Leqvio® Injection for High Cholesterol

Leqvio® is an injection used with statins to lower LDL cholesterol. This page explains how it works, who it suits, and what to discuss with your prescriber. We support US shipping from Canada so you can plan care confidently, and you can compare Leqvio cost without insurance when budgeting with your clinic.

What Leqvio Is and How It Works

Leqvio® (inclisiran) is a small interfering RNA that helps reduce LDL cholesterol. It targets the production of PCSK9 in the liver, increasing LDL receptor activity and clearing LDL from the blood. It is used in adults with primary hyperlipidemia, including heterozygous familial hypercholesterolemia, as an add-on to diet and maximally tolerated statin therapy.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

The treatment is administered by a healthcare professional. It is not a daily medicine, which may simplify long-term routines. For condition background, see our guide to High Cholesterol.

Who It’s For

This medicine is for adults with primary hyperlipidemia who need additional LDL reduction beyond statins and lifestyle changes. It may be appropriate for those with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease where LDL goals are not met.

People with known hypersensitivity to inclisiran should not receive it. Discuss use if you are pregnant, planning pregnancy, or breastfeeding, as data are limited. People with severe liver problems or significant injection-site skin conditions should consult a clinician before treatment. For broader lipid conditions, review our Mixed Dyslipidemia category and the Cardiovascular section.

Dosage and Usage

Standard dosing follows the product label. A healthcare professional gives a first dose, a second dose at 3 months, and then doses every 6 months. The injection is given under the skin, typically in the abdomen, upper arm, or thigh. Rotating sites helps limit local irritation.

Your clinic will check your current lipid therapy and recent labs before administration. You may be asked to wait briefly after the injection for observation. Keep your statin and other lipid medicines unchanged unless your prescriber advises otherwise. When in doubt, follow the official label and your clinic’s protocol.

Strengths and Forms

The product is supplied as a single-dose prefilled syringe for subcutaneous use. A commonly available presentation is 284 mg/1.5 mL. Availability may vary by market and stock. Always verify the exact presentation listed on your prescription and shipment.

The prefilled syringe is designed for professional administration in a clinic setting. Packaging typically includes a protective carton to shield the syringe from light until use.

Missed Dose and Timing

If a scheduled clinic dose is missed, contact your prescriber to reschedule. The dose is usually given as soon as practical, and the clinic may adjust your future timing to maintain the every-6-month schedule. Do not attempt to self-inject unless your clinician explicitly arranges appropriate training and oversight. Keep other lipid therapies consistent unless your prescriber advises changes.

Storage and Travel Basics

Store the prefilled syringe refrigerated in the original carton. Do not freeze. Protect it from light. Your clinic typically manages storage, but if you transport it to an appointment, follow the labelled storage range and keep it insulated. Let the syringe reach room temperature per clinic guidance before administration. Do not use if the solution looks cloudy, discolored, or contains particles.

If you travel to an appointment, bring your prescription details and a copy of your invoice. Use a cooler pack when needed, and keep the carton upright and secure. Avoid leaving the medicine in a hot car or direct sun. Ask your clinic about any temporary room temperature allowances and never refreeze the product.

Pen Handling and Sharps Disposal

This therapy comes as a prefilled syringe and is administered by a professional. Your clinic handles syringe setup and disposal in an approved sharps container. If you ever transport an unused or used syringe, keep the needle protected and place any used device in a puncture-resistant sharps container. Follow local regulations for disposal or return it to the clinic for safe handling.

Benefits

This medicine reduces LDL cholesterol by limiting PCSK9 production within liver cells. It can complement a statin and lifestyle measures. The maintenance schedule is twice yearly after the second dose, which may support adherence. Clinic administration means trained staff prepare and give the injection, which can reduce handling steps for you.

Lowering LDL can help lower the risk linked to atherosclerotic cardiovascular disease over time when combined with diet, exercise, and guideline-directed therapy. Your prescriber will tailor goals to your health history and existing treatment plan.

