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Daxas® (roflumilast) 500 mcg Tablet for Severe COPD
$96.99
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What Daxas® Is and How It Works
Daxas® (roflumilast) is a phosphodiesterase-4 (PDE4) inhibitor used as maintenance therapy in adults with severe chronic obstructive pulmonary disease (COPD) associated with chronic bronchitis and a history of frequent exacerbations. It is an oral tablet taken once daily. Many shoppers compare daxas 500 mg price and also look up daxas price without insurance when planning long-term therapy. Daxas is not a rescue bronchodilator and does not relieve sudden breathing symptoms.
YouDrugstore is a licensed Canadian pharmacy in Manitoba. Orders are reviewed by licensed pharmacists before dispensing, and you can shop brand and generic medicines at Canadian prices along with select OTC products. We offer secure online ordering and friendly customer-service chat during posted office hours. Our pharmacy partners are licensed and vetted, helping ensure authentic brand medications, a broad selection, and fair pricing.
Dosage and Usage
Daxas is prescribed by healthcare professionals for long-term reduction of COPD exacerbations. It targets airway inflammation and is used in addition to inhaled therapies.
- Usual adult dose: roflumilast 500 mcg by mouth once daily.
- Titration: some prescribers start at 250 mcg once daily for 4 weeks, then increase to 500 mcg to improve tolerability if a starter strength is available.
- Administration: may be taken with or without food; take at the same time each day.
- Missed dose: if a dose is missed, take the next dose at the usual time. Do not double doses.
- Not for acute symptoms: keep a fast-acting inhaler available as prescribed for sudden breathing issues.
- Contraindication: moderate to severe hepatic impairment (Child-Pugh B or C).
Storage and travel tips:
- Store at room temperature (15–30°C) in the original blister to protect from moisture.
- Keep tablets dry and away from heat, freezing, and direct sunlight.
- When traveling, carry your supply in a carry-on bag and keep a copy of your prescription.
- Use a daily pill organizer only if it stays dry and closes tightly.
- Keep out of reach of children and pets.
Benefits and Savings
Daxas reduces the rate of COPD exacerbations in suitable adults who remain symptomatic despite inhaled maintenance therapy. Studies show modest improvements in lung function and fewer flare-ups over time. The once-daily tablet is convenient and can fit into established inhaler regimens. It is not a steroid and does not cause bronchodilation.
You can order through YouDrugstore online or by phone (where available). Many US customers see 60–80% savings versus typical US retail prices, even without insurance. Reorder reminders help you avoid gaps, and multi-month supplies may lower the effective per-month cost when allowed by your prescription.
Our team can answer general product questions, and pharmacists are available to address medication questions related to your order.
Side Effects and Safety
Roflumilast affects inflammatory pathways and can cause gastrointestinal and neuropsychiatric effects. Many side effects lessen as treatment continues, though some require medical review.
- Common: diarrhea, nausea, stomach pain, headache, decreased appetite, weight loss, dizziness, trouble sleeping.
- Less common: vomiting, back pain, flu-like symptoms.
- Serious: new or worsening depression, anxiety, mood changes, suicidal thoughts, severe or persistent diarrhea, significant unintended weight loss, allergic reactions (rash, swelling, trouble breathing), and signs of liver problems (dark urine, jaundice).
- Drug interactions: strong CYP3A4/1A2 inducers (for example rifampin, carbamazepine, phenytoin, phenobarbital) may reduce effectiveness; strong inhibitors (for example ketoconazole, erythromycin, fluvoxamine) may increase exposure.
- Not recommended in moderate to severe hepatic impairment. Use caution in patients with a history of depression or underweight.
Report concerning symptoms to a healthcare professional. Emergency symptoms such as severe allergic reactions require urgent care.
Onset Time
Daxas does not work like a rescue inhaler. Modest improvements in lung function may appear within 1–2 weeks. Reductions in COPD exacerbations are typically evaluated over 4–12 weeks, with fuller benefits often seen by 3–6 months of continuous therapy. Continue prescribed inhaled maintenance treatments unless directed otherwise by a clinician.
Compare With Alternatives
Inhaled bronchodilators remain first-line maintenance therapy in COPD. Short-acting beta agonists such as Salbutamol are used for quick relief. Long-acting inhalers, including LABA/LAMA combinations and devices such as Ventolin® Diskus, help control daily symptoms.
