Leqvio® (inclisiran) for LDL Cholesterol Lowering and Dosing Guide

What Leqvio® Is and How It Works

Leqvio® (inclisiran) is a small interfering RNA (siRNA) medicine that lowers LDL cholesterol. It targets PCSK9 production in the liver, which increases LDL receptor recycling and removal of LDL from the blood. Adults use it as an adjunct to diet and statin therapy for primary hyperlipidemia, including heterozygous familial hypercholesterolemia. It is given as a subcutaneous injection by a healthcare professional, not self-administered. If you are comparing options, the leqvio price from Canadian pharmacies can help lower out-of-pocket costs.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing. We also partner with licensed, vetted international pharmacies to source authentic brand medicines, offering a broad selection at affordable pricing.

Leqvio® has a simple dosing cadence. After the first injection, a second dose is given at 3 months, then maintenance injections every 6 months. This long interval supports adherence and provides steady LDL-C lowering between visits. These points reflect common leqvio uses and leqvio indications. Novartis is the leqvio manufacturer, and the product gained initial inclisiran FDA approval in 2021. If you need leqvio patient information for clinic coordination, your prescriber and pharmacist can supply the correct carton and syringe details before your appointment.

Dosage and Usage

• Schedule: initial dose, second dose at 3 months, then every 6 months thereafter.
• Administration: subcutaneous injection by a healthcare professional in the abdomen, thigh, or upper arm.
• Device: supplied as a single-dose prefilled syringe. The clinic handles preparation and injection.
• Before your visit: confirm the clinic accepts shipments and can store the medication on arrival.
• Missed appointment: reschedule as soon as possible. Your provider will set the next dates based on the dose you received.
• Do not attempt self-injection unless specifically trained and instructed by your clinician.

• Storage (pharmacy/clinic): refrigerate at 2–8 °C (36–46 °F). Do not freeze. Keep in original carton to protect from light.
• Short-term room temperature: if needed, unopened syringes may be kept below 30 °C (86 °F) for a limited time; follow the label on your specific lot and pharmacist guidance.
• Handling: do not shake. Inspect for particles or discoloration; the clinic will check before use.
• Shipping: we use prompt, express, cold-chain shipping. Ensure someone is available to receive and refrigerate on arrival.
• Travel to clinic: transport in an insulated container with cold packs if your clinic asks you to bring the dose. Avoid direct sunlight and heat.

Benefits and Savings

Leqvio® reduces LDL-C by about 50% on average when added to statin therapy. The twice-yearly maintenance schedule supports adherence and clinic-based monitoring. Many people appreciate the predictable visit schedule and the lack of daily dosing. These benefits make this leqvio injection a practical choice when high-intensity statins and ezetimibe are not enough, or when statin intolerance limits options.

Buying from Canada can lower the leqvio cost. Typical savings are 60–80% compared with many US retail prices, depending on dose and supply. Patients comparing the cost of leqvio often consider the full year of therapy; the leqvio annual cost reflects two maintenance doses following the second dose at month three. If you are reviewing the leqvio cost per year, include clinic administration fees charged in your area, since those vary. We list transparent inclisiran injection price details at checkout, and you can message us if you have questions about leqvio inclisiran price for your prescribed quantity.

Coverage and billing differ by setting. In the US, some patients receive in-office leqvio injections that may be billed under medical benefits, including leqvio Medicare Part B in certain cases. Others choose direct purchase to manage timing or total cash costs. If you are researching leqvio price Medicare information, confirm details with your plan or clinic billing office.

For current offers, see our leqvio coupon.

Side Effects and Safety

• Injection-site reactions (pain, redness, or swelling)
• Arthralgia or musculoskeletal pain
• Back pain or pain in extremity
• Fatigue
• Diarrhea
• Bronchitis or upper respiratory symptoms
• Urinary tract infection
• Nausea

Serious reactions are uncommon. Hypersensitivity, including rash or angioedema, has been reported. Seek urgent care for severe allergic symptoms after an injection. Inclisiran is not known to cause hypoglycemia. Discuss pregnancy and breastfeeding plans with your clinician, as data are limited. Dose adjustments are not usually needed for mild to moderate renal impairment; your prescriber will manage special populations.

Onset Time

LDL-C begins to fall within 1–2 weeks after the first dose. A larger, sustained reduction appears by about 4–8 weeks. After the second dose at 3 months, LDL-C lowering is reinforced, and the effect remains stable with each 6‑month maintenance injection. Your healthcare provider will schedule lipid panels to track changes over time and align future injections with your targets.

Compare With Alternatives

Repatha (evolocumab) and Praluent (alirocumab) are monoclonal antibody PCSK9 inhibitors. They also reduce LDL-C by about 50–60% and are self-injected either every 2 weeks or monthly. They provide flexibility for those who prefer home administration, while Leqvio® offers twice-yearly clinic dosing for those who prefer fewer treatment days.

Ezetimibe is an oral option that lowers LDL-C by about 15–20% and is often used with statins. Bempedoic acid (with or without ezetimibe) is another oral therapy that can aid statin-intolerant patients. These choices may be used before or with Leqvio® depending on LDL-C goals and tolerance.

Combination Therapy

• Leqvio® plus a maximally tolerated statin is standard for primary hyperlipidemia.
• Add ezetimibe if LDL-C goals are not met with statin alone.
• Consider bempedoic acid in statin-intolerant patients, guided by your prescriber.
• Lifestyle changes, including diet and exercise, remain important alongside any lipid-lowering drug.
• No known interaction with insulin or sulfonylureas regarding hypoglycemia risk.

Patient Suitability and Cost-Saving Tips

Good candidates include adults with primary hyperlipidemia, including HeFH, who need additional LDL-C lowering beyond statins and diet. It may also suit those who cannot tolerate higher statin doses. It is not indicated for children. Use caution in pregnancy and breastfeeding due to limited data. People with severe liver disease require individualized assessment.

Money-saving steps can help when reviewing the cost of leqvio. You can set a reorder reminder in your account so you do not miss clinic dates. Multi-dose orders or periodic bulk promotions may lower the per‑month cost across a year of therapy. Coordinate shipping with your clinic to avoid storage delays. If comparing leqvio price across settings, include local administration fees and lab costs. In the US, some clinics bill injections under leqvio Medicare Part B when supplied and administered in-office; coverage varies by plan and provider.

Authoritative Sources

Novartis Leqvio product website

FDA Prescribing Information for inclisiran

Health Canada Drug Product Database

Order Leqvio® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This content is for educational purposes and is not a substitute for professional medical advice, diagnosis, or treatment.