Kesimpta® Injection for Relapsing Multiple Sclerosis

This medicine is a prescription treatment for relapsing multiple sclerosis. It helps reduce relapses by targeting specific immune cells. This page explains how it works, dosing, storage, and access, with US delivery from Canada. It also covers ways to pay without insurance.

What Kesimpta® Is and How It Works

This therapy contains ofatumumab, a monoclonal antibody that targets CD20 on B cells. Depleting these cells can lower inflammatory activity in relapsing disease. Ofatumumab injection 20 mg is given under the skin, not into a vein.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

It is designed for self-injection at home after a prescriber shows how to use the device. The treatment binds to B cells and may reduce new lesions on MRI. Always follow the official label and your prescriber’s guidance.

Who It’s For

Kesimpta for relapsing MS is approved for adults with relapsing forms, including clinically isolated syndrome, relapsing-remitting, and active secondary progressive disease. People with active infections should generally wait until the infection resolves. Those with a history of hepatitis B need screening and monitoring based on label guidance.

Live vaccines are usually avoided during and for some time after therapy. Review your vaccination records with your healthcare professional before starting. Learn more about the condition on our Relapsing Multiple Sclerosis page or browse our Neurology category.

Dosage and Usage

The standard schedule includes three starter doses, then monthly maintenance. Your prescriber may adjust the day based on the official label and your clinical situation. The initial schedule is weekly for the first three doses, then once every four weeks.

Kesimpta loading dose refers to the first three injections given at week 0, week 1, and week 2. The maintenance dose is then given every four weeks starting at week 4. Use on the same day of the week or month when possible.

General administration tips: let the device reach room temperature out of the refrigerator. Do not shake. Check the solution; it should be clear to slightly opalescent and free of particles. Rotate injection sites. Do not inject into areas that are tender, bruised, red, or hardened.

Strengths and Forms

This therapy is available as a Sensoready pen and a prefilled syringe for subcutaneous use. The commonly supplied strength is 20 mg/0.4 mL. Availability may vary by presentation and pack size.

The Sensoready device supports home use after proper instruction. The prefilled syringe may be chosen by clinicians for those who prefer manual control. Ask your prescriber which format is right for your situation.

Kesimpta 20 mg pen is a common presentation for self-injection. A prefilled syringe option at 20 mg/0.4 mL is also widely published on the label.

Missed Dose and Timing

If a dose is missed, the general approach is to take it as soon as remembered and then follow the label’s timing instructions. The exact steps differ for loading versus maintenance doses. Do not double doses to make up for a missed injection.

Set reminders on your calendar and use a medication tracker to support adherence. Ask your prescriber or pharmacist for help if you are unsure how to resume after a missed dose.

Storage and Travel Basics

Store the pens or syringes in the refrigerator in the original carton. Protect from light. Do not freeze or shake. When needed, a single pen or syringe may be kept at room temperature for up to 7 days; once at room temperature, do not return it to the refrigerator.

When traveling, use an insulated pouch with cold packs to keep products within the recommended range. Keep the device with your carry-on to avoid extremes. Allow the device to warm to room temperature before injection. Keep out of reach of children and dispose of used devices safely.

Pen Handling and Sharps Disposal

Allow the pen or syringe to warm up out of the fridge for about 15 to 30 minutes. Do not use external heat sources. Inspect the device; do not use if it is cracked or the solution is cloudy or contains flakes.

Common injection sites include the abdomen, thigh, or upper outer arm if a caregiver is available. Rotate sites to reduce local reactions. Use a proper sharps container for disposal; do not throw used devices in household trash. Local regulations may allow pharmacy-based take-back programs.

Benefits

This medicine can be administered at home after training, which may reduce clinic visits. A monthly maintenance schedule can be simpler than more frequent dosing. The class works by depleting B cells, which may help reduce relapses and MRI activity in relapsing disease.

