Cefoxitin for Injection (Cefoxitin Sodium) – Uses, Dosing, Safety

What Cefoxitin Is and How It Works

Cefoxitin for Injection is a cephamycin antibiotic (related to cephalosporins) used to treat many bacterial infections, including intra-abdominal, gynecologic, urinary tract, skin, and bone infections. It is supplied as cefoxitin sodium powder in vials for reconstitution, given by IV infusion or IM injection at intervals set by the prescriber. Patients often compare cefoxitin injection price without insurance when planning treatment access. YouDrugstore is a licensed Canadian pharmacy based in Manitoba that meets Canadian pharmacy standards, and our pharmacists review all prescriptions before dispensing.

We work with licensed, screened partner pharmacies internationally to provide authentic medications, a broad selection, and fair pricing for customers who want Canadian value. You can order online or by phone where available, and our friendly customer-service chat is open during posted office hours. Pharmacists are available to address medication questions related to your prescription.

Dosage and Usage

Dosing is individualized by infection type, severity, site of care, kidney function, and patient weight/age. Cefoxitin sodium injection is usually given every 6 to 8 hours. Typical adult totals range from 2 g to 12 g per day in divided doses. For surgical prophylaxis, a single preoperative dose is commonly used, with additional doses if surgery is prolonged. Pediatric dosing is by weight. Dose adjustments are usually needed in renal impairment.

• Administration: Reconstituted and diluted IV solutions are infused over a short period as directed. IM administration is an option for some patients.
• Course length: Therapy continues for the duration your prescriber recommends, often several days after symptoms improve.
• Missed dose: If infusions are coordinated at home and a dose is missed, contact the care team promptly for instructions. Do not double doses.
• Concomitant therapy: Cefoxitin may be used alone or with other antibiotics when mixed aerobic and anaerobic coverage is needed.

Storage and travel guidance:

• Store unopened vials at 15–25°C, dry, and protected from light.
• After reconstitution/dilution, follow the compounding label for stability and storage conditions. Some solutions need refrigeration and have short beyond-use times.
• Keep medication in the original carton with the label visible during travel.
• If a cooled pack is required for a prepared infusion, use an insulated bag and avoid direct contact with ice. Do not freeze.
• Carry supplies in hand luggage when flying. Bring a copy of the prescription and infusion schedule.

Benefits and Savings

Cefoxitin is active against many Gram-negative, Gram-positive, and anaerobic bacteria. It has proven efficacy in intra-abdominal infections, pelvic inflammatory disease, and surgical prophylaxis for colorectal and gynecologic procedures. In some settings it can simplify regimens by covering anaerobes without adding a separate agent. Hospital teams value its predictable pharmacology and broad clinical experience.

Ordering through YouDrugstore offers Canadian pricing on brand and generic medicines with secure checkout and support. Many customers report 60–80% savings versus typical U.S. prices, which can be meaningful for patients paying without insurance. We also offer helpful reorder reminders on request so you can plan upcoming therapy or supplies.

Side Effects and Safety

Most people tolerate cefoxitin well. Side effects can occur with any antibiotic.

• Common: GI upset (nausea, diarrhea), mild rash, pruritus, headache, injection site soreness or inflammation, transient liver enzyme changes.
• Less common: Positive Coombs test without hemolysis, mild eosinophilia, dizziness, vasculitis, or candidiasis.
• Serious: Severe allergic reactions (anaphylaxis), Stevens–Johnson syndrome, Clostridioides difficile-associated diarrhea, severe skin reactions, hemolytic anemia, seizures (usually with very high levels or renal impairment), significant liver injury, or serious bleeding events.

Allergy to cefoxitin, other cephamycins, or cephalosporins is a contraindication. Cross-reactivity can occur in patients with certain penicillin allergies. Kidney dosing adjustments are commonly required; monitoring is recommended in renal impairment and in the elderly. Probenecid can increase cefoxitin levels. Effects on coagulation may be seen with warfarin or other anticoagulants, so INR monitoring is often intensified. Cefoxitin can interfere with some lab tests (for example, certain urine glucose assays). Report severe diarrhea, rash, breathing trouble, or unusual bleeding promptly.

Onset Time

With effective therapy, symptom improvement often begins within 24 to 72 hours. Fever and pain trends help gauge response. Cultures, imaging, and labs guide duration and adjustments. Lack of improvement or worsening symptoms should prompt medical reassessment to confirm susceptibility, source control, or alternative diagnoses.

Compare With Alternatives

Cefoxitin is a cephamycin with reliable anaerobic activity, which distinguishes it from many first- and second-generation cephalosporins. It is comparable to cefotetan for many indications. Cefotetan may carry a higher risk of hypoprothrombinemia and a disulfiram-like reaction with alcohol due to its side chain; cefoxitin does not have that side chain. For surgical prophylaxis in colorectal procedures, cefoxitin or cefotetan are common choices based on local resistance patterns and availability.

Cefazolin plus metronidazole is a frequently used alternative to cover Gram-positive organisms and anaerobes when a cephalosporin alone is insufficient. Broader options such as piperacillin–tazobactam or a carbapenem may be selected for severe polymicrobial infections or when resistant organisms are suspected. The reference brand name for cefoxitin is Mefoxin® in some markets, and therapeutic decisions are guided by susceptibility, site of infection, and patient factors.

Combination Therapy

Combination therapy is often used when mixed flora are likely. For pelvic inflammatory disease, a common regimen is cefoxitin with doxycycline, with or without metronidazole for extended anaerobic coverage. In intra-abdominal infections, cefoxitin can be used alone for mild-to-moderate community-acquired disease if local resistance is low, or combined with other agents when broader Gram-negative coverage is required. The prescriber will tailor the regimen to culture results, penetration to the infection site, and patient comorbidities.

Patient Suitability and Cost-Saving Tips

Cefoxitin for Injection may be considered for adults and children with susceptible infections, including intra-abdominal and pelvic infections, skin/soft-tissue infections, UTIs, and bone/joint infections. It is not used for viral illnesses. Dose adjustments are standard in renal impairment. Cefoxitin has long clinical use in obstetric and gynecologic settings; the prescriber weighs benefits and risks in pregnancy or lactation. Pediatric dosing is weight based and guided by pediatric protocols.

Budget planning matters for infusion therapies. Customers often compare cefoxitin injection cost, cefoxitin injection cash price, and cefoxitin injection out of pocket estimates before starting treatment. Multi-month quantities and bulk purchases can reduce the per-month price when appropriate. We can send reorder reminders on request to help prevent therapy gaps.

For current offers and bulk options, see cefoxitin injection coupon. If you want background reading on abdominal conditions, our article The Abdomen Part Iii The Right Lower Quadrant provides general context. If you need to buy cefoxitin injection or arrange a cefoxitin vial purchase, our team can help with next steps online or by phone during office hours. This pharmacy also supports customers who must manage cefoxitin injection without insurance, with transparent pricing and support.

Authoritative Sources

Mefoxin® (cefoxitin) U.S. Prescribing Information

Health Canada Drug Product Database: Cefoxitin Listings

Drugs@FDA Database Search (cefoxitin)

YouDrugstore offers Canadian pricing on brand and generic medicines with caring service and pharmacist oversight. Order cefoxitin for injection online with confidence, and we will ship using prompt, express, cold-chain shipping practices as required by the product.

Disclaimer: This page provides general information and is not a substitute for professional medical advice. Always follow your prescriber’s directions and the dispensing label for dosing, preparation, and storage. Seek urgent care for severe reactions.