Gemfibrozil (generic for Lopid®) 600 mg tablets for high triglycerides

What Gemfibrozil Is and How It Works

Gemfibrozil is a fibrate used to lower very high triglycerides and improve some cholesterol measures. Most people take Gemfibrozil 600 mg twice daily by mouth. It helps reduce pancreatitis risk in severe hypertriglyceridemia and can raise HDL cholesterol. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Our pharmacists review prescriptions for safety before dispensing, and you can order online with support from our customer-service chat during posted office hours.

We work with licensed, vetted partner pharmacies abroad to keep a wide selection available, including authentic brands, while keeping prices fair. Gemfibrozil decreases triglycerides by activating PPAR-α. This increases lipoprotein lipase activity and lowers VLDL production. The medicine is oral and is usually taken 30 minutes before the morning and evening meals.

Dosage and Usage

Follow your prescriber’s directions. Typical adult dosing targets severe hypertriglyceridemia.

• Start: 600 mg twice daily, 30 minutes before breakfast and dinner.
• Swallow tablets whole with water. Do not crush or chew.
• If your dose differs, follow the exact regimen your prescriber gave.
• Diet and exercise plans are often used with gemfibrozil.
• Lab checks monitor triglycerides, liver enzymes, and response.

Missed dose:

• If you miss a dose, take it when you remember unless it is near the next dose.
• If it is close to the next dose, skip the missed dose. Do not double up.

Storage and travel:

• Store at room temperature, about 15–30°C (59–86°F).
• Keep tablets dry and in the original container with the label.
• Protect from moisture and light. Do not freeze.
• When you travel, carry it in your hand luggage with the prescription label.
• If crossing time zones, keep the twice-daily schedule about 12 hours apart.

Benefits and Savings

Gemfibrozil is effective at lowering triglycerides, often within weeks. It helps reduce the risk of pancreatitis in people with severe elevations. HDL can rise modestly. LDL changes vary and may not be the main goal with a fibrate. Tablets are taken by mouth and do not require injections or special devices.

Ordering through YouDrugstore is simple and supported. We offer Canadian pricing on brand and generic medicines, and we ship to the US. Many customers save 60–80% compared to typical US prices. Our team can help with ordering steps and transfer requests during posted office hours.

Side Effects and Safety

Most side effects are mild and improve with time. Serious effects are uncommon but require prompt medical attention.

• Common: stomach pain, indigestion, nausea, diarrhea, headache, fatigue, rash.
• Less common: dizziness, constipation, taste changes, muscle aches.
• Serious: muscle pain or weakness with dark urine, severe stomach pain, yellowing of skin or eyes, unusual bleeding or bruising, severe allergic reaction.

Muscle side effects can occur, and the risk increases when gemfibrozil is combined with certain statins. Your prescriber may avoid simvastatin with gemfibrozil and use other options if a statin is needed. Gemfibrozil can raise the levels of some drugs. Notable interactions include repaglinide, dasabuvir, simvastatin, rosuvastatin, warfarin, and colchicine. Your healthcare professional will review your full medication list.

Do not use gemfibrozil if you have active liver disease, severe kidney impairment, preexisting gallbladder disease, or persistent abnormal liver tests. Tell your care team about alcohol use, pregnancy, or breastfeeding. Ask about a fasting lipid panel schedule and follow diet plans to support treatment.

Onset Time

Triglycerides often start to drop within 1–2 weeks of regular use. A fuller response is usually seen within 4–8 weeks. Your prescriber will check labs to confirm the effect and may adjust therapy based on targets and tolerance.

Compare With Alternatives

Fenofibrate is the most common alternative in the fibrate class. It is effective for triglycerides and tends to be preferred when combination therapy with a statin is needed. You can review Fenofibrate to compare options and strengths.

Statins are first-line for LDL reduction and for overall cardiovascular risk reduction. Some people with very high triglycerides may still need a fibrate or omega-3 product alongside diet. If a statin is required, prescribers may choose agents and doses carefully, and often avoid combining with gemfibrozil. See Crestor® for a brand statin option.

Prescription omega-3 products, such as icosapent ethyl, can lower triglycerides and are sometimes combined with statins. Niacin has fallen out of favor due to tolerability and outcome data but may still be used in select cases.

Combination Therapy

Gemfibrozil is often used alone for severe hypertriglyceridemia. In some cases, it may be combined with prescription omega-3s for further triglyceride reduction. Combining gemfibrozil with statins increases the risk of muscle problems. Many clinicians avoid this combination, especially with simvastatin. If LDL reduction is also needed, the care team may switch to fenofibrate or choose a statin plan without gemfibrozil. Ezetimibe or PCSK9 inhibitors target LDL and are not substitutes for fibrates when the main goal is lowering triglycerides.

Patient Suitability and Cost-Saving Tips

Gemfibrozil suits adults with very high triglycerides, especially when pancreatitis risk is a concern. It may also help in mixed dyslipidemia when HDL is low. It is not usually the first choice to lower LDL. Avoid use in active liver disease, severe kidney impairment, and gallbladder disease. Your prescriber will consider history of muscle disorders, thyroid issues, and alcohol use. Report any unexplained muscle pain, severe abdominal pain, or jaundice right away.

Interactions matter. Gemfibrozil can increase effects of warfarin and repaglinide. Check all prescriptions, OTC medicines, and supplements. Review your list regularly. You can read our guide on interactions in Drug Interactions The Top Interactions That Should Be On Your Radar.

Order on a schedule that aligns with your lab checks and follow-up visits. Choose a multi-month supply when appropriate to reduce per-month cost. You can turn on simple reorder reminders so you do not run short while traveling. For extra value, see current Gemfibrozil discount and bulk options on our promotions page.

Explore our condition pages to learn more about goals and lifestyle support. Start with High Cholesterol and High Triglycerides.

Authoritative Sources

See these trusted references for official product and safety information:

• FDA Gemfibrozil Prescribing Information
• Health Canada Drug Product Database: Gemfibrozil
• DailyMed gemfibrozil tablet listings

YouDrugstore offers brand and generic medicines at Canadian prices. Our team in Manitoba fills your prescription with care, and answers questions about the ordering process. Order online or by phone where available. We provide prompt, express, cold-chain shipping when required, with clear tracking for US delivery.

This information is not a substitute for professional medical advice. Always follow your prescriber’s directions and read the patient information that comes with your medicine. Contact your healthcare professional if you have questions about your therapy, dosing, or side effects.