Pregnyl HCG® for Fertility and Hormone Therapy

What Pregnyl® Is and How It Works

Pregnyl HCG is a prescription form of human chorionic gonadotropin. It helps trigger ovulation in women undergoing fertility treatment and supports testosterone production in certain men with hypogonadism. It is supplied as a powder with diluent for injection. Clinicians may use it for anovulation, luteal support in assisted reproduction, cryptorchidism in boys, and some forms of male factor infertility.

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Pregnyl acts like luteinizing hormone (LH). In women, it prompts final maturation of follicles and ovulation after stimulation with FSH or hMG. In men with gonadotropin deficiency, it stimulates Leydig cells to increase testosterone and helps initiate or maintain spermatogenesis, often together with FSH. Your clinic will decide on intramuscular or subcutaneous administration based on your protocol.

Patients often ask about pregnyl uses and how a pregnyl shot fits into treatment. Your fertility team sets the exact day and hour because timing is critical. For men and boys, dosing is scheduled several times weekly over weeks to months.

Dosage and Usage

• Wash hands and gather supplies. Check the vial labels and expiry dates.
• Use a new sterile syringe and needle for mixing and for injection.
• Draw the supplied diluent into a syringe. Inject it into the powder vial.
• Swirl gently until the powder dissolves. Do not shake vigorously.
• Draw up the full prescribed dose. Inspect for particles or discoloration.
• For subcutaneous use, inject into abdomen or thigh. For intramuscular use, inject into outer thigh or upper buttock as directed.
• Rotate injection sites to reduce irritation.
• Dispose of needles in a sharps container. Do not reuse needles or syringes.
• If you miss a scheduled dose, follow your clinic’s instructions. Do not double a dose without guidance.
• Typical women’s dosing: single 5,000–10,000 IU to trigger ovulation after follicular stimulation, or lower doses for luteal support per protocol.
• Typical men’s dosing: 500–4,000 IU two to three times weekly for hypogonadotropic hypogonadism; for cryptorchidism, clinic-specific IU and duration are used.

• Before mixing: keep vials in the original carton, protected from light, at 15–25 °C (59–77 °F). Do not freeze.
• After mixing: use promptly. If your pharmacist’s label allows temporary storage, refrigerate at 2–8 °C (36–46 °F) and follow the time limit on your label.
• Do not use if the solution is cloudy, colored, or contains particles.
• For travel, carry vials and syringes in your hand luggage. Keep them in an insulated pouch; use cold packs only if your label requires refrigeration after mixing.
• Avoid extreme heat or freezing during transit. Keep supplies upright and secured.
• Store all medications out of reach of children and pets.

Benefits and Savings

Pregnyl provides predictable LH activity to complete follicular maturation and induce ovulation on schedule. For men with specific pituitary deficiencies, it can raise testosterone and support sperm production when used long enough. Many patients appreciate flexible dosing options (1,500, 5,000, or 10,000 IU) and clinic-tested protocols.

Ordering pregnyl online from YouDrugstore helps you access Canadian pricing and prompt, express, cold-chain shipping for temperature-sensitive orders. Typical savings are 60–80% compared with many U.S. cash prices. You can compare pregnyl 10000 price or pregnyl injection price easily on the product page. Multi-month supplies and occasional bulk promotions can lower the per-month cost.

We also offer discreet packaging and optional reorder reminders so you do not run short during a cycle. Patients seeking pregnyl for sale often compare strengths; you can review pregnyl 5000 and hcg pregnyl 10000 iu details on this page.

Side Effects and Safety

• Injection-site pain, redness, or bruising
• Headache or fatigue
• Mood changes or irritability
• Nausea or stomach discomfort
• Acne or oily skin
• Fluid retention or mild swelling
• Gynecomastia in males (breast tenderness or enlargement)
• Local itching or rash

Serious but less common risks include ovarian hyperstimulation syndrome (OHSS), multiple pregnancy, blood clots, allergic reactions, and precocious puberty in boys. Seek urgent care for severe pelvic pain, rapid weight gain, shortness of breath, chest pain, or signs of an allergic reaction. Tell your prescriber about hormone-sensitive cancers, prostate issues, thyroid or adrenal disorders, and prior OHSS.

Onset Time

When used as an ovulation trigger, ovulation typically occurs about 24–48 hours after the injection. Pregnancy rates depend on many factors, including age, ovarian reserve, semen parameters, timing, and the wider protocol (IUI, IVF, or timed intercourse). For men with hypogonadotropic hypogonadism, testosterone may rise within weeks, but improvements in sperm counts can take 3–6 months or longer.

Compare With Alternatives

Ovidrel (choriogonadotropin alfa) is a recombinant hCG supplied in a prefilled syringe for subcutaneous use. Dosing is often simpler, and some clinics prefer its predictable device, though costs may differ compared with pregnyl 5000 or pregnyl 10000 iu vials.

Novarel is another urinary-derived hCG brand. It is reconstituted similarly to Pregnyl and used for comparable indications. Clinics may choose based on availability, protocol preference, or pricing. Your prescriber will advise which option fits your cycle.

Some patients also receive luteinizing hormone (LH) support. Luveris® contains recombinant LH and can be used with FSH in specific cases. You can review background topics such as Anovulation and Infertility to learn how these therapies fit into care plans.

To explore practical guidance on timing and technique, read our articles Pregnyl Hcg Uses Dosage And Side Effects Explained and Using Iui And Pregnyl Injection.

Combination Therapy

• With FSH or hMG to stimulate follicle growth, followed by a single Pregnyl trigger dose.
• With luteal-phase progesterone after IVF or IUI, as directed by your clinic.
• With FSH in men with hypogonadotropic hypogonadism to support spermatogenesis over months.
• With clomiphene citrate in some ovulation-induction protocols, per prescriber guidance.
• Dose adjustments may be needed to balance response and minimize adverse effects.

Patient Suitability and Cost-Saving Tips

Pregnyl may be appropriate for women who do not ovulate regularly or who need a timed trigger in IUI or IVF cycles. It can also be used in boys with certain types of cryptorchidism and in men with pituitary-related hypogonadism. Your clinician will confirm eligibility based on lab results, ultrasound findings, age, and treatment goals.

It may not be suitable if you have hormone-sensitive cancers, uncontrolled thyroid or adrenal disease, prostate carcinoma, ovarian enlargement not due to polycystic ovary syndrome, or unexplained vaginal bleeding. It is not used in primary ovarian failure. Tell your prescriber about all medicines and supplements you take.

To manage costs, consider longer supplies when appropriate for your plan, since ordering two or three months at once can reduce shipping fees and per-month costs. You can check pregnyl online availability and compare pregnyl 5000 for sale options on this page. Enable reorder reminders so you have your dose ready on the day your clinic schedules the injection.

For more background on treatment choices, see our condition pages for Hypogonadism and Human Chorionic Gonadotropin, and the article How Does Lupron Work During Ivf for context on IVF protocols.

Authoritative Sources

Organon Pregnyl product information

Health Canada Drug Product Database: Pregnyl

FDA prescribing information: chorionic gonadotropin injection

Order Pregnyl® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This page is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s guidance and the directions on your pharmacy label.