Ubrelvy® (ubrogepant) Tablets for Acute Migraine Relief

What Ubrelvy® Is and How It Works

Ubrelvy® (ubrogepant) is an oral calcitonin gene-related peptide (CGRP) receptor antagonist used for the acute treatment of migraine with or without aura in adults. It is not a preventive medicine. Strengths include 50 mg and ubrelvy 100 mg tablets. You can order through YouDrugstore, a licensed Canadian pharmacy based in Manitoba that follows Canadian pharmacy standards. Prescriptions are checked by licensed pharmacists before dispensing. Many shoppers compare the cost of ubrelvy without insurance when choosing a supplier. We partner with licensed, vetted international pharmacies to source authentic brand products at fair prices and a broad selection.

Ubrelvy® blocks CGRP receptors. CGRP is a key peptide involved in migraine pain and related symptoms. By blocking the receptor, ubrogepant helps reduce headache pain, sensitivity to light or sound, and nausea during an attack. It can be taken with or without food.

Dosage and Usage

The dosing schedule is simple and flexible for acute attacks. Follow your prescriber’s instructions and the product insert.

• Initial dose: 50 mg or 100 mg taken at the start of a migraine.
• Second dose: If needed, a second dose may be taken at least 2 hours after the first.
• Maximum: Do not exceed 200 mg in 24 hours.
• Frequency: The safety of treating more than 8 migraines in 30 days has not been established.
• Missed dose: Ubrelvy® is used as-needed for an attack, not on a schedule.
• Hepatic impairment: Severe impairment (Child-Pugh C) usually warrants a 50 mg dose; a second 50 mg may be taken after 2 hours if needed.
• Renal impairment: Mild to moderate usually needs no change; severe impairment often uses 50 mg. Avoid in end-stage renal disease unless directed by a specialist.
• Drug interactions: Avoid strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin). Use lower doses with moderate CYP3A4 or certain P-gp/BCRP inhibitors (e.g., verapamil, cyclosporine). Avoid strong CYP3A4 inducers which can reduce efficacy.
• Grapefruit: Limit intake because it can raise ubrogepant levels.

Storage and travel

• Store at 20–25°C (68–77°F). Brief excursions 15–30°C are acceptable.
• Keep tablets dry in the original container.
• Pack in carry-on luggage when you travel.
• Keep out of reach of children and pets.

Benefits and Savings

Ubrelvy® offers targeted relief without vasoconstriction. This makes it an option for some patients who cannot use triptans. Many people experience pain relief within two hours, and some reach pain freedom. It is available as small oral tablets, which are easy to carry and use on the go.

Ordering from YouDrugstore helps you access Canadian prices and support from a licensed team. Typical savings range from 60–80% compared with many US retail prices, depending on strength and pack size. We publish clear pricing, including ubrelvy cost per month estimates and ubrelvy price per pill details where available. Savings can be significant for those paying without insurance.

Side Effects and Safety

Most people tolerate ubrogepant well. Side effects are usually mild to moderate. Read the Medication Guide and speak with your prescriber if you have concerns.

• Common: nausea, sleepiness, dry mouth, and fatigue.
• Less common: dizziness, indigestion, or abdominal discomfort.
• Allergic reactions: rash, swelling, shortness of breath; seek urgent care if severe.
• Liver considerations: report unusual fatigue, dark urine, or yellowing of the skin or eyes.
• Drug interactions: strong CYP3A4 inhibitors are contraindicated; moderate inhibitors and P-gp/BCRP inhibitors often need dose reductions.
• Pregnancy and breastfeeding: discuss risks and benefits with a clinician.

If side effects limit use, ask your prescriber about alternative options or dosing changes.

Onset Time

Ubrelvy® starts working promptly. Many patients report meaningful relief within 1–2 hours after the first dose. Some achieve pain freedom at 2 hours. Individual results vary by timing, dose, and attack severity.

Compare With Alternatives

Triptans such as Sumatriptan remain a common first-line therapy for acute migraine. They act as serotonin 5-HT1B/1D agonists and can be very effective, but they cause vasoconstriction and are not suitable for some cardiovascular conditions.

Rimegepant (Nurtec ODT) is another gepant for acute treatment and prevention in some markets. It also blocks CGRP receptors and is taken as an orally disintegrating tablet. Ubrelvy® offers flexible dosing (50 mg or 100 mg with an optional second dose) which some patients prefer.

Atogepant, sold as Qulipta®, is a gepant used for prevention, not for acute attacks. Some patients use an acute agent like ubrogepant while taking a preventive like Qulipta®. For migraine-related nausea, prescribers may add an antiemetic such as Metoclopramide during attacks.

Your prescriber will weigh medical history, cardiovascular risk, prior response, and convenience when selecting therapy.

Combination Therapy

Ubrelvy® may be used with preventive treatments, including CGRP monoclonal antibodies, when directed by a clinician. It can be combined with NSAIDs or acetaminophen for added relief. Avoid exceeding the maximum daily dose or treating more than the recommended number of attacks per month. Do not use two gepants together for the same attack unless a specialist advises it. Confirm timing and interactions if triptans are also prescribed for rescue.

Patient Suitability and Cost-Saving Tips

Ubrelvy® can suit adults who need an acute option without vasoconstriction, or who have not responded to triptans. It may also fit patients on migraine prevention who still need a reliable rescue medicine. People with severe liver disease, end-stage kidney disease, or on certain interacting drugs may need a different plan. Discuss the cost of ubrelvy without insurance and dosing goals during your visit.

You can increase value by choosing larger pack sizes when appropriate, which often lowers the per-month cost. We offer reorder reminders to help you avoid gaps. For current offers and bulk options, see our ubrelvy coupon page.

Browse our condition pages, including Headaches and Migraine, to learn about related products and care pathways.

Authoritative Sources

Review official prescribing details and safety information before use. See these resources for in-depth guidance:

• Ubrelvy official patient site (AbbVie)
• Ubrelvy Prescribing Information (FDA)
• Health Canada Drug Product Database

Order from YouDrugstore with confidence. Our team supports your prescription needs and ships from Canada to the US with prompt, express shipping. Temperature-sensitive items use cold-chain shipping when required.

This content is for general information. It does not replace medical advice. Always follow your prescriber’s directions and the product insert. Product availability and packaging may vary by supplier.