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Humulin N® KwikPen for Type 1 and Type 2 Diabetes
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This prefilled insulin pen delivers intermediate-acting insulin for daily glucose control. Humulin N® KwikPen can support basal needs in adults and children with diabetes. You can access Canadian pharmacy pricing with US delivery from Canada, which may help if you pay without insurance.
What Humulin N Is and How It Works
Humulin N® is human insulin isophane suspension, often called NPH insulin. It works by lowering blood sugar between meals and overnight. After injection, it has a slower onset than rapid insulins and a longer duration than regular insulin. This profile helps provide background coverage as part of a basal plan.
YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.
This medicine is usually taken once or twice daily. It must be gently mixed before each dose so the suspension is evenly cloudy. It is injected under the skin, not into a vein or muscle. Use it exactly as prescribed by your clinician.
Who It’s For
This treatment is indicated for adults and children with type 1 diabetes, and for some people with type 2 diabetes who need basal insulin. It may be used alone or with mealtime insulin. People with recurring severe hypoglycemia or insulin allergy should discuss alternatives. Do not use if the liquid remains clear after gentle mixing, or if clumps or particles persist.
Tell your healthcare professional if you have kidney or liver problems, heart failure, low potassium, or frequent low sugars. Share all medicines and supplements you take, including over-the-counter products and herbal remedies.
Dosage and Usage
Follow your prescriber’s directions on timing and dose. Many patients use this insulin once or twice daily, at the same times each day. If you also use a rapid or regular insulin for meals, keep the dosing schedules consistent and separate pens for each insulin type.
Administration tips:
- Prepare the pen: roll gently between your palms 10 times, then invert 10 times until uniformly cloudy.
- Attach a new needle for each injection. Prime the pen per the label to see insulin at the needle tip.
- Inject subcutaneously into the abdomen, thigh, upper arm, or buttocks. Rotate sites to avoid lumps.
- Do not inject into areas that are tender, bruised, scarred, or thickened.
- Do not use this pen in an insulin pump. Do not inject intravenously or intramuscularly.
- Never share your pen or needles with anyone, even if the needle is changed.
If your clinician recommends mealtime coverage, they may prescribe a separate rapid or short-acting insulin such as Humulin® R Vial. Do not attempt to mix insulins inside a pen.
Strengths and Forms
The KwikPen is a prefilled disposable pen containing insulin human isophane suspension at U-100 (100 units/mL). Each pen typically delivers multiple doses in 1-unit increments with a dial.
Availability can vary by region and supply. Packaging, device characteristics, and labeling may differ by manufacturer lot. Your pharmacist will dispense what is prescribed on your valid prescription.
Missed Dose and Timing
If you miss a dose, check your blood sugar and follow your prescriber’s guidance. In general, do not double your next dose to catch up. If you are unsure what to do, contact your healthcare professional for individualized advice. Keep consistent daily timing when possible to support stable background coverage.
Storage and Travel Basics
Store unopened pens in the refrigerator. Do not freeze. Protect from heat and direct light. If a pen has been frozen, discard it. In-use pens may be kept at room temperature for the labeled in-use period; keep the cap on when not in use. Always check the product insert for exact time limits once opened.
Before use, the suspension should appear evenly cloudy after gentle mixing. If you see clumps, strings, or particles after resuspending, do not use the pen. Keep all medicines out of reach of children and pets.
When traveling, carry pens and supplies in your hand luggage. Bring back-up needles, a spare pen, and glucose treatment for lows. Keep a copy of your prescription with you. Use an insulated case to avoid excess heat or cold. Do not leave pens in a parked car or checked baggage.
Pen Handling and Sharps Disposal
Use a new sterile needle for every injection. Prime before each dose according to the pen instructions. After injecting, hold the needle in place for several seconds to ensure a full dose. Remove the needle after each injection and recap the pen.
Dispose of used needles in an FDA-cleared sharps container or a puncture-resistant household container with a tight lid. Follow local regulations for disposal. Never throw loose needles into household trash or recycling.
Benefits
This insulin provides basal coverage that can complement mealtime doses. Many patients find a pen device convenient, with dose dialing and portable size. The suspension profile may help overnight and between-meal control when used as directed. Mixing before each use is required, but dosing is straightforward once you learn the routine.
Side Effects and Safety
- Common: low blood sugar, injection site redness or itching, mild swelling, weight gain
- Less common: lipodystrophy at injection sites, fluid retention, headache
- Rare but serious: severe allergic reactions, hypokalemia, significant hypoglycemia
Severe low blood sugar can occur. Know the signs such as shakiness, sweating, confusion, or fast heartbeat. Carry a quick source of glucose. Risk of lows increases with missed meals, excess activity, or alcohol use. Seek urgent care for signs of a severe reaction such as trouble breathing or widespread rash.
