Juluca® (dolutegravir/rilpivirine) tablets for HIV-1 maintenance

What Juluca Is and How It Works

Juluca® is a complete, once-daily HIV-1 maintenance regimen that combines dolutegravir 50 mg and rilpivirine 25 mg in one tablet. It is used for adults who are already virologically suppressed and have no known or suspected resistance to either component. This page covers Juluca usage, juluca tablets information, common Juluca side effects, and ways to manage Juluca cost. Many customers compare the Juluca price and ask about juluca without insurance options when switching therapy. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Our pharmacists review prescriptions before dispensing, and you can order online with support from our friendly customer-service chat during posted hours. We also work with licensed, vetted international partner pharmacies so you can access authentic brand medication at fair prices and a broad selection.

Dosage and Usage

Juluca is a fixed-dose tablet taken with a meal once daily. There is no titration. It is designed for ongoing maintenance therapy in patients who are already suppressed on a stable antiretroviral regimen.

• Take one tablet by mouth once daily with a meal. Do not take it on an empty stomach.
• If you miss a dose and it is less than 12 hours since your usual time, take it with a meal as soon as possible.
• If it is more than 12 hours, skip the missed dose and take the next dose at the usual time.
• If you vomit within 4 hours of a dose, take another tablet with a meal.
• Do not use proton pump inhibitors (for example, omeprazole). They reduce rilpivirine absorption.
• H2 blockers (for example, famotidine): take at least 12 hours before or 4 hours after Juluca.
• Antacids: take at least 2 hours before or at least 4 hours after Juluca.

Strong enzyme inducers (such as rifampin, carbamazepine, oxcarbazepine, phenobarbital, phenytoin, rifapentine, and St. John’s wort) can lower drug levels and should not be used. Dofetilide is contraindicated with dolutegravir. Patients should ask a healthcare provider to review interacting medicines, including over-the-counter products and supplements.

• Storage: store at room temperature, in the original bottle with the desiccant, and keep the bottle tightly closed.
• Travel: pack the original labeled container in your carry-on. Keep tablets dry and avoid heat. Bring enough doses plus extra for delays.

Benefits and Savings

Juluca is a two-drug complete regimen. It simplifies therapy with one pill and may reduce cumulative exposure to nucleoside analogues in select patients. Studies support non-inferior efficacy to standard three-drug regimens in virologically suppressed adults. Many people value the convenience, stable lipid profile, and the ability to maintain suppression with fewer agents. YouDrugstore offers brand and generic medicines at Canadian prices, and you can speak to our team about practical ordering needs. Patients often compare the juluca tablets price and look for savings without insurance. Ordering from a licensed Canadian pharmacy can bring typical savings of 60–80% versus common US retail prices.

Side Effects and Safety

Most patients tolerate Juluca well. Some effects relate to either dolutegravir or rilpivirine and are usually mild. Serious reactions are less common but require prompt medical attention.

• Common: headache, nausea, diarrhea, dizziness, fatigue, insomnia, abnormal dreams.
• Less common: depression, mood changes, anxiety, rash, abdominal pain, increased liver enzymes.
• Serious: severe skin reactions or hypersensitivity, significant depression or suicidal thoughts, hepatotoxicity, and post-treatment acute exacerbation of hepatitis B in coinfected patients when HBV-active therapy is withdrawn.

Rilpivirine requires gastric acidity for absorption. Concomitant proton pump inhibitors are contraindicated. H2 blockers and antacids must be separated as described above. Use caution with drugs that prolong the QT interval. Dolutegravir must not be used with dofetilide. Pregnancy and breastfeeding decisions should be made with a clinician. People living with HIV should not breastfeed where safe alternatives exist to prevent postnatal transmission. Patients with active hepatitis B need an HBV-active agent because Juluca does not treat HBV.

Onset Time

Juluca is intended for those already suppressed. When switching, viral suppression is maintained when the regimen is appropriate and taken with food. Providers often check viral load within the first 4–8 weeks after a switch and at routine intervals. Consistent daily dosing with a meal supports steady absorption and continued efficacy.

Compare With Alternatives

Several single-tablet or simplified regimens are used for maintenance in suitable patients. Biktarvy® (bictegravir/emtricitabine/tenofovir alafenamide) is a three-drug single-tablet regimen often used for treatment initiation and maintenance. It includes a nucleoside backbone and may be preferred where resistance or co-infections guide selection. Kaletra® (lopinavir/ritonavir) is an older boosted protease inhibitor that is taken with a nucleoside backbone. It is less commonly used today due to pill burden and tolerability considerations. Isentress® (raltegravir) is an integrase inhibitor used with companion agents and can be part of tailored regimens. Long-acting cabotegravir/rilpivirine (Cabenuva®) given monthly or every two months is another maintenance option for eligible patients who prefer injections and can keep clinic appointments. Choice depends on resistance profile, co-morbidities, drug interactions, dosing preferences, and access.

Combination Therapy

Juluca is a complete regimen and should not be combined with other antiretroviral drugs for HIV-1 treatment. In patients with chronic hepatitis B, an HBV-active agent is required because Juluca lacks HBV activity. Acid-reducing agents require timing adjustments, and interacting medicines should be reviewed carefully. For a broad overview of high-impact interactions, see our article Drug Interactions The Top Interactions That Should Be On Your Radar.

Patient Suitability and Cost-Saving Tips

Suitable candidates are adults with HIV-1 who are already virologically suppressed on a stable regimen, have no known or suspected resistance to dolutegravir or rilpivirine, and have no history of virologic failure. Patients with active HBV need additional therapy. Contraindications include use with dofetilide or proton pump inhibitors, and with strong enzyme inducers that reduce drug levels. Caution is needed in those with significant depression or a history of QT prolongation. See our condition pages for background on Hiv 1 Infection and Hiv Infection. For public health context and testing, you can read National Hiv Testing Day 2025 Get Tested Know Your Status.

To lower the juluca cash price, consider a larger supply when appropriate, as multi-month orders can reduce the per-month cost. We offer quick reorder reminders so you can maintain consistent therapy. For current offers and bulk options, see our juluca coupon page. Many customers also look for juluca promotions or a Juluca discount to manage the out-of-pocket spend. If you are juluca no insurance, our team can explain payment options and help you compare choices.

Authoritative Sources

ViiV Healthcare Juluca product page

Health Canada Drug Product Database: Juluca

FDA Prescribing Information for Juluca

You can order from YouDrugstore, a licensed Canadian pharmacy that meets Canadian pharmacy standards. Our pharmacists review every prescription, and our team supports you from checkout to delivery. We ship to the US with prompt, express, cold-chain shipping where required.

Content on this page is for general information. It does not replace advice from a qualified healthcare professional. Always follow your prescriber’s instructions and the official product information supplied with the medication.