Invokamet® Canagliflozin/Metformin Tablets for Type 2 Diabetes

What Invokamet® Is and How It Works

Invokamet® combines canagliflozin and metformin to help adults with type 2 diabetes improve blood glucose, alongside diet and exercise. Many people look up Invokamet price to plan therapy costs, including invokamet price without insurance. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and prescriptions are reviewed by licensed pharmacists before dispensing.

Canagliflozin is an SGLT2 inhibitor; metformin is a biguanide. This dual approach lowers glucose through two pathways. The SGLT2 component increases urinary glucose excretion. Metformin reduces hepatic glucose output and improves insulin sensitivity. Together, the Invokamet drug class components can reduce A1C more than either alone.

Invokamet® comes as immediate-release tablets taken twice daily with meals, and as Invokamet XR once daily with a meal. Common strength pairs include invokamet 50 500 mg, invokamet 50 1000, 150/500, and invokamet 150 mg 1000 mg. Extended-release options include invokamet xr 50 1000 and invokamet xr 150 mg 1000 mg. Not for type 1 diabetes or diabetic ketoacidosis.

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Dosage and Usage

• Follow your prescriber’s plan. If switching from separate tablets, choose a strength that matches the current canagliflozin and metformin doses.
• Immediate-release Invokamet®: take twice daily with morning and evening meals.
• Invokamet XR: take once daily with a meal, preferably at the same time each day.
• Swallow XR tablets whole. Do not crush, split, or chew.
• Typical maximum daily doses: canagliflozin up to 300 mg (renal limits apply) and metformin up to 2000 mg, depending on tolerance and kidney function.
• Missed dose (IR): take when remembered unless it is close to the next dose; then skip. Do not double.
• Missed dose (XR): take the same day when remembered. If the next dose is near, skip the missed dose. Do not take two doses at once.
• Hydration matters with SGLT2 inhibitors. Drink fluids regularly unless otherwise instructed.
• You may see an XR tablet shell in your stool. The medicine has already been released.

• Store at 20–25°C (68–77°F); short excursions 15–30°C (59–86°F) are allowed.
• Keep tablets dry and in the original container with desiccant. Close the cap tightly.
• Protect from excess heat, humidity, and direct sunlight. Do not store in a bathroom.
• For travel, carry your medication in your hand luggage with a copy of your prescription.
• Bring extra tablets for delays. Keep in labeled packaging for security checks.
• Use a pill organizer for time-zone changes, and set phone reminders for dosing.

Benefits and Savings

Invokamet® can lower A1C, improve fasting and post-meal glucose, and support modest weight loss due to urinary glucose excretion. Many patients also see small reductions in blood pressure. The XR version offers once-daily convenience, which can simplify routines compared with twice-daily immediate-release tablets.

Canadian pharmacy pricing often provides meaningful savings. You may see 60–80% lower Invokamet cost versus typical U.S. pricing. This can apply to both Invokamet XR price and the immediate-release options. If you shop without insurance, transparent totals help you compare the cost of invokamet across strengths before checkout.

Looking for extra savings tools? See our invokamet coupon page for current promotions.

Side Effects and Safety

• Very common: gastrointestinal upset from metformin (nausea, diarrhea, stomach discomfort), especially during dose increases.
• Common: increased urination, thirst, genital yeast infections, and urinary tract infections due to the SGLT2 effect.
• Other: headache, dizziness, mild blood pressure drop, and changes in taste or appetite.
• Lab changes: small increases in LDL-C or potassium can occur in some patients.

Serious but less common risks include lactic acidosis with metformin (higher risk with significant renal impairment), ketoacidosis (can occur even with near-normal glucose), dehydration, acute kidney injury, hypotension, and rare necrotizing fasciitis of the perineum (Fournier’s gangrene). Canagliflozin has reported increased risk of lower-limb amputation in some studies; watch for foot problems. Hypoglycemia risk rises if used with insulin or a sulfonylurea; dose reductions of those agents may be needed.

Onset Time

Glucose-lowering from the SGLT2 component begins within days. Metformin effects build over 1–2 weeks as the dose is titrated. You may see fasting and post-meal glucose improvements in the first 2 weeks, with A1C changes becoming clear after 8–12 weeks. Weight and blood pressure changes generally emerge over 1–3 months.

Compare With Alternatives

Synjardy combines empagliflozin with metformin. It is similar to Invokamet XR in concept but uses a different SGLT2 inhibitor. Cardiovascular outcome data for empagliflozin are strong; choice often depends on individual health factors and tolerance.

Xigduo XR pairs dapagliflozin with metformin XR. It provides once-daily extended-release dosing with another member of the SGLT2 class. Selection may consider kidney function thresholds, side-effect profiles, and dosing preferences.

Janumet combines sitagliptin (a DPP-4 inhibitor) with metformin. It does not increase urinary glucose loss, so genital infections are less common, but weight loss benefits are also less pronounced than with SGLT2-based combinations.

Combination Therapy

• GLP-1 receptor agonists: often paired with SGLT2/metformin therapy for further A1C and weight reductions.
• Basal insulin: may be combined; consider lowering insulin doses to reduce hypoglycemia risk.
• DPP-4 inhibitors: sometimes used if GLP-1 agents are not suitable, though GLP-1 + SGLT2 is more common.
• Sulfonylureas: monitor closely for hypoglycemia; dose reductions are often required.
• ACE inhibitors, ARBs, or statins: used for cardiovascular and renal protection where indicated.

Patient Suitability and Cost-Saving Tips

Invokamet® is intended for adults with type 2 diabetes who need combination therapy. It is not for type 1 diabetes or for treating ketoacidosis. Significant renal impairment limits use, especially for metformin (eGFR below 30 mL/min/1.73 m² is a contraindication). Risk factors for lactic acidosis include advanced kidney disease, severe liver disease, unstable heart failure, heavy alcohol use, and acute illness with hypoxia.

Those with recurrent genital or urinary infections, peripheral vascular disease, neuropathy, or a history of foot ulcers should review risks and foot care. Older adults, people on diuretics, and those with low blood pressure need careful hydration planning. Pregnancy and breastfeeding require individualized assessment.

To manage costs, choose multi-month quantities when appropriate, as per-month pricing often drops at higher supplies. You can turn on reorder reminders so you never run short. Bulk promotions may be available on select strengths. These steps can lower the cost of invokamet without insurance for long-term therapy.

Authoritative Sources

INVOKAMET Prescribing Information (Janssen)

Official INVOKAMET Website (Janssen)

FDA Label for Canagliflozin/Metformin

Order Invokamet® from Youdrugstore.com: add to cart, upload your prescription, and we ship with prompt, express handling.

This content is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s directions and the medication guide that comes with your prescription.