Baclofen Tablets (Generic Lioresal®) for Muscle Spasticity Relief

What Baclofen Is and How It Works

Baclofen is a prescription skeletal muscle relaxant used to reduce spasticity from conditions like multiple sclerosis and spinal cord injury. Oral tablets are commonly dispensed in 5 mg, baclofen 10 mg, and 20 mg strengths. It acts as a GABA-B receptor agonist that dampens spinal reflexes. This lowers the frequency and severity of muscle spasms and related pain. Many patients compare Baclofen cost without insurance when planning long-term therapy, and generic options can help.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Orders meet Canadian pharmacy standards, and a licensed pharmacist reviews each prescription before dispensing. We ship to the US and support safe, responsible access to needed medicines at Canadian prices.

We also source through licensed, vetted international partner pharmacies when appropriate, offering authentic brand medicines alongside generics, wide selection, and fair pricing. Baclofen is the generic for Lioresal®. It is taken by mouth, usually three times daily. Dosing is titrated to effect and tolerance.

Dosage and Usage

Baclofen dosing is individualized. Tablets are swallowed with water. Food or milk may reduce stomach upset. Do not stop suddenly due to withdrawal risks.

• Typical initiation: 5 mg three times daily.
• Titrate by 5 mg per dose every 3 days based on response.
• Usual effective range: 40–80 mg per day in divided doses.
• Maximum labeled dose: 80 mg per day.
• Older adults and those with kidney impairment often need slower titration and lower doses.

Missed dose guidance:

• If a dose is missed, take it when remembered unless it is close to the next dose.
• If near the next dose, skip the missed dose and resume the schedule.
• Do not double up.

Other practical tips:

• Swallow tablets whole. Some strengths are scored; splitting should follow prescriber directions.
• Alcohol and other sedatives can increase drowsiness and dizziness.
• Use caution with driving or tasks that require alertness, especially during titration.
• In kidney impairment, monitoring and dose adjustments are often required.

Storage and travel:

• Store your tablets at 15–25°C (59–77°F) in a dry place.
• Keep your medication in the original, child-resistant bottle.
• Protect your supply from moisture and direct heat.
• When traveling, keep your medication in your carry-on with the prescription label.

Benefits and Savings

Baclofen helps reduce muscle spasm frequency and intensity. Many patients report less pain, better sleep, and improved mobility in daily tasks. It is a long-used option for spasticity linked to multiple sclerosis and spinal cord injury. Some clinicians also use it for persistent hiccups when standard measures fail.

Tablets are available in multiple strengths, which supports careful dose titration. Generic baclofen offers significant cost relief, often delivering 60–80% savings compared with typical US prices. That can make treatment more accessible even without insurance. YouDrugstore offers Canadian pricing and clear product selection to help match your prescription needs.

Side Effects and Safety

Most side effects are dose related and may lessen after dose adjustments. Seek medical help for severe or persistent symptoms.

• Common: drowsiness, dizziness, weakness, fatigue, headache, nausea, constipation, dry mouth, insomnia.
• Less common: hypotension, confusion, clumsiness, blurred vision, increased urination, edema.
• Serious: hallucinations, severe confusion, breathing problems, seizures, fainting, mood changes.
• Allergic reaction: rash, itching, swelling, severe dizziness, trouble breathing.
• Withdrawal (if abruptly stopped): agitation, hallucinations, seizures, rapid return of severe spasticity.

Drug interactions can occur with alcohol, opioids, benzodiazepines, sedating antihistamines, or other central nervous system depressants. Kidney function affects baclofen clearance, so reduced dosing is often needed in renal impairment. Discuss pregnancy, breastfeeding, or plans to conceive with a clinician. Avoid abrupt discontinuation; any taper should be supervised.

Onset Time

Oral baclofen usually starts to reduce spasm frequency within about 1 hour, with peak effect around 2–3 hours after a dose. A steadier response often appears over several days as doses are adjusted. Optimal benefit may take 1–2 weeks or more during careful titration.

Compare With Alternatives

Several medicines can treat muscle spasticity. Choice often depends on cause, side effects, interactions, and coexisting conditions.

Tizanidine reduces spasticity through alpha-2 agonist effects. It may cause more hypotension and dry mouth, and it is processed by the liver, so interactions can be important.

Cyclobenzaprine is often used for short-term muscle spasm after injury. It is chemically similar to tricyclic antidepressants and can cause dry mouth and daytime sedation. It is not usually favored for long-term neurologic spasticity.

Methocarbamol is another option for acute musculoskeletal spasm. It can cause dizziness and sedation but is often used in short courses.

Diazepam reduces spasm but has dependence and sedation risks, so many clinicians use it sparingly.

For severe, refractory spasticity, intrathecal baclofen (not oral) may be considered. Brand options such as Lioresal® and Gablofen® exist for intrathecal use. This approach requires specialized assessment and device management.

Combination Therapy

Baclofen is often part of a broader plan. Physical therapy, stretching, and occupational therapy can improve mobility and function. Analgesics such as acetaminophen or NSAIDs may be used for pain relief if appropriate. Combining multiple sedating agents increases risk; clinicians often avoid overlapping therapies that depress the central nervous system.

Patient Suitability and Cost-Saving Tips

Baclofen may suit adults with spasticity from multiple sclerosis, spinal cord injury, or other neurologic causes. It can help those with painful spasms that limit daily activities. People with significant renal impairment usually need lower doses and close monitoring. Those sensitive to drowsiness may require slower titration.

Safety notes: avoid abrupt discontinuation. Report new confusion, mood changes, or breathing problems. Discuss alcohol use. Let prescribers know about all medicines and supplements.

Ways to manage costs:

• Ask your prescriber about a multi-month supply; longer fills can lower per-month cost.
• Use our reorder reminders to stay on track and prevent gaps.
• Generic strengths (5 mg, 10 mg, 20 mg) may allow tablet splitting when prescribed, which can reduce waste.
• Check promotions before checkout; bulk options can reduce total cost.

For current promotions and bulk options, see our Baclofen coupon page. If you are paying cash, options at Canadian pricing can help when managing therapy Baclofen without insurance. Our customer-service chat is available during posted office hours, and pharmacists can address medication questions.

Authoritative Sources

FDA DailyMed: Baclofen Tablets Prescribing Information

Health Canada Drug Product Database: Baclofen

Lioresal® (baclofen) Canadian Product Monograph

You can order online through YouDrugstore, a licensed Canadian pharmacy. Prescriptions are checked by licensed pharmacists before dispensing. We offer friendly support and US shipping with prompt, express, cold-chain shipping options for temperature-sensitive medicines.

This content is for general information. It does not replace care from your own healthcare professional. Always follow your prescriber’s instructions and your local regulations.