How should I take this tablet with meals?

Take one tablet once daily with a meal. A meal increases rilpivirine absorption and supports consistent exposure. Try to dose at the same time each day and avoid skipping food when you take it. If your schedule varies, plan a reliable mealtime and set reminders. If you have difficulty swallowing tablets, ask your clinician about safe administration options. Review the official label for detailed instructions and food requirements.

Can I use antacids or heartburn medicines with this regimen?

Proton pump inhibitors are not recommended with rilpivirine-containing regimens. H2-receptor antagonists and antacids may be used only if spaced appropriately from the dose per the official label. Timing helps maintain rilpivirine levels. Always tell your prescriber about all acid-reducing agents, including over-the-counter products and supplements, before combining them.

What are common side effects to watch for?

Common effects include nausea, headache, dizziness, abnormal dreams, and trouble sleeping. Some people report rash, diarrhea, or fatigue. Mood changes including depression can occur and should be discussed promptly. Rare but serious risks include kidney issues, liver problems, severe skin reactions, and bone mineral density loss. Read the patient information leaflet and contact a healthcare professional if you notice concerning symptoms.

What if I miss a dose or vomit after taking it?

If you miss a dose, take it with a meal as soon as possible. If it is close to your next scheduled dose, skip the missed dose and take the next one on time. Do not double up. If you vomit shortly after taking the tablet, check the official label for specific guidance and call your healthcare professional if you are unsure how to proceed.

Who should avoid this HIV-1 regimen?

People with confirmed resistance to any component, significant kidney impairment, or those needing proton pump inhibitors may need a different therapy. Discuss pregnancy, liver disease, and hepatitis B status with your prescriber. Your clinician will review your full medical history, labs, and co-medications to confirm whether this complete regimen is appropriate for you.

How do I store the tablets at home and when traveling?

Keep tablets at room temperature in the original, tightly closed container with the desiccant. Store in a dry place away from excess heat and moisture. When traveling, keep the bottle in your carry-on, bring the original label and a copy of your prescription, and plan doses around meals. Do not store in a bathroom. Use reminders to maintain your schedule.

Is there a generic or lower-cost version available?

Availability of generics can vary by region and time. In many markets, a direct generic for the fixed-dose combination may not be available. Your prescriber can advise on comparable complete regimens that fit your clinical profile. If cost is a concern, ask about multi-month fills, pharmacist support for reminders, and alternatives that align with your medical needs and budget.

Promotion

Complera

Complera® Tablets for HIV-1

HIV

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What Complera Is and How It Works

This fixed-dose tablet is a complete HIV-1 regimen for eligible patients. It combines three antiretrovirals in one pill taken once daily. You can access it with US delivery from Canada, which may help if paying without insurance. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

Complera® contains emtricitabine, rilpivirine, and tenofovir disoproxil fumarate (TDF). Emtricitabine and TDF are nucleoside/nucleotide reverse transcriptase inhibitors. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor. Together, they inhibit HIV-1 reverse transcriptase at two sites, which helps reduce viral replication when taken as directed. Learn more about the condition at our HIV page. Buy emtricitabine rilpivirine tenofovir online is a common search when comparing complete regimens, and we provide details below.

Who It’s For

This medicine is indicated as a complete regimen for adults and adolescents who meet label criteria. It may be used in people starting therapy with no known resistance to its components. It can also replace a stable regimen in those who are virologically suppressed and have no history of treatment failure. People with significant kidney disease, confirmed resistance, or who require proton pump inhibitors may need a different option. Discuss pregnancy, liver conditions, and hepatitis B status with a healthcare professional before use. For broader therapy options, see our Antivirals category.

Dosage and Usage

Take one tablet by mouth once daily with a meal. A meal improves rilpivirine absorption; do not take it on an empty stomach. Swallow the tablet whole with water. Try to take it at the same time each day. Do not change your prescribed schedule without consulting your prescriber. If acid-reducing therapy is needed, review the label and speak with a healthcare professional about appropriate timing. Keep regular lab monitoring as advised by your clinician.

Strengths and Forms

The tablet is supplied as emtricitabine 200 mg, rilpivirine 25 mg, and tenofovir disoproxil fumarate 300 mg in a single tablet, typically dispensed in bottles of 30. Availability may vary by jurisdiction and stock. Emtricitabine/rilpivirine/tenofovir DF tablets price questions often come up when comparing options and budgeting for ongoing therapy.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember with a meal. If it is almost time for the next dose, skip the missed one and resume your schedule. Do not take two tablets at the same time. If vomiting occurs within a few hours of dosing, consult the official label for instructions and contact your prescriber if unsure. Maintaining a consistent routine helps support treatment goals.

Storage and Travel Basics

Store tablets at room temperature in the original, tightly closed container. Keep the desiccant in the bottle and protect from moisture. Do not store in a bathroom. For travel, keep medicine in your carry-on with the original label and a copy of your prescription. Plan doses around meals when flying or changing time zones. Use a daily reminder to help maintain your schedule and avoid missed doses.

Benefits

This treatment offers once-daily dosing in a single tablet. Using one complete regimen can simplify routines compared with multi-pill combinations. Taking it with a meal may fit well with daily habits. The therapy may replace an existing suppressive regimen if label criteria are met, which can support continuity of care.

Side Effects and Safety

Common effects: nausea, headache, dizziness, abnormal dreams, trouble sleeping
Other reported: rash, fatigue, diarrhea, depression or mood changes

Serious or rare risks include severe skin reactions, liver problems, kidney issues, lactic acidosis, and bone mineral density loss. Worsening of hepatitis B can occur after stopping medicines that treat both HIV and HBV; do not discontinue without medical guidance. Seek urgent care for signs of severe rash, yellowing skin or eyes, dark urine, or thoughts of self-harm. Review the full safety profile in the official label.

