Adcirca® for Pulmonary Arterial Hypertension (PAH)

What Adcirca® Is and How It Works

Adcirca contains tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor approved for pulmonary arterial hypertension (PAH). It helps relax blood vessels in the lungs and decreases pulmonary vascular resistance. That can improve exercise capacity and symptoms. The usual route is oral tablets taken once daily. Many shoppers compare Adcirca 20 mg price early in treatment decisions, including Adcirca 20 mg price without insurance, to plan long-term therapy costs.

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For PAH, the standard dose is 40 mg once daily (two 20 mg tablets). Some people may start at 20 mg once daily based on kidney or liver function and drug interactions. Tadalafil has a long half-life, so levels remain steady with daily use. Adcirca belongs to the PDE5 inhibitor drug class, which increases nitric-oxide mediated vasodilation in the pulmonary circulation.

Dosage and Usage

• Recommended PAH dose: 40 mg once daily (two Adcirca 20 mg tablets). Swallow tablets with water, with or without food.
• Patients with moderate renal impairment may start at 20 mg once daily. Do not use in severe kidney disease unless your prescriber directs otherwise.
• In mild to moderate hepatic impairment, 20 mg once daily may be used. Avoid in severe hepatic impairment unless specifically advised.
• Take your dose at the same time each day to keep steady levels.
• If you miss a dose, take it when remembered unless it is near the next dose. Do not double doses.
• Avoid nitrates (e.g., nitroglycerin, isosorbide) and guanylate cyclase stimulators (riociguat). This combination can cause dangerous hypotension.
• Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin) can raise tadalafil levels; your prescriber may adjust the dose or avoid use.
• CYP3A4 inducers (e.g., rifampin, carbamazepine) can lower exposure and reduce efficacy.
• Limit grapefruit juice as it can increase tadalafil levels.
• Adcirca uses a once-daily schedule; do not split tablets to change the dose without prescriber guidance.

• Store at 20–25 °C (68–77 °F). Short excursions 15–30 °C (59–86 °F) are acceptable.
• Keep tablets in the original container, tightly closed, away from moisture and heat.
• When you travel, carry your medication in your hand luggage with a copy of your prescription.
• Do not store in a bathroom. Avoid direct sunlight and excessive humidity.
• Keep out of reach of children and pets.

Benefits and Savings

Adcirca for pulmonary hypertension offers once-daily dosing, which many find convenient. Clinical studies show improved 6‑minute walk distance and symptom relief when used as prescribed. The 40 mg target regimen supports steady coverage across the day.

Ordering Adcirca online from a Canadian pharmacy can reduce your monthly spend. Typical savings are 60–80% compared with many US retail prices. You may also reduce your Adcirca cost by choosing multi-month supplies, which often lower the per‑month total. We can send friendly reorder reminders so you stay on track. These options help if you are comparing Adcirca cash price or managing therapy without insurance.

We source through licensed, vetted international partner pharmacies when needed, offering authentic brand medicines, a broad selection, and affordable pricing.

For current promotions, see our Adcirca coupon page.

Side Effects and Safety

• Headache
• Flushing
• Indigestion or stomach discomfort
• Back pain
• Muscle aches
• Nasal congestion
• Dizziness

Serious but uncommon risks include a sudden drop in blood pressure (especially with nitrates), vision changes or sudden vision loss (non‑arteritic anterior ischemic optic neuropathy), sudden hearing decrease, and prolonged or painful erections (priapism). Seek emergency care for chest pain, fainting, or signs of an allergic reaction. Do not combine with nitrates or riociguat. People with recent heart attack or stroke, severe hypotension, or certain eye conditions may need alternative therapy. For more detail on tolerability, review Tadalafil Side Effects Common Rare And When To Worry.

Onset Time

Some people notice easier breathing and improved activity within 2–4 weeks as daily dosing stabilizes. Gains in walk distance and symptom scores typically accrue over 8–12 weeks. Clinical trials assessed outcomes over 12–16 weeks. Your prescriber may evaluate progress at regular intervals and adjust your plan if needed.

Compare With Alternatives

Sildenafil (Revatio for PAH) is another PDE5 inhibitor. It is usually taken three times daily rather than once daily. Some patients prefer Adcirca tablets for the simpler schedule, while others tolerate sildenafil better. Choice often depends on response, side effects, and dosing preferences.

Riociguat (Adempas) is a soluble guanylate cyclase stimulator. It should not be used with PDE5 inhibitors such as tadalafil Adcirca because of profound hypotension risk. It can be an alternative when a prescriber decides to switch classes.

Endothelin receptor antagonists such as macitentan or ambrisentan are also common options in PAH. These may be used alone or combined with a PDE5 inhibitor in appropriate patients to increase benefit. If you are reviewing tadalafil’s other indications, you can read What Is Erectile Dysfunction And How To Treat It.

Combination Therapy

• PDE5 inhibitor plus endothelin receptor antagonist (e.g., Adcirca with macitentan or ambrisentan) under specialist care.
• PDE5 inhibitor plus prostacyclin pathway therapy (e.g., inhaled or parenteral prostacyclins) for advanced disease.
• Diuretics for fluid management when indicated.
• Oxygen therapy if prescribed for hypoxemia.
• Anticoagulation only if your prescriber recommends it for a specific reason.
• Avoid with nitrates or riociguat. The combination can cause severe hypotension.

Patient Suitability and Cost-Saving Tips

Adcirca uses include treatment of PAH (WHO Group 1) to improve exercise ability and symptoms. It may not suit those taking nitrates, those on riociguat, or those with severe hypotension. People with recent myocardial infarction or stroke, unstable angina, severe hepatic disease, severe renal impairment, retinitis pigmentosa, or a history of non‑arteritic anterior ischemic optic neuropathy should discuss alternatives with their specialist. Men with anatomical penile deformation or conditions predisposing to priapism also need careful review.

Tell your prescriber about all medicines, including alpha‑blockers, antihypertensives, antifungals, HIV/HCV antivirals, antibiotics, seizure medicines, and herbal products. Grapefruit products can raise tadalafil levels. If you are pregnant, planning pregnancy, or breastfeeding, discuss PAH treatment risks and benefits with your care team.

To manage Adcirca price, compare Adcirca generic price where available and ask about multi‑month fills. Larger quantities can reduce the per‑month amount. You can turn on simple reorder reminders so you do not run out. If you are shopping without insurance, reviewing tadalafil Adcirca price against your budget can help you plan steady therapy.

Authoritative Sources

Adcirca official product site (United Therapeutics)

FDA Prescribing Information for Adcirca (tadalafil)

Health Canada Drug Product Database

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This page is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s directions for diagnosis, treatment, and monitoring.