Durolane® Hyaluronic Acid Injection for Knee Osteoarthritis Pain

What Durolane® Is and How It Works

Durolane is a sterile, non-animal hyaluronic acid gel used for osteoarthritis knee pain. It is a single-shot viscosupplement that cushions and lubricates the joint. You can buy durolane online from Youdrugstore at Canadian prices with US shipping. Youdrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and a licensed pharmacist reviews every prescription before dispensing.

We also partner with licensed, vetted international pharmacies to supply authentic brand medicines with broad selection and fair pricing. Durolane hyaluronic acid injection contains 60 mg of stabilized sodium hyaluronate in 3 mL (20 mg/mL). The crosslinked gel increases synovial fluid viscoelasticity and helps reduce pain with movement. This product is supplied in a prefilled, single-use syringe.

Bioventus Durolane is indicated for pain relief in knee osteoarthritis. A trained healthcare professional administers one intra-articular injection into the affected knee. Durolane fda approval covers use in the knee joint for patients who have not gained adequate relief from simple analgesics or physical therapy. Some clinicians may consider other joints based on local approvals.

Dosage and Usage

• Each syringe contains Durolane 60 mg in 3 mL. It is a single intra-articular dose.
• Only a qualified healthcare professional should perform the injection. Do not self-inject.
• The clinician injects the gel directly into the knee joint space. Joint effusion may be aspirated first.
• Typical treatment is one Durolane shot per knee. Repeat dosing may be considered by your prescriber after several months if symptoms return.
• After the procedure, many providers recommend light activity for 24–48 hours. Avoid intense exercise until cleared by your clinician.
• If you miss an injection appointment, contact the clinic to reschedule. Do not attempt to administer at home.
• Use only if the packaging is intact and the solution is clear. Single-use only; do not reuse any portion.

• Store Durolane at 2–25 °C (36–77 °F). Do not freeze.
• Keep the syringe in its original blister to protect from light.
• Do not shake or heat. Keep out of reach of children.
• For travel, carry the unopened syringe in an insulated pouch. Use cool packs if ambient temperatures exceed 25 °C, and avoid direct contact with ice. Do not allow the product to freeze.
• Do not use after the expiration date or if the packaging is damaged.

Benefits and Savings

Durolane hyaluronic acid can provide long-lasting knee pain relief. Many patients need only one visit, which simplifies scheduling. The single-injection approach reduces clinic time compared with 3–5 week series used with some alternatives. The 60 mg dose is designed to persist in the joint for months.

With Youdrugstore, you access Canadian pricing for brand Durolane. This can lower your Durolane injection cost by 60–80% versus typical US prices. Many shoppers compare Durolane price, Durolane 60 mg price, and Durolane 60mg 3ml price across pharmacies. Our site shows transparent Durolane injection price once you select your quantity and destination.

If you are treating both knees or planning a future cycle, your prescriber may authorize more than one syringe. Ordering together can reduce per-injection costs when bulk promotions apply. We also offer reminders to help you reorder on time. For potential rebates or deals, you can view any current durolane coupon information on our promotions page.

Side Effects and Safety

• Common effects after injection include temporary knee pain, warmth, swelling, stiffness, and mild bruising.
• Some patients notice joint effusion, localized tenderness, or a feeling of fullness in the knee.
• Less common effects include back pain or headache.
• Pain after Durolane injection often settles within a few days.

Rare but serious risks include joint infection, intense inflammation, or severe pain after durolane injection. Seek urgent care for fever, marked redness, rapidly increasing swelling, or rash. Do not use if you have an infection or skin disease at the injection site. Avoid use with known hypersensitivity to hyaluronate or to proteins from bacterial fermentation. Durolane is for intra-articular use only; do not inject into blood vessels or tissues outside the joint.

Onset Time

Some people feel improvement within the first week. Most report meaningful pain relief over 2–4 weeks as inflammation settles and the gel distributes. Peak benefit often appears around 4–6 weeks. Relief can last up to six months, though duration varies by disease severity, activity level, and prior treatments.

Compare With Alternatives

Synvisc-One is a single-injection hylan G-F 20 made from avian sources. It offers similar convenience but uses a different polymer. Patients with avian protein sensitivity may prefer non-animal products like Durolane.

Monovisc and other hyaluronic acid brands can be single-injection or multi-injection series. Some, such as Orthovisc or Euflexxa, are given once weekly for three weeks. Series products may offer gradual relief but require more clinic visits.

Corticosteroid injections tend to act faster, often within days, but the effect may fade after 4–8 weeks. Steroids can be useful for short-term flare control. Hyaluronic acid is often chosen for longer duration and for patients looking to delay more invasive options.

Combination Therapy

• Clinicians may pair Durolane with physical therapy and activity modification.
• Oral options like acetaminophen or NSAIDs may still be used as directed by your prescriber.
• Bracing, shoe inserts, or walking aids can improve stability and comfort.
• If a corticosteroid injection is planned, your clinician will time it appropriately relative to viscosupplementation.

Patient Suitability and Cost-Saving Tips

Good candidates include adults with knee osteoarthritis who still have pain despite exercise, weight management, and simple analgesics. Durolane composition is non-animal stabilized hyaluronic acid. It is not a cure, but it may reduce pain and improve function for months.

Do not use if you have a knee joint infection, a skin condition over the injection site, or a known allergy to hyaluronate. Safety in pregnancy or breastfeeding has not been established. It is not approved for children. If you take anticoagulants or have bleeding risks, your clinician will assess injection suitability.

To lower your durolane cost, compare Durolane 60 mg and Durolane 60mg 3ml packaging and confirm the quantity on your prescription. Ordering multiple syringes when treating both knees can reduce shipping cost per unit. Reorder reminders help you plan the next cycle if your provider recommends repeating treatment after several months.

If you have searched for “durolane injection near me,” you can order online instead. We ship nationwide to the US with prompt, express handling. The durolane injection manufacturer is Bioventus; we supply the authentic brand product from licensed sources.

Authoritative Sources

Bioventus Durolane product information

Health Canada Drug Product Database: Durolane

Order Durolane® from Youdrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This content is educational and does not replace advice from your healthcare professional. Always follow guidance from your prescriber and the product labeling.