Janumet XR® Tablets for Type 2 Diabetes

This prescription medicine combines two agents for type 2 diabetes. It helps lower blood sugar as part of a plan with diet and activity. We offer US shipping from Canada, and you can review options without insurance.

What Janumet XR Is and How It Works

Janumet XR® pairs sitagliptin, a DPP-4 inhibitor, with metformin in an extended-release tablet. The DPP-4 component helps raise incretin hormones, which can increase insulin release and reduce glucagon when glucose is high. Metformin reduces liver glucose production and improves insulin sensitivity. Together, the combination works throughout the day to support glycemic control.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

As Sitagliptin metformin XR tablets, this medicine is typically taken once daily with food. The extended-release core allows gradual metformin release. Do not crush or split the tablet, as that can change absorption. Your prescriber determines the schedule and strength based on your current therapy and goals.

For background on metformin’s role in therapy, see Metformin And Its Role.

Who It’s For

This treatment is for adults with type 2 diabetes who need improved glycemic control, used along with diet and exercise. It may be started in those already taking one of the components, or when combination therapy is appropriate.

It is not for type 1 diabetes or for treating diabetic ketoacidosis. People with severe kidney problems or metabolic acidosis should not use this therapy. Tell your healthcare professional about your medical history and all medicines you take.

Explore our condition hub: Type 2 Diabetes.

Dosage and Usage

Your prescriber sets the dose and schedule. The tablets are generally taken once daily with a meal. Swallow whole with water. Do not crush, cut, or chew. Taking with your main meal may help stomach tolerability.

If you currently use one component, your clinician may transition you to a combination strength suited to your regimen. If you use insulin or a sulfonylurea, your prescriber may adjust that agent to lower hypoglycemia risk. Follow the official label and your clinician’s guidance.

Routine monitoring, including blood glucose and A1C, is part of ongoing care. Keep regular appointments and lab checks as directed by your prescriber.

Strengths and Forms

This medicine is supplied as extended-release oral tablets. Strengths commonly available include:

• Sitagliptin metformin XR 50/500 mg
• 50/1000 mg combination
• 100/1000 mg combination

Availability may vary by pack size and manufacturer packaging.

Missed Dose and Timing

If you miss a dose, take it when you remember the same day with food. If it is nearly time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses at once.

Storage and Travel Basics

Store tablets at room temperature in a dry place. Keep the bottle tightly closed and away from excess heat and moisture. Protect from light. Keep out of reach of children and pets.

For travel, pack enough for your trip and a small extra supply. Keep medicines in original labeled containers. Carry a copy of your prescription and a medication list. If you cross borders, allow time for security checks. Use a daily reminder to stay on schedule when time zones change.

Benefits

This combination brings two complementary actions to support daylong glucose control. Once-daily extended-release dosing may fit your routine. Using both mechanisms in one tablet can reduce pill burden compared with separate components. The regimen is used with nutrition and activity to help meet individualized targets.

Side Effects and Safety

• Upset stomach or nausea
• Diarrhea or loose stools
• Gas or abdominal discomfort
• Headache
• Upper respiratory symptoms

Serious effects are uncommon but can include lactic acidosis with metformin, pancreatitis with sitagliptin, severe allergic reactions, and worsening kidney function. Stop the medicine and seek immediate care if you have symptoms suggestive of these events, such as severe abdominal pain, unusual muscle pain, extreme fatigue, or breathing problems.

When used with insulin or sulfonylureas, hypoglycemia can occur. Know the signs of low blood sugar and how to treat it per your clinician’s advice.

If you are concerned about GI tolerability, see Does Metformin Cause Diarrhea.

Drug Interactions and Cautions

Tell your prescriber about all medicines, vitamins, and supplements you take. Cautions include:

• Iodinated contrast procedures
• Excess alcohol intake
• Drugs that may impair kidney function
• Carbonic anhydrase inhibitors
• Insulin or secretagogues increasing low-sugar risk

People with kidney or liver disease, heart failure, or conditions that can cause hypoxia should discuss risks. If you become pregnant, plan pregnancy, or are breastfeeding, talk with your healthcare professional.

What to Expect Over Time

Your clinician will check glucose logs and lab tests to assess response. Many people see gradual A1C changes as part of a comprehensive plan. Take your tablets daily, maintain meal routines, and follow activity recommendations. If your targets are not reached, your prescriber may adjust your regimen.

Compare With Alternatives

Other prescription options include a DPP-4 single agent such as Januvia or another combination like Komboglyze. Some people may also use SGLT2 inhibitors or GLP-1 therapies, based on individual needs and clinician guidance. Each option has distinct considerations, including dosing, side effects, and monitoring.

Pricing and Access

See our current Janumet XR price and compare options that fit your plan. We provide Canadian pricing with clear checkout and itemized receipts for your records.

If you prefer to pay cash, you can review Janumet XR cash price details on the product page. We support US households with reliable fulfilment and tracking.

Looking for a deal? Check our seasonal offers on Promotions. We maintain transparent pricing and prescription required and verified.

Orders Ships from Canada to US with careful packaging for tablets.

Availability and Substitutions

Supply can vary. If the item is temporarily unavailable, your prescriber may recommend a suitable alternative or a different strength. We do not promise restock dates.

For cross-border service notes, see the product page; Janumet XR ships to US when in stock and when a valid prescription is received.

Patient Suitability and Cost-Saving Tips

This medicine may suit adults who need dual therapy and prefer a once-daily tablet. It may not be appropriate for those with severe kidney disease or a history of lactic acidosis. Your prescriber will evaluate your health status and set goals.

To save over time, consider multi-month fills if your prescriber supports them. Set refill reminders so you do not run out. Review our Diabetes Care category for compatible supplies.

Watch for a Janumet XR coupon when available through site offers. Compare options, then choose the fill that matches your schedule and travel plans.

Questions to Ask Your Clinician

• Starting goals: A1C targets and monitoring
• Dosing: timing with meals and adherence tips
• Side effects: what to watch for and when to seek help
• Interactions: insulin or sulfonylurea coordination
• Imaging: contrast procedure planning
• Travel: how to manage time zones and refills

Authoritative Sources

Need to get started? Place your order with prompt, express shipping and temperature-controlled handling when required. US delivery from Canada. This information is not a substitute for professional medical advice; always follow your prescriber’s directions and the official label.