Addyi® for Hypoactive Sexual Desire Disorder (HSDD) in Premenopausal Women

What Addyi® Is and How It Works

Addyi (flibanserin) is a nonhormonal prescription medicine for acquired, generalized hypoactive sexual desire disorder in premenopausal women. It is taken as an addyi 100 mg tablet once nightly at bedtime. Many shoppers compare addyi price and addyi pill cost, including the addyi cost without insurance, when planning therapy. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing.

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Flibanserin works on serotonin, dopamine, and norepinephrine receptors in the brain. It helps rebalance neurotransmitters that affect desire and sexual interest. It is not an on‑demand medicine and it is not a hormone. Addyi tablets are for daily use, and effects build over weeks. It is not approved for men or for use after menopause. For background on the condition, see Hypoactive Sexual Desire Disorder Hsdd In Premenopausal Women.

Dosage and Usage

• Standard dose: 100 mg (one addyi tablet) by mouth at bedtime.
• Do not take during the day. Bedtime dosing reduces risk of low blood pressure, dizziness, and sleepiness.
• Do not drink alcohol with addyi medication. Alcohol is contraindicated due to severe hypotension and syncope risk.
• Evaluate benefit after 8 weeks. If desire has not improved, prescribers often advise stopping.
• Missed dose: skip it and take the next dose at bedtime. Do not double the dose or take in the morning.
• Administration: swallow the addyi pill whole with water; take with or without food.
• Drug interactions: avoid strong or moderate CYP3A4 inhibitors (for example, ketoconazole, clarithromycin, ritonavir). Ask about other interacting medicines (including fluconazole).
• Health conditions: do not use in hepatic impairment. Use caution with low blood pressure, fainting history, or if taking other central nervous system depressants.

Storage and travel

• Store at 20–25 °C (68–77 °F); short excursions 15–30 °C (59–86 °F) are acceptable.
• Keep in the original blister until use. Protect from moisture.
• Travel with a copy of your prescription. Keep tablets in carry‑on bags.
• If temperatures may exceed 30 °C (86 °F), use an insulated pouch and avoid car trunks.
• Keep out of reach of children and pets.

Benefits and Savings

In clinical studies, more premenopausal women on flibanserin tablets reported improved sexual desire and reduced distress versus placebo. Daily bedtime dosing is simple, and tablets are small and easy to take. Addyi for women is not hormonal, so it avoids estrogen‑related effects. Many patients also value that it is taken daily rather than timed to sexual activity.

Ordering through Canadian pricing can lower the addyi cost by 60–80% compared with typical US pharmacy prices. This can help even for those paying without insurance. Multi‑month supplies often reduce the per‑month addyi price, and gentle reorder reminders can help you stay on schedule.

To see current offers, visit our promotions page: addyi coupon.

Side Effects and Safety

• Very common: dizziness, sleepiness, nausea, fatigue, insomnia, dry mouth.
• Common: anxiety, constipation, abdominal pain, vertigo, increased urination at night.
• Daytime somnolence may occur, especially if taken outside bedtime.
• Blood pressure can drop; fainting may happen, especially with alcohol or interacting drugs.

Serious or rare risks include severe hypotension and syncope, particularly with alcohol, moderate or strong CYP3A4 inhibitors, or in hepatic impairment. Stop the medicine and seek care if fainting, severe dizziness, or injury occurs. Risk of hypoglycemia is not a known concern with Addyi alone, but combined use with sedatives or antihypertensives may increase dizziness and falls.

Onset Time

Addyi is not an instant or on‑demand therapy. Some women notice early changes in desire and reduced distress by week 4. A meaningful benefit often requires 4–8 weeks of nightly dosing. If no improvement is seen after 8 weeks, prescribers usually discontinue. Results vary by individual history, co‑medications, and adherence.

Compare With Alternatives

Vyleesi (bremelanotide) is an on‑demand injection for premenopausal HSDD. It is used before anticipated sexual activity, rather than daily. Nausea and flushing are common. Addyi suits those who prefer a daily pill and nonhormonal approach, while Vyleesi suits those who want as‑needed use.

Non‑drug options include counseling, stress reduction, and addressing relationship or health factors. These may be used alone or with medication. Explore condition education in Hypoactive Sexual Desire Disorder Hsdd In Premenopausal Women.

Hormonal therapies are not indicated for premenopausal HSDD without other diagnoses. Addyi after menopause is not approved; discuss other options if symptoms occur post‑menopause.

Combination Therapy

• Addyi plus counseling or sex therapy: supports behavioral changes while medication addresses neurochemical balance.
• Avoid alcohol entirely during treatment to reduce hypotension and syncope risk.
• Avoid moderate/strong CYP3A4 inhibitors; consider alternative agents to prevent interactions.
• Use caution with CNS depressants; combined sedation can impair driving and increase falls.
• Do not combine with other HSDD prescription therapies without prescriber guidance.

Patient Suitability and Cost-Saving Tips

Candidates include premenopausal adults with acquired, generalized HSDD that causes distress, not explained by relationship issues, other mental health conditions, medical illness, or another medication. It is not for use in men, in pregnancy, or while breastfeeding.

Who should not use flibanserin 100 mg tablet: those with hepatic impairment; those who drink alcohol; those on moderate or strong CYP3A4 inhibitors; or those with a history of fainting with low blood pressure. Review all medicines, including over‑the‑counter and herbal products.

Ways to save: compare addyi cost and addyi discount options across quantities. Ordering a multi‑month supply can lower monthly spend. Reorder reminders by email help you avoid gaps. If paying without insurance, look for bulk promotions to decrease the per‑tablet cost of addyi 100mg.

Authoritative Sources

FDA Prescribing Information for Addyi (flibanserin)

Manufacturer product page: Addyi

FDA Medication Guide for patients

Order Addyi® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express handling.

This material is educational and does not replace medical advice from your healthcare professional. Always follow your prescriber’s instructions and the official labeling.