Adalat XL® (nifedipine extended-release) for hypertension and angina

What Adalat XL® Is and How It Works

Adalat XL® is the brand name for nifedipine extended-release tablets. It is a dihydropyridine calcium channel blocker used to treat high blood pressure and chronic stable angina. The extended-release tablet provides once-daily dosing. It lowers blood pressure by relaxing vascular smooth muscle and reducing peripheral resistance. It also improves oxygen supply-demand balance in the heart. Many patients search for adalat xl without insurance options to manage long-term therapy costs.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Orders are reviewed by licensed pharmacists before dispensing, and you can order online. Our customer-service chat is available during posted office hours, and pharmacists can address medication questions. We work with licensed, audited partner pharmacies to source authentic brand medicines at fair Canadian prices and with a wide selection.

Adalat XL® tablets use a gastric retention and osmotic delivery system that releases nifedipine slowly across the day. This helps reduce blood pressure variability and may improve tolerability versus immediate-release forms. It is not meant for acute angina attacks or hypertensive emergencies.

Dosage and Usage

• Typical adult starting dose for hypertension: 30 mg once daily. Some patients start at 60 mg once daily based on response and tolerance.
• Maintenance dose: 30–90 mg once daily. Maximum dose is usually 120 mg once daily.
• For chronic stable angina, similar dosing ranges are used under prescriber guidance.
• Tablets should be swallowed whole with liquid. Do not crush, chew, or split.
• Take at the same time each day, with or without food. Avoid grapefruit or grapefruit juice.
• Titration often occurs at 7–14 day intervals to reach blood pressure or angina goals.
• Missed dose: it may be taken when remembered unless the next scheduled dose is near; do not double doses.

• Storage: store at 15–30°C (59–86°F) in a dry place.
• Travel: keep tablets in original packaging in your carry-on. Bring enough for your trip plus a few extra days.
• Refills: set reminders so your supply does not run out. You can use your YouDrugstore account for reorder prompts.

A harmless tablet shell may pass in the stool. This is the empty delivery matrix and does not mean the dose was missed.

Benefits and Savings

Adalat XL® offers once-daily control, steady nifedipine levels, and proven blood pressure reduction. It may reduce angina frequency and improve exercise tolerance. The extended-release design can lower the risk of rapid blood pressure drops seen with short-acting forms. Many patients appreciate its predictable profile and simple routine.

You can buy at Canadian prices and often save 60–80% versus common US retail. This can help patients paying without insurance maintain therapy. YouDrugstore offers brand and select generics, with online ordering and friendly help if questions arise.

Side Effects and Safety

• Common: headache, flushing, dizziness, lightheadedness, peripheral edema (ankle swelling), fatigue, nausea, heartburn, palpitations.
• Less common: constipation, rash, nasal congestion, gingival overgrowth, muscle cramps.
• Serious: severe hypotension, fainting, worsening angina or rare myocardial infarction on initiation or dose increase (especially in severe coronary disease), shortness of breath, allergic reaction, liver enzyme elevation.

Contraindications include known hypersensitivity to nifedipine and use in cardiogenic shock. Use with caution in severe aortic stenosis, advanced heart failure, or marked hypotension. Drug interactions are important. Strong CYP3A4 inhibitors can increase levels (for example, clarithromycin, erythromycin, azole antifungals, protease inhibitors). Strong inducers can reduce levels (for example, rifampin, carbamazepine, phenytoin, St. John’s wort). Avoid grapefruit products, which raise nifedipine exposure. Alcohol may enhance blood pressure lowering. Monitor when used with other antihypertensives, nitrates, or beta blockers.

Pregnancy and lactation considerations require prescriber guidance. Dose adjustments may be needed in hepatic impairment. Do not switch between immediate-release and extended-release forms without clinical supervision.

Onset Time

Nifedipine extended-release begins to lower blood pressure on the first dose, with a gradual effect over the day. Symptom improvement in angina may appear within several days. Full antihypertensive effect is often reached after 1–2 weeks of steady dosing, and sometimes longer during titration.

Compare With Alternatives

Amlodipine is another once-daily dihydropyridine calcium channel blocker. It has a long half-life, similar blood pressure reduction, and a low risk of reflex tachycardia. Peripheral edema can occur with both agents, sometimes slightly more often with higher doses. Some patients respond better to one agent than the other.

Felodipine extended-release is a related option. It offers once-daily dosing and comparable efficacy, with a similar side-effect profile. Choice may depend on response, tolerability, and prescriber experience.

Diltiazem extended-release is a non-dihydropyridine calcium channel blocker. It lowers blood pressure and heart rate and may be preferred when rate control is also desired. It has more potential for bradycardia and drug interactions with beta blockers. Nifedipine products generally do not slow the heart rate.

Generic nifedipine extended-release is available in many markets. Formulations differ, so products are not always interchangeable. Prescribers may prefer a specific brand or release system for consistent response.

Combination Therapy

Adalat XL® is commonly combined with ACE inhibitors or ARBs and thiazide diuretics for hypertension. These combinations target different mechanisms and can improve blood pressure control. For angina, it can be used with long-acting nitrates and beta blockers when appropriate, with monitoring for hypotension or edema. Lipid-lowering therapy, antiplatelet agents, and lifestyle changes are often part of a broader cardiovascular plan as directed by a clinician.

Patient Suitability and Cost-Saving Tips

Adalat XL® may suit adults who need steady, once-daily calcium channel blockade. It may be less suitable in severe aortic stenosis, very low blood pressure, or cardiogenic shock. Those with significant edema on high doses may need a dose change or a different class. Discuss options if liver disease, drug interactions, or pregnancy are present.

YouDrugstore offers competitive Canadian pricing and helpful support. Multi-month supplies can lower the per-month cost. Reorder reminders in your account help avoid gaps in therapy. For current promotions and bulk deals, see our adalat xl coupon page. Patients paying adalat xl without insurance can compare 30 mg and 60 mg pack sizes to find the best value.

Authoritative Sources

Review the manufacturer monograph on the Bayer Adalat XL product page for detailed product information. Health Canada listings can be found in the Drug Product Database entry for Adalat XL. For US-label guidance on nifedipine ER, see the FDA prescribing information for Procardia XL (nifedipine ER).

You can shop at YouDrugstore knowing each prescription is checked by a licensed pharmacist before dispensing. Order online, and use our chat during posted office hours if you need help. We offer prompt, express shipping from Canada to the US.

This information is educational and does not replace advice from your prescriber or pharmacist. Always follow the directions provided with your prescription and speak with a healthcare professional about your specific situation.