Baraclude

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Baraclude (entecavir) is an antiviral medication used for the treatment of chronic hepatitis B virus (HBV) infection in adults and children aged 2 years and older. It works by inhibiting the replication of HBV, helping to reduce liver inflammation, lower viral load, and prevent liver damage such as cirrhosis and liver cancer.

Benefits

Effectively suppresses hepatitis B virus replication
Helps improve liver function and reduce liver inflammation
Reduces the risk of complications like cirrhosis and hepatocellular carcinoma
Well-tolerated with a low risk of resistance when used properly
Available in tablet and oral solution formulations

Dosage

Adults (treatment-naive or lamivudine-resistant):
- Treatment-naive: 0.5 mg once daily
- Lamivudine-resistant: 1 mg once daily
Children (≥2 years, ≥10 kg): Dose based on weight (oral solution or tablets)
Should be taken on an empty stomach (at least 2 hours before or after a meal)
Dose adjustment required for patients with renal impairment

Warnings and Precautions

May cause lactic acidosis and severe hepatomegaly with steatosis—monitor closely
Risk of exacerbation of hepatitis B after stopping treatment—discontinue only under medical supervision
Use with caution in patients with kidney disease—dose adjustment may be necessary
Long-term use may lead to resistance in some patients, particularly with prior antiviral exposure
Safety during pregnancy not fully established—use only if benefits outweigh risks

Usage Instructions

Take at the same time each day on an empty stomach
Do not skip doses—adherence is critical to prevent viral resistance
If a dose is missed, take it as soon as remembered unless it is close to the next dose
Do not stop treatment without medical advice
Continue regular blood tests to monitor liver enzymes and HBV DNA levels

Storage Information

Store tablets and oral solution at room temperature between 15°C and 30°C (59°F and 86°F)
Protect from light and moisture
Use oral solution within the expiration date provided
Keep out of reach of children

Common Side Effects

Headache
Fatigue
Dizziness
Nausea
Insomnia
Elevated liver enzymes may occur in some patients
More serious side effects include lactic acidosis, liver enlargement, and post-treatment flare of hepatitis

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