Irbesartan/Hydrochlorothiazide Tablets for High Blood Pressure (Generic Avalide®)

What Irbesartan HTC Is and How It Works

Irbesartan HTC refers to the fixed-dose combination of irbesartan and hydrochlorothiazide. It treats high blood pressure in adults. The tablet pairs an angiotensin II receptor blocker (ARB) with a thiazide diuretic. Dosing is once daily. Many people compare prices for Irbesartan HTC without insurance to lower out-of-pocket costs. YouDrugstore is a licensed Canadian pharmacy in Manitoba that follows Canadian pharmacy standards, and our pharmacists review prescriptions before dispensing.

This combination reduces blood pressure in two ways. Irbesartan relaxes blood vessels by blocking angiotensin II effects. Hydrochlorothiazide increases salt and water excretion to reduce fluid volume. Together, they help improve blood pressure control. Irbesartan/HCT tablets are available as 150/12.5 mg, 300/12.5 mg, and 300/25 mg strengths. Most patients take one tablet daily, with or without food, at the same time each day.

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Dosage and Usage

This is general information and does not replace your prescriber’s advice. Follow the directions on your prescription label and the patient leaflet.

• Typical initiation: patients already on either component may be switched to an equivalent combination dose once daily.
• Common strengths: 150/12.5 mg, 300/12.5 mg, 300/25 mg tablets.
• Titration: the dose may be adjusted after evaluation of blood pressure response.
• With or without food: the tablet can be taken with meals or on an empty stomach.
• Missed dose: take it when remembered the same day. If it is almost time for the next dose, skip the missed dose. Do not double doses.

Storage and travel:

• Store tablets at room temperature in the original bottle or blister.
• Keep dry and away from excess heat and humidity.
• When traveling, carry tablets in hand luggage with a copy of the prescription.
• Use a daily pill organizer if advised to support adherence.

Benefits and Savings

The irbesartan/hydrochlorothiazide combination offers convenient once-daily dosing with two mechanisms. It helps reduce systolic and diastolic blood pressure. Better control lowers the risk of stroke, heart attack, and kidney problems over time. A fixed-dose tablet can simplify therapy versus taking two separate medicines, which may support adherence.

Ordering from YouDrugstore offers budget advantages. Many customers see 60–80% savings compared to typical U.S. pharmacy prices. Transparent pricing helps you compare the Irbesartan HTC price across strengths. This can be helpful for those paying without insurance. You can also select multi-month supplies when appropriate to reduce per-month costs.

Side Effects and Safety

Most people tolerate this medicine, but side effects can occur. The list below is not complete.

• Common: dizziness, headache, fatigue, nausea, and increased urination.
• Fluid and electrolytes: low sodium, low or high potassium, dehydration, and increased calcium or uric acid.
• Blood pressure effects: lightheadedness or symptomatic low blood pressure, especially after dose changes or dehydration.
• Kidney: changes in kidney function, especially in those with kidney artery narrowing or chronic kidney disease.
• Metabolic: small increases in blood sugar or cholesterol may occur with thiazides.
• Skin: photosensitivity or rash. Use sun protection.
• Serious but uncommon: allergic reactions, angioedema, severe electrolyte imbalance, or acute kidney injury.

Important safety points:

• Pregnancy: ARBs can harm or end pregnancy. Discontinue if pregnancy occurs and contact the prescriber.
• Breastfeeding: discuss risks and alternatives before use.
• Do not use in anuria. Use caution with gout, severe kidney or liver disease, or volume depletion.
• Interactions may involve potassium supplements, potassium-sparing diuretics, lithium, NSAIDs, and other antihypertensives.

Onset Time

Blood pressure improvement is often seen within 1 to 2 weeks. Maximum effect may take 4 to 6 weeks at a stable dose. Individual responses vary based on baseline blood pressure, dose, and adherence.

Compare With Alternatives

Irbesartan/HCT can be compared with irbesartan alone. Monotherapy may suit mild hypertension, but the combination may be used when one agent is insufficient. Your prescriber selects based on targets and response.

Other ARB/thiazide combinations include losartan/hydrochlorothiazide (Hyzaar®) and valsartan/hydrochlorothiazide (Diovan HCT®). These options work similarly by combining an ARB with a thiazide diuretic. Choice may depend on tolerance, kidney function, drug interactions, and availability. Some patients may instead use a calcium channel blocker or ACE inhibitor, alone or with a diuretic, based on individual needs.

Combination Therapy

The fixed-dose combination already contains two agents with complementary actions. Some patients may also use another class under prescriber guidance. Examples include adding a calcium channel blocker for additional control. Medication changes should be guided by clinical monitoring, lab results, and blood pressure readings.

Patient Suitability and Cost-Saving Tips

This medicine is intended for adults with essential hypertension who may benefit from an ARB plus a thiazide diuretic. It may be considered when blood pressure is not controlled on a single agent or when initiating combination therapy is appropriate. It is not suitable in pregnancy or for people with anuria. Caution is needed with a history of gout, significant kidney or liver impairment, or electrolyte disturbances.

Ways to manage costs include choosing generic Irbesartan HTC, comparing strengths, and selecting longer supplies when appropriate to reduce monthly expense. Set simple reorder reminders so you do not run out. If you are looking for promotions, see our Irbesartan HTC coupon page for current offers and bulk options. This can help if you pay out of pocket or prefer to manage therapy without insurance.

YouDrugstore offers brand and generic medicines at Canadian prices, with online ordering and phone support. Our customer-service chat is available during posted office hours for ordering help, and pharmacists can answer medication questions. Prescriptions are reviewed by licensed pharmacists before dispensing.

Authoritative Sources

For detailed prescribing information, review these resources:

• FDA Prescribing Information for irbesartan and hydrochlorothiazide
• Health Canada Product Monograph for irbesartan/hydrochlorothiazide
• Avalide® (brand) consumer information

Order from YouDrugstore, a licensed Canadian pharmacy headquartered in Manitoba, for careful prescription review, fair Canadian pricing, and secure checkout. We ship to the U.S. with prompt, express, cold-chain shipping options as needed.

This page offers general information and is not medical advice. Always follow your prescriber’s directions and the patient leaflet that comes with your medicine. Seek medical help for severe side effects or signs of an allergic reaction.