Jentadueto® Tablets for Type 2 Diabetes: Uses, Dosing, and Safety

What Jentadueto® Is and How It Works

Jentadueto is a tablet that combines linagliptin and metformin to improve blood glucose in adults with type 2 diabetes. It is taken by mouth and is used alongside diet and exercise. Many shoppers compare Jentadueto price options, including Jentadueto XR price, to manage therapy costs, especially when budgeting without insurance. Youdrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing.

The two active ingredients work in different ways. Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. By inhibiting DPP-4, it increases incretin hormones, which raise insulin after meals and lower glucagon. Metformin is a biguanide that reduces hepatic glucose production and increases insulin sensitivity. Together, the combination lowers fasting and post-meal glucose with a low intrinsic risk of hypoglycemia when used without insulin or sulfonylureas. This dual approach supports A1C reduction and convenient dosing in one Jentadueto tablet.

Forms include immediate-release (IR) tablets, typically taken twice daily with meals, and Jentadueto XR extended-release tablets, usually taken once daily with the evening meal. Common strengths include 2.5/500 mg and 2.5/1000 mg for IR, and XR options such as 2.5/1000 mg and 5/1000 mg. The Jentadueto generic name components are linagliptin and metformin hydrochloride. The product’s drug class is a DPP-4 inhibitor plus biguanide combination.

Jentadueto is used for glycemic control in type 2 diabetes and is not indicated for type 1 diabetes or diabetic ketoacidosis. If you are comparing products by strength, listings may include jentadueto 2.5 500 mg, jentadueto 2.5 mg 1000 mg tab, jentadueto 2.5 1000 mg 60 tablets, and jentadueto XR 2.5 1000 mg or jentadueto XR 5 1000. Some shoppers also search for linagliptin 2.5 metformin 1000 when looking up specific tablet details on a Jentadueto website.

Dosage and Usage

• Usual dosing is twice daily with meals for immediate-release tablets.
• Jentadueto XR is generally taken once daily with the evening meal.
• Swallow XR tablets whole; do not split, crush, or chew.
• Dosing is individualized based on current metformin use and A1C goals.
• Do not exceed the total daily linagliptin dose of 5 mg.
• Maximum recommended metformin dose is typically 2000 mg per day.
• If switching from separate components, match the nearest equivalent strength.
• Patients with reduced kidney function may require dose changes or avoidance.
• If a dose is missed, take it when remembered unless it is near the next dose.
• Do not take two doses at once to make up for a missed dose.
• Continue blood glucose monitoring as directed by the prescriber.
• Report persistent gastrointestinal upset or new severe symptoms.

• Store tablets at 20–25°C (68–77°F); short excursions 15–30°C (59–86°F) are acceptable.
• Keep in a dry place, away from bathroom humidity and direct sunlight.
• Leave tablets in the original container with the desiccant until use.
• Do not freeze; avoid temperatures above 30°C (86°F) during travel.
• When flying, carry medicine in hand luggage with a copy of your prescription.
• Pack an extra supply for delays, and keep medicines out of checked luggage.
• Use a small insulated pouch in hot climates; do not place near heating vents.
• Check expiry dates before travel, and keep tablets away from children and pets.

Benefits and Savings

Combining two mechanisms in one tablet simplifies therapy. Many patients see meaningful A1C reductions when Jentadueto is added to diet and exercise. The metformin component may be weight neutral or support slight weight loss, while linagliptin is generally weight neutral. XR dosing offers once-daily convenience. Hypoglycemia risk is low when not used with insulin or a sulfonylurea.

Buying from Canada can lower monthly out-of-pocket costs. Typical savings run about 60–80% versus common US retail prices, which helps many patients afford care, even when managing jentadueto cost without insurance. Multi-month supplies can further lower the per-month cost, and reorder reminders can help you stay on track.

We partner with licensed, vetted international pharmacies to supply authentic brand medications, provide a broad selection, and keep pricing affordable.

For promotions, see the jentadueto coupon listing on our deals page.

