Afinitor® (everolimus) Tablets for Selected Cancers and TSC

What Afinitor® Is and How It Works

Afinitor® (everolimus) is an oral targeted therapy used for several cancers and certain tuberous sclerosis complex (TSC) conditions. Many people compare Afinitor 5 mg price and Everolimus 5 mg price when planning treatment costs, and we make those options clear at Canadian pricing. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and our pharmacists review prescriptions before dispensing. We also work with licensed, vetted international partner pharmacies to offer authentic brands and a broad selection at affordable prices.

Everolimus is the generic name; Afinitor is the everolimus brand name and everolimus trade name in oncology. The everolimus class of drug is an mTOR inhibitor. Its target is the mammalian target of rapamycin (mTOR), a key regulator of cell growth, angiogenesis, and metabolism. By inhibiting mTOR, everolimus can slow tumor cell proliferation and reduce blood vessel formation in tumors.

Approved uses include advanced renal cell carcinoma, progressive neuroendocrine tumors of pancreatic, gastrointestinal, or lung origin, and postmenopausal hormone receptor–positive, HER2‑negative breast cancer in combination with exemestane. It is also indicated for TSC-associated renal angiomyolipoma and subependymal giant cell astrocytoma (SEGA) when surgery is not an option. This page offers concise Afinitor patient information to help you discuss therapy with your care team.

Afinitor is taken as oral tablets once daily. Common adult dosing is 10 mg once daily; some patients use 5 mg once daily based on interactions or tolerability. Pediatric dosing for SEGA is based on body surface area. Your oncology team sets the exact dose and adjusts as needed.

For further background, see our article Afinitor® Uses How This Targeted Therapy Helps Fight Cancer or browse related care topics in Cancer. If you need the formal label, ask your provider for the Afinitor FDA label to review alongside the pharmacy insert.

Dosage and Usage

• Take Afinitor at the same time each day, with or without food. Keep the choice consistent.
• Swallow tablets whole with water. Do not crush, chew, or split.
• Typical adult dose: 10 mg once daily. Some patients use 5 mg once daily.
• Dose adjustments may occur with hepatic impairment or drug interactions.
• Avoid grapefruit or grapefruit juice. It can change everolimus levels.
• If you miss a dose, take it when remembered unless it is close to the next dose. Do not double doses.
• If vomiting occurs after a dose, do not redose. Resume the regular schedule.
• Keep regular blood tests for levels, counts, lipids, glucose, and kidney and liver function.

• Store at 20–25°C (68–77°F). Short excursions 15–30°C (59–86°F) are acceptable.
• Keep tablets in original packaging to protect from moisture. Close the container tightly.
• Store out of reach of children and pets. Keep dry and away from heat.
• For travel, pack in carry-on baggage with your prescription label.
• Do not leave medicine in a hot car. Avoid bathroom humidity.
• If a package is damaged or wet, consult the pharmacy before use.

Benefits and Savings

Everolimus treatment has shown progression-free survival benefits across several indications. In renal cell carcinoma and neuroendocrine tumors, many patients see slower disease progression versus placebo or prior standard care. In breast cancer, Afinitor combined with exemestane can improve response in certain hormone receptor–positive, HER2‑negative cases. Oral dosing once daily offers convenience compared to some infusion regimens.

Ordering through our Canadian pharmacy can reduce costs. Many customers report 60–80% savings versus typical US prices across both brand and generic for Afinitor. You can set gentle reminders in your account to reorder on time, and multi-month supplies can lower per‑month costs when your prescription allows. For current offers, see our promotions page for an Afinitor coupon.

We ship to the US with prompt, express shipping, and offer responsive customer-service chat during posted office hours.

Side Effects and Safety

• Stomatitis or mouth ulcers
• Rash, pruritus, or acneiform eruptions
• Fatigue or weakness
• Cough or shortness of breath
• Headache, dizziness, or taste change
• Nausea, vomiting, diarrhea, or abdominal pain
• Decreased appetite and weight loss
• Peripheral edema
• Infections, including upper respiratory infections
• Lab changes: anemia, low platelets, low white cells
• Lab changes: high blood sugar and high lipids

Serious risks may include non‑infectious pneumonitis, serious infections, kidney failure, impaired wound healing, mouth ulcers with secondary infection, and rare hepatic reactivation. Everolimus can cause embryo‑fetal harm. Avoid live vaccines during therapy. Concomitant ACE inhibitors may increase angioedema risk. Strong CYP3A4/P‑gp inhibitors or inducers can alter exposure; dose changes or alternatives may be required.