Drug Interactions and Cautions

Proton pump inhibitors are contraindicated with rilpivirine. Space antacids and H2-receptor antagonists per label guidance. Strong CYP3A inducers, including rifampin, carbamazepine, phenytoin, and St. John’s wort, can reduce rilpivirine levels and should not be used together. Tell your prescriber about all medicines and supplements. Monitor renal function and bone health as advised. Discuss QT prolongation risk and depression history with your clinician. If you have chronic hepatitis B, do not stop therapy without medical supervision.

What to Expect Over Time

With consistent dosing and follow-up, many patients maintain viral suppression on a complete regimen that fits their profile. Your prescriber will monitor labs and tolerability and may adjust care if your needs change. Set reminders, pair dosing with a regular meal, and keep appointments to support long-term goals. If you experience side effects, contact a healthcare professional for guidance.

Compare With Alternatives

Some patients who are eligible for TAF-based therapy may consider Odefsey®, which uses a related backbone. Others may review NNRTI-sparing or different NNRTI options such as Delstrigo®, depending on history and lab results. Selection depends on resistance patterns, kidney and bone considerations, and co-medications. Your prescriber will decide which complete regimen is appropriate.

Pricing and Access

Canadian pricing can offer value for patients paying cash. Check today’s Complera price on the product page to review options. We also list Emtricitabine rilpivirine tenofovir price details to help you compare budgets for complete regimens. Ships from Canada to US for qualified orders with a valid prescription. For current deals, visit our Promotions page. See our article on alternatives like Delstrigo for broader context: Delstrigo Medication For HIV. For TAF-based comparisons, read Genvoya Medication Uses.

Availability and Substitutions

Supply can vary. If the product is temporarily unavailable, a prescriber may recommend a comparable complete regimen that suits your history. Order emtricitabine rilpivirine tenofovir discussions can help align expectations before any change. Do not switch or stop treatment without medical advice. Your pharmacist can coordinate with your clinician if alternatives are needed.

Patient Suitability and Cost-Saving Tips

This medicine suits patients who meet label criteria and can reliably take a daily tablet with a meal. It may not be right for those with significant renal impairment, confirmed resistance, or who require contraindicated acid-reduction therapy. Ask your clinician about bone and kidney monitoring if you have risk factors. Consider multi-month fills when appropriate, and set refill reminders so you do not run out. Some patients look at Complera cost per month when planning budgets and scheduling refills. Using one complete regimen may reduce separate copays and simplify adherence routines.

Questions to Ask Your Clinician

Meal requirements: what counts as an adequate meal for my dose?
Baseline labs: which tests confirm I’m a candidate for this regimen?
Interactions: how should I manage antacids or H2 blockers?
Monitoring: how often will kidney and liver labs be checked?
Switching: what factors would prompt a change to another regimen?
HBV status: how do we manage treatment if I have hepatitis B?
Travel: how should I time doses across time zones?

Authoritative Sources

FDA DailyMed Health Canada DPD Gilead Sciences

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View All FAQs

How should I take this tablet with meals?
Take one tablet once daily with a meal. A meal increases rilpivirine absorption and supports consistent exposure. Try to dose at the same time each day and avoid skipping food when you take it. If your schedule varies, plan a reliable mealtime and set reminders. If you have difficulty swallowing tablets, ask your clinician about safe administration options. Review the official label for detailed instructions and food requirements.
Can I use antacids or heartburn medicines with this regimen?
Proton pump inhibitors are not recommended with rilpivirine-containing regimens. H2-receptor antagonists and antacids may be used only if spaced appropriately from the dose per the official label. Timing helps maintain rilpivirine levels. Always tell your prescriber about all acid-reducing agents, including over-the-counter products and supplements, before combining them.
What are common side effects to watch for?
Common effects include nausea, headache, dizziness, abnormal dreams, and trouble sleeping. Some people report rash, diarrhea, or fatigue. Mood changes including depression can occur and should be discussed promptly. Rare but serious risks include kidney issues, liver problems, severe skin reactions, and bone mineral density loss. Read the patient information leaflet and contact a healthcare professional if you notice concerning symptoms.
What if I miss a dose or vomit after taking it?
If you miss a dose, take it with a meal as soon as possible. If it is close to your next scheduled dose, skip the missed dose and take the next one on time. Do not double up. If you vomit shortly after taking the tablet, check the official label for specific guidance and call your healthcare professional if you are unsure how to proceed.
Who should avoid this HIV-1 regimen?
People with confirmed resistance to any component, significant kidney impairment, or those needing proton pump inhibitors may need a different therapy. Discuss pregnancy, liver disease, and hepatitis B status with your prescriber. Your clinician will review your full medical history, labs, and co-medications to confirm whether this complete regimen is appropriate for you.
How do I store the tablets at home and when traveling?
Keep tablets at room temperature in the original, tightly closed container with the desiccant. Store in a dry place away from excess heat and moisture. When traveling, keep the bottle in your carry-on, bring the original label and a copy of your prescription, and plan doses around meals. Do not store in a bathroom. Use reminders to maintain your schedule.
Is there a generic or lower-cost version available?
Availability of generics can vary by region and time. In many markets, a direct generic for the fixed-dose combination may not be available. Your prescriber can advise on comparable complete regimens that fit your clinical profile. If cost is a concern, ask about multi-month fills, pharmacist support for reminders, and alternatives that align with your medical needs and budget.