Histantil® (Hydroxyzine HCl) 50 mg Tablets for Itching and Anxiety

What Histantil® Is and How It Works

Histantil® contains hydroxyzine hydrochloride, a first-generation antihistamine with antipruritic and anxiolytic effects. It blocks histamine H1 receptors and reduces activity in key brain centers. This helps relieve itching from allergic skin conditions, hives, and dermatitis. It is also used as short-term therapy for anxiety and tension. Many people look for Histantil 50mg when symptoms are more intense, including those comparing histantil without insurance options.

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Histantil® is taken by mouth as tablets. Dosing varies by condition and age. Sedation is common, so evening dosing is often preferred when practical. Your prescriber will decide the dose and schedule that fit your situation.

We offer brand and generic medicines at Canadian prices and also carry OTC health products. You can order online, and customer-service chat is available during posted office hours.

Dosage and Usage

Follow your prescriber’s directions. Typical adult guidance for hydroxyzine HCl includes:

• Pruritus: 25 mg three to four times daily. Some adults use 50 mg at bedtime if daytime drowsiness is a concern.
• Anxiety: 50–100 mg per day in divided doses. Many start at lower doses and adjust as tolerated.
• Elderly or those with liver or kidney concerns often require lower doses to reduce anticholinergic and sedation risks.
• Take with or without food. If stomach upset occurs, take with food.
• Avoid alcohol and other sedatives. Hydroxyzine can intensify CNS depression.

If your prescription includes Histantil® 50 mg tablets, your clinician may direct a single bedtime dose or split doses during the day based on response and drowsiness.

• Missed dose: Take it when remembered unless it is close to the next dose. Skip the missed dose if timing is tight. Do not double up.
• Driving and machinery: Wait to see how you react. Hydroxyzine may cause drowsiness, blurred vision, or slowed reaction time.
• Children: Doses are weight-based. Only use under pediatric guidance.

Storage and travel:

• Store at 15–25 °C (59–77 °F) in a dry place, away from light.
• Keep tablets in the original container with the child-resistant cap.
• Do not freeze. Avoid temperatures above 30 °C (86 °F), such as a hot car.
• For travel, carry in your cabin bag with a copy of your prescription.
• Use a daily pill organizer if it helps you stay on schedule.

Benefits and Savings

Histantil® can calm itching within hours and improve sleep disturbed by pruritus. For anxiety, scheduled dosing reduces tension and restlessness. The sedating profile may help at night when symptoms are worst. Tablets are easy to use and available in several strengths, including 50 mg.

Ordering from Canada often reduces your total spend. Many customers see 60–80% savings compared with typical US prices. That can matter if you pay the histantil cash price or face higher histantil cost without insurance. Multi-month supplies and selective bulk offers can lower your per-month expense, and reorder reminders help you avoid gaps.

For extra value, check our histantil coupon page for current site promotions.

Side Effects and Safety

• Drowsiness, fatigue, or dizziness
• Dry mouth, constipation, or urinary retention
• Blurred vision
• Headache or mild confusion, especially in older adults
• Upset stomach or nausea
• Rarely, skin rash or paradoxical agitation

Serious risks are uncommon but include QT prolongation and arrhythmias, particularly with other QT-prolonging drugs, electrolyte disturbances, or in those with known cardiac issues. Avoid alcohol and opioids due to additive sedation and breathing suppression. Hydroxyzine has anticholinergic effects; use caution with glaucoma, prostatic hypertrophy, or severe constipation. It is generally avoided in early pregnancy; discuss risks if pregnant or breastfeeding.

If hydroxyzine is combined with other sedatives, dose adjustments may be needed to reduce excess drowsiness.

Onset Time

Relief of itching often starts within 30–60 minutes after a dose, with maximal effect over a few hours. Nighttime symptoms and sleep disruption usually ease after the first evening dose. For anxiety, some calming can occur on day one, but steadier benefits are seen after several days on a regular schedule. Your prescriber may adjust the dose to balance effect with drowsiness.

Compare With Alternatives

Non-drowsy antihistamines such as cetirizine or loratadine are preferred for daytime allergies. They tend to cause less sedation but may be less soothing for intense nocturnal itch. People sometimes use a non-sedating agent by day and hydroxyzine at night, under medical guidance.

Diphenhydramine is another sedating antihistamine. It can be effective for hives and sleep, but anticholinergic effects are comparable or greater, especially in older adults. Hydroxyzine is often favored for chronic itch because of its anxiolytic properties.

Hydroxyzine pamoate (often marketed in the US) and hydroxyzine hydrochloride (Histantil® in Canada) deliver the same active hydroxyzine base. Clinical differences are small, though individual tolerance and sedation may vary. Your prescriber can help select the best option for your symptoms and daily routine.

Combination Therapy

• Day–night strategy: Use a non-drowsy antihistamine in the daytime and hydroxyzine at bedtime for refractory itch.
• Skin care: Combine with moisturizers and, if prescribed, topical corticosteroids for eczema or dermatitis flares.
• Allergic rhinitis: Pair with intranasal corticosteroids or saline rinses for nasal symptoms.
• Antiemetic plan: Hydroxyzine may be used with other anti-nausea agents if directed by your prescriber.
• CNS depressants: If used with opioids, benzodiazepines, or sleep aids, lower doses and closer monitoring are often required due to additive sedation.

Patient Suitability and Cost-Saving Tips

Histantil® may suit adults and adolescents with significant itch, hives, or short-term anxiety symptoms where sedation at night is acceptable. It may not be appropriate if you have narrow-angle glaucoma, severe urinary retention, certain heart rhythm disorders, or if you are pregnant or breastfeeding. Older adults are at higher risk of confusion, falls, and anticholinergic effects; lower doses are often used.

Discuss all medicines and supplements with your prescriber. Important interactions include other sedatives, anticholinergics, QT-prolonging agents, and drugs that disturb electrolytes. Avoid alcohol. If you have liver or kidney impairment, dosing may need adjustment.

To manage the histantil price, consider a longer supply if stable on therapy. Multi-month fills can reduce shipping frequency and per-month costs. Watch for histantil discount offers, and compare histantil 50mg cost across quantities. Reorder reminders help prevent rush purchases. If you are uninsured, look for histantil out of pocket savings during seasonal sales or when histantil bulk pricing is available.

Authoritative Sources

Paladin Labs Histantil product page

Health Canada Drug Product Database: Hydroxyzine

DailyMed FDA labeling for Hydroxyzine

Order Histantil® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This page is educational and does not replace medical advice. Always speak with your healthcare professional about diagnosis, treatment, and your specific circumstances.