Cosopt® (Dorzolamide/Timolol) Ophthalmic Solution for Glaucoma and Ocular Hypertension

What Cosopt® Is and How It Works

Dorzolamide 2% / Timolol 0.5% Ophthalmic Solution is a fixed-dose combination used to lower intraocular pressure in open-angle glaucoma and ocular hypertension. Many people compare it to Cosopt®, the branded reference product. You can buy dorzolamide timolol ophthalmic solution online to fill a valid prescription. If paying out of pocket, dorzolamide timolol without insurance often costs much less at Canadian pharmacy pricing. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and our pharmacists review every prescription before dispensing.

The two active ingredients work by reducing aqueous humor production. Dorzolamide is a topical carbonic anhydrase inhibitor. Timolol is a nonselective beta blocker. Using both targets pressure from two angles and can reduce the number of bottles needed. The usual dosing cadence is one drop in the affected eye or eyes twice daily.

This solution is preserved in most bottles; preservative-free single-use vials also exist for those who need them. The formulation is for ophthalmic use only. Do not inject or swallow.

Dosage and Usage

• Typical dose: one drop in the affected eye(s) twice daily, morning and evening.
• If switching from single-agent therapy, start at the next scheduled dose of the prior drop on the following day.
• If using other eye medications, space each product by at least 10 minutes.
• Contact lenses: remove before dosing; wait 15 minutes before reinserting.
• Instillation steps: wash hands; tilt head back; pull lower eyelid to form a pocket; hold the bottle tip down without touching the eye; instill one drop; close the eye gently.
• After each drop, press the inner corner of the eye (nasolacrimal occlusion) for 1–2 minutes to reduce systemic absorption.
• Missed dose: apply when remembered unless it is almost time for the next dose; do not double up.
• Do not use more than prescribed. Overuse does not improve control and may increase side effects.

• Storage: keep at room temperature, 15–30 °C (59–86 °F), in the original carton to protect from light.
• Do not freeze. Keep the cap tightly closed. Do not touch the dropper tip.
• For preservative-free single-use containers: open immediately before use and discard after a single application.
• Travel: pack in your carry-on, upright if possible. Use a sealable plastic bag to prevent leaks.
• Avoid leaving the bottle in a hot car or near heaters. Check the solution; do not use if cloudy or discolored.

Benefits and Savings

This combination simplifies therapy and supports adherence by combining two proven agents in one bottle. Clinical studies show meaningful pressure reductions, comparable to using each component separately. Fewer bottles can also reduce exposure to preservatives for some patients. Many people find the dosing schedule straightforward.

Ordering through a Canadian pharmacy can reduce costs. Typical savings are 60–80% versus usual US prices, depending on supply size and market conditions. You can compare dorzolamide timolol ophthalmic solution price options and select the quantity that fits your needs. Multi-month supplies and bulk promotions can lower the per-month dorzolamide 2% timolol 0.5% cost. Savings apply whether using insurance or paying the dorzolamide timolol cash price, and many customers still prefer lower Canadian pricing without insurance.

We work with licensed, vetted international partner pharmacies to supply authentic brand medications and a wide selection at budget-friendly pricing.

For extra value, see promotions; a dorzolamide 2% / timolol 0.5% coupon may be available.

Side Effects and Safety

• Common: transient burning or stinging, blurred vision, eye redness or irritation, tearing, dry eyes, and a bitter or unusual taste after instillation.
• Less common: eyelid inflammation, conjunctivitis, corneal changes, headache, or fatigue.
• Systemic (from timolol absorption): slow heart rate, low blood pressure, dizziness, shortness of breath, or worsening asthma/COPD.

Serious risks are uncommon but include severe breathing problems in asthma or advanced COPD, heart block or heart failure worsening, and allergic reactions. Dorzolamide is a sulfonamide derivative; rare sulfonamide-type reactions can occur. Timolol may mask symptoms of hypoglycemia or hyperthyroidism. Use caution with systemic beta blockers, certain calcium channel blockers, or digoxin. People with severe renal impairment, bradycardia, second- or third-degree AV block, or overt heart failure may not be candidates. Seek urgent care for breathing difficulty, chest pain, fainting, or swelling of the face or throat.

Onset Time

Pressure lowering begins within hours of the first dose. Many patients see a meaningful intraocular pressure reduction within the first week. Peak effect often stabilizes over 1–2 weeks with regular twice-daily use. Ongoing monitoring guides dose timing and any adjustments alongside other eye drops.

Compare With Alternatives

Prostaglandin analogs are common first-line options. Travoprost, for example, is typically dosed once nightly. Some patients move to combination therapy when a single agent is not enough. You can review Travatan® Z with a clinician if night dosing is preferred.

Alpha-2 agonists like brimonidine can be added or substituted when needed. They reduce aqueous production and increase outflow. See details for Alphagan® Ophthalmic Solution as another option.

Other choices include latanoprost, bimatoprost, betaxolol, brinzolamide, or oral carbonic anhydrase inhibitors for selected cases. The right plan depends on target pressure, tolerance, and response.

Combination Therapy

• With a prostaglandin analog (e.g., latanoprost) at night plus dorzolamide/timolol twice daily for stronger IOP control.
• With an alpha-2 agonist (e.g., brimonidine) spaced at least 10 minutes apart to avoid washout.
• Avoid combining with another ophthalmic beta blocker to limit additive systemic effects.
• Patients on insulin or sulfonylureas may need closer glucose monitoring, since timolol can mask hypoglycemia symptoms.
• Use nasolacrimal occlusion after drops to reduce systemic absorption and potential side effects.

Patient Suitability and Cost-Saving Tips

This product suits adults who need dual-mechanism pressure control and prefer fewer bottles. It may be unsuitable in asthma, severe COPD, bradycardia, second- or third-degree AV block, decompensated heart failure, or severe renal impairment. Those with a history of sulfonamide reaction need careful evaluation. Pregnancy and breastfeeding require individualized risk–benefit discussions.

To save, compare dorzolamide timolol ophthalmic solution savings across quantities. Many patients choose a 2–3 month supply to decrease shipping frequency and per-month cost. Reorder reminders help you avoid gaps. Even the dorzolamide timolol discount without insurance can be meaningful compared with typical US pharmacy pricing.

Authoritative Sources

US Prescribing Information for Cosopt (dorzolamide hydrochloride/timolol maleate)

Health Canada Product Monograph: Cosopt (dorzolamide/timolol) Ophthalmic Solution

Bausch + Lomb Cosopt Professional Product Information

Order Cosopt® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This information is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s directions for use.