Works

You can get US delivery from Canada with a valid prescription. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing. Komboglyze® pairs a DPP-4 inhibitor (saxagliptin) with metformin. The DPP-4 inhibitor helps raise incretin levels, which can increase insulin release and lower glucagon when blood sugar is high. Metformin reduces hepatic glucose production and improves insulin sensitivity. Together, the combination can help lower A1C when used consistently alongside nutrition and physical activity. For background on metformin, see Metformin Role.

Who It’s For

This medicine is used in adults with type 2 diabetes when diet and exercise alone are not enough. It may be appropriate for those already taking saxagliptin and metformin separately or switching from another metformin-based regimen. People with severe kidney problems, metabolic acidosis, or a history of serious hypersensitivity to components should avoid it. Those with heart failure, pancreatitis history, or liver disease need careful evaluation by a clinician. Review the official label and consult your clinician before starting.

Dosage and Usage

This treatment is typically taken with meals to reduce stomach upset. Many patients take it twice daily with the morning and evening meals. Swallow tablets whole with water. Do not crush or chew unless your prescriber confirms it is appropriate for your specific product. If you switch from separate tablets, your clinician will choose comparable doses. Keep a daily routine, set reminders, and log blood glucose per your care plan. When uncertain, follow the product monograph and your prescriber’s instructions.

Strengths and Forms

The tablets are available in multiple fixed-dose combinations of saxagliptin and metformin. Commonly published strengths include 2.5/500 mg, 2.5/850 mg, and 2.5/1000 mg for immediate-release tablets, and some markets carry extended-release options. Availability may vary by country and supplier. One example strength often referenced is saxagliptin/metformin 2.5/1000 mg. Your prescription will specify the exact strength and quantity.

Missed Dose and Timing

If you miss a dose, take it with food when you remember. If it is close to your next scheduled dose, skip the missed dose and resume your regular schedule. Do not double doses. Maintaining a consistent schedule helps your clinician interpret glucose readings and adjust therapy when needed.

Storage and Travel Basics

Store tablets in the original container with the lid closed. Keep at room temperature and away from excessive heat, moisture, and light. Protect from freezing. Keep out of reach of children and pets. When traveling, pack enough medicine plus a small buffer, carry it in hand luggage, and bring a copy of your prescription. A pill organizer can help maintain your schedule across time zones; confirm local time conversions for morning and evening doses.

Benefits

This combination can simplify therapy by putting two agents in one tablet. It works on complementary pathways, which may help with overall glycemic control when paired with lifestyle measures. Using a single prescription may reduce pill burden versus taking components separately. Taking doses with food can also help gastrointestinal tolerability.

Side Effects and Safety

• Digestive upset: nausea, diarrhea, stomach discomfort, or gas
• Headache or mild dizziness
• Upper respiratory symptoms, cough, or sore throat
• Fatigue or weakness

Serious but uncommon risks can include lactic acidosis with metformin, pancreatitis, severe hypersensitivity reactions, and heart failure risk in susceptible patients. Stop the medicine and seek urgent care if you develop severe abdominal pain, shortness of breath, swelling in legs, allergic symptoms, or signs of profound weakness. Discuss vitamin B12 monitoring if you take metformin long term. For GI guidance, see Metformin Cause Diarrhea.

Drug Interactions and Cautions

Tell your clinician about all medicines and supplements. Strong CYP3A4/5 inhibitors or inducers can affect saxagliptin levels. Contrast dye procedures may require temporary metformin interruption. Excessive alcohol use increases metformin-related risks. Diuretics, steroids, certain HIV medicines, and other agents may alter glucose control. Kidney function, liver status, and heart health should be assessed before and during treatment. Follow label guidance and your clinician’s advice; do not change your dose on your own.

What to Expect Over Time

Your clinician will review blood glucose logs and may check A1C periodically to evaluate response. Many people notice fasting and post-meal readings improve with consistent use, diet adjustments, and activity. Tolerability often improves when doses are taken with meals. If readings drift, your prescriber may adjust the plan or add other agents. Keep routine follow-ups and inform your care team about any new symptoms or medicines.

Compare With Alternatives

Other metformin-based combinations may fit your plan if you need different mechanisms or dosing. DPP-4 plus metformin alternatives include Jentadueto® (linagliptin/metformin). An SGLT2 plus metformin choice is Synjardy® (empagliflozin/metformin). Some regions offer extended-release combinations and strengths such as saxagliptin metformin XR 5/1000 mg; your prescriber will confirm suitability. For broader context, browse our Type 2 Diabetes category.

Pricing and Access

We use Canadian pricing to help you compare options for your prescription. If you are checking the Komboglyze price, review the product page for current availability and pack sizes. We support secure checkout and card payments; your data is protected with encrypted checkout. For offers, see our Promotions page where applicable. This service Ships from Canada to US with a prescription. If you are exploring generic saxagliptin metformin pricing or supply differences, your prescriber can advise suitable substitutes. Some customers ask about a Komboglyze coupon; check our site for any active promotions, then compare with your plan benefits.

Availability and Substitutions

Supply can vary by strength and manufacturer. If a specific tablet is not in stock, your prescriber may suggest an alternative combination or separate components. We cannot guarantee restock dates. Your clinician will decide whether a substitution is medically appropriate.

Patient Suitability and Cost-Saving Tips

This medicine may suit adults needing dual therapy when metformin alone is insufficient. It may be less suitable for those with significant renal impairment or recurrent pancreatitis. To manage costs, consider multi-month fills when appropriate, use refill reminders, and maintain adherence to avoid gaps. Ask your clinician for a cost comparison if you are weighing combination tablets versus separate agents. Cash-pay buyers can also review Canadian pricing and pay cash at checkout when it fits their situation. Browse more options in Diabetes Care. For prevention topics, see Reverse Prediabetes and seasonal updates like Diabetes Month 2025.

Questions to Ask Your Clinician

• Is this combination right for my A1C goal and kidney function?
• Should I start with once or twice-daily dosing, and with which meals?
• What signs suggest pancreatitis, lactic acidosis, or heart failure risk?
• How should I time doses around imaging contrast or surgeries?
• What labs should I monitor, including B12 and renal function?
• Would a different class or an extended-release option be better for me?

Authoritative Sources

See official information and labels here:

• FDA Prescribing Information
• Health Canada Product Monograph
• DailyMed Reference

Ready to continue? You can buy Komboglyze online through YouDrugstore with prompt US shipping from Canada. Standard tablets are shelf-stable; temperature-controlled handling when required applies to select items. Always follow your prescription. This information is not a substitute for professional medical advice.