Durolane® Injection for Knee Osteoarthritis

Durolane is a hyaluronic acid injection for knee osteoarthritis. This page explains how it works, who it suits, and key safety notes for patients and caregivers. We also support US delivery from Canada and show ways to save, including Durolane without insurance.

What Durolane Is and How It Works

Durolane® is a single-injection viscosupplement used for symptomatic relief of knee osteoarthritis. It contains non-animal stabilized hyaluronic acid that helps restore joint lubrication and cushioning. By supplementing the synovial fluid, the treatment can reduce friction during movement and may ease pain during daily activities.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This medicine is administered by a trained clinician into the knee joint. The gel-like hyaluronic acid stays local to the joint space and supports shock absorption. It is not an opioid or a steroid. If you are comparing options, you can also read our overview of Arthritis Drugs to understand where viscosupplementation fits among therapies.

Who It’s For

This treatment is for adults with knee osteoarthritis whose symptoms persist despite measures such as exercise, weight management, and oral or topical pain relievers. It can be considered when nonprescription options are insufficient or not well tolerated. It is not intended for acute sports injuries or for use in other joints unless specifically advised by a clinician.

Avoid use if there is a skin disease, open wound, or infection at the intended injection site. People with known hypersensitivity to hyaluronic acid components should not receive this therapy. Those with bleeding disorders or on anticoagulants should discuss risks with a healthcare professional. For condition background, visit our category on Osteoarthritis.

Dosage and Usage

The product is designed as a single intra-articular injection given by a qualified prescriber or trained injector. The procedure follows aseptic technique and may include joint aspiration if needed. Treatment intervals are determined by your prescriber based on your response and clinical guidelines. Do not attempt self-injection.

Your clinician will prepare the knee, position the needle correctly, and inject the full contents as directed. Tell the provider about any recent procedures, fevers, or flare-ups before scheduling your appointment. Some clinicians may recommend avoiding intense activity for a short period after the procedure. Label-guided schedules vary; follow your prescriber’s instructions and the official product information. If your prescription specifies Durolane 60 mg, that refers to the hyaluronic acid amount in a prefilled syringe.

Strengths and Forms

This therapy is supplied as a single-use, prefilled syringe for intra-articular administration.

• Prefilled intra-articular syringe: Durolane 60mg 3mL (non-animal stabilized hyaluronic acid)

Availability may vary by market and inventory. The syringe is for single use only. Do not reuse any portion. For broader pain-care products, you can browse our Pain Inflammation category.

Missed Dose and Timing

Because this is an in-clinic injection, a “missed dose” usually means a missed appointment. If that happens, contact your clinician to reschedule. Do not attempt to catch up at home. Only a trained professional should administer this therapy. If you experience new swelling, redness, or fever after an injection, seek medical advice.

Storage and Travel Basics

Patients generally do not handle the syringe for long, but proper storage matters if you are transporting it to a clinic. Keep the syringe in its original carton until use. Protect it from light. Store at room temperature per the official label. Do not freeze and do not expose to excessive heat. Do not use the product if the package is opened, damaged, or past its labeled expiry date.

If you need to travel with your medication, carry it in a protective container and keep it with you rather than in checked luggage. Bring a copy of your prescription and your appointment details. Ask your clinic how they prefer items to be delivered before the procedure. For anatomy and symptom context, see our article on Back Of The Knee Pain. A micro-cue for safety: temperature-controlled handling when required.

Benefits

This treatment delivers hyaluronic acid directly into the joint space. It supplements the synovial fluid, which can help reduce friction and support smoother motion. Many people value the convenience of a single clinical visit per treatment cycle compared with multi-injection regimens. Because it works locally within the knee, it may be an option when oral agents cause stomach upset or interact with other therapies. Responses vary by individual, and your clinician will assess fit based on symptoms and goals.

