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Pregnyl® Injection for Infertility
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Pregnyl is a prescription human chorionic gonadotropin medicine used in fertility care and certain hormone disorders. It supports ovulation in women and helps stimulate testosterone production in some men. This page explains how it works, who it may suit, and how to use it safely. It also shows how to order with US delivery from Canada and what to know if paying without insurance.
What Pregnyl Is and How It Works
YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.
Pregnyl® contains human chorionic gonadotropin (hCG). As a luteinizing hormone analogue, it helps trigger the final maturation of ovarian follicles and ovulation after follicle stimulation. In men, it can stimulate Leydig cells to produce testosterone, supporting treatment of hypogonadism and selected cases of undescended testis when appropriate. This medicine is usually given as an intramuscular injection, following your prescriber’s plan and the official label.
Learn more about therapy steps and safety by reading our overview, Pregnyl Hcg Uses, and related fertility topics like How Does Ovidrel and Iui And Pregnyl Injection.
Who It’s For
This treatment may be used to induce ovulation in women undergoing monitored infertility protocols. It may also be used in adult men with certain forms of hypogonadism and in boys for selected cases of cryptorchidism when a specialist recommends it. A Pregnyl shot is not for primary ovarian failure, hormone-sensitive tumors, or patients with unexplained vaginal bleeding. It should be avoided in pregnancy and in people with known hypersensitivity to hCG.
If you are exploring broader options and education, see our condition pages for Infertility and our category hubs for Fertility, Womens Health, and Mens Health.
Dosage and Usage
Use exactly as prescribed. For women in assisted reproduction or ovulation induction, the injection is typically given after follicle stimulation when monitoring shows the right timing. For men with hypogonadism, schedules may include multiple injections per week for a clinician-defined period. Your prescriber will set the dose, timing, and duration according to clinical goals and safety monitoring.
Administration is by intramuscular route into a large muscle. A trained healthcare professional should teach preparation, proper needle handling, site rotation, and disposal. Do not inject into swollen, tender, or infected skin. Follow the mixing steps on the package insert if a diluent is provided. Some fertility protocols may reference Pregnyl 10000 IU as an ovulation trigger; always follow the dose on your prescription and the official label.
If you are coordinating with IUI or IVF schedules, confirm your exact appointment timing, ultrasound findings, and instructions with your clinic before use. Keep a record of the date, time, lot number, and injection site for your own tracking.
Strengths and Forms
This medicine is supplied as a powder with a separate diluent for intramuscular injection. Commonly published presentations include Pregnyl 5000 IU and 10000 IU vials. Availability can vary by distributor and market. Some packages are single-use vials with one ampule of solvent, intended to be reconstituted immediately before administration.
For a broader look at hormone-based treatments, browse Hormones as well as our dedicated Fertility category.
Missed Dose and Timing
If you miss a scheduled dose in a fertility protocol, contact your clinic for guidance. Timing matters for cycle coordination. Do not double up unless your prescriber instructs you to do so. If a recurring dose is used for male hypogonadism, take the next dose as soon as you remember, unless it is nearly time for the next dose. Maintain consistent intervals as directed by your healthcare professional.
Storage and Travel Basics
Before mixing, store vials as directed on the package insert and protect from light. After reconstitution, follow label instructions regarding stability and whether refrigeration is advised. Do not freeze reconstituted solution. Keep all medicines out of reach of children and pets. Use a sturdy travel case for vials, syringes, and needles when you travel.
When flying, keep this treatment in your carry-on with your prescription label and clinic letter if needed. Allow extra time for security screening. Dispose of used sharps in an approved container and pack a small, travel-rated sharps container for convenience. If you must store the mixed solution, follow your prescriber’s guidance and avoid extreme temperatures.
Benefits
This therapy can complete follicle maturation and ovulation in coordinated fertility protocols. It may support luteal function when part of a guided plan. In men with selected endocrine conditions, it can stimulate endogenous testosterone production under supervision. Single-dose use for ovulation induction can be convenient in monitored cycles. Clear scheduling and clinic oversight may help simplify coordination with insemination or egg retrieval.
Side Effects and Safety
- Injection site pain, redness, or swelling
- Headache or fatigue
- Nausea or abdominal discomfort
- Mood changes or irritability
- Acne or fluid retention
Serious risks are uncommon but can occur. Ovarian hyperstimulation syndrome may develop in some women using gonadotropins. Multiple pregnancy is a known risk with ovulation induction. Blood clots, allergic reactions, and severe abdominal pain require urgent care. In males, gynecomastia and changes in libido can occur. If you also use insulin or a sulfonylurea, low blood sugar is not expected from hCG alone, but discuss your overall plan with your clinician.
For deeper reading on fertility safety topics, see articles like Ovidrel To Trigger Ovulation.
Drug Interactions and Cautions
Tell your prescriber about all medicines, supplements, and herbal products you use. Concurrent use with other fertility medicines such as FSH, LH, or clomiphene is common in protocols but should be coordinated by a specialist. Androgen therapy may alter outcomes in men. This therapy can affect certain hormone lab tests. Do not use if you have hormone-dependent tumors, active blood clots, or untreated endocrine disorders that make gonadotropin use unsafe. Always rely on the official label and your clinic’s plan for decision-making.
