Visanne® (Dienogest) for Endometriosis: Uses, Dosing, and Safety

What Dienogest Is and How It Works

Dienogest is a progestin used to treat endometriosis. It helps reduce pelvic pain and bleeding by suppressing endometrial tissue growth. The usual form is a 2 mg oral tablet taken once daily. Many people search for dienogest online to access Canadian pricing and dependable supply to the USA. In Canada, 2 mg dienogest is approved for endometriosis. It is not approved by the FDA for this use, though estradiol valerate and dienogest are FDA-approved together in certain contraceptives.

YouDrugstore is a licensed Canadian pharmacy based in Manitoba, and pharmacists review prescriptions before dispensing. We also work with licensed, vetted international partner pharmacies so you can access authentic brand medicines, a wide selection, and fair pricing.

Dienogest lowers estrogen activity in endometrial tissue and directly opposes endometrial proliferation. This dual action eases inflammation and pain. The dienogest mechanism of action includes antiandrogenic effects and endometrial decidualization. Over time, lesions shrink and symptoms improve. Brands such as Bayer dienogest (Visanne) are well known in Canada and other regions.

The standard strength is dienogest 2 mg. Some markets list different strengths, such as dienogest 3 mg, but 2 mg is the most common dose for endometriosis therapy. Combination products also exist, including estradiol valerate and dienogest for contraception and heavy menstrual bleeding. Separate combined oral contraceptives may use dienogest with ethinylestradiol in specific regimens.

Dosage and Usage

• Typical regimen for endometriosis: 2 mg once daily, taken at the same time each day, with or without food. Follow the prescriber’s directions on duration.
• Start on any day, unless the prescriber advises alignment with a menstrual cycle day or switch from another therapy.
• Dienogest is not a contraceptive. Use a non-hormonal method if pregnancy prevention is needed.
• Missed dose: take one tablet as soon as remembered. Do not double the next dose. Resume the regular schedule.
• If vomiting or severe diarrhea occurs within several hours of dosing, a replacement tablet may be needed per prescriber guidance.
• When switching from other hormonal therapies, clinicians may give specific timing to reduce irregular bleeding.
• Do not stop abruptly without medical advice, especially if used for chronic symptom control.

• Store at 15–30 °C (59–86 °F) in the original blister to protect from moisture and light.
• Keep out of reach of children and pets.
• For travel, carry tablets in a purse or carry-on bag. Avoid leaving them in hot cars or checked luggage.
• Pack an extra strip for delays. Keep a copy of the prescription and pharmacy receipt.
• If crossing time zones, keep roughly the same 24-hour interval between doses.

Benefits and Savings

Dienogest helps reduce endometriosis pain, breakthrough bleeding, and dysmenorrhea. Many patients also notice fewer flare days and better daily function. The once-daily, continuous dosing is convenient. Compared with injectable options, tablets avoid clinic visits and refrigeration.

Buying dienogest generic from Canada can offer meaningful savings. Typical prices are 60–80% lower than many U.S. cash prices. Asking about multi-month supplies often lowers the per-month dienogest 2 mg price. You can also set gentle reorder reminders so therapy stays on track and shipping remains efficient.

Those looking for a dienogest 2 mg substitute or a specific manufacturer may compare options. We may carry products from well-known suppliers, including Sun Pharma and Aristo in some markets. Branded Bayer dienogest is available in certain regions, and Endovelle dienogest is known in others.

Side Effects and Safety

• Common: headache, breast tenderness, mood changes, acne or oily skin, nausea, abdominal discomfort.
• Menstrual changes: spotting, irregular bleeding, or lighter periods over time.
• Weight change, decreased libido, or fluid retention may occur.
• Skin changes such as mild acne may improve after the first few months.
• GI effects like bloating or constipation can happen and often ease with continued use.

Serious risks are uncommon but require attention. Avoid use during pregnancy. People with current or past thromboembolic events, hormone-sensitive cancers, liver tumors, active liver disease, or unexplained vaginal bleeding may not be candidates. Rare events include severe depression, significant blood pressure elevation, or cholestatic jaundice. Enzyme inducers (for example, rifampin, carbamazepine, phenytoin, St. John’s wort) can lower exposure and reduce effect. Strong CYP3A4 inhibitors can increase exposure. Discuss all medicines and supplements with a clinician.

Onset Time

Pain relief often begins within 4–8 weeks, with steady improvement through 3–6 months. Irregular bleeding or spotting is common in the first 1–3 cycles and tends to stabilize with continued use. Endometriosis-associated dysmenorrhea typically improves by three months. Optimal benefit may take several months, especially for chronic pelvic pain.

Acne or mood effects, if present, can appear early and may diminish over time. If side effects persist or worsen, clinicians may adjust therapy or consider alternatives.

Compare With Alternatives

Estradiol valerate dienogest is a combined oral contraceptive that regulates cycles and treats heavy menstrual bleeding. In the U.S., this combination is approved for contraception. It uses a multi-phase regimen and may suit patients seeking both cycle control and symptom relief.

Norethindrone acetate is another oral progestin commonly used for endometriosis pain. It can be effective but may differ in androgenic effects and bleeding patterns. Some patients respond better to one progestin than another.

Levonorgestrel intrauterine systems offer long-acting local progestin delivery. They can reduce pain and bleeding and avoid daily pills. Surgical options, including laparoscopy, remain important for selected cases, especially when medical therapy is insufficient.

Combined ethinyl estradiol products with dienogest exist in some countries. These may be labeled as a dienogest ethinyl estradiol brand or described as dienogest with ethinylestradiol. Some list strengths such as dienogest 2 mg ethinyl estradiol 30 mcg, depending on the formulation and market.

Combination Therapy

• Non-hormonal contraception is recommended if pregnancy prevention is desired, since dienogest alone is not a contraceptive.
• NSAIDs can be used for breakthrough pain as advised by a clinician.
• Avoid combining with estrogen-containing contraceptives unless directed, as this changes the risk profile and bleeding pattern.
• When enzyme-inducing drugs are required, clinicians may adjust plans or choose alternatives.

Patient Suitability and Cost-Saving Tips

Suitable candidates include those with confirmed endometriosis who need continuous symptom control and prefer oral therapy. People who cannot use estrogen or who want to avoid injections often consider dienogest 2 mg. It can be continued long term under medical supervision, depending on symptom response and tolerability.

People who may not be candidates include those with current or prior thromboembolic disorders, severe liver disease, hormone-sensitive malignancies, undiagnosed vaginal bleeding, or pregnancy. Breastfeeding and adolescent use require individualized clinical judgment and monitoring. A careful review of personal and family history helps guide safe selection.

For affordability, compare dienogest 2 mg generic options and available pack sizes. Multi-month supplies can reduce monthly costs and consolidate shipping. Ask customer service about current inventory from different manufacturers, such as dienogest 2 mg Sun Pharma or dienogest Aristo 2 mg, when available. Reorder reminders help prevent gaps in therapy.

If a clinician recommends a switch, options include estradiol and dienogest combinations or different progestins. Those in the U.S. who want Canadian pricing often search for dienogest USA sources. We ship to the U.S. with professional packaging and support through our customer-service chat during posted hours.

Authoritative Sources

Health Canada Drug Product Database (search for Visanne/dienogest)

FDA Prescribing Information for estradiol valerate/dienogest (U.S. contraceptive)

Bayer Pharmaceuticals – Women’s Healthcare Portfolio

Order Dienogest from Youdrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This material is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s directions and the patient information supplied with your medicine.