Juluca® Tablets for HIV-1 Maintenance

Juluca is a prescription HIV-1 maintenance treatment for adults who are already undetectable. It helps you stay on a simple, once-daily regimen and shows how to switch safely. This page explains clinical basics, usage, and access with US delivery from Canada, including options if you pay Juluca without insurance.

What Juluca Is and How It Works

Juluca® combines dolutegravir, an integrase inhibitor, and rilpivirine, a non-nucleoside reverse transcriptase inhibitor. Together, they block HIV replication at two different steps. It is used as a replacement regimen for people whose HIV-1 is already virologically suppressed on a stable therapy, with no history of treatment failure and no known or suspected resistance to either component.

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This medicine must be taken with a meal, as food improves rilpivirine absorption. It is not suitable for starting therapy in untreated patients. Your clinician may order periodic labs to confirm that suppression is maintained.

Who It’s For

This treatment is for adults with HIV-1 who are undetectable on their current regimen. It may be considered when you want to reduce pill count while maintaining suppression. People with known resistance to integrase inhibitors or NNRTIs, or with a history of virologic failure, should not use this combination.

Those with significant liver disease, a history of depression or other mood disorders, or who take medicines that strongly affect CYP3A should discuss risks and alternatives. For pregnancy or breastfeeding, decisions are individualized; review the official label and speak with a healthcare professional. For broader condition support, see our HIV Care category.

Dosage and Usage

The usual dose is one tablet once daily with a meal. A meal is required; a protein drink alone does not replace food. Swallow the tablet whole with water. If you take antacids, mineral supplements, or H2 blockers, follow spacing rules noted below to avoid lowering absorption.

Do not change your regimen on your own. When uncertain about timing with other medicines, refer to the official prescribing information or ask a clinician. This therapy is not indicated for children or for initial HIV treatment.

Strengths and Forms

The fixed-dose tablet contains dolutegravir 50 mg and rilpivirine 25 mg. Bottles commonly contain 30 tablets; availability may vary by market and stock.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember with a meal. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. If you vomit within about 4 hours after taking it, the label advises taking another tablet with food; if more time has passed, usually wait until the next dose. When timing questions are unclear, check the official label.

Storage and Travel Basics

Store at room temperature in the original bottle with the desiccant. Keep the cap tightly closed to protect from moisture, and keep out of reach of children and pets. Do not store in a bathroom. For travel, carry it in your hand luggage, bring your prescription label, and keep dosing aligned with meals as you cross time zones. If your trip involves security checks, keep the pharmacy label attached to avoid delays.

Benefits

This two-drug regimen reduces daily pill burden while maintaining a complete antiretroviral therapy. Once-daily dosing with food simplifies routines. The treatment avoids tenofovir and abacavir, which may be helpful for some patients with kidney or cardiovascular considerations. Many people report fewer regimen components to manage, though individual experiences can vary.

Side Effects and Safety

• Common: headache, nausea, diarrhea
• Other reported: insomnia, dizziness, abnormal dreams
• Skin: rash, which is usually mild

Serious effects are uncommon but can include severe skin reactions, liver problems, mood changes, or depression. Rilpivirine has been associated with QT prolongation at higher exposures; use caution with other QT-prolonging drugs. Immune reconstitution syndrome may occur in some patients as the immune system recovers. Seek urgent care for symptoms of severe rash, yellowing of skin or eyes, or worsening mood.

Drug Interactions and Cautions

Avoid proton pump inhibitors (such as omeprazole), as rilpivirine requires stomach acidity. H2 blockers should be spaced (take them at least 12 hours before or 4 hours after your dose). Antacids or products with aluminum, magnesium, calcium, or iron can bind dolutegravir; take this medicine at least 2 hours before or 6 hours after them, or take mineral supplements with the dose if taken with a meal.

Avoid strong CYP3A inducers such as rifampin, carbamazepine, phenobarbital, phenytoin, and St. John’s wort. Multiple-dose systemic dexamethasone is also not recommended. For a broader overview, see our Drug Interactions Guide. Review all medicines, including over-the-counter and herbal products, with your prescriber.

What to Expect Over Time

If taken correctly with food, most patients who switch from a stable, suppressive regimen remain undetectable on follow-up testing. Mild gastrointestinal or sleep-related effects may occur early and often lessen. Keep scheduled lab monitoring and report new symptoms promptly. Adherence matters; set reminders tied to meals and bring enough tablets for travel. For additional context on HIV care choices, you may find our overview on Delstrigo Medication and the awareness feature on HIV Testing Day helpful.

Compare With Alternatives

Two other complete options many clinicians consider are once-daily combinations. Dovato® pairs dolutegravir with lamivudine and is a two-drug complete regimen for treatment-naive adults without certain baseline resistance or hepatitis B coinfection. Odefsey® combines emtricitabine, rilpivirine, and tenofovir alafenamide; it is food-dependent and is commonly used for suppressed patients or select initial therapy situations. Your prescriber will match therapy to your history, lab results, and drug interaction profile.

Pricing and Access

We list current Dolutegravir rilpivirine tablets price transparently, with Canadian pricing and US delivery from Canada. Check live availability on this page and review generic status when applicable. For potential savings, explore our Promotions page. Checkout is encrypted.

If you want to Order dolutegravir rilpivirine online, add it to your cart and upload your prescription. Our team can coordinate transfers if your prescriber sends a script directly. You can also browse related options within Antivirals for context before you decide.

Availability and Substitutions

Supply varies by distributor and lot timing. If an item is temporarily unavailable, your prescriber may recommend an alternative in the same class or a complete regimen that fits your history. You can still discuss whether to Order Juluca tablets once stock returns or consider another maintenance option guided by your clinician.

Patient Suitability and Cost-Saving Tips

Good candidates are adults who are virologically suppressed, have no resistance to the components, and can reliably take a daily dose with a meal. Those with significant liver disease, certain psychiatric conditions, or complex polypharmacy may need closer oversight. It is not designed for children or for starting HIV therapy.

To manage costs, consider 60- or 90-day fills if prescribed, and set refill reminders before you run low. Compare Canadian pricing against local pharmacy quotes. If you prefer smaller quantities, you may still Buy Juluca 30 tablets to align with a monthly schedule. Keep all documentation ready for refills to avoid delays.

Questions to Ask Your Clinician

• Is my resistance and treatment history suitable for this two-drug regimen?
• How should I time doses with meals during travel or shift work?
• Do any of my current medicines or supplements interact with this treatment?
• Which labs will you monitor and how often?
• What signs of liver or mood problems should prompt a call?
• Could an alternative regimen fit better with my comorbidities?

Authoritative Sources

ViiV Healthcare

FDA DailyMed

Health Canada DPD

Ready to proceed? Add to cart to Buy dolutegravir rilpivirine 50/25 mg with US delivery from Canada, and choose prompt shipping; temperature-controlled handling when required. This content is for general information and does not replace your prescriber’s advice.