Braftovi

Braftovi is a targeted cancer therapy known as a BRAF inhibitor, used in the treatment of specific types of cancer that involve a BRAF V600E or V600K gene mutation. It works by blocking the activity of the mutated BRAF protein, which helps slow or stop the growth of cancer cells. Braftovi is commonly used in combination with other medications, such as binimetinib (for melanoma) or cetuximab (for colorectal cancer).

Benefits

• Improves overall survival and progression-free survival in patients with BRAF V600E/K-mutant melanoma and BRAF V600E-mutant metastatic colorectal cancer.
• Directly targets cancer cells with BRAF V600 mutations, helping to reduce tumour growth and spread.
• Offers a precision medicine approach with fewer off-target effects than traditional chemotherapy.
• When combined with other targeted agents, helps delay the development of resistance.
• Better tolerability profile compared to some other BRAF inhibitors, with a lower incidence of fever and skin reactions.
• Administered orally, allowing for at-home treatment without hospital visits.

Dosage

• Melanoma (with binimetinib): Recommended dose is 450 mg once daily (six 75 mg capsules).
• Colorectal cancer (with cetuximab): Recommended dose is 300 mg once daily (four 75 mg capsules).
• Dosage may be adjusted by a healthcare provider based on tolerance, side effects, and patient response.
• Taken orally, with or without food, at the same time each day.

Warnings and Precautions

• Only for patients with a confirmed BRAF V600 mutation; testing is required before starting treatment.
• May cause cardiac issues, including decreased heart function and QT prolongation. Cardiac monitoring is advised.
• Risk of new skin cancers (cutaneous squamous cell carcinoma). Regular skin checks are recommended.
• Can cause serious eye problems, including retinal detachment and uveitis; patients should report any vision changes immediately.
• May lead to liver toxicity; liver function tests should be monitored during treatment.
• Risk of bleeding complications, especially when used with cetuximab.
• Can mask symptoms of low blood sugar in diabetic patients; caution is advised.
• Not recommended during pregnancy or breastfeeding due to potential fetal harm. Effective contraception is required.
• Use with caution in patients with kidney or liver impairment.
• Should not be stopped suddenly without medical supervision.

Usage Instructions

• Take exactly as prescribed by your healthcare provider.
• Swallow capsules whole with water; do not crush or chew.
• Take at the same time each day to maintain consistent drug levels.
• If a dose is missed, take it as soon as possible unless it is near the time for the next dose. Do not double the dose to make up for a missed one.
• Continue treatment unless advised otherwise by a doctor, even if you feel well.

Storage Information

• Store at 20°C to 25°C (68°F to 77°F).
• Keep in the original packaging to protect from moisture and light.
• Do not store in the bathroom or near heat sources.
• Keep out of reach of children.

Common Side Effects

Mild effects: Fatigue, nausea or vomiting, rash, dry skin, or itching, joint or muscle pain, headache, constipation or diarrhea.

Serious effects (seek medical help): Irregular heartbeat or chest pain, vision changes, signs of liver problems (e.g., yellowing of skin or eyes, dark urine), severe , pain or bleeding, unexplained swelling or shortness of breath.