Daxas® 500 mcg Tablets for COPD Maintenance

What Daxas® Is and How It Works

Daxas is the brand name for roflumilast, a once-daily tablet for chronic obstructive pulmonary disease (COPD). People often search for Daxas 500 mg price, but the marketed strength is 500 micrograms (mcg). It helps reduce COPD flare-ups in adults with severe COPD linked to chronic bronchitis and a history of exacerbations. Many patients also compare Daxas without insurance options to manage costs.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, where licensed pharmacists review each prescription before dispensing; you can order online or by phone, and chat support is available during posted office hours.

Daxas is a selective phosphodiesterase-4 (PDE4) inhibitor. By blocking PDE4, it lowers inflammatory activity in the airways. It is not a bronchodilator and does not work as a rescue medication for sudden breathing problems. It is used as maintenance therapy, often alongside inhaled bronchodilators.

The usual indication is to reduce the risk of COPD exacerbations in adults with severe COPD associated with chronic bronchitis and prior flare-ups. Clinical studies show modest improvements in lung function and fewer exacerbations over time.

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Dosage and Usage

• Usual adult dose: 500 mcg by mouth once daily, with or without food.
• Some clinicians use a 250 mcg lead-in for about 4 weeks to improve tolerability, then increase to 500 mcg once daily. The 250 mcg strength is not a maintenance dose.
• Swallow tablets whole with water. Do not crush or split.
• Take at the same time each day to build routine dosing.
• Not a rescue therapy. Keep a short-acting bronchodilator on hand for sudden symptoms.
• If a dose is missed and it is close to the next dose, skip the missed dose. Do not double up.
• Tell a healthcare professional about liver disease, mental health history, or low body weight before starting.
• Check for interactions with strong enzyme inducers or inhibitors (for example, rifampin, carbamazepine, phenytoin, or fluvoxamine).

• Store at room temperature (15–30°C / 59–86°F) in a dry place.
• Keep tablets in the original package to protect from moisture.
• Do not store in the bathroom. Keep away from children and pets.
• For travel, carry tablets in a cool, dry hand luggage compartment.
• If crossing time zones, keep a 24-hour spacing between doses.
• Do not freeze. Avoid prolonged heat exposure in cars or windows.

Benefits and Savings

Daxas helps reduce the number and severity of COPD exacerbations in appropriate patients. Some people notice modest gains in FEV1 and less cough and mucus over time. A once-daily tablet is convenient and can complement inhaled long-acting bronchodilators or triple therapy. Discuss Daxas efficacy and safety with a healthcare professional to see if it fits your COPD plan.

Ordering from Canadian pharmacies can lower your monthly spend. Typical savings are 60–80% compared with many US retail prices. We also support those managing Daxas cost without insurance by offering competitive pricing, optional multi-month supplies, and reminders so you can plan ahead.

Looking for extra value? See current offers on our promotions page under the single phrase daxas coupon.

Side Effects and Safety

• Common effects: diarrhea, nausea, stomach pain, decreased appetite, and weight loss.
• Headache, dizziness, or insomnia may occur.
• Back pain, muscle cramps, or mild tremor have been reported.
• Upper respiratory symptoms, cough, or sinus discomfort may occur.
• Some patients report anxiety or low mood.

Rare but serious risks include significant weight loss, severe diarrhea, mood changes, depression, or suicidal thoughts. Stop the medicine and seek medical attention if severe psychiatric symptoms appear. Daxas is contraindicated in moderate to severe liver impairment (Child-Pugh B or C). Use caution in those who are underweight or have a history of depression. Report any serious allergic reactions such as rash, swelling, or difficulty breathing.

Onset Time

Daxas works gradually. Lung function changes may be measurable after several weeks. Exacerbation risk reduction becomes clearer after consistent daily use for 8–12 weeks and continues over several months as part of a stable COPD regimen. It does not provide instant relief of breathlessness, so maintain any prescribed rescue inhaler for sudden symptoms.

Compare With Alternatives

Roflumilast is the only oral PDE4 inhibitor indicated for COPD exacerbation reduction. Inhaled long-acting bronchodilators (LABA, LAMA) remain first-line therapy for symptom control. Daxas is often added when exacerbations continue despite optimized inhaled therapy.

Inhaled corticosteroids can help select COPD patients with frequent exacerbations, often as part of triple therapy. For those using an inhaled steroid for airway inflammation, see the Qvar® Aerosol Inhaler page. Short-acting relievers such as Salbutamol support quick symptom relief but do not replace maintenance medicines.

Theophylline offers bronchodilation but has a narrow therapeutic range and more monitoring needs. Combining theophylline with roflumilast is generally avoided due to additive adverse effects and limited added benefit.

Combination Therapy

• Often used with a LAMA (for example, tiotropium) to reduce exacerbations.
• Commonly combined with LABA/LAMA dual therapy when exacerbations persist.
• May be used alongside ICS/LABA/LAMA triple therapy for high-risk patients.
• Avoid combining with theophylline due to increased side-effect risk.
• Review interacting drugs; adjust other COPD medicines if tolerability issues occur.

Patient Suitability and Cost-Saving Tips

Daxas is for adults with severe COPD associated with chronic bronchitis and a history of flare-ups. It is not intended for mild COPD or for acute bronchospasm. It may not be suitable for those with significant liver disease, active depression with suicidal thoughts, or those who are underweight. Discuss pregnancy and breastfeeding with a clinician.

To manage ongoing costs, consider larger fills when appropriate. Multi-month orders can lower the per-month price, and bulk promotions sometimes apply to tablet packs. Set reorder reminders in your account so you do not run short. These steps can help if you are paying Daxas out of pocket or comparing Daxas no insurance options.

Authoritative Sources

AstraZeneca Canada medicines page (manufacturer)

Health Canada Drug Product Database: roflumilast (Daxas)

FDA Prescribing Information: Daliresp (roflumilast)

Order Daxas® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This page is for educational purposes and does not replace professional medical advice. Always follow your prescriber’s directions.