Monopril® (Fosinopril) Tablets for Hypertension and Heart Failure

What Fosinopril Is and How It Works

Fosinopril is an angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure and as adjunct therapy in heart failure. It relaxes blood vessels by reducing angiotensin II and aldosterone. Lower resistance makes it easier for your heart to pump blood. When you order fosinopril online, you receive prescription medication shipped from Canada at competitive pricing, including options for fosinopril without insurance.

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Fosinopril comes as oral tablets, commonly 10 mg, 20 mg, and 40 mg strengths. Brands may include legacy Monopril in some markets, while Canadian generics include Apo-Fosinopril and Teva Fosinopril. Most people take it once daily, with or without food. Your prescriber may combine it with a diuretic or other antihypertensive if needed.

Dosage and Usage

• Hypertension: typical start is 10 mg once daily; some start at 5 mg if on a diuretic or volume depleted. Usual range is 10–40 mg daily.
• Heart failure (adjunct): start low (e.g., 5–10 mg daily) and titrate to effect and tolerability up to 40 mg daily.
• Take with a glass of water, with or without food, at the same time each day.
• Your clinician may check kidney function and potassium after starting or changing the dose.
• If you are on a diuretic, your clinician may pause or reduce it for a few days before starting fosinopril to lower the risk of low blood pressure.
• Do not use during pregnancy. Tell your clinician if you plan to become pregnant or are breastfeeding.
• Missed dose: take it when remembered unless it is close to the next dose. Do not double up.
• Do not combine with aliskiren if you have diabetes. Avoid use within 36 hours of sacubitril/valsartan.

• Storage: store tablets at 15–30 °C (59–86 °F) in a dry place, away from moisture and heat.
• Keep tablets in the original container with the label intact and the lid tightly closed.
• Travel: carry your medicine in your hand luggage; pack a copy of your prescription.
• Avoid leaving tablets in hot cars or direct sun. Use a small insulated pouch if needed.
• If a tablet chips or crumbles, discard it and use a new tablet.

Benefits and Savings

Lowering blood pressure reduces the risk of stroke, heart attack, and kidney problems. In heart failure, ACE inhibitors help reduce symptoms and hospitalizations. Once-daily fosinopril tablets are convenient and work across 10 mg, 20 mg, and 40 mg strengths, making dose adjustments straightforward.

You can save 60–80% vs typical US prices by purchasing through a Canadian pharmacy. Your fosinopril cost often drops further with larger fills. Many customers order a multi-month supply to lower the per-month fosinopril price, including those paying without insurance. You can also set gentle reminders to reorder so you do not run out.

For current deals, see our fosinopril coupon page for promotions available at checkout.

Side Effects and Safety

• Cough (dry), throat irritation
• Dizziness or lightheadedness, especially when starting or increasing the dose
• Headache or fatigue
• Nausea, diarrhea, or stomach discomfort
• Rash or mild itching
• Elevated potassium (hyperkalemia)
• Small, usually reversible increases in creatinine

Serious but less common risks include angioedema (swelling of face, lips, tongue, or throat), severe hypotension, kidney function changes, liver problems (rare), or low white blood cell counts (very rare). Stop the drug and seek urgent care for signs of angioedema. Do not use during pregnancy due to the risk of fetal harm. Combining with potassium supplements, potassium-sparing diuretics, or high-potassium salt substitutes can increase hyperkalemia risk.

Onset Time

Blood pressure may start to fall within an hour, with peak effect about 3–6 hours after a dose. The full antihypertensive effect appears over 1–2 weeks, and may continue to improve by week 4 as your dose is stabilized. Heart failure symptom improvements often emerge over weeks to months, with ongoing benefits when combined with guideline-directed therapy. Your clinician may check labs within 1–2 weeks of initiation or dose changes.

Compare With Alternatives

Lisinopril is another ACE inhibitor commonly used once daily. It has similar effectiveness and side-effect profile, including the potential for dry cough. Some patients find either one better tolerated. You can compare options like Lisinopril by dose and tablet size.

Enalapril is an ACE inhibitor often dosed once or twice daily. It may suit patients who need finer dose titration. Enalapril has a comparable risk of cough and angioedema.

Losartan is an angiotensin receptor blocker (ARB). It is less likely to cause cough and may be a choice when ACE inhibitors are not tolerated. If you and your prescriber prefer an ARB, consider Losartan as an alternative.

Combination Therapy

• Thiazide diuretic (e.g., hydrochlorothiazide): often combined to increase blood-pressure control; a fixed-dose pairing like fosinopril hydrochlorothiazide or Monopril Plus 20 mg/12.5 mg may simplify dosing.
• Calcium channel blocker (e.g., amlodipine): complementary mechanisms; can lower edema risk compared to amlodipine alone.
• Beta-blocker: common in heart failure or coronary disease; start low and monitor blood pressure.
• Loop diuretic in heart failure: adjust doses to avoid excessive volume depletion and hypotension.
• Potassium-sparing diuretics (e.g., spironolactone): monitor potassium closely to reduce hyperkalemia risk.
• Avoid dual renin–angiotensin system blockade (ACE inhibitor + ARB or aliskiren in diabetes).

Patient Suitability and Cost-Saving Tips

Fosinopril may suit adults with hypertension or heart failure who are candidates for ACE inhibitor therapy. It may be less effective as monotherapy in some Black patients; combination therapy is often used. People with mild to moderate kidney impairment can often use fosinopril because it is cleared by both liver and kidneys, though monitoring is still needed.

Do not use if you are pregnant, planning pregnancy, or have a history of ACE inhibitor–related angioedema. Use caution with bilateral renal artery stenosis, severe kidney impairment, high potassium, dehydration, or when taking NSAIDs, lithium, or potassium-sparing diuretics. Discuss all medicines and supplements with your prescriber.

To manage your fosinopril cost, compare strengths (10 mg, 20 mg, 40 mg) and manufacturers such as Apo-Fosinopril and Teva Fosinopril. A multi-month supply can reduce your monthly price, and bulk promotions may apply. Many customers paying out of pocket or fosinopril uninsured find Canadian pricing helps keep therapy accessible. Set simple reminders so you can reorder before you run out.

Authoritative Sources

FDA Prescribing Information for Monopril (fosinopril sodium)

Health Canada Drug Product Database: Fosinopril entries

Summary of Product Characteristics: Fosinopril (UK reference)

Order Fosinopril from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This page is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s directions and your medication label.