Self-injection devices are designed to be straightforward for many people. Written instructions and device guides support proper technique. Your care team can reinforce key steps if you need a refresher.

Side Effects and Safety

• Common: upper respiratory tract infection
• Common: headache
• Common: injection-related reactions such as fever, chills, or fatigue
• Common: local injection site redness, itch, or pain
• Common: urinary tract infection

Serious risks can include serious infections, reactivation of hepatitis B, and rare brain infection called PML. Decreases in immunoglobulins may occur. Allergic reactions can happen. Discuss risks and benefits with your prescriber and review the official label before starting.

Drug Interactions and Cautions

Live or live-attenuated vaccines are generally avoided during therapy and for a period afterward. Complete needed vaccinations before starting when possible. Using it with other immunosuppressants can increase infection risk.

People with chronic or recurrent infection, or those with active hepatitis B, need careful evaluation. Let your healthcare professional know about all medicines, including over-the-counter products and supplements. Screening and baseline labs may be recommended before initiating treatment.

What to Expect Over Time

This treatment begins with three starter doses, then moves to a monthly schedule. Some people notice mild injection reactions with early doses. Over time, adherence to the schedule is important to maintain effect.

Your clinician may monitor clinical relapses and MRI findings as part of routine care. If you need to pause for vaccines or procedures, your prescriber will guide that timing. Report new or worsening neurological symptoms promptly.

For broader lifestyle context, you can read our article on MS and lipids: Cholesterol And Multiple Sclerosis The Surprising Relationship.

Compare With Alternatives

Several disease-modifying therapies are used for relapsing disease. Glatiramer acetate is a long-standing option administered by subcutaneous injection; see Copaxone for details. Fingolimod is an oral sphingosine 1-phosphate receptor modulator; review Gilenya for another approach. Interferon beta-1b products, such as Betaseron, are injectable immune modulators used in certain cases.

If one therapy is not suitable, your prescriber may recommend switching within the class or to an alternative with a different mechanism. Consider tolerability, administration schedule, monitoring, and your personal goals.

Pricing and Access

We provide transparent Canadian pricing and US fulfilment options. You can review Kesimpta price on the product page and compare against typical cash-pay ranges. For those looking to Buy Ofatumumab injection, the listing shows current availability and formats we carry.

Use our Promotions page to check current offers. Our checkout is encrypted to protect your information. Orders Ships from Canada to US with clear status updates once processed.

Availability and Substitutions

Supply can vary by presentation and pack size. If the exact device or carton is unavailable, a prescriber may suggest a suitable alternative. We cannot promise dates for restock, but our team updates listings as stock changes.

Brand and generic availability differ by market and time. Your clinician will decide if a substitution is appropriate for your prescription.

Patient Suitability and Cost-Saving Tips

This treatment suits adults diagnosed with relapsing forms who can self-inject or have caregiver support. It may not be suitable for those with active infections or certain chronic hepatitis B situations. Screening and vaccination planning are part of routine initiation.

To manage costs, consider multi-month supplies when appropriate. Sign up for refill reminders so doses are not missed. If paying cash, compare formats and plan ahead for travel and storage. Your prescriber and pharmacist can help align supply with your schedule.

Questions to Ask Your Clinician

• Confirm fit: Is this therapy appropriate for my specific relapsing MS?
• Vaccines: Do I need any vaccines before starting, and which should I avoid?
• Monitoring: What labs or imaging will we check during treatment?
• Injections: Which sites are best for me, and how should I rotate them?
• Side effects: What signs of infection or rare risks should I watch for?
• Travel: How should I store and transport doses on trips?
• Change plans: If I miss a dose, what steps should I follow per label?

Authoritative Sources

Novartis HCP | FDA Prescribing Information | Health Canada DPD

When you are ready, add to cart at YouDrugstore for prompt, express, cold-chain shipping and US shipping from Canada. This page is informational and does not replace medical advice from your clinician.