Side Effects and Safety

• Injection site pain
• Redness or swelling at the site
• Rash or itching at the site
• Joint pain
• Upper respiratory symptoms

Serious allergic reactions are uncommon but possible. Seek urgent care for signs such as hives, swelling of the face or throat, trouble breathing, or severe dizziness. Talk with your clinician about any new or worsening symptoms. People with a history of severe hypersensitivity to this medicine should not receive it again. Report suspected reactions to your prescriber promptly.

Drug Interactions and Cautions

Inclisiran is not known for many drug–drug interactions, as it is not a CYP enzyme substrate. Still, provide a full list of your medicines and supplements. Tell your clinician about active infections or skin issues at potential injection sites. Safety data in pregnancy and breastfeeding are limited, so individualized decisions are needed. Liver problems may require added monitoring. Follow the label and your prescriber’s advice.

What to Expect Over Time

You can expect clinic visits at the start, at 3 months, and then every 6 months for maintenance dosing. Your clinician may check lipids to track response and guide overall therapy. Keep appointments and set reminders. If you need to reschedule, aim to stay close to the planned interval. Adherence to statins, diet, and exercise remains important for long-term cardiovascular care.

Plan ahead for clinic availability, transport, and any coordination with your primary care or cardiology team. If you have questions about insurance paperwork or receipts, your clinic or pharmacy can help with documentation and timing.

Compare With Alternatives

Other LDL-lowering options include PCSK9 monoclonal antibodies and additional oral agents. Some patients use evolocumab or alirocumab when further LDL reduction is needed despite statins. For injectables, see Praluent® or Repatha® and discuss the dosing style, clinic support, and monitoring differences with your prescriber. If you are comparing Inclisiran injection price across options, note that administration models and support programs may differ.

Many people continue a statin such as atorvastatin while adding another LDL-lowering therapy. If you want lifestyle tips or background, read our article The Skinny On High Cholesterol.

Pricing and Access

We source Canadian supply for US delivery from Canada. Your clinic may charge an administration fee for the injection visit. To compare across pharmacies, look at the leqvio price for the syringe, then add clinic services and any courier needs. Separation of product and administration can make line items look different from single-site care models.

If you are paying cash, consider manufacturer help and patient support options from your clinician. Ask your prescriber’s office about documentation that might assist with reimbursement. You can also review Inclisiran price without insurance when planning appointments and refills. For periodic deals and neutral information on current offers, see our Promotions page. A prescription is required and verified for dispensing.

Availability and Substitutions

Supply can vary by market and demand. If stock is limited, your prescriber may recommend another LDL-lowering therapy until it returns. Clinics sometimes coordinate timing with your lab work to streamline care. When comparing options, consider schedule, monitoring, and Inclisiran 284 mg price alongside clinic service charges. If a substitution is needed, your clinician will choose an appropriate alternative based on your health history.

Patient Suitability and Cost-Saving Tips

This medicine may fit adults who need additional LDL reduction despite maximized statins and lifestyle changes. It may not suit those with past severe hypersensitivity to inclisiran or people unable to attend clinic appointments on a regular schedule. People who are pregnant, planning pregnancy, or breastfeeding should discuss risks and benefits with a healthcare professional.

To manage costs, ask about multi-appointment scheduling so your follow-up dose is pre-booked. Align visits with routine labs to reduce extra trips. Set calendar alerts for the 3-month and 6-month windows. If you have a health savings account, keep invoices for documentation. Your prescriber can advise on timing so you avoid rush fees and last-minute rescheduling.

Questions to Ask Your Clinician

• My LDL goal: what is a realistic target for me?
• How will this therapy work with my current statin?
• What side effects should I watch for after the injection?
• How are clinic administration fees handled at my visits?
• What lab checks will we use to track progress?
• If I miss an appointment, when should I reschedule?
• Is this treatment suitable during pregnancy or breastfeeding?
• Are there support programs that could reduce my out-of-pocket costs?

Authoritative Sources

• Novartis Leqvio Product Information
• FDA DailyMed: Inclisiran
• Health Canada Drug Product Database

Ready to proceed? You can place your order with prompt, cold-chain shipping that Ships from Canada to US. Always follow your prescriber’s instructions. This page is educational and does not replace medical advice.