How does the combination in this tablet work?

It pairs an SGLT2 inhibitor with metformin. The SGLT2 part helps the kidneys remove excess glucose in urine. Metformin reduces glucose production in the liver and improves insulin sensitivity. Used together with diet and activity, the combination supports lower fasting and after-meal readings. Your clinician chooses the dose based on your prior therapy and kidney function. Always follow the official label for detailed directions and safety information.

What is the difference between immediate- and extended-release tablets?

Immediate-release is generally taken twice daily with meals, while extended-release is usually once daily with the evening meal. Extended-release tablets must be swallowed whole and may have fewer stomach-related effects for some people. Your prescriber selects the version that fits your glucose targets, tolerability, and schedule. Do not split or crush extended-release tablets.

Can I take this medicine with insulin or a sulfonylurea?

It is sometimes used alongside insulin or a sulfonylurea. However, those combinations can raise the risk of low blood sugar. Your healthcare professional may recommend closer monitoring or adjustments to other therapies. Watch for symptoms such as shakiness, sweating, or confusion, and carry a quick source of glucose as advised by your clinician.

What side effects should I watch for early on?

In the first weeks, some people notice increased urination, thirst, or genital yeast infections. Metformin can cause nausea or diarrhea, especially if doses are increased quickly. Severe symptoms like extreme weakness, trouble breathing, or persistent vomiting require urgent care. Staying hydrated and taking doses with food may help reduce mild stomach upset.

How should I handle sick days or dehydration risk?

Illness with vomiting, fever, or poor fluid intake can increase dehydration risk. Your clinician may give a sick-day plan, which can include holding certain medicines until you recover. Keep oral rehydration options at home, monitor blood glucose more often, and contact your prescriber if levels rise or you cannot keep fluids down. Do not change doses without guidance.

What labs or checks are usually monitored?

Clinicians often monitor A1C, kidney function, and sometimes electrolytes. Vitamin B12 levels can be checked with long-term metformin use. Your team may also review blood pressure, weight, and signs of infections or foot problems. Bring home glucose logs to appointments. These data help tailor therapy while watching for side effects and interactions.

How do I store it when traveling?

Keep tablets in the original labeled container, stored at room temperature and away from moisture. Pack in carry-on luggage to avoid temperature swings. Bring a copy of your prescription and a medication list for security. Keep doses aligned with your meal schedule at your destination. Carry extra tablets to cover delays and a spare organizer if you use one.

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Invokamet

Invokamet® Tablets for Type 2 Diabetes

Type 2 Diabetes

Please note: a valid prescription is required for all prescription medication.

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Invokamet is a prescription tablet that helps adults manage blood sugar. It combines canagliflozin and metformin in one dose. This guide explains how it works, safety tips, and how to access Canadian pricing with US delivery from Canada, even without insurance.

What Invokamet Is and How It Works

Invokamet® contains two medicines. Canagliflozin is an SGLT2 inhibitor that helps your kidneys remove excess glucose in urine. Metformin reduces glucose production by the liver and improves how your body uses insulin. Together, the combination supports lower fasting and post-meal readings when used with diet and exercise.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

The treatment is taken by mouth with meals to reduce stomach upset from the metformin part. The SGLT2 component can increase urination and may reduce blood pressure slightly. Your prescriber will base the dose on your current regimen and kidney function.

People sometimes compare Canagliflozin metformin price when planning for long-term therapy.

Who It’s For

This medicine is for adults diagnosed with Type 2 Diabetes who need additional glucose control on diet and activity, or on metformin alone. It is not for type 1 diabetes or for diabetic ketoacidosis. It may not be appropriate if you have severe kidney impairment, active metabolic acidosis, or a history of serious hypersensitivity to its components.

Discuss foot problems, dehydration risk, frequent urinary infections, or heavy alcohol use with your prescriber. Those factors can affect suitability and monitoring. If budgeting for therapy, you can review Invokamet tablets price on our product page.

