Apremilast

Please note: a valid prescription is required for all prescription medication.

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Apremilast is a prescription medication used to treat plaque psoriasis, psoriatic arthritis, and mouth ulcers in Behcet’s disease. Apremilast improves the symptoms of plaque psoriasis, including scaling, itching, and skin redness, and reduces symptoms in the nails and scalp. When used to treat psoriatic arthritis, apremilast helps reduce inflammation, joint swelling, and pain.

Benefits

Helps reduce joint pain, stiffness, and swelling in psoriatic arthritis
Improves red, scaly skin patches in moderate to severe plaque psoriasis
Can also be used for oral ulcers in Behçet’s disease
Non-biologic option — no injections required
Easy-to-take tablet form taken twice daily

Dosage

Usually started on a gradual dose increase over the first 5 days to reduce side effects
Maintenance dose is typically 30 mg twice daily
Take with or without food
Swallow tablets whole — do not crush or chew
Always follow the dosing plan your doctor gives you

Warnings and Precautions

May cause weight loss — monitor your weight during treatment
Can lead to depression or mood changes — tell your doctor if you feel unusually sad or anxious
Not recommended for people with severe kidney problems unless dose is adjusted
May interact with other medications — inform your doctor of all the medicines you take
Not advised during pregnancy or breastfeeding unless clearly needed

How to Use

Take exactly as prescribed, at the same times each day
Drink a full glass of water with each dose
If you miss a dose, take it as soon as you remember — if it’s close to your next dose, skip the missed one
Do not suddenly stop taking it without medical advice

Storage

Store at room temperature (20–25°C)
Keep tablets in their original container
Protect from moisture and heat
Keep out of reach of children

Side Effects

Common: diarrhea, nausea, headache, fatigue, loss of appetite
Other possible: weight loss, back pain, cold-like symptoms
Serious (seek help): mood changes, signs of allergic reaction (rash, swelling, trouble breathing), severe diarrhea or vomiting leading to dehydration

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