Side Effects and Safety

• Common effects: diarrhea, nausea, stomach upset, gas, or abdominal pain.
• Headache or mild dizziness.
• Upper respiratory symptoms such as runny nose or sore throat.
• Back pain or joint discomfort.
• Metallic taste with metformin in some patients.
• Decreased vitamin B12 over time with metformin.
• Skin rash or itching.
• Rare allergic reactions including swelling of the face, lips, or tongue.
• Very rare skin blistering disorders (bullous pemphigoid) with DPP-4 inhibitors.
• Hypoglycemia risk increases when combined with insulin or sulfonylureas.

Serious but rare risks include lactic acidosis with metformin, more likely with severe kidney impairment, hypoxia, or heavy alcohol use. Pancreatitis has been reported with DPP-4 inhibitors; seek urgent care for severe abdominal pain. The side effects of Jentadueto XR are generally similar to the immediate-release version. Discuss personal risks, including kidney and liver function, heart failure history, and alcohol intake.

Onset Time

Metformin begins lowering glucose within days, and linagliptin helps control post-meal spikes from the first doses. Fasting glucose often improves within 1–2 weeks as dosing stabilizes. A1C changes typically appear over 8–12 weeks. Weight effects are usually neutral for linagliptin and modest for metformin. If treatment is adjusted, allow several weeks to see full A1C impact.

Compare With Alternatives

Other DPP-4 combinations include sitagliptin plus metformin (for example, Janumet), and saxagliptin plus metformin (Kombiglyze XR). These offer similar A1C reductions and low hypoglycemia risk, with differences in dosing frequency, renal dosing, and pill sizes. Patients already stable on metformin may also consider adding single-agent linagliptin (Trajenta) in place of a fixed-dose combo.

Glucagon-like peptide-1 (GLP-1) therapies provide larger A1C and weight reductions but are injections. Options include tirzepatide in the Mounjaro® Vial, or weight-management-focused agents such as Zepbound®. These are not direct substitutes for Jentadueto but may be considered for patients needing additional A1C lowering and weight loss support.

Basal and mealtime insulin are effective alternatives when oral agents are insufficient. Some patients use rapid-acting insulin, such as Apidra, around meals; see our listing for Apidra® Vials for more details. Choice of therapy depends on A1C goals, hypoglycemia risk, weight considerations, and comorbidities. For background on the condition, see our overview of Type 2 Diabetes.

Combination Therapy

• With SGLT2 inhibitors (for example, empagliflozin) to improve A1C and support weight and cardiovascular benefits.
• With basal insulin when oral agents alone do not meet A1C targets.
• With GLP-1 receptor agonists in selected patients needing additional A1C reduction.
• With sulfonylureas; consider lowering sulfonylurea dose to reduce hypoglycemia risk.
• With statins, ACE inhibitors, or ARBs for cardiovascular risk management as prescribed.
• Metformin may be paused around iodinated contrast procedures if directed.

Patient Suitability and Cost-Saving Tips

Good candidates include adults with type 2 diabetes who need dual oral therapy or a simplified regimen. It is not for type 1 diabetes or diabetic ketoacidosis. Avoid use in severe renal impairment. Caution is advised with hepatic disease, heart failure, heavy alcohol use, or conditions linked to hypoxia. A history of pancreatitis or bullous pemphigoid warrants careful consideration. Pregnant or breastfeeding patients should review all options with their clinician.

To manage costs, compare jentadueto 2.5 1000 mg price to jentadueto 2.5 500 mg price and jentadueto XR cost to match dosing needs. If budget planning for jentadueto cost without insurance, a 90-day supply can lower the monthly average. You can order online, or by phone where available, and use customer-service chat during posted hours for order help. Set a reminder before your last refill so you can reorder in time.

For patients with hypertension or vascular risks, lifestyle measures support overall health; you can read more in our article How To Treat Hypertension Effective Methods And Tips. Explore broader diabetes topics in Diabetes and Diabetes Mellitus categories.

Authoritative Sources

Boehringer Ingelheim Jentadueto product information

FDA Prescribing Information for Jentadueto and Jentadueto XR

Health Canada Drug Product Database: Jentadueto

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This page is educational and does not replace medical advice from your healthcare professional.