Dosage and Usage

The regimen depends on your prior medications:

Starting from metformin alone: a low dose of the combination, taken with food
Switching from separate canagliflozin plus metformin: use equivalent total daily amounts
From other therapies: your clinician will individualize based on response and kidney status

General guidance from labeling:

Immediate-release tablets are usually taken twice daily with meals
Extended-release tablets are usually taken once daily with the evening meal
Swallow tablets whole with water; do not crush or split extended-release
Stay hydrated, especially during illness, heat, or exercise

Check the official label for detailed instructions. Your prescriber may adjust the dose cautiously to balance glucose control and tolerability.

Strengths and Forms

This combination is available as immediate-release and extended-release tablets. Common pairings include canagliflozin 50 mg or 150 mg with metformin 500 mg or 1000 mg. Availability may vary by market and supplier.

Missed Dose and Timing

If you miss a dose, take it when you remember with food. If it is close to your next scheduled dose, skip the missed dose. Do not take two doses at once. For extended-release tablets, keep doses at the same time daily.

Storage and Travel Basics

Store tablets at room temperature in a dry place, away from excess moisture. Keep the bottle tightly closed and out of reach of children and pets. For travel, carry your medicine in the original labeled container in your hand luggage. Bring a medication list and your prescription. If crossing borders, keep documentation accessible for screening.

When at your destination, continue with meals and dosing times as directed. Use a pill organizer only if it does not expose tablets to humidity. For long trips, pack extra to cover delays.

Benefits

This combination can simplify your routine by pairing two proven agents in one tablet. It may lower the number of pills you take and supports glucose control alongside nutrition and activity. Some people also appreciate the modest weight and blood pressure effects often seen with SGLT2 inhibitors. These advantages can reduce Invokamet out of pocket cost related to separate copays or duplicate fills when applicable.

Side Effects and Safety

Common effects can include:

Urination increase and thirst
Genital yeast infections
Urinary tract infections
Nausea, stomach upset, or diarrhea
Headache or dizziness

Serious but uncommon risks include lactic acidosis with metformin in the setting of significant kidney or liver disease, dehydration, ketoacidosis, severe urinary infections, bone fracture risk, and rare limb complications. Hypoglycemia can occur if used with insulin or a sulfonylurea. Stop and seek urgent help for signs of severe dehydration, trouble breathing, extreme weakness, or unusual sleepiness.

Learn more about metformin tolerability and tips to minimize stomach upset in Metformin Diarrhea.

Drug Interactions and Cautions

Tell your healthcare professional about all medicines and supplements. Notable interactions can involve diuretics, ACE inhibitors or ARBs, NSAIDs, rifampin, enzyme inducers, and digoxin. Alcohol increases the risk of lactic acidosis with metformin. Hold the medicine as directed around iodinated contrast procedures. Combining with insulin or sulfonylureas can raise the risk of low blood sugar; monitoring may be needed.

What to Expect Over Time

With steady use and meal planning, you may see improved home glucose readings. Digestive side effects often lessen after the first weeks as your body adapts to metformin. Staying hydrated can help reduce dizziness and cramps. Regular A1C checks and kidney assessments guide ongoing therapy decisions. If readings trend higher or you experience new symptoms, contact your prescriber for review instead of changing your dose on your own.

For background reading on this cornerstone ingredient, see Metformin’s Role.

Compare With Alternatives

Some people consider another SGLT2 inhibitor such as Dapagliflozin, paired with metformin separately. Others may use a DPP-4 inhibitor with metformin, such as Sitagliptin, based on tolerability and goals. Discuss the pros and cons of each approach with your prescriber to match your medical history and targets. Some compare Canagliflozin metformin cost from Canada with these options when reviewing budgets.

Pricing and Access

You can view Invokamet price without insurance after selecting strength and quantity. We also list Invokamet XR price from Canada for patients who are prescribed the extended-release version. Canadian pricing with US delivery from Canada may offer meaningful cash-pay savings compared to many local options. For periodic offers, see our Promotions page.

