Dasatinib (Sprycel®) Tablets for CML and Ph+ ALL

What Dasatinib Is and How It Works

Dasatinib is a tyrosine kinase inhibitor used to treat Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML) and Ph+ acute lymphoblastic leukemia (Ph+ ALL). It targets BCR‑ABL and SRC family kinases that drive cancer cell growth. Tablets are taken by mouth, usually once daily. Strengths vary, and so does dasatinib cost, which can differ by brand, strength, and supply size. YouDrugstore is a licensed Canadian pharmacy in Manitoba that meets Canadian pharmacy standards, and a pharmacist reviews each prescription before dispensing. We offer brand and generic options at Canadian prices, with online ordering and helpful customer-service chat during posted office hours.

We source authentic medicines through licensed, vetted partner pharmacies worldwide to keep selection broad and pricing accessible. Sprycel® is the original brand from Bristol Myers Squibb; several generics are also available from reputable manufacturers.

Dosage and Usage

Typical dosing depends on the disease phase and treatment plan. A hematology or oncology specialist sets the dose and adjusts it based on response and side effects.

• CML, chronic phase: common starting dose is 100 mg once daily.
• CML, accelerated or blast phase: common starting dose is 140 mg once daily.
• Ph+ ALL: often 140 mg once daily, sometimes within a multi‑agent regimen.
• Tablets are swallowed whole with water; do not crush, cut, or chew.
• May be taken with or without food.
• Avoid grapefruit or grapefruit juice.
• Acid-reducing drugs can lower absorption. Avoid proton pump inhibitors. If needed, separate antacids by at least 2 hours before or after dasatinib.
• If a dose is missed, skip it and take the next scheduled dose. Do not double up.

Storage and travel:

• Store your tablets at 20–25°C (68–77°F) in the original container.
• Keep your supply dry and away from light and moisture.
• Keep out of reach of children and pets.
• When you travel, carry your medicine in hand luggage with the label visible.
• Do not store your tablets in a hot car or bathroom.

Benefits and Savings

Dasatinib helps control Ph+ CML and Ph+ ALL by blocking BCR‑ABL signaling. Many patients achieve a complete hematologic response in the first months, with deeper molecular responses over time. Once‑daily dosing is convenient for long‑term therapy. Your care team monitors blood counts and disease markers and adjusts treatment as needed.

Buying through YouDrugstore can reduce costs. Many customers see 60–80% savings compared with typical US prices, depending on strength and brand. You can choose brand Sprycel® or a lower‑cost generic, when suitable for your prescription.

Side Effects and Safety

Dasatinib has known risks. A clinician should monitor blood counts, liver function, and disease response. This information supports discussions with your care team and does not replace their guidance.

• Common: headache, fatigue, diarrhea, nausea, skin rash, musculoskeletal pain.
• Blood effects: anemia, neutropenia, thrombocytopenia; may require dose changes or temporary holds.
• Fluid retention: peripheral edema, pleural effusion; report new or worsening shortness of breath.
• Infections: fever, chills, or signs of infection can occur with low white blood cells.
• Bleeding risk: nosebleeds, bruising; risk increases with anticoagulants or antiplatelets.
• Cardiac and lung: QT prolongation, pulmonary arterial hypertension; report chest pain, palpitations, fainting, or breathing issues.
• Liver: elevated liver enzymes. Report yellowing of skin or eyes, dark urine, or abdominal pain.
• Other: tumor lysis syndrome in high‑burden disease; careful monitoring may be needed.

Drug interactions are common. Strong CYP3A4 inhibitors or inducers can change levels. Acid suppression reduces absorption. Discuss all medicines, vitamins, and herbal products with a prescriber or pharmacist. Use effective contraception during treatment and for a period after the last dose. Do not breastfeed while taking dasatinib.

Onset Time

Some patients see symptom relief within weeks. A complete hematologic response often develops in 1 to 3 months. Cytogenetic and molecular responses may take several months or longer. Ongoing monitoring of BCR‑ABL transcripts guides long‑term goals.

Compare With Alternatives

First‑line and subsequent options for Ph+ CML include imatinib, nilotinib, bosutinib, and ponatinib. Choice depends on disease phase, risk score, mutation profile, comorbidities, and tolerance.

Compared with imatinib, dasatinib can induce deeper responses for some patients, but fluid retention and pleural effusion are more common. Nilotinib requires fasting windows and has metabolic and QT considerations; see Tasigna® for details on that option. Ponatinib is potent for certain BCR‑ABL mutations, but vascular risks are higher. Bosutinib often causes diarrhea early, which can be managed with supportive care.

Discuss goals, side‑effect profiles, and mutation testing with your hematologist to tailor therapy over time.

Combination Therapy

Dasatinib is used alone for most CML cases. In Ph+ ALL, it is often combined with chemotherapy or steroids in induction and consolidation phases. Supportive care may include antimicrobial prophylaxis, tumor lysis monitoring, and transfusions as needed. Avoid overlapping QT‑prolonging drugs when possible. Acid suppression strategies should be coordinated to preserve dasatinib absorption.

Patient Suitability and Cost-Saving Tips

Dasatinib is intended for adults and some pediatric patients with Ph+ disease, based on a prescriber’s judgment. Baseline cardiac history, pulmonary status, drug interactions, and blood counts help assess suitability. Prior pleural effusion, uncontrolled cardiac disease, or significant interactions may steer therapy toward another TKI.

Ways to save on therapy include choosing an appropriate generic when available, comparing strengths for the prescribed daily dose, and selecting a longer supply. Multi‑month packs can lower the per‑month price. You can turn on reorder reminders in your account so you do not run short. Our team can provide a quote for brand and generic options so you can decide what fits your budget and plan.

For education about related conditions, explore Chronic Myeloid Leukemia and broader Blood Cancer topics. You may also find these articles helpful for navigating oncology care: Common Darzalex Side Effects And Tips To Manage Them and Darzalex® Mechanism Of Action How It Treats Multiple Myeloma.

Authoritative Sources

Review official information for more detail:

• Sprycel (dasatinib) Prescribing Information from Bristol Myers Squibb
• Health Canada Drug Product Database: Dasatinib Entry
• FDA Label for Sprycel (dasatinib)

You can order securely from YouDrugstore. Our pharmacy team verifies your prescription and prepares your order with care. We offer prompt, express, cold-chain shipping to the US where required, and friendly support if you have questions about your order status.

This content is for general information only. It does not replace advice from your oncologist or pharmacist. Always follow the treatment plan set by your healthcare team.