What to Expect Over Time
In cycle-based fertility care, the injection is typically administered once at a precise time, with monitoring before and after as your clinic directs. You may notice mild, fleeting injection site tenderness. In men with hypogonadism, dosing plans may continue for weeks to months under supervision. Track your response and attend all recommended appointments. Consistency, adherence to timing, and documentation of doses can support the goals of therapy.
Compare With Alternatives
Other prescription options may be considered by your clinician. Recombinant choriogonadotropin alfa is a well-known alternative in ovulation triggering; see our educational content such as Why Use Ovidrel. In some protocols, luteinizing hormone support may be added; see the product page for Luveris for details on that medicine. In selected men with hyperprolactinemia contributing to infertility, other therapies may be used as directed by a specialist.
Pricing and Access
Canadian pharmacy channels may offer competitive pricing compared with some local options. You can review the Pregnyl HCG price on our product page and compare formats before you order. We provide transparent information so you can discuss affordability with your prescriber. For current opportunities, see our Promotions page. Orders are processed with US shipping from Canada once your prescription is verified.
We support secure transactions and privacy. A valid prescription is required and verified before fulfillment. If you have questions about coverage, ask your clinic or insurer to see how this medicine fits within your plan.
Availability and Substitutions
Supply can vary by strength, pack size, and distributor. If a specific vial size is temporarily unavailable, your prescriber may recommend an alternative presentation or a different hCG product to meet your treatment goals. Organon manufactures this brand in several markets. We cannot promise restock dates, but our team can help you review options available at the time you place your order.
Patient Suitability and Cost-Saving Tips
Candidates include women in monitored ovulation induction or IVF cycles and men with selected endocrine diagnoses. It is not suitable for patients with certain tumors, uncontrolled thyroid or adrenal disease, or for use during pregnancy. Share your medical history, medications, and fertility plan so your prescriber can confirm suitability.
To manage out-of-pocket costs, ask about larger quantities when appropriate and align refill timing with cycle plans. Set reminders for injection timing and reorders to avoid delays. Consider discussing generics or recombinant alternatives if they fit your protocol and availability. Category resources such as Fertility and Hormones can help you compare options.
Questions to Ask Your Clinician
- Cycle timing plan: when exactly to inject and why
- Monitoring: which labs or ultrasounds are needed
- Dose and route: how to prepare and inject safely
- Risks: warning signs of ovarian hyperstimulation
- Alternatives: when recombinant options may be preferred
- Coordination: how this fits with IUI or IVF scheduling
- Cost: suitable formats that align with your budget
Authoritative Sources
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How is Pregnyl prepared and injected?
This medicine is supplied as a powder with a separate diluent. Your clinic or pharmacist should teach you how to reconstitute it and give the intramuscular dose safely. Use a clean surface, wash your hands, and follow the steps on the label. Draw up the diluent, add it to the vial, gently swirl to dissolve, then withdraw the solution. Rotate injection sites and never reuse needles. Dispose of sharps in an approved container. If you are unsure, ask a healthcare professional to demonstrate before attempting self-injection.
What conditions is Pregnyl used to treat?
It is used to trigger ovulation in women undergoing monitored fertility protocols, and to stimulate testosterone production in some men with hypogonadism. Specialists may also consider it in boys for certain cases of undescended testis. It is not used in pregnancy, in primary ovarian failure, or in patients with hormone-sensitive cancers. Your prescriber will decide if it fits your treatment plan based on diagnosis and safety considerations.
What side effects should I watch for?
Common effects include injection site pain, headache, nausea, mood changes, and fluid retention. Women using gonadotropins should be alert for symptoms of ovarian hyperstimulation, such as rapid weight gain, severe abdominal pain, or shortness of breath. Men may notice acne, gynecomastia, or changes in libido. Seek urgent care for signs of allergic reaction or blood clots. This summary does not list every effect; review the official labeling and discuss concerns with your clinician.
How is timing coordinated with IUI or IVF?
Clinics typically schedule the injection after monitoring follicle growth with ultrasound and labs. The dose is timed to complete maturation and align with insemination or retrieval procedures. Your team will provide exact timing instructions and follow-up steps. Keep records of the date, time, and lot number, and confirm any schedule changes with your clinic. Do not adjust timing on your own without professional guidance in a supervised cycle.
How should I store Pregnyl at home?
Store vials as directed on the package insert, protected from light. Before mixing, many products can be kept at room temperature within a labeled range. After reconstitution, follow the label regarding stability and whether refrigeration is recommended; do not freeze the mixed solution. Keep all supplies out of reach of children, and use a travel case when transporting. If you are unsure about storage details, ask your pharmacist or consult the official labeling.
Can I use this therapy with other fertility medicines?
Many protocols combine gonadotropins, such as FSH or LH products, with hCG to trigger ovulation. Only a fertility specialist should design these combinations. Provide a full list of your medicines, vitamins, and herbal products. Some therapies may increase risks, and additional monitoring might be needed. Do not start, stop, or change your regimen without speaking to your prescriber and reviewing the official label for interaction information.
What if I miss a dose or inject late?
Contact your clinic if you miss a scheduled dose in a fertility cycle, as timing can be critical. Do not take extra doses unless instructed. For ongoing regimens in men, take the next planned dose when remembered unless it is close to the next scheduled time. Keep a consistent schedule and use reminders or alarms to help with adherence. Your healthcare professional can advise on adjustments based on your specific plan.


