Kisqali® Tablets for HR+ HER2- Breast Cancer

CDK4/6 inhibitor tablets used with hormone therapy to treat certain advanced breast cancers. This page explains how the medicine works, who it may suit, dosing basics, and safety. It also covers access options and ways to manage costs.

What Kisqali Is and How It Works

Kisqali® (ribociclib) is an oral CDK4/6 inhibitor used with an aromatase inhibitor or fulvestrant for hormone receptor–positive, HER2‑negative advanced or metastatic breast cancer. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing. Ships from Canada to US. Many people compare options to understand Kisqali price without insurance; this page outlines factors that influence overall affordability. The treatment slows cancer cell growth by blocking cyclin‑dependent kinases 4 and 6, which helps keep tumor cells from moving through the cell cycle. It is typically continued in 28‑day cycles as long as you are benefiting and tolerating therapy, per the official label.

Who It’s For

This medicine is indicated for adults with HR‑positive, HER2‑negative advanced or metastatic breast cancer. It is used with an aromatase inhibitor in postmenopausal patients, or with fulvestrant in adults regardless of menopausal status. Your prescriber may also consider ovarian suppression where appropriate. People with known hypersensitivity to components should avoid it. Those with significant baseline QT prolongation, uncontrolled electrolyte abnormalities, or severe liver issues need careful assessment. For information on the condition, see our Breast Cancer category. If your plan includes fulvestrant, you can review product details here: Fulvestrant.

Dosage and Usage

The usual starting regimen is 600 mg once daily for 21 days, followed by 7 days off treatment, to complete a 28‑day cycle. Your prescriber may adjust or interrupt therapy based on blood tests and tolerability. Take the tablets about the same time each day, with or without food. Swallow whole; do not crush, chew, or split. Avoid grapefruit or grapefruit juice. Follow the co‑prescribed hormone therapy schedule as directed. If instructions differ in your local labeling, follow your prescriber’s guidance and the official package insert. For background on a common partner medicine, see Exemestane 25 Mg.

Strengths and Forms

Film‑coated tablets are commonly supplied in 200 mg strength. Packaging and pack sizes can vary by market and program availability.

Missed Dose and Timing

If you miss a dose, skip it and take the next dose at the usual time. Do not take an extra tablet to make up for the missed dose. If you vomit after taking a dose, do not take an additional tablet that day. Keep a consistent daily routine during treatment days and resume after the 7‑day break to begin the next cycle as directed by your prescriber.

Storage and Travel Basics

Store the tablets at room temperature in the original package to protect from moisture. Keep out of reach of children and pets. When traveling, carry your medicine in your hand luggage along with a copy of your prescription. Maintain your dosing schedule across time zones by planning ahead with your healthcare professional. Do not store in a bathroom or other high‑humidity areas.

Benefits

This therapy offers an oral option that pairs with endocrine treatment. Once‑daily dosing on a 21‑days‑on, 7‑days‑off cycle may support routine. Using the class with hormone therapy can help delay disease progression in the indicated population, as reflected in official labeling. Availability as tablets helps many patients continue care outside an infusion center. For broader oncology information, explore our Cancer category.

Side Effects and Safety

• Low white blood cells (neutropenia)
• Tiredness or weakness
• Nausea or vomiting
• Diarrhea or constipation
• Headache
• Hair thinning
• Infections
• Abnormal liver tests

Serious risks can include QT interval prolongation, severe neutropenia with infection, liver injury, or interstitial lung disease/pneumonitis. Call your clinician or seek care if you notice signs like chest palpitations, shortness of breath, fever, or yellowing of the skin or eyes. Use effective contraception during treatment and for a period after the last dose, as outlined in the label. For more on a frequently co‑used endocrine agent’s tolerability, read Exemestane Side Effects.

Drug Interactions and Cautions

Ribociclib is metabolized by CYP3A. Strong CYP3A inhibitors or inducers can change levels and increase risks; your prescriber may adjust or avoid combinations. Limit or avoid drugs known to prolong the QT interval. Correct low potassium, magnesium, or calcium before starting. Avoid grapefruit products and St. John’s wort. Tell your healthcare professional about all medicines, vitamins, and herbs you take. People with hepatic impairment or renal impairment may need closer monitoring based on label guidance.

What to Expect Over Time

It may take several cycles to understand how you are responding. Your team will schedule regular blood counts, liver tests, and ECG monitoring at baseline and periodically. Some side effects improve with temporary interruptions or dose reductions. Staying consistent with dosing days and keeping all lab appointments can help your clinician manage therapy effectively. Practical supports like pill organizers and reminders can assist adherence during on‑treatment days.

Compare With Alternatives

CDK4/6 inhibitors differ in dosing schedules and side‑effect profiles. Two alternatives your prescriber may consider are Ibrance (palbociclib) and Verzenio (abemaciclib). Some patients with PIK3CA‑mutated disease may be candidates for alpelisib with endocrine therapy, as guided by testing and indication. Your clinician will match the option to your medical history, comedications, and goals of care.

Pricing and Access

We list options to help you review Kisqali price alongside comparable therapies. Factors like tablet count per pack and your prescriber’s regimen affect overall costs. You can also compare ribociclib US shipping details and timing at checkout for your address. Pricing reflects Canadian supply programs for eligible patients. If you are seeking savings, visit our Promotions page for current offers. We provide clear information to help you and your care team plan therapy within budget. This service supports US delivery from Canada for eligible prescriptions, and your order is prescription required and verified.

Availability and Substitutions

Supply can vary by pack size and manufacturer schedule. If a requested pack is unavailable, your prescriber may recommend an alternative strength, a different pack size, or another approved agent. When comparing access options, many patients ask whether Kisqali ships to US; availability depends on prescription verification and program eligibility.

Patient Suitability and Cost-Saving Tips

Ribociclib may suit adults with HR‑positive, HER2‑negative advanced disease who can complete regular lab monitoring. It may not suit those with significant baseline QT prolongation or poorly controlled liver disease. Ask your prescriber about contraception and plans if you are pregnant or breastfeeding. To manage costs, consider multi‑month refills when appropriate, which can reduce per‑fill fees. Setting calendar reminders before each cycle can prevent gaps in therapy. Discuss Kisqali cost per month with your care team so you can align follow‑up visits, labs, and refills.

Questions to Ask Your Clinician

• How will labs and ECGs be scheduled during my first cycles?
• Which warning signs mean I should call the office promptly?
• What other medicines or supplements should I avoid?
• Could side effects be managed with a temporary interruption?
• Is ovarian suppression appropriate in my treatment plan?
• How does this therapy pair with my specific hormone medicine?
• What affects ribociclib cost per month for me?

Authoritative Sources

Novartis Kisqali Prescribing InformationFDA DailyMed: RibociclibHealth Canada Drug Product Database

Ready when you are. Order from YouDrugstore for prompt US shipping from Canada; temperature-controlled handling when required. This information is not a substitute for medical advice; always follow your prescriber and the official label.