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Genvoya is a combination medication used for the treatment of HIV-1 infection. It includes four active ingredients: elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide. Elvitegravir is an Integrase Strand Transfer Inhibitor (INSTI), while emtricitabine and tenofovir alafenamide are Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTIs), respectively. Cobicistat acts as a pharmacokinetic enhancer to increase the effectiveness of elvitegravir. Genvoya is a complete treatment regimen and should not be used with other antiretroviral medications.
Benefits
Genvoya is effective in managing HIV-1 infection in adults and children weighing at least 25 kg. It helps in reducing the viral load in the body, thereby improving immune function and reducing the risk of HIV-related complications.
How to Use
Genvoya is taken as one tablet by mouth daily with food. It is suitable for patients with mild to moderate liver dysfunction but should not be used in those with severe liver impairment. It is also appropriate for patients with a creatinine clearance of 30 mL/min or higher.
Possible Side Effects
- Immune reconstitution syndrome
- Reduced bone mineral density
- Nausea
- Diarrhea
- Headache
- Fatigue
- Redistribution of body fat
Rare cases of suicidal ideation and behavior have been reported. For a complete list of potential side effects, refer to the product monograph.
Warnings and Precautions
Genvoya may cause serious conditions such as lactic acidosis or hepatomegaly with steatosis, particularly in patients with obesity, liver dysfunction, or prolonged nucleoside exposure. Patients should be screened for renal dysfunction and co-infections like HBV and HCV before starting treatment. Genvoya is not recommended for use in pregnant women, and breastfeeding should be avoided to prevent HIV transmission.
Storage
Store Genvoya at room temperature, away from excessive heat and moisture. Keep it out of reach of children.
Additional Information
Genvoya has numerous drug interactions and should not be used with medications that are strong inducers of CYP3A. In case of overdose, standard supportive care should be provided, and some components of the drug can be removed by dialysis.
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