Everolimus can raise glucose, so diabetes management may change. It is not known to cause low blood sugar by itself. If used with insulin or sulfonylureas in appropriate cases, clinicians may reduce doses to limit hypoglycemia risk.

Onset Time

Everolimus reaches steady state in about one week, with a half‑life near 30 hours. Symptom relief is variable and depends on indication. Many patients see early tolerability effects, such as mouth sores, within the first two to eight weeks. Tumor response assessments often occur after 8–12 weeks and at regular intervals thereafter.

Metabolic changes, including glucose and lipid elevations, can appear within weeks. Blood counts can drop over the first cycles and then stabilize with monitoring and dose adjustments. Your oncology team will schedule imaging and lab checks to track progress.

Compare With Alternatives

Everolimus tablets 5mg and Everolimus tablets 10 mg represent the generic for Afinitor and contain the same active ingredient and strength options as the brand. Patients may switch between brand and generic per prescriber approval and local regulations.

Other targeted agents are used for different tumor types. For example, Zytiga® (abiraterone) is a hormonal agent for metastatic prostate cancer and is not an mTOR inhibitor. Bavencio® (avelumab) is an immune checkpoint inhibitor used in select urothelial and skin cancers. These medicines serve distinct indications and have different safety profiles.

Within the mTOR class, temsirolimus is an intravenous option used in specific kidney cancer settings. Choice among pathways, such as VEGF, mTOR, endocrine, or immunotherapy, depends on tumor biology and prior treatments. Discuss options with an oncology specialist.

Combination Therapy

• Postmenopausal HR+/HER2‑ breast cancer: everolimus plus exemestane.
• Renal cell carcinoma: everolimus may be paired with lenvatinib in certain settings.
• Neuroendocrine tumors: somatostatin analogs such as octreotide or lanreotide may be used in the care plan.
• When combining with agents that lower glucose, clinicians may adjust doses to reduce hypoglycemia risk.
• Review all concomitant drugs for CYP3A4/P‑gp interactions; modify doses or change therapy as advised by the prescriber.

Patient Suitability and Cost-Saving Tips

Afinitor may be suitable for adults with advanced renal cell carcinoma, progressive pancreatic, GI, or lung neuroendocrine tumors, or HR+/HER2‑ breast cancer when paired with exemestane. It is also used for TSC-associated renal angiomyolipoma and SEGA when surgery is not recommended. Your medical history, organ function, and prior therapies guide eligibility.

It may not be suitable for those with uncontrolled infections, recent major surgery, severe hepatic impairment without adjustment, or known hypersensitivity to everolimus or related compounds. Pregnancy and breastfeeding are not recommended during treatment. Reliable contraception is advised for both males and females of reproductive potential during therapy and for a time after the last dose as guided by the label.

Routine monitoring is key: complete blood counts, fasting glucose and lipids, renal and hepatic function, and assessments for stomatitis and pneumonitis symptoms. Report new or worsening cough, dyspnea, fever, or mouth pain promptly to your care team.

To reduce costs, consider multi‑month supplies when your prescription allows. Use account reminders so you reorder on time. We offer both brand and generic presentations, including Afinitor 10 mg and the common Afinitor 5 mg tablet strengths. You can compare strengths and formats under everolimus class of drug listings.

Authoritative Sources

Review the manufacturer details at Novartis Afinitor Healthcare Professional Site. For Canadian product information, see the Health Canada Drug Product Database: Afinitor. For US prescribing information and the Afinitor FDA label, consult DailyMed: Afinitor Prescribing Information.

Order Afinitor® from Youdrugstore.Com: add to cart, upload your prescription, and we ship with prompt, express shipping.

This page is educational and does not replace professional medical advice. Always consult your healthcare provider about diagnosis, treatment, and medication choices.