Genvoya® Tablets for HIV‑1 (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide)

What Genvoya Is and How It Works

Genvoya® is a once-daily complete HIV-1 treatment in one tablet. It combines four medicines: elvitegravir (an integrase inhibitor), cobicistat (a booster), emtricitabine, and tenofovir alafenamide (two nucleoside reverse transcriptase inhibitors). The tablet is taken by mouth with food. People looking for genvoya without insurance often choose licensed international pharmacies to lower costs. Youdrugstore is a licensed Canadian pharmacy based in Manitoba that meets Canadian pharmacy standards. A licensed pharmacist reviews your prescription before dispensing.

We also work with licensed, vetted international partner pharmacies to source authentic brand medications across a wide range at competitive prices. You can order online, and our customer-service chat can help during posted office hours. Pharmacists are available to address medication questions.

How it works: elvitegravir blocks HIV integrase, stopping viral DNA from inserting into human DNA. Cobicistat increases elvitegravir levels by slowing CYP3A metabolism. Emtricitabine and tenofovir alafenamide (TAF) block reverse transcriptase, which reduces viral replication. TAF delivers tenofovir more efficiently to lymphocytes while keeping blood levels lower than TDF, which supports kidney and bone safety.

Dosage and Usage

• Usual dose: one tablet once daily with food.
• Swallow tablets whole. Do not crush, split, or chew.
• Missed dose: take as soon as remembered unless it is almost time for the next dose. Do not double up.
• If vomiting occurs within 1 hour of a dose, take another tablet. If more than 1 hour has passed, do not take an extra dose.
• Antacids with aluminum or magnesium can reduce absorption. Separate by at least 2 hours.
• Avoid strong CYP3A inducers (for example rifampin, carbamazepine, phenytoin, phenobarbital, St. John’s wort).

• Storage: store at 20–25 °C (68–77 °F). Keep the desiccant in the original container with the lid tightly closed.
• Travel: keep tablets in your carry-on. Avoid heat in parked cars. Bring extra doses. Use a pill case if needed, and keep a copy of your prescription.

Benefits and Savings

Genvoya® simplifies therapy into one pill per day. It supports viral suppression when taken as prescribed. TAF may be easier on kidneys and bones than TDF-based options, and many patients report good tolerability. Once-daily dosing can improve adherence, which is key for sustained viral load control.

Buying through Youdrugstore can reduce costs by 60–80% versus typical US prices. Many patients paying without insurance use multi-month supplies to lower the per-month cost. You can also set gentle reorder reminders to avoid gaps.

Side Effects and Safety

• Common: nausea, diarrhea, headache, fatigue, abnormal dreams.
• Lab changes: mild increases in serum creatinine from cobicistat (tubular secretion effect), increased cholesterol or triglycerides.
• Skin and hair: rash can occur; hair loss is uncommon.
• Less common: abdominal pain, insomnia, dizziness, pruritus.

• Serious: lactic acidosis, severe liver problems, acute hepatitis flares after stopping in patients with chronic HBV, new or worsening kidney issues, severe rash or hypersensitivity.
• Drug interactions: avoid lovastatin and simvastatin; use caution with other statins. Avoid strong CYP3A inducers. Review all medicines, including OTCs and herbals.
• Not typically recommended in pregnancy because elvitegravir levels may be lower; alternatives are often preferred.

Patients with chronic hepatitis B need monitoring if therapy is changed or stopped because HBV can flare. Baseline and periodic kidney and liver tests are usually recommended.

Onset Time

Viral load often starts to drop within the first weeks. Many adherent patients reach undetectable levels within 8–24 weeks, depending on baseline viral load, resistance profile, and adherence. CD4 counts may rise over months. Individual responses vary.

Compare With Alternatives

Stribild® combines the same integrase inhibitor and booster (elvitegravir/cobicistat) but pairs them with emtricitabine and tenofovir disoproxil fumarate (TDF). TDF can affect kidneys and bone more than TAF. Patients with renal risk often prefer TAF-based regimens like Genvoya®. You can review details about Stribild® if comparing options.

Biktarvy (bictegravir/emtricitabine/TAF) is a once-daily single-tablet regimen without a booster. It has fewer drug-interaction concerns than cobicistat-boosted regimens. Many patients compare Genvoya® and Biktarvy based on interactions, tolerability, and insurance coverage.

Some regimens still use a ritonavir booster with protease inhibitors. Norvir® (ritonavir) boosts other agents but may add interaction complexity and GI side effects compared with cobicistat. Choice depends on resistance, comorbidities, and co-medications.

Combination Therapy

Genvoya® is a complete regimen. It should not be used with other antiretrovirals for routine treatment. It can be used with medicines for other conditions, but many interactions exist due to cobicistat. Antacids with aluminum or magnesium need dose spacing. Discuss acid-reducing therapies and statins with a clinician to avoid unsafe combinations.

Patient Suitability and Cost-Saving Tips

Genvoya® is indicated for adults and adolescents who meet weight and clinical criteria. It is not recommended for severe renal impairment except in specific dialysis settings. It may not be preferred in pregnancy due to lower elvitegravir levels. People with chronic HBV need careful management when starting or stopping therapy.

To cut costs, consider a 90-day supply when appropriate, which can lower per-month pricing. You can turn on reorder reminders in your account so you never run short. For current promotions and bulk options, see our genvoya coupon page.

If you are comparing offers as an online pharmacy shopper, Youdrugstore provides Canadian pricing and pharmacist review before dispensing. Our team can help with invoice copies or documents often needed for personal import records. People paying out of pocket often evaluate genvoya cost without insurance alongside other single-tablet regimens.

Explore condition information in our Hiv and Hiv Infection categories. For timely education, see our article National Hiv Testing Day 2025 Get Tested Know Your Status. If you take multiple medicines, our overview Drug Interactions The Top Interactions That Should Be On Your Radar outlines common risks and review tips.

Authoritative Sources

Gilead Genvoya Prescribing Information

FDA Label: Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide)

Health Canada Drug Product Database: Genvoya

Ready to get started? You can upload your prescription and check out online or by phone. Our licensed team supports safe dispensing and ships to the US with prompt, express, cold-chain shipping when required.

This information is educational and does not replace advice from a healthcare professional. Always follow your prescriber’s directions and the patient information that comes with the medicine.