Addyi® Tablets for Hypoactive Sexual Desire Disorder

What Addyi Is and How It Works

Addyi® contains flibanserin, a non-hormonal prescription medicine for acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal adults. It is taken daily to help increase sexual desire and reduce the distress related to low desire. This page explains how it works, who it may suit, and how to use it safely, with US delivery from Canada and options for those without insurance.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

Flibanserin acts on serotonin, dopamine, and norepinephrine pathways in the brain. By modulating these neurotransmitters, the treatment may help rebalance signals tied to sexual desire. It is not designed for use around sexual activity and is taken at bedtime to lower the risk of dizziness, sleepiness, and low blood pressure. For background on the condition itself, see our overview of Sexual Desire Disorder.

Who It’s For

This medicine is indicated for premenopausal adults with acquired, generalized HSDD, where low desire is not due to relationship issues, a medical or psychiatric condition, other medicines, or substance use. The Addyi pill is not for postmenopausal adults, men, or children. It is not a treatment for pain, dryness, or arousal disorders.

People who are pregnant or breastfeeding should discuss risks and benefits with a healthcare professional. If partners are exploring erectile concerns, see our guide to What Is Tadalafil, and for broader women’s health support, browse Womens Health.

Dosage and Usage

The usual schedule is one tablet at bedtime. Taking it at night helps reduce the risk of dizziness, sleepiness, and low blood pressure. Swallow the tablet whole with water. Do not take it with alcohol.

If you do not feel an improvement in desire or a reduction in distress after eight weeks, your prescriber may advise stopping. Do not drive or operate machinery for at least six hours after taking a dose. If you are unsure about your schedule, follow the official label or your prescriber’s instructions.

Avoid grapefruit or grapefruit juice, as it can increase levels of the medicine. If you use other therapies that cause sleepiness, talk with your prescriber about timing and safety.

Strengths and Forms

This therapy is supplied as a flibanserin 100 mg tablet in standard retail packaging. Availability can vary by market. Your prescription will specify the strength and quantity to dispense.

Missed Dose and Timing

If you miss a dose, skip it and take the next one at bedtime the following day. Do not take extra tablets to make up for a missed dose. Taking more than prescribed increases the chance of dizziness and fainting.

Storage and Travel Basics

Store tablets at room temperature in a dry place away from direct light. Keep the blister or bottle closed and out of reach of children. Do not store in a bathroom. If traveling, keep the original labeled container in your carry-on. Bring your prescription details for security checks. For long trips across time zones, continue taking your dose at local bedtime. If your itinerary is complex, ask your clinician how best to align the schedule.

Benefits

This daily therapy may increase sexual desire and lower the stress associated with low desire in appropriate candidates. It is non-hormonal, so it may be considered when estrogen therapy is not suitable. Taking it at night can fit predictable routines. Because flibanserin tablets are taken daily, you do not need to plan doses around intimacy.

Side Effects and Safety

• Dizziness or lightheadedness, especially after starting
• Sleepiness or fatigue
• Nausea or stomach upset
• Trouble sleeping
• Dry mouth
• Feeling faint

Serious reactions can include very low blood pressure and fainting, which are more likely with alcohol, certain antibiotics or antifungals, or liver disease. Stop the medicine and seek urgent care if you faint, cannot stay awake, or feel severely dizzy when standing. Mood changes can occur; contact your prescriber if you notice worsening depression or anxiety.

Drug Interactions and Cautions

Alcohol is contraindicated due to risks of severe low blood pressure and fainting. Avoid strong or moderate CYP3A4 inhibitors such as ketoconazole, itraconazole, clarithromycin, and some HIV protease inhibitors. Avoid CYP3A4 inducers like rifampin and carbamazepine, which can reduce effectiveness. Grapefruit and grapefruit juice may raise concentrations and should be avoided.

Use caution with other central nervous system depressants, including sedatives or sleep aids. The medicine is contraindicated in hepatic impairment. If you take antidepressants or other therapies that can affect sexual function, a medication review may help; see our overview on Fluoxetine Side Effects. Never start, stop, or change doses without professional guidance.

What to Expect Over Time

Many people evaluate benefit over several weeks of nightly dosing. If distress related to low desire does not improve by about eight weeks, your prescriber may decide to discontinue. Side effects like dizziness or sleepiness often appear early and may lessen with continued use. Keeping a brief symptom and wellness log can help you and your clinician track how you feel over time and make informed decisions.

Compare With Alternatives

Another FDA-approved option for HSDD is bremelanotide injection (on-demand use), which is administered differently and has its own safety profile. We also offer therapies for related issues that can contribute to discomfort, such as vaginal dryness in menopause. For example, Imvexxy Estradiol supports vaginal health when estrogen is appropriate. For context about sexual medicine in partners, see What Happens If and Generic Viagra. We also discuss contraception considerations in Nuvaring Benefits.

Pricing and Access

Canadian pharmacy options can help you compare Addyi tablet price and evaluate potential savings versus typical cash-pay rates. We provide clear pricing and secure checkout so you can plan refills confidently. With our cross-border model, orders Ships from Canada to US with tracking.

If you want to understand Addyi cost based on quantity, sign in to view current pricing on the product page. We use encrypted checkout, and your prescription is verified before dispensing. Looking for offers? See our current Promotions.

Availability and Substitutions

Supply can vary by manufacturer and pack size. If stock is limited, your prescriber may recommend a therapeutic alternative suited to your history and goals. When comparing flibanserin price across regions, focus on the strength, quantity, and any dispensing fees included. We will not substitute without your prescriber’s approval.

Patient Suitability and Cost-Saving Tips

You may be a candidate if you are a premenopausal adult with acquired, generalized HSDD and your clinician has ruled out other causes. You should avoid this medicine if you have liver problems, drink alcohol, or take certain CYP3A4 inhibitors. Always review your full medication list with your prescriber.

To manage costs long term, consider multi-month fills if appropriate, which can reduce per-fill fees. Set refill reminders so you do not run out unexpectedly. Keep tablets in one location at home and add a calendar note for nightly dosing. If your situation changes, schedule a check-in so your treatment plan stays aligned with your goals.

Questions to Ask Your Clinician

• Is my low desire consistent with HSDD based on the clinical definition?
• How will we assess benefit after several weeks of nightly use?
• Which medicines, supplements, or foods should I avoid with this therapy?
• What signs of low blood pressure or fainting should prompt urgent care?
• Could counseling or medication adjustments help alongside this treatment?
• How should I manage travel or shift-work so I can dose at bedtime?

Authoritative Sources

FDA DailyMed Prescribing InformationHealth Canada Drug Product DatabaseManufacturer Website

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