Hyzaar® Losartan/Hydrochlorothiazide Tablets for High Blood Pressure

What Hyzaar® Is and How It Works

Hyzaar is a prescription blood pressure medicine that combines losartan potassium and hydrochlorothiazide in one tablet. It treats hypertension in adults who need more than one medicine to reach their target. You take it by mouth once daily. Many people search for hyzaar online to manage ongoing refills at a better price.

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Losartan is an angiotensin II receptor blocker (ARB). It relaxes blood vessels by blocking the AT1 receptor, which reduces vasoconstriction and aldosterone effects. Hydrochlorothiazide is a thiazide diuretic that helps your body remove extra salt and water. Together, the two ingredients lower blood pressure more than either alone. Hyzaar tablets come in several strengths, including hyzaar 50 12.5 mg tablet, hyzaar 100 mg 12.5 mg tablet, and hyzaar 100 25 mg.

Controlling blood pressure reduces the risk of stroke and heart attack over time. Hyzaar therapy also lowers the chance of certain complications in people with left ventricular hypertrophy, when appropriate per your prescriber.

Dosage and Usage

• Typical starting dose: 1 hyzaar 50 12.5 mg tablet once daily. Your prescriber may adjust after 2–4 weeks.
• If blood pressure remains above goal, the dose may increase to hyzaar 100 mg 12.5 mg tablet once daily, then to hyzaar 100 25 mg if needed.
• Take at the same time each day, preferably in the morning to limit nighttime urination.
• Swallow tablets with water. You can take Hyzaar with or without food.
• If you are volume depleted or on high-dose diuretics, a lower ARB dose may be considered before moving to a combination tablet.
• Missed dose: take it when remembered unless it is near the next dose. Do not double doses.
• Check blood pressure regularly. Share readings with your healthcare professional.
• Ask your prescriber before using potassium supplements, potassium-sparing diuretics, or salt substitutes that contain potassium.

• Store Hyzaar at 20–25 °C (68–77 °F). Short excursions 15–30 °C (59–86 °F) are allowed.
• Keep tablets dry and in the original container with the label intact.
• Protect from moisture and direct light. Do not store in bathrooms.
• When traveling, pack in carry-on luggage. Keep below 30 °C and away from car glove boxes.
• Bring enough supply for your trip and a copy of your prescription.
• Use a pill organizer if it helps you stay on schedule.

Benefits and Savings

Hyzaar combines two proven medicines in one daily tablet. The ARB component lowers blood pressure without the dry cough seen with ACE inhibitors. The thiazide diuretic adds a modest diuretic effect that enhances control. Many patients reach targets faster with this combination than with stepwise titration of one medicine.

This convenience reduces the number of pills you take and can improve adherence. Different strengths support dose flexibility. If you need a stronger diuretic effect, your prescriber may choose the hyzaar 100 25 mg strength. If you need a lighter dose, hyzaar 50 mg with 12.5 mg hydrochlorothiazide is widely used.

Ordering Hyzaar online from a Canadian pharmacy often lowers your out-of-pocket hyzaar cost. Typical savings are 60–80% compared with many US pharmacy prices, depending on strength and quantity. Multi‑month supplies can reduce the per‑month hyzaar price, and bulk promotions may apply when available.

Looking for deals? See current hyzaar discount options on our promotions page.

Generics are available in many markets. If your prescriber approves a generic for hyzaar, it may further reduce the cost of hyzaar while offering the same active ingredients.

Side Effects and Safety

• Dizziness or lightheadedness, especially after starting or increasing the dose
• Headache or fatigue
• Increased urination
• Low sodium or low potassium; less often, high potassium
• Increased uric acid, possible gout flare
• Upset stomach, nausea, or diarrhea
• Muscle cramps
• Photosensitivity or mild skin rash

Serious reactions are uncommon but can include allergic reactions or angioedema, severe low blood pressure, kidney function changes, electrolyte disturbances, and eye problems like acute angle‑closure glaucoma or choroidal effusion with thiazides. ARBs carry a boxed warning for fetal toxicity. Do not use during pregnancy. Avoid combining with aliskiren in diabetes. Discuss lithium, NSAIDs, and other interacting medicines with your prescriber.

Onset Time

Blood pressure often starts to drop within one week. You may notice steadier readings after 2–4 weeks as the dose stabilizes. Full effect can take up to six weeks in some people. Your prescriber may check electrolytes and kidney function within 1–2 weeks of starting or changing the dose, then periodically.

Compare With Alternatives

ARB/thiazide options vary. Telmisartan/hydrochlorothiazide offers potent 24‑hour coverage in some patients, similar to Hyzaar. If you and your prescriber are comparing combinations, you can review Telmisartan Hct for a once‑daily alternative.

Some patients need a higher hydrochlorothiazide dose within the same brand family. In those cases, Hyzaar® DS provides the 100/25 mg option in a single tablet.

ACE inhibitor combinations like lisinopril/hydrochlorothiazide can be effective but may cause cough or angioedema more often than ARBs. Your prescriber will match the class to your history and tolerability.

Combination Therapy

• With a calcium channel blocker (e.g., amlodipine) for additional 24‑hour control
• With a beta blocker when indicated for coexisting conditions
• With a loop diuretic in resistant hypertension under specialist care
• Avoid routine use with potassium‑sparing diuretics unless monitored for potassium
• Use caution with NSAIDs; they may blunt effect and impair kidney function
• Do not combine with aliskiren in diabetes; avoid in renal impairment unless directed

Patient Suitability and Cost-Saving Tips

Hyzaar is intended for adults with hypertension who need combination therapy or who did not reach goals with a single agent. It is not approved for children in many regions. It is not for pregnancy, and it may not be suitable during breastfeeding. People with anuria or severe kidney problems should not take hydrochlorothiazide‑containing products.

Tell your prescriber about kidney or liver disease, dehydration, low sodium, gout, diabetes, or a history of angioedema. Hydrochlorothiazide is a sulfonamide‑derived medicine; discuss any severe “sulfa” reactions you have had. Limit alcohol intake, rise slowly from sitting, and monitor blood pressure at home as advised.

To manage the hyzaar price, consider these tips:

– Ask about generic hyzaar (losartan/hydrochlorothiazide). Many patients find it lowers the hyzaar cost without changing their regimen.

– Ordering a 90‑day supply can reduce the monthly cost when approved. This applies to common strengths like hyzaar 50 12.5 and hyzaar 100 mg 12.5 mg tablet.

– Enable reorder reminders so you do not run out between visits.

For education on cardiovascular risk, you can browse our Hypertension condition page.

Authoritative Sources

FDA Prescribing Information for Hyzaar (losartan/hydrochlorothiazide)

Health Canada Drug Product Database

Manufacturer Product Monograph (Merck) for Hyzaar

Order Hyzaar® from Youdrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This page is for educational purposes only and does not replace advice from your healthcare professional.