Amilzide® 5/50 mg Tablets for Edema and Hypertension

What Amilzide® Is and How It Works

Amilzide® is a prescription tablet that treats high blood pressure and edema. Each tablet contains amiloride 5 mg and hydrochlorothiazide 50 mg (Amilzide 5 50 mg). The two ingredients work in different ways inside the kidney. Hydrochlorothiazide increases urine output by reducing sodium reabsorption in the distal tubule. Amiloride blocks epithelial sodium channels, which helps conserve potassium. This balance reduces swelling and supports blood pressure control while limiting potassium loss. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing. If you need Amilzide without insurance, Canadian pricing can help lower out-of-pocket costs.

Amilzide® is usually taken by mouth once daily. It may be used when a thiazide diuretic caused low potassium, or when potassium conservation is desired. Many people prefer this fixed-dose combination because it simplifies therapy and reduces the need for separate potassium supplements. We also work with licensed, vetted international partner pharmacies to offer authentic brand medications, a wide selection, and affordable pricing.

Dosage and Usage

• Typical starting dose: one tablet (5 mg amiloride/50 mg hydrochlorothiazide) once daily, preferably in the morning.
• Your prescriber may adjust the dose. Some patients take divided doses to improve tolerance.
• Take with food or milk if stomach upset occurs. Swallow tablets with water.
• Try to take it at the same time each day. Avoid taking it right before bedtime.
• Do not use potassium supplements or salt substitutes unless your prescriber advises it.
• Missed dose: take it when remembered the same day. If it is close to the next dose, skip the missed dose. Do not double up.
• Lab monitoring may include potassium, sodium, kidney function, and uric acid.
• Stand up slowly to reduce dizziness. Increased urination is expected early in therapy.

• Store at 20–25 °C (68–77 °F). Excursions 15–30 °C (59–86 °F) are usually acceptable.
• Keep tablets dry in the original, child-resistant bottle. Protect from moisture and light.
• Do not freeze. Do not store in a bathroom or near a sink.
• When you travel, keep medicine in your carry-on in the labeled container with your prescription.
• Avoid leaving tablets in a hot car or in direct sun. Use a small insulated pouch in extreme temperatures.
• If a dose organizer is used, refill it in a clean, dry area and keep it closed.

Benefits and Savings

Amilzide® helps reduce blood pressure and swelling while conserving potassium. The fixed 5/50 mg strength gives steady diuretic action and helps avoid hypokalemia linked to thiazide therapy. One tablet may replace separate diuretic and potassium products, which can simplify your routine. Many people see better adherence with a single daily dose.

Ordering Amilzide tablets through our Canadian pharmacy can lower costs. Many customers save 60–80% compared with typical US prices. Savings can be meaningful for those paying cash or buying Amilzide without insurance. Multi-month quantities can reduce the per-month cost, and bulk promotions may offer extra value. You can set gentle reorder reminders so you do not run out.

To view current promotions, see our Amilzide coupon details.

Side Effects and Safety

• More frequent urination
• Dizziness or lightheadedness, especially when standing
• Nausea or stomach upset
• Headache
• Muscle cramps or weakness
• Fatigue
• Increased potassium levels
• Low sodium
• Higher uric acid or a gout flare
• Sun sensitivity or mild rash

Serious but uncommon risks include high potassium (hyperkalemia), severe dehydration, kidney problems, severe skin reactions, or a drop in blood pressure with fainting. The risk of hyperkalemia increases with ACE inhibitors, ARBs, aliskiren, spironolactone, eplerenone, trimethoprim, potassium supplements, or potassium salts. NSAIDs may reduce the diuretic effect. Lithium levels can rise. Hydrochlorothiazide can raise blood sugar and may worsen gout. This medicine does not cause low blood sugar on its own. Seek urgent care for severe weakness, irregular heartbeat, trouble breathing, or severe vomiting or diarrhea.

Onset Time

Diuretic action starts within hours of a dose. Swelling often improves over two to three days as fluid shifts. Blood pressure usually begins to fall within the first week. The full effect on blood pressure may take two to four weeks as the dose is stabilized and sodium balance resets. Potassium-conserving effects appear early and are tracked with periodic lab tests.

Compare With Alternatives

Hydrochlorothiazide alone is a common first-line option for blood pressure. It is effective and low cost, but it often lowers potassium. Some patients need potassium supplements or a second agent to offset this.

Chlorthalidone is a thiazide-like diuretic that lasts longer and can be more potent than hydrochlorothiazide. It may provide stronger blood pressure control, but low potassium and low sodium can be more frequent and may require careful monitoring or the addition of a potassium-sparing agent.

Triamterene/hydrochlorothiazide is another combination that conserves potassium. It has a similar role to amiloride/hydrochlorothiazide, but triamterene has its own interaction and kidney stone profile. Choice depends on your history, lab results, and prescriber preference.

Spironolactone is a potassium-sparing diuretic used in resistant hypertension and heart failure. It can cause breast tenderness or menstrual changes. It is helpful when aldosterone is a driver of hypertension but needs potassium monitoring, especially with ACE inhibitors or ARBs.

Loop diuretics such as furosemide are stronger diuretics for edema due to heart, liver, or kidney disease. They are not first-line for hypertension and can cause greater electrolyte shifts, requiring close follow-up.

Combination Therapy

• ACE inhibitor or ARB: often paired for hypertension; monitor potassium and kidney function. Doses may need adjustment to reduce hyperkalemia risk.
• Calcium channel blocker: complementary mechanism; helpful to reach blood pressure targets.
• Beta blocker: consider lower starting doses to limit dizziness or low blood pressure.
• Loop diuretic for edema: coordinate timing and monitor electrolytes to avoid dehydration.
• SGLT2 inhibitor in diabetes: monitor volume status; diuretics may enhance urination.

Patient Suitability and Cost-Saving Tips

Amilzide® may suit adults with hypertension or edema who developed low potassium on a thiazide or who need potassium conservation. It may not be appropriate with pre-existing high potassium, severe kidney impairment, or anuria. Use caution with significant liver disease. Review all medications for interactions, especially ACE inhibitors, ARBs, aliskiren, spironolactone, eplerenone, trimethoprim, potassium products, NSAIDs, and lithium.

People with diabetes should know that hydrochlorothiazide can raise blood sugar. Those with gout may see higher uric acid. Sun sensitivity can occur, so consider protective clothing and sunscreen. During illness with vomiting or diarrhea, contact a clinician about holding diuretics to reduce dehydration risk. Discuss pregnancy or breastfeeding with your healthcare provider to weigh risks and benefits.

To lower costs, compare brand and generic options and consider larger quantities. Multi-month fills can reduce the per-month Amilzide price. A planned Amilzide bulk order may also lower shipping cost per bottle. You can set a reorder reminder so you do not miss a dose. These approaches help if you are paying the Amilzide cash price or buying uninsured Amilzide. Always keep enough on hand for trips.

Authoritative Sources

DailyMed: amiloride hydrochloride and hydrochlorothiazide tablets labeling

Health Canada Drug Product Database (DPD)

FDA Drugs@FDA database

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This page is educational and does not replace advice from your own healthcare professional.