Pregnyl HCG® (Human Chorionic Gonadotropin) Injection Uses and Dosing

What Pregnyl® Is and How It Works

Pregnyl® is a brand of human chorionic gonadotropin (hCG) supplied as a powder for injection. It is used to trigger ovulation in women, support fertility treatment, and treat certain hormone-related conditions in males, including hypogonadism and cryptorchidism. Many people search for Pregnyl HCG information when planning a treatment cycle or comparing options to buy pregnyl online.

hCG acts like luteinizing hormone (LH). In women, it completes follicle maturation and prompts ovulation after follicle-stimulating therapy. In males, it stimulates the testes to produce testosterone and may support sperm production when part of a broader plan. Most regimens use single or repeated intramuscular injections. Doses vary by condition and clinical protocol, such as 5,000 IU or 10,000 IU for the ovulation trigger.

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Dosage and Usage

Dosing is individualized. The prescriber sets the exact dose, timing, and number of injections. Pregnyl® is commonly given intramuscularly by a trained person or by a patient taught to self-inject.

• Confirm the vial strength. Common packs include 5,000 IU and 10,000 IU.
• Wash hands and gather supplies. Use sterile technique when mixing.
• Reconstitute the powder with the provided diluent as instructed.
• Withdraw the prescribed dose. Remove any air bubbles from the syringe.
• Inject intramuscularly in the designated site at the directed time.
• Dispose of all sharps in an approved container.

Missed dose: Contact the clinic or prescriber for guidance. Timing is critical for ovulation triggers, and the next steps depend on the protocol. Do not double the next dose.

• Storage before mixing: Keep unopened vials at room temperature away from light.
• After mixing: Refrigerate the solution. Follow the labeled beyond-use date or clinic instructions.
• Do not freeze the mixed solution. Discard if the solution changes color or contains particles.
• Travel: Carry medication in the original box with a copy of the prescription. Use insulated packaging with cold packs for mixed vials.

Only a prescriber can decide between intramuscular and subcutaneous administration for a given protocol. Do not share syringes or needles. Keep out of reach of children.

Benefits and Savings

Clinical benefits include predictable ovulation timing in assisted reproduction and support for testosterone production in select males. The ovulation trigger is often scheduled 34 to 36 hours before egg retrieval, insemination, or timed intercourse. In male hypogonadism, therapy can raise testosterone and help preserve testicular volume compared with exogenous testosterone alone.

YouDrugstore helps reduce costs by offering Canadian pricing on fertility medicines. Typical savings are 60–80% compared with many US retail prices, which can lower the overall pregnyl injection cost in a treatment plan. We also carry related fertility products and supplies, so you can purchase pregnyl online together with other cycle needs and reduce separate shipments.

We offer convenient ordering online and by phone where available. Friendly customer-service chat is available during posted office hours, and our pharmacists can address medication questions before dispensing.

Side Effects and Safety

Most effects are mild and temporary, but monitoring is important. Seek medical care for severe or persistent symptoms.

• Common: injection site pain, headache, fatigue, nausea, bloating, irritability.
• Women: abdominal discomfort and temporary water retention. Breast tenderness may occur.
• Men: acne, mood changes, gynecomastia, and fluid retention can appear.
• Serious: ovarian hyperstimulation syndrome (OHSS), blood clots, severe pelvic pain, sudden weight gain, shortness of breath.
• Allergic reactions: rash, swelling, hives, wheezing. Stop treatment and seek care if these occur.
• Pediatrics: signs of early puberty in boys receiving therapy for cryptorchidism should be reported.

Pregnyl® can increase the chance of multiple pregnancy when used for ovulation induction. It should not be used during pregnancy except as directed for fertility protocols before conception. It is not approved for weight loss; combining any hCG with a very low-calorie diet is unsafe and not recommended.

Onset Time

Ovulation typically occurs about 36 hours after an hCG trigger injection when used for ovulation induction. In male hypogonadism, rises in testosterone can appear within days to weeks, depending on dose and baseline function. Clinical goals, such as sperm parameters, may take several months of directed therapy.

Compare With Alternatives

Ovidrel (choriogonadotropin alfa) is a recombinant form of hCG supplied as a prefilled subcutaneous syringe. Many clinics use it for convenience and consistent dosing. Pregnyl® requires reconstitution and is often injected intramuscularly, but both products deliver an LH surge for ovulation.

Novarel and generic urinary hCG products offer similar clinical effects with different packaging and suppliers. Your clinic may specify a brand based on availability, protocol, and experience.

Some protocols add luteinizing hormone support. For example, Luveris® (recombinant LH) can be combined with FSH therapy when LH supplementation is needed.

Discuss options with the fertility clinic if product substitutions occur due to pregnyl availability. Equivalent dosing and timing can often be arranged within the same protocol window.

Combination Therapy

Pregnyl® is often part of a structured fertility plan. In women, it can follow clomiphene, letrozole, or injectable FSH or hMG therapy to complete follicular maturation. The hCG trigger sets a clear timeline for insemination, egg retrieval, or intercourse. Luteal support may follow per clinic practice.

In males with hypogonadotropic hypogonadism, hCG may be combined with FSH-containing products to support spermatogenesis over several months. Treatment plans vary and require regular lab and clinical monitoring.

Patient Suitability and Cost-Saving Tips

Potential candidates include women undergoing ovulation induction, males with secondary hypogonadism seeking fertility, and boys with certain forms of cryptorchidism when surgery is not immediately indicated. It is unsuitable in hormone-sensitive cancers, unexplained vaginal bleeding, or when pregnancy is already established. Clinics tailor therapy to the patient’s goals and risks.

Working with a clinic that tracks response helps reduce unused medication and lower overall pregnyl hcg cost. Consider multi-month options when appropriate, as bulk promotions can lower the per-month expense. Reorder reminders help keep cycles on schedule and avoid last-minute rush shipping.

For educational reading, see our articles Pregnyl Hcg Uses Dosage And Side Effects Explained and Using Iui And Pregnyl Injection. You can also explore condition pages such as Infertility and Hypogonadism to review related therapies.

For extra value, check our promotions for pregnyl 10000 price and bulk options.

Authoritative Sources

Review the manufacturer and regulatory details for more information:

• Organon Pregnyl product information
• Health Canada Drug Product Database: Pregnyl (hCG)
• FDA label for chorionic gonadotropin injection

YouDrugstore makes it simple to purchase pregnyl online or place an order by phone where available. Our team supports you from checkout to delivery, and we offer prompt, express, cold-chain shipping when needed to protect temperature-sensitive products.

This page is for general information and is not a substitute for medical advice. Always follow the directions and precautions from your prescriber and the product insert supplied with your medication.