Side Effects and Safety

• Injection-site pain or tenderness
• Joint swelling or effusion
• Warmth, redness, or stiffness
• Temporary limitation in range of motion

Less commonly, patients may experience significant swelling, severe pain, or signs of infection such as fever, marked redness, or drainage. Allergic reactions, including hives or breathing difficulty, are rare but possible. If you have sudden severe symptoms or think you are having an allergic reaction, seek urgent medical care. This therapy is not known to cause systemic side effects typical of oral pain medicines, but report all new or worsening symptoms to your prescriber.

Drug Interactions and Cautions

Because the gel is injected into the joint, systemic interactions are unlikely. Still, tell your clinician about all medicines and supplements you use. Mention any anticoagulant or antiplatelet therapy, as injection can provoke minor bleeding. Do not use the product for joints with active infection or severe inflammation at the skin surface. Avoid using disinfectants containing quaternary ammonium salts on the skin before injection, as they may affect hyaluronic acid. If you are pregnant, planning to become pregnant, or breastfeeding, discuss potential risks and benefits with your healthcare professional.

For broader pain-care context, you can explore Pain Inflammation treatments and learn about related conditions in Most Common Forms Of Arthritis.

What to Expect Over Time

After the procedure, some people notice short-term injection-site discomfort. Your clinician may suggest icing or reduced activity for a day, depending on your situation. Symptom changes can be gradual. Many patients evaluate benefit over follow-up visits rather than hours or days. Keep a simple activity and pain log so you can share observations at your next appointment. If your clinician recommends additional cycles, timing will depend on your response and local guidance. Avoid high-impact activity immediately after the injection unless your prescriber advises otherwise.

Compare With Alternatives

Viscosupplementation is one option within a broader osteoarthritis plan. Alternatives may include oral NSAIDs or topical diclofenac gel, depending on tolerance and health history. For oral therapy, your clinician may consider Meloxicam. For localized care, some patients use Voltaren Emulgel Extra Strength. Your prescriber will match therapy to your medical profile, symptom severity, and goals.

Pricing and Access

Many people want to understand Durolane price before scheduling an injection visit. Canadian pharmacy pricing can offer value for US patients. We display transparent details on each product page. For those comparing costs and timing, we support US shipping from Canada with prescription verification. We also offer an Promotions page where current offers are published when available.

You can review Durolane Canadian pricing on this page and place an order once your prescriber provides a valid script. We use encrypted checkout and trained pharmacy staff process orders. Speak with your clinic about coordinating product arrival with your appointment date.

Availability and Substitutions

Stock status can change. If this item is temporarily unavailable, your prescriber may recommend a different viscosupplement or an alternative pain plan. When relevant to your therapy, we can source Durolane from Canada or suggest comparable options based on your prescription. We do not promise restock dates. Your clinician should review any substitution to ensure clinical suitability.

Patient Suitability and Cost-Saving Tips

This medicine may suit adults with radiographic and symptomatic knee osteoarthritis who have tried non-drug measures and topical or oral options. It may not suit people with joint or skin infections, certain bleeding risks, or known hypersensitivity to ingredients. Children are generally not candidates. The treatment is administered by professionals; it is not a home injection.

Saving ideas include planning ahead for clinic visits, ordering both knees’ supplies together if your prescriber treats bilaterally, and setting refill reminders in your account for future cycles. Ask your clinic about appointment windows so you can align pharmacy fulfilment with your schedule. If comparing Durolane cost to other care, consider total episode expenses, including clinic fees and follow-up visits.

Questions to Ask Your Clinician

• Is viscosupplementation appropriate for my knee findings and activity goals?
• How will you manage discomfort during and after the injection?
• What signs of infection or reaction should prompt follow-up?
• Could topical or oral options work instead, or alongside this therapy?
• How should I adjust activity in the days after the procedure?
• When will we reassess response and discuss future cycles?
• Do my other medicines or conditions change the risk profile?

Authoritative Sources

Bioventus Durolane – Official SiteFDA Device Premarket DatabasesHealth Canada Medical Devices Active Licence Listing

Ready to proceed? Place your order with express checkout and secure handling. Ships from Canada to US with prescription verification; clinic-friendly packing. This information is not a substitute for medical advice. Always follow your prescriber’s directions and the official label.