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Combivir® Tablets for HIV
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Combivir® is a prescription antiretroviral tablet used with other HIV therapies. It combines lamivudine and zidovudine to help suppress the virus. You can order from YouDrugstore for US delivery from Canada. If you self-pay, Lamivudine zidovudine cost without insurance is outlined below so you can plan your budget.
What Combivir Is and How It Works
YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.
This medicine contains two nucleoside reverse transcriptase inhibitors. Lamivudine blocks reverse transcriptase by mimicking natural nucleosides, and zidovudine interferes with viral DNA chain elongation. Together, they help reduce viral load when used as part of a combination regimen. The product is not a cure and should always be taken with other approved HIV treatments. Lamivudine zidovudine 150/300 mg tablets are intended for adults and adolescents who meet label criteria.
The combination may also help increase CD4 cell counts over time. Consistent dosing is important for maintaining activity and supporting your overall regimen. For guidance on related conditions, see HIV resources and our broader Antivirals category.
Who It’s For
This treatment is indicated, in combination with other antiretrovirals, for adults and adolescents living with HIV-1. It is not recommended for people who require dose adjustments of either component due to advanced kidney problems or significant blood disorders. Those with chronic hepatitis B should be monitored, as stopping lamivudine can lead to HBV flare.
Avoid use if you are allergic to lamivudine, zidovudine, or any tablet ingredient. People with a history of severe anemia, neutropenia, or myopathy should discuss risks with a healthcare professional. Breastfeeding is generally not recommended for individuals with HIV.
Dosage and Usage
The usual adult schedule is one tablet by mouth twice daily, taken with or without food. Swallow tablets whole with water. Take it at the same times each day to support adherence. Do not use as monotherapy; it must be part of a complete regimen as directed by your prescriber.
If you need an altered dose of lamivudine or zidovudine due to kidney impairment or blood toxicity, your prescriber may recommend the individual components instead of the fixed-dose tablet. Always follow the official label for complete instructions. Do not change your dose, stop treatment, or add other medicines without speaking with a clinician.
Administration tips:
- Take consistently twice daily to maintain drug levels
- Use a pill organizer to support routine
- If nausea occurs, try taking with a light snack
- Record other medicines you use and share the list with your prescriber
Strengths and Forms
The tablet is available as 150 mg lamivudine with 300 mg zidovudine per tablet. Pack sizes may differ by supplier and market; availability can vary.
Questions about Combivir tablets price often relate to pack count and dispensing pharmacy. We outline access details in the Pricing section below.
Missed Dose and Timing
If you miss a dose, take it as soon as you remember. If it is close to the next scheduled time, skip the missed dose and resume your regular schedule. Do not take two doses at the same time. Try setting reminders to help keep doses on track.
Storage and Travel Basics
Store tablets at room temperature in a dry place. Keep the bottle tightly closed and away from excess heat and moisture. Always keep out of reach of children and pets. When traveling, carry your medicine in hand luggage in the original labeled container, and bring enough for the full trip plus a buffer. A copy of your prescription or a pharmacy receipt can be helpful at security checkpoints. Our pharmacy uses temperature-controlled handling when required.
Benefits
As part of a complete regimen, this combination helps suppress HIV replication. Using two NRTIs in a single tablet can simplify treatment planning. The schedule is straightforward, which may support adherence when paired with appropriate third agents. Many people appreciate the familiarity and long clinical experience with these components.
Side Effects and Safety
- Headache or fatigue
- Nausea, vomiting, or abdominal discomfort
- Insomnia or dizziness
- Muscle aches
- Diarrhea
- Loss of appetite
Serious risks can include lactic acidosis, severe hepatomegaly with steatosis, anemia, neutropenia, and myopathy with prolonged use. People coinfected with hepatitis B may experience HBV exacerbations after stopping therapy that contains lamivudine. Pancreatitis and hypersensitivity reactions are uncommon but reported. Contact a clinician right away if you develop unusual weakness, persistent nausea, rapid breathing, dark urine, yellowing of the skin or eyes, or signs of infection like fever or sore throat.
Drug Interactions and Cautions
Tell your prescriber about all medicines, vitamins, and herbal products you use. Medicines that suppress bone marrow, such as ganciclovir or interferon, may increase hematologic risks with zidovudine. Ribavirin and doxorubicin can interact and are typically avoided with this combination. Do not take other products containing lamivudine or emtricitabine at the same time. Sorbitol-containing solutions may reduce lamivudine exposure. Alcohol misuse can increase liver risks. For an overview of common interaction patterns, see our guide on Drug Interactions.