Daxas provides an oral, non-steroid anti-inflammatory option for adults with severe COPD tied to chronic bronchitis and frequent flare-ups despite inhaled therapy. Some clinicians consider macrolide prophylaxis or theophylline in select cases; each has distinct side-effect profiles and monitoring needs. Unlike bronchodilators, roflumilast does not open airways acutely and should not replace rescue therapy.
Combination Therapy
Daxas is typically added to existing inhaled regimens, such as LAMA or LABA/LAMA with or without inhaled corticosteroids, to reduce exacerbation frequency. It complements but does not replace inhaled maintenance or rescue treatments. Selection and sequencing depend on exacerbation history, spirometry, symptoms, and risk factors. Weight, mood, and liver status should be monitored over time.
Patient Suitability and Cost-Saving Tips
Adults with severe COPD associated with chronic bronchitis and frequent exacerbations despite optimized inhaled therapy may be considered for roflumilast. It is not indicated for asthma or for sudden breathing symptoms. It is not established in pediatric patients. People with moderate to severe hepatic impairment should avoid use.
Cost planning helps with long-term therapy. Multi-pack or multi-month orders, when permitted by your prescription, can reduce per-month costs. Set up email reminders so you can reorder before supply runs low. For current offers and bulk options, see our daxas discount page. Customer-service chat is available during posted hours if you need help with checkout or shipping details.
Explore our condition resources for Chronic Obstructive Pulmonary Disease and Bronchitis. For deeper reading, see Daxas Key Uses Benefits And Side Effects To Know and Treatment And Medications For Acute And Chronic Bronchitis And Copd. Many patients find value even without insurance through Canadian pricing and careful refill planning.
Authoritative Sources
Review official information from regulators and manufacturers for comprehensive safety and prescribing details: see the Health Canada Drug Product Database and the European Medicines Agency Daxas EPAR.
YouDrugstore provides a simple ordering experience, pharmacist review of prescriptions, and prompt, express, cold-chain shipping where needed. Start your order online, or contact our team if you have questions about availability or shipping to your location.
This information is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional about your specific situation. A valid prescription is required. Product images, labels, and packaging may vary by manufacturer or country of origin.
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What is Daxas and what is it used for?
Daxas (roflumilast) is a PDE4 inhibitor used as maintenance therapy to reduce COPD exacerbations in adults with severe COPD associated with chronic bronchitis and a history of frequent flare-ups. It is taken once daily by mouth and is used along with inhaled maintenance therapies. It does not treat sudden breathing symptoms.
How long does Daxas take to work?
Daxas does not work like a rescue inhaler. Some lung function improvement can appear within one to two weeks, but reduced COPD flare-ups are usually assessed over several weeks. Many patients and clinicians expect clearer benefits after 4–12 weeks, with fuller effects by about three to six months of regular use.
What are common side effects of Daxas?
Common effects include diarrhea, nausea, stomach pain, headache, decreased appetite, weight loss, dizziness, and insomnia. Serious effects can include mood changes, depression, suicidal thoughts, severe diarrhea, significant weight loss, allergic reactions, and liver problems such as jaundice. Contact a healthcare professional if concerning symptoms occur or persist.
How much does Daxas cost without insurance?
Prices vary by source, quantity, and strength. Many compare the daxas 500 mg price when budgeting for long-term therapy. Buying through a Canadian pharmacy often lowers out-of-pocket costs, with potential savings of 60–80% versus typical US retail prices. Taxes, shipping, and promotions may affect your final price.
Can Daxas be taken with inhalers or other COPD medicines?
Yes. Roflumilast is usually added to inhaled maintenance therapies such as long-acting bronchodilators, with or without inhaled corticosteroids, to help reduce exacerbations. It does not replace a rescue inhaler. Clinicians consider history, spirometry, exacerbation frequency, and side-effect risks when combining treatments.
Is a prescription required to buy Daxas online?
Yes. A valid prescription is required. At YouDrugstore, prescriptions are reviewed by licensed pharmacists before dispensing. Orders can be placed online, and customer-service chat is available during posted hours if you need help with checkout, shipping options, or providing prescription details.
How should I store and travel with Daxas?
Store tablets at room temperature, 15–30°C, in the original blister to protect from moisture. Keep them dry and away from heat and sunlight. When traveling, keep your medicine in a carry-on bag, bring a copy of your prescription, and avoid leaving tablets in a hot car or checked luggage.