Dovato® Tablets for HIV-1 Treatment

Dovato® is a prescription HIV-1 treatment taken as one tablet daily. It helps start or maintain viral suppression in eligible adults and adolescents. This page explains how it works, dosing, safety, and practical ways to manage Dovato cost without insurance, with US delivery from Canada.

What Dovato Is and How It Works

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing. This medicine combines two antiretrovirals: dolutegravir, an integrase strand transfer inhibitor, and lamivudine, a nucleoside reverse transcriptase inhibitor. Together they block HIV replication at different steps. It is used for initial therapy or to replace a stable regimen in certain patients with no known resistance to its components. The fixed dose contains dolutegravir lamivudine 50 mg/300 mg as a co-formulated tablet.

It may not be suitable for people with active hepatitis B without an additional antiviral that targets HBV. Stopping lamivudine can lead to HBV flares in those who are coinfected. This treatment is not recommended with some enzyme inducers because they can lower dolutegravir levels. If you are comparing options, you can also review our condition page for HIV for broader context.

Who It’s For

This treatment is for adults and adolescents who weigh at least 40 kg and have HIV-1 without known resistance to dolutegravir or lamivudine. It may be used to start therapy or switch from a stable regimen with sustained suppression. People with chronic hepatitis B generally need additional HBV-directed therapy if this tablet is considered. Those with severe kidney impairment may need a different regimen because lamivudine exposure increases when renal function is reduced.

Do not use it with dofetilide. Caution is advised with metformin, enzyme inducers, and products containing polyvalent cations. Discuss your medical history and all medicines with your healthcare professional before starting.

Dosage and Usage

The usual schedule is one Dovato tablet once daily, with or without food. Take it at the same time each day to support adherence. If you take antacids or supplements containing aluminum, magnesium, calcium, or iron, separate administration. Taking the HIV medicine at least two hours before or six hours after these products may help avoid reduced absorption.

This therapy is not recommended with rifampin or certain anticonvulsants, because the needed dose adjustments for dolutegravir cannot be made with this fixed-dose tablet. If you have questions about timing and spacing with other medicines, consult the official label and your prescriber.

Strengths and Forms

Dovato 50 mg/300 mg tablets are film-coated and supplied in a bottle. Availability can vary by market. The co-formulated strength is designed for once-daily use in eligible patients. If you are looking for other HIV drug classes, browse Antivirals on our site.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember the same day. If it is almost time for the next scheduled dose, skip the missed dose and resume the regular schedule. Do not take two doses at once. Building a routine, setting reminders, and keeping a small supply with you can help you stay on track.

Storage and Travel Basics

Store the bottle at room temperature as directed on the label. Keep the container tightly closed with the desiccant inside to protect from moisture. Protect from excessive heat and humidity, and keep out of reach of children and pets. When traveling, carry your medication in original packaging with a copy of your prescription. Place it in your carry-on bag to avoid temperature swings.

For longer trips, pack enough tablets plus a few extra in case of delays. If crossing borders, allow additional time for security screening and carry a medication list. Our checkout is encrypted to help protect your information.

Benefits

This two-drug regimen simplifies therapy with a single daily pill for eligible patients. It may help maintain viral suppression when starting or switching in appropriate cases. Fewer components can reduce pill burden compared with some three-drug combinations. The treatment’s integrase inhibitor component is generally well tolerated. Many people value straightforward once-daily use.

As with all antiretrovirals, consistent daily dosing is essential to support long-term effectiveness. Keep communication open with your clinician for monitoring and support.

Side Effects and Safety

Common side effects can include headache, nausea, diarrhea, insomnia, and fatigue. Some people notice weight gain over time with integrase-inhibitor–based regimens. Skin rash can occur. This medicine may affect liver enzymes, particularly in those with hepatitis B or C.

• Headache or nausea
• Trouble sleeping
• Diarrhea
• Fatigue
• Rash

Serious reactions are uncommon but can include hypersensitivity, severe rash, depression or anxiety, and liver problems. Immune reconstitution syndrome may occur when the immune system improves. Hypoglycemia is not typical unless other glucose-lowering drugs are used, but always monitor symptoms of concern and seek urgent care for signs of a severe reaction.

Drug Interactions and Cautions

Avoid dofetilide due to potentially dangerous increases in dofetilide concentrations. Rifampin, carbamazepine, oxcarbazepine, phenobarbital, phenytoin, and St. John’s wort may reduce dolutegravir levels; the fixed-dose tablet does not allow the recommended dolutegravir adjustment, so alternative therapy may be needed. Metformin concentrations can rise; your prescriber may adjust metformin.

Products with aluminum, magnesium, calcium, or iron can bind dolutegravir in the gut. Separate dosing as described above. Always review all medications, vitamins, and herbal products with your healthcare professional.

What to Expect Over Time

Your clinician will check your viral load and CD4 counts at regular intervals. If you are switching from a stable regimen, they will confirm ongoing suppression. Expect routine lab monitoring of kidney and liver function as part of standard care. Most people take this tablet at a consistent time each day to support adherence. If challenges arise, ask about tools and reminders that fit your routine.

Do not stop HIV therapy without medical guidance. If you have hepatitis B, your prescriber will plan for HBV coverage to reduce the risk of flares when changing therapy.

Compare With Alternatives

Several approved single-tablet options exist. Triumeq combines dolutegravir with abacavir and lamivudine and is a three-drug regimen for eligible adults. You can review Triumeq for a comparison. Another option is Juluca, which pairs dolutegravir with rilpivirine for maintenance therapy in select patients who are already suppressed.

Pricing and Access

Canadian pharmacies often list competitive rates for HIV medicines. You can check generic dolutegravir lamivudine price details on our product page and compare with local cash quotes. We provide transparent information so you can discuss options with your prescriber and plan refills in advance.

For those tracking budgets, you can also research dolutegravir lamivudine tablets price and consider multi-bottle orders when appropriate. We support US patients with Ships from Canada to US fulfilment. See our current Promotions for periodic offers.

Availability and Substitutions

Supply can vary. If the tablet is temporarily unavailable, your prescriber may recommend an alternative within the same class or another appropriate regimen. Pharmacists will not substitute this co-formulation without your prescriber’s direction. If you need background reading on related products, explore our article library, including Delstrigo Medication and Genvoya Uses, as well as awareness content like HIV Testing Day 2025.

Patient Suitability and Cost-Saving Tips

Good candidates are those with HIV-1 who do not have known resistance to its components and who do not require HBV treatment from the same pill. People with severe renal impairment may need a different regimen due to fixed lamivudine dosing. If you take supplements with minerals or other interacting medicines, ask about timing strategies.

To stretch your budget, ask your prescriber about extended supplies, such as 60- or 90-day quantities if appropriate. Compare local cash quotes with online Canadian rates for dolutegravir/lamivudine 50 mg/300 mg price considerations. Set refill reminders so you do not miss doses while waiting for your next bottle. If your insurance changes, review coverage early to avoid gaps.

Questions to Ask Your Clinician

• Starter or switch plan: Is this the right two-drug option for my history?
• Resistance testing: Do my labs support using this co-formulation?
• HBV status: Do I need separate hepatitis B treatment now or later?
• Other medicines: How should I separate doses from antacids or iron?
• Monitoring: Which labs will you check and how often?
• Side effects: What symptoms should prompt a call or visit?

Authoritative Sources

ViiV Healthcare – Dovato

FDA DailyMed – Dovato

Health Canada DPD – Dovato

Ready to proceed? You can place your order with US shipping from Canada and choose prompt, express shipping with temperature-controlled handling when required. This information is educational and does not replace your prescriber’s advice.