Kazano® (alogliptin/metformin) Tablets for Type 2 Diabetes

What Kazano® Is and How It Works

Kazano combines alogliptin and metformin in one oral tablet for type 2 diabetes. It helps lower A1C and fasting blood glucose when diet and exercise are not enough. If you compare Kazano price across pharmacies, Canadian pricing can offer meaningful value. Many patients also look at Kazano cost without insurance when budgeting long term care.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and licensed pharmacists review every prescription before dispensing.

Alogliptin is a DPP-4 inhibitor. It increases active incretin hormones, which boost glucose-dependent insulin release and reduce glucagon. Metformin reduces liver glucose production and improves insulin sensitivity in muscles and the gut. The combination targets fasting and post‑meal glucose, and is generally weight neutral.

Kazano is taken by mouth, usually twice daily with food. Strengths commonly include 12.5 mg alogliptin paired with 500 mg or 1000 mg metformin. Your prescriber chooses a tablet based on your current metformin dose and glucose targets.

We work with licensed, vetted international partner pharmacies to provide authentic brands, broad selection, and competitive pricing.

Dosage and Usage

• Start with a tablet that matches your current metformin dose; many begin at 12.5 mg/500 mg twice daily with meals.
• Titrate every 1–2 weeks based on glucose and tolerance. Typical maximum is 12.5 mg/1000 mg twice daily (metformin 2000 mg/day; alogliptin 25 mg/day total).
• Swallow tablets whole with food to reduce stomach upset. Do not crush or chew.
• If you are switching from metformin alone, replace the metformin dose with the nearest Kazano strength.
• For kidney impairment, dose selection may be limited; the drug may not be appropriate in severe renal impairment.
• Missed dose: take it when remembered unless it is close to the next dose. Skip if near the next dose. Do not double up.
• If you use insulin or a sulfonylurea, your prescriber may lower those doses to reduce hypoglycemia risk.

• Store at room temperature 20–25°C (68–77°F). Excursions 15–30°C (59–86°F) are acceptable.
• Keep tablets dry in the original, tightly closed container. Protect from moisture and excessive heat.
• For travel, carry enough tablets in your hand luggage with a copy of your prescription.
• Avoid leaving medicine in a hot car or near windows. Use a small insulated pouch if needed.
• Keep out of reach of children and pets.

Benefits and Savings

Kazano offers two complementary mechanisms in one tablet. It can reduce A1C by roughly 1% or more from baseline, depending on prior therapy. Many people see improved fasting and post‑meal control, with low intrinsic hypoglycemia risk unless combined with insulin or sulfonylureas. Convenience may improve adherence versus taking separate agents.

Ordering through Canadian pricing often means 60–80% savings versus typical US prices. That can ease monthly costs for long‑term therapy, including for those managing Kazano cost without insurance. Multi‑month supplies and occasional bulk promotions can reduce your per‑month spend. You can buy Kazano online for US delivery, and our customer‑service chat is available during posted office hours if you need help.

To see current offers, visit our promotions page for a kazano coupon.

Reorder reminders are available so you can refill on time and avoid gaps in therapy. Many shoppers also compare Kazano tablets price with alternative strengths to find the best fit for their budget.

Side Effects and Safety

• Nausea, diarrhea, stomach upset, or gas
• Headache or dizziness
• Upper respiratory symptoms, nasopharyngitis, or cough
• Back pain or joint pain
• Loss of appetite or metallic taste

Serious but less common risks include lactic acidosis with metformin (higher risk with severe kidney disease, dehydration, heavy alcohol use, or hypoxia), pancreatitis, severe allergic reactions or angioedema, liver enzyme elevations, heart failure worsening, and rare skin reactions such as bullous pemphigoid. Hypoglycemia can occur if used with insulin or sulfonylureas; those doses may need adjustment.

Onset Time

Initial glucose improvements may appear within 1–2 weeks as metformin begins to act. Alogliptin supports post‑meal control early as well. A1C reductions build gradually over 8–12 weeks as dosing stabilizes and lifestyle measures continue. Weight is usually neutral. Your prescriber will review labs and adjust the dose over the first few months.

Compare With Alternatives

SGLT2 inhibitors lower glucose by increasing urinary glucose excretion and can support weight and blood pressure reductions. If you need an SGLT2 option, Invokana® (canagliflozin) is an oral alternative often combined with metformin.

Incretin‑based injectables can deliver larger A1C drops and more weight loss for some people. Mounjaro® Vial (tirzepatide) is a weekly injection that activates GIP and GLP‑1 receptors and is typically used when more potent effects are needed.

Other DPP‑4 plus metformin combinations exist, and individual tolerability, kidney function, cardiovascular history, and weight goals help guide selection. Your clinician can compare classes and choose the right fit for your plan.

Combination Therapy

• With SGLT2 inhibitors: common add‑on for broader A1C reduction and cardio‑renal benefits.
• With basal insulin: consider reducing insulin dose to lower hypoglycemia risk; monitor fasting glucose closely.
• With sulfonylureas: dose reductions may be needed to prevent low blood sugar.
• With statins, ACE inhibitors, and ARBs: commonly co‑prescribed for cardiovascular risk management.
• Avoid combining with other DPP‑4 inhibitors.

Patient Suitability and Cost-Saving Tips

Kazano is for adults with type 2 diabetes. It is not for type 1 diabetes or diabetic ketoacidosis. People with severe kidney impairment (eGFR below 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, or unstable cardiovascular or respiratory disease may not be candidates for metformin‑containing therapy. A history of pancreatitis or serious allergic reactions to DPP‑4 inhibitors warrants caution.

Discuss liver disease, alcohol intake, dehydration risk, and heart failure history with your prescriber. Long‑term metformin use can lower vitamin B12 levels; periodic monitoring may be advised. If pregnancy is planned or possible, review options to support healthy glucose targets.

To save on treatment, compare Kazano cost across strengths and pack sizes. Multi‑month fills can lower shipping costs per month. Reorder reminders help you stay on schedule. Bulk offers can bring down the Kazano cash price when available. If you prefer an online experience, Kazano online purchase through our site is straightforward: create an account, upload your prescription, and check out. This can be helpful for those paying out of pocket or managing a Kazano cash pay cost.

Authoritative Sources

FDA Prescribing Information for Kazano (alogliptin and metformin)

FDA Medication Guide: Alogliptin and Metformin Tablets

Manufacturer medicines overview (Takeda)

Order Kazano® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This material is educational and does not replace guidance from your healthcare professional.