Drug Interactions and Cautions
Medicines that may increase insulin effect include certain blood pressure drugs, salicylates, and alcohol. Medicines that may reduce effect include corticosteroids, some diuretics, and sympathomimetics. Beta blockers may mask symptoms of hypoglycemia. Using insulin with thiazolidinediones can increase risk of fluid retention and heart failure; monitor closely with your prescriber.
If you also take a sulfonylurea or use another insulin, your risk of low blood sugar may rise. Always discuss new prescriptions, supplements, or major diet changes with your healthcare professional.
What to Expect Over Time
After subcutaneous injection, onset is typically within a couple of hours, with an intermediate peak and extended duration. Your exact response can vary based on dose, site, activity, and meal timing. Many patients use this therapy as part of a long-term basal plan, adjusting doses only under medical supervision.
Keeping a glucose log, using reminders, and rotating injection sites can support stable results. If readings trend high or low, contact your prescriber rather than self-adjusting. Consistent technique and timing often make day-to-day results more predictable.
Compare With Alternatives
For once-daily basal coverage without mixing, your prescriber may consider a long-acting analog such as Basaglar® Kwikpen. If you prefer vials and syringes for NPH, a comparable formulation is available as Humulin® N Vial. The choice depends on goals, cost, dosing frequency, and your clinician’s advice.
Pricing and Access
See current pricing on this page and compare options. Many patients explore Canadian pricing to help manage out-of-pocket costs. We provide US shipping from Canada so you can order to your address after your prescription is verified.
Want to save time at refill? Consider a longer supply if approved by your prescriber. You can also set reminders in your account to re-order before your pen runs out.
Availability and Substitutions
Supply can vary. If this item is unavailable, your prescriber may recommend a similar basal insulin or a different device presentation. Your pharmacist will dispense the exact product written on your prescription unless a substitution is permitted by your clinician and local regulations.
Patient Suitability and Cost-Saving Tips
This therapy may suit people who need basal coverage and prefer a pen device. It may not suit those with recurring severe hypoglycemia, insulin allergy, or individuals who cannot reliably resuspend a cloudy insulin. If you are pregnant, breastfeeding, or planning surgery, discuss individualized management with your healthcare professional.
To manage costs, ask your prescriber about multi-month supplies if appropriate. Align your refills with routine checkups. Use your account tools to track orders and set reminders. Review your technique with a pharmacist if readings vary; small changes in timing or site rotation can help stabilize control.
Questions to Ask Your Clinician
- Dose schedule: once daily or twice daily for my plan?
- How to coordinate with mealtime insulin on busy days?
- What signs of lows should I watch for with my other medicines?
- Best injection sites for me and how to rotate them?
- When to adjust for travel, illness, or increased activity?
- How long can an in-use pen stay at room temperature?
Authoritative Sources
Learn more from official labeling and regulators:
Helpful Resources
For broader diabetes care topics, see Type 1 Diabetes and browse Diabetes Care. For injection know-how, you might find Inject Mounjaro and Reverse Prediabetes useful.
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How does Humulin N work compared with long-acting insulin?
Humulin N is an intermediate-acting insulin. It starts working later than rapid insulins and has a defined peak before wearing off. Long-acting analogs such as glargine tend to have a flatter, longer profile with less pronounced peaks. The choice depends on your targets, dosing routine, and how your clinician balances mealtime and basal coverage for you.
Can I mix Humulin N with other insulins?
Do not mix insulins inside a pen. In certain cases, a clinician may instruct mixing NPH with a short-acting insulin in a syringe, using proper sequence and technique. If you use pens for both basal and bolus, keep separate devices and follow each label. Never mix with non-insulin medicines or use in an insulin pump.
What are the common side effects?
Common effects include low blood sugar, mild injection site reactions, swelling, and weight gain. Lumps or dents at injection sites can develop if you inject in the same spot. Rotate sites to lower this risk. Severe allergic reactions and significant lows are uncommon but require urgent care. Discuss symptoms and management with your healthcare professional.
How should I store the pen at home and while traveling?
Keep unopened pens refrigerated and never freeze them. Protect from heat and light. In-use pens can be kept at room temperature for the in-use time on the label, with the cap on. When traveling, keep pens in carry-on baggage, avoid extreme temperatures, and carry a copy of your prescription. Do not leave pens in a parked car.
What if I miss a dose of Humulin N?
Check your blood sugar and contact your prescriber if you are unsure. In general, do not double your next dose to make up for a missed one. Try to take doses at the same times daily to support steady background coverage. Keep quick sugar on hand and monitor more frequently when your routine changes.
Can I drive after taking my insulin?
You can usually drive if your blood sugar is in a safe range and you feel well. Check before driving if you are unsure. Carry glucose tablets or a quick sugar source in the vehicle. If you have frequent lows or unawareness, discuss precautions with your healthcare professional to reduce risks while driving.
Is a prescription required to order this pen?
Yes. A valid prescription is required and verified before dispensing. Your order will proceed only after pharmacist review. This helps ensure the correct product, dose, and usage for your treatment plan. If your prescription changes, update your account and upload the new document before you place your next order.


