Arava

Please note: a valid prescription is required for all prescription medication.

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Arava (leflunomide) is a disease-modifying antirheumatic drug (DMARD) used to treat active rheumatoid arthritis and psoriatic arthritis. It works by suppressing the immune system and reducing inflammation, helping to slow disease progression and improve joint function and pain over time.

Benefits

Helps relieve symptoms of rheumatoid and psoriatic arthritis
Slows joint damage and disease progression
Improves physical function and quality of life
May be used alone or in combination with other DMARDs
Once-daily oral dosing for convenience

Dosage

Loading dose (optional): 100 mg once daily for 3 days
Maintenance dose: 20 mg once daily
A reduced dose of 10 mg daily may be used to improve tolerability
Tablets should be taken at the same time each day, with or without food
Dose adjustments may be necessary in patients with liver impairment

Warnings and Precautions

Not recommended during pregnancy—can cause severe birth defects
Women of childbearing potential must use effective contraception during and after treatment until the drug is cleared from the body
May cause liver toxicity—regular liver function monitoring required
Can suppress bone marrow function—monitor blood counts regularly
Increased risk of serious infections due to immune suppression
Not recommended in patients with severe liver disease or significant immunosuppression

Usage Instructions

Take exactly as prescribed, once daily
Can be taken with or without food
Do not stop treatment without consulting your doctor
If treatment needs to be stopped quickly (e.g., for pregnancy), a drug elimination procedure using cholestyramine or activated charcoal may be required
Keep all scheduled blood tests to monitor liver function and blood cell counts

Storage Information

Store at room temperature between 15°C and 30°C (59°F and 86°F)
Protect from moisture and light
Do not use past expiration date
Keep out of reach of children

Common Side Effects

Diarrhoea
Nausea or indigestion
Hair thinning
Rash or skin reactions
Elevated liver enzymes
More serious side effects may include liver damage, severe infections, or blood disorders

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