Imvexxy® Vaginal Inserts for Dyspareunia

Imvexxy is a low-dose estradiol vaginal insert used to treat painful intercourse related to menopause. It works locally to restore vaginal tissue and moisture. This page explains how it is used, who may benefit, and how to order with US shipping from Canada, including options if you need Imvexxy without insurance.

What Imvexxy Is and How It Works

Imvexxy® (Estradiol Vaginal Inserts) is a local estrogen therapy for moderate to severe dyspareunia due to menopause. Each softgel insert releases estradiol into vaginal tissues. The treatment helps rebuild the thin, dry lining and supports natural lubrication. Systemic exposure is low compared with oral estrogen.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This medicine is part of a class known as local estrogen therapies. It acts on estrogen receptors in the vaginal epithelium, increasing superficial cells and reducing pH. These changes can improve comfort and reduce dryness. Use it exactly as directed by your prescriber and the product label.

For broader context on related conditions, see Vaginal Atrophy and Dyspareunia.

Who It’s For

This treatment is indicated for postmenopausal adults with moderate to severe pain during sex caused by vulvar and vaginal atrophy. It may also help dryness and irritation linked to low estrogen in menopause. It is not a contraceptive and does not treat infections.

Do not use if you have vaginal bleeding of unknown cause, known or suspected estrogen-dependent cancers, active or past blood clots, stroke, heart attack, or severe liver disease. Discuss personal risks if you have a history of breast cancer, high blood pressure, high triglycerides, or thyroid disease. Tell your clinician about all medicines and supplements you take.

Dosage and Usage

Follow your prescriber’s directions and the official label. Usual dosing begins with a short daily phase, followed by a maintenance schedule twice weekly. Many people insert a dose at bedtime for comfort and to reduce leakage. Wash hands before and after each use. Gently place the softgel high in the vagina with a fingertip.

A common regimen starts with once-daily use for two weeks, then a consistent twice-weekly plan such as Monday and Thursday. Your prescriber may adjust the schedule based on response and tolerability. Avoid douching unless directed. If symptoms persist or vaginal bleeding occurs, contact your healthcare professional.

Ask your clinician which strength best fits your needs, including Estradiol vaginal inserts 4 mcg when a lower local dose is desired. Refer to the approved product information for complete directions.

Strengths and Forms

This therapy is supplied as unit-dose softgel vaginal inserts in blister packaging. Pack sizes can vary by strength and quantity. Availability may differ by market and over time.

• Imvexxy 10 mcg vaginal inserts — softgel units in sealed blisters
• Also offered in a lower-strength softgel presentation for individualized dosing

Check the product page for currently stocked presentations. Your prescription determines which strength we can dispense.

Missed Dose and Timing

If you miss a dose, use it when you remember unless it is close to the next scheduled dose. If it is almost time for your next dose, skip the missed one and resume your regular plan. Do not use extra inserts to make up for a missed dose. Try to keep a simple weekly pattern for maintenance use to help adherence.

Storage and Travel Basics

Keep inserts in their original blisters until use. Store at room temperature away from moisture and heat. Protect from light and keep out of reach of children and pets. Do not use inserts that are damaged, sticky, or misshapen. Check the packaging for the expiry date before use.

When traveling, carry your medication in your hand luggage with a copy of your prescription. Keep the carton and blister packs intact to protect the inserts. If you are away from home, set reminders on your phone to maintain your schedule. Ask your prescriber for documentation if you will cross borders or be away for an extended period.

Benefits

This local estrogen therapy can improve vaginal tissue health and comfort. It may reduce dryness, irritation, and pain during sexual activity associated with menopause. Because it acts locally, overall systemic exposure is low compared with many oral estrogens. The twice-weekly maintenance schedule can be convenient once your regimen is established.

This medicine is one option within a broader set of therapies. Some prefer a ring or a cream based on ease of use and personal comfort. Your clinician can help match the product to your goals and medical history.

Side Effects and Safety

• Headache
• Vaginal discharge
• Vaginal discomfort or irritation
• Breast tenderness
• Abdominal or pelvic pain
• Nausea or bloating

Serious but less common risks with estrogen therapies include endometrial cancer, blood clots, stroke, and cardiovascular events. Report any vaginal bleeding, chest pain, shortness of breath, severe headache, or vision changes right away. The endometrial risk is primarily linked to unopposed systemic estrogen; low-dose local therapy typically has minimal systemic absorption, but evaluation of bleeding is still important. Review your personal risk factors regularly with your prescriber.

Drug Interactions and Cautions

Because this is a local therapy, drug interactions are less likely than with systemic estrogen, but they can still occur. Tell your clinician if you use thyroid replacement, anticoagulants, antifungals, anticonvulsants, or herbal products such as St. John’s wort. Mention any prior hormone therapy and current supplements during your medication review. Avoid starting or stopping other estrogen products unless instructed by your prescriber.

What to Expect Over Time

Comfort changes can be gradual. Consistent use is important during the initial daily phase and maintenance schedule. Many people notice improved moisture and less irritation as tissue health is supported. Keep open communication with your healthcare professional about progress, side effects, and any bleeding. Periodic check-ins help confirm that the lowest effective local dose is being used.

Compare With Alternatives

Local estrogen therapies and other options can support comfort in menopause. Your prescriber may consider a tablet insert such as Vagifem, or a continuous ring like the Estring Vaginal Ring. Each choice differs in how it is placed, dosing frequency, and feel during use. Discuss preferences, medical history, and ease of adherence to select the right fit.

Pricing and Access

We list transparent options to help you compare Imvexxy price and quantities. You may see Canadian pricing with Ships from Canada to US fulfillment, which can support savings for some patients. Check current availability on this page before adding to cart. If you are looking for coupons, visit our Promotions page for current offers. We provide secure, encrypted checkout for your order.

Availability and Substitutions

Stock levels can change. If a strength is unavailable, your prescriber may suggest a comparable local estrogen product or a different dose. Reach out to your clinician before changing products. You can also explore category options in Womens Health if you want to Buy estradiol vaginal inserts in other forms, then return to your prescriber with questions.

Patient Suitability and Cost-Saving Tips

You may be a candidate if you are postmenopausal and have pain during sex due to vulvar and vaginal atrophy. Avoid use with active or past clots, estrogen-dependent cancer, undiagnosed bleeding, or serious liver disease, unless your prescriber advises otherwise. If you still have a uterus and are on systemic estrogen, discuss whether a progestin is needed; low-dose local therapy alone generally does not require one, but your clinician will assess your situation.

To manage costs, consider multi-month fills if appropriate, set refill reminders, and compare quantities for better per-unit pricing. Ask your clinician about the lowest effective local dose. Using one pharmacy for refills can also simplify coordination with your prescriber.

Questions to Ask Your Clinician

• Is a local insert the right choice for my symptoms?
• Which starting schedule and strength should I use?
• How long should I stay on maintenance dosing?
• What warning signs require a call or visit?
• Could a ring or a cream be a better fit for me?
• How should I handle a missed dose?

Authoritative Sources

Learn more from official references and product labeling:

• DailyMed: IMVEXXY
• FDA Prescribing Information
• Health Canada DPD

Ready to proceed? Add your prescription and select your quantity to place an order with US delivery from Canada, with prompt, temperature-controlled handling when required. This information is not a substitute for medical advice; always follow your prescriber and the official label.