Payment methods are shown at checkout, and taxes vary by destination. Prescription is required and verified before dispensing. If you have questions about coverage, our team can explain how to upload your script and where to find invoice details for reimbursement.

Availability and Substitutions

Supply can vary by strength and package size. If a specific tablet is temporarily unavailable, your prescriber may recommend a suitable alternative or separate components. Pharmacists can coordinate with your clinic for a comparable option within the same class when appropriate. Patients sometimes review Canagliflozin metformin price versus filling the two ingredients separately.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults whose diet and activity are not enough to reach targets on metformin alone. It may not be suitable if you have severe kidney disease, frequent urinary infections, active foot ulcers, or are prone to dehydration. If you are pregnant, planning, or breastfeeding, ask your clinician about safer choices.

To manage costs, consider multi-month fills if your prescriber approves. Setting refill reminders helps prevent gaps that can lead to avoidable clinic visits. Use Diabetes Care supplies like glucose meters and strips as directed to track progress and reduce waste. Keep an eye on your online account for order history and renewal needs.

Questions to Ask Your Clinician

How will this combination fit with my current regimen?
What lab tests do I need before and during treatment?
How should I adjust during illness or poor intake?
What signs mean I should stop and call for help?
Could I use separate tablets instead of a combination?
Are there interactions with my heart or blood pressure medicines?

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View All FAQs

How does the combination in this tablet work?
It pairs an SGLT2 inhibitor with metformin. The SGLT2 part helps the kidneys remove excess glucose in urine. Metformin reduces glucose production in the liver and improves insulin sensitivity. Used together with diet and activity, the combination supports lower fasting and after-meal readings. Your clinician chooses the dose based on your prior therapy and kidney function. Always follow the official label for detailed directions and safety information.
What is the difference between immediate- and extended-release tablets?
Immediate-release is generally taken twice daily with meals, while extended-release is usually once daily with the evening meal. Extended-release tablets must be swallowed whole and may have fewer stomach-related effects for some people. Your prescriber selects the version that fits your glucose targets, tolerability, and schedule. Do not split or crush extended-release tablets.
Can I take this medicine with insulin or a sulfonylurea?
It is sometimes used alongside insulin or a sulfonylurea. However, those combinations can raise the risk of low blood sugar. Your healthcare professional may recommend closer monitoring or adjustments to other therapies. Watch for symptoms such as shakiness, sweating, or confusion, and carry a quick source of glucose as advised by your clinician.
What side effects should I watch for early on?
In the first weeks, some people notice increased urination, thirst, or genital yeast infections. Metformin can cause nausea or diarrhea, especially if doses are increased quickly. Severe symptoms like extreme weakness, trouble breathing, or persistent vomiting require urgent care. Staying hydrated and taking doses with food may help reduce mild stomach upset.
How should I handle sick days or dehydration risk?
Illness with vomiting, fever, or poor fluid intake can increase dehydration risk. Your clinician may give a sick-day plan, which can include holding certain medicines until you recover. Keep oral rehydration options at home, monitor blood glucose more often, and contact your prescriber if levels rise or you cannot keep fluids down. Do not change doses without guidance.
What labs or checks are usually monitored?
Clinicians often monitor A1C, kidney function, and sometimes electrolytes. Vitamin B12 levels can be checked with long-term metformin use. Your team may also review blood pressure, weight, and signs of infections or foot problems. Bring home glucose logs to appointments. These data help tailor therapy while watching for side effects and interactions.
How do I store it when traveling?
Keep tablets in the original labeled container, stored at room temperature and away from moisture. Pack in carry-on luggage to avoid temperature swings. Bring a copy of your prescription and a medication list for security. Keep doses aligned with your meal schedule at your destination. Carry extra tablets to cover delays and a spare organizer if you use one.