What to Expect Over Time
When used as prescribed with a compatible regimen, viral load may decrease over weeks to months. You may not feel different day to day, so lab monitoring guides response. Adherence matters. Set reminders, pair doses with daily routines, and plan refills early. Your prescriber will monitor blood counts, liver enzymes, kidney function, and overall treatment response. Report persistent side effects, as supportive care or regimen adjustments may be considered by your care team.
Community resources can support testing, prevention, and care. For general awareness, visit our overview of HIV Testing Day.
Compare With Alternatives
Several complete or partial regimens may be appropriate depending on resistance, comorbidities, and prior therapy. Ask your clinician whether a single-tablet regimen like Delstrigo® fits your plan. For regimens using a protease inhibitor backbone, some patients may use products like Kaletra® Oral Solution when suitable. Learn more about background options in HIV Key Facts.
Pricing and Access
Canadian pharmacy pricing can offer meaningful value for US patients. We provide transparent information so you can compare options. Lamivudine zidovudine tablets cost depends on pack size and supplier. Generic lamivudine zidovudine price may differ from the brand depending on market and availability. Orders ship discreetly and securely, and your checkout is encrypted. For limited-time offers, visit Promotions. Your order Ships from Canada to US with prescription validation.
Availability and Substitutions
Supply can vary by manufacturer and batch. If this product is unavailable, your prescriber may recommend an equivalent regimen using separate components or a different NRTI backbone. Combivir tablet cost can also fluctuate with supply dynamics and pack sizes. We cannot guarantee restock dates, but our team can help you discuss alternatives with your clinician.
Patient Suitability and Cost-Saving Tips
This therapy may be appropriate if your clinician selects an NRTI backbone that includes lamivudine and zidovudine. It may not suit people who require dose adjustments or have significant hematologic toxicity. Ask about multi-month fills to reduce refill trips. Set reminders in your calendar for renewals and lab visits. If you self-pay, Self pay Combivir price can sometimes be reduced by choosing a generic when available and comparing pack sizes.
Questions to Ask Your Clinician
- Is this NRTI combination the best backbone for my regimen?
- What third agent pairs well with this tablet for my history?
- How will we monitor blood counts and liver health?
- What side effects should prompt a call or urgent visit?
- Could any of my current medicines interact with this treatment?
- If I need dose changes, can we use the individual components?
- What should I do if I miss a dose more than once?
Authoritative Sources
See official information from the manufacturer and regulators:
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How does this tablet fit into an HIV regimen?
It is an NRTI backbone that must be combined with other antiretrovirals selected by your clinician. The goal is to suppress HIV replication and support immune recovery. Choice of third agent depends on factors like resistance profile, tolerability, comorbidities, and prior treatment history. Your prescriber will also monitor lab values and overall response to ensure the regimen remains effective for you.
What serious risks should I know about before starting?
Serious risks include lactic acidosis, severe hepatomegaly with steatosis, anemia, neutropenia, and myopathy with prolonged use. People with hepatitis B may have flares after stopping lamivudine. Contact a clinician right away if you notice persistent nausea, unusual weakness, rapid breathing, or yellowing of the skin or eyes. Your healthcare professional may monitor blood counts and liver tests during therapy.
Can I take it with other medicines?
Tell your prescriber about all medicines and supplements. Some agents increase bone marrow suppression with zidovudine, such as ganciclovir and interferon. Ribavirin and doxorubicin can interact and are usually avoided. Products containing lamivudine or emtricitabine should not be taken together. Sorbitol-containing solutions may lower lamivudine levels. Your clinician will review your list and advise on safe combinations.
What if I miss a dose?
Take the missed dose as soon as you remember unless it is close to your next dose. If it is almost time for your next dose, skip the missed tablet and resume your schedule. Do not double up. Using reminders, pill boxes, and routine cues can help you take doses consistently. Ask your pharmacist for tips that fit your routine and travel plans.
How should I store it and travel with it?
Store at room temperature, away from moisture and heat, in the original container. Keep out of reach of children. When traveling, pack it in your carry-on with a copy of the prescription or receipt. Bring extra tablets for delays and keep dosing times consistent across time zones. Do not store in a car or a bathroom where temperature and humidity can fluctuate.
Is pregnancy or breastfeeding allowed with this treatment?
Use in pregnancy should be guided by your prescriber, considering benefits and risks. Medicines in this class have a long history of use in preventing transmission, but individual regimens vary. Breastfeeding is generally not recommended for people with HIV. Discuss family plans and alternatives with your healthcare professional so your regimen supports maternal and infant safety.
Can I split or crush the tablet?
The tablet is intended to be swallowed whole. Crushing or splitting can affect how the medicine is absorbed and is not recommended unless your prescriber specifically advises it. If swallowing is difficult, ask your clinician or pharmacist about suitable alternatives, such as using individual components or another regimen that better fits your needs.
