Invokamet® (canagliflozin/metformin) tablets for type 2 diabetes

What Invokamet® Is and How It Works

Invokamet® combines canagliflozin, an SGLT2 inhibitor, with metformin, a biguanide. It is an oral tablet for adults with type 2 diabetes. It helps lower blood glucose and A1C when used with diet and exercise. Immediate-release tablets are taken twice daily with meals. Extended-release Invokamet XR is taken once daily. Many shoppers compare Invokamet price and Invokamet without insurance options to manage ongoing therapy costs.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. We meet Canadian pharmacy standards, and licensed pharmacists review prescriptions before dispensing. We offer brand and select generic medicines at Canadian prices, and carry OTC health products. Ordering is available online, and our customer-service chat is available during posted office hours.

Invokamet® works in two ways. Canagliflozin helps the kidneys remove glucose through urine. Metformin reduces liver glucose output and improves insulin sensitivity. Together, they lower fasting and post-meal glucose. Typical dosing is individualized by a prescriber. Invokamet® belongs to the Invokamet drug class combination of SGLT2 inhibitor plus metformin.

We source through licensed, vetted partner pharmacies internationally. You receive authentic brand medication with a wide selection and fair pricing.

Dosage and Usage

Strengths include 50/500 mg, 50/1000 mg, 150/500 mg, and 150/1000 mg. The same strengths exist for Invokamet XR. Common examples are Invokamet 50 500 mg and Invokamet 50 1000 mg twice daily with meals, or Invokamet XR 50 1000 once daily with food. Invokamet 150 mg 1000 mg and Invokamet XR 150 mg 1000 mg may be used after titration if tolerated and appropriate.

• Starting: Some patients start with canagliflozin 50 mg plus the current metformin dose. Others convert from separate tablets to the nearest Invokamet® strength.
• Titration: Doses increase based on response and tolerability. Maximum daily amounts are usually metformin 2000 mg and canagliflozin up to 300 mg, if renal function allows.
• Administration: Take immediate-release twice daily with meals. Take Invokamet XR once daily with the morning meal. Swallow XR tablets whole. Do not crush or split. A “ghost” tablet may appear in stool with XR.
• Missed dose: Take it with food when remembered. If the next dose is near, skip the missed dose. Do not double.
• Kidney function: Not recommended to initiate if eGFR is very low. Dosing depends on renal function. Metformin is contraindicated in severe renal impairment.
• Contrast procedures: Metformin-containing products may be held around iodinated contrast and restarted after renal function is reassessed.

• Storage: Store at room temperature 15–30°C (59–86°F) in a dry place. Keep in the original container with the lid closed.
• Travel: Carry tablets in your hand luggage. Keep a copy of your prescription. Bring extra doses and pack a small pill organizer.
• Daily use: Take with food to reduce stomach upset. Maintain hydration to lower the risk of volume depletion.

Benefits and Savings

Invokamet® lowers A1C by combining two proven mechanisms. Many patients see fasting glucose improvements within days and A1C reductions over 12–24 weeks. Weight often decreases modestly, and blood pressure may drop slightly. The risk of hypoglycemia is low unless combined with insulin or a sulfonylurea.

You can order Invokamet® at Canadian pricing through YouDrugstore. Typical savings are 60–80% compared with many US retail prices. This can help when paying without insurance, or when plans have high deductibles. We also carry a range of strengths, including Invokamet XR, to match prescribed regimens.

Side Effects and Safety

• Common: Genital yeast infections, urinary tract infections, increased urination, thirst, mild dehydration, nausea, diarrhea, stomach upset, gas, and headache.
• Metformin-related: Metallic taste, loss of appetite, and B12 level reduction over long-term use.
• Serious: Lactic acidosis (rare but medical emergency), diabetic ketoacidosis (including euglycemic DKA), severe dehydration, acute kidney injury, low blood pressure, severe UTIs, pyelonephritis, and rare Fournier’s gangrene.
• Bone and limb: Canagliflozin has reported fracture and amputation risks. Risk is higher in patients with peripheral vascular disease, neuropathy, foot ulcers, or prior amputation.
• Hypoglycemia: More likely when used with insulin or insulin secretagogues.
• Allergic reactions: Rash, hives, or swelling require urgent care.

Invokamet® is not for type 1 diabetes or for treating ketoacidosis. It may not suit patients with severe kidney disease, unstable heart failure, heavy alcohol use, or advanced liver disease. Discuss all medicines, including diuretics, RAAS inhibitors, and CYP inducers like rifampin, with a prescriber.

Onset Time

Effects on fasting and post-meal glucose can begin within the first several days. A1C moves gradually, with meaningful changes seen after 4–12 weeks, and full effect by about 24 weeks. Weight and blood pressure changes often appear within the first few months.

Compare With Alternatives

Several SGLT2/metformin combinations are available. Synjardy (empagliflozin/metformin) and Xigduo XR (dapagliflozin/metformin) offer similar mechanisms. Segluromet (ertugliflozin/metformin) is another option. Choice depends on renal thresholds, cardiovascular and kidney outcomes data, dosing preference, and prior tolerance of each agent.

Compared with taking metformin and an SGLT2 inhibitor separately, Invokamet® or Invokamet XR can simplify the regimen. XR provides once-daily dosing, which many patients prefer. Price varies by brand and strength, so patients often compare Invokamet XR price across strengths like Invokamet XR 50 1000 and Invokamet XR 150 mg 1000 mg.

Combination Therapy

Invokamet® is used with diet and exercise. It can be combined with insulin, sulfonylureas, DPP-4 inhibitors, GLP-1 receptor agonists, or pioglitazone when appropriate. Hypoglycemia risk increases with insulin or sulfonylureas, so prescribers may adjust those doses. Avoid overlapping metformin products. Monitor hydration and renal function when using diuretics. Stop and seek care for symptoms of ketoacidosis, severe infection, or lactic acidosis.

Patient Suitability and Cost-Saving Tips

Invokamet® may suit adults with type 2 diabetes who need additional A1C reduction beyond metformin alone and who have adequate renal function. It may not be suitable for those with recurrent UTIs, active foot ulcers, or a history of severe peripheral vascular disease, unless a prescriber determines benefits outweigh risks. Patients with heavy alcohol use or advanced liver disease have higher lactic acidosis risk with metformin.

To manage costs, consider multi-month supplies, which can lower the per-month price. You can set gentle reorder reminders in your account so you never run short. If you are looking for deals, see our Invokamet coupon page for current offers and bulk options. Many compare cash price for Invokamet across strengths to match budgets and dosing. This can help when asking how much does Invokamet cost for long-term care plans.

You can buy Invokamet online through YouDrugstore with a valid prescription. Our pharmacists can address medication questions, and customer-service chat is available during posted office hours.

Authoritative Sources

Janssen Prescribing Information for Invokamet

FDA Drugs@FDA Listing for Invokamet

Janssen Canada Product Page for Invokamet

Ready to get started? You can order on YouDrugstore for delivery to the US. Our team supports your request from checkout to shipment. We offer prompt, express, cold-chain shipping as needed, careful packaging, and responsive service if questions arise.

This information is not a substitute for medical advice. Always rely on your prescriber for diagnosis, individualized dosing, and monitoring. Read the patient information that comes with your medicine.