Leukeran® Tablets for Chronic Lymphocytic Leukemia and Lymphoma

What Leukeran® Is and How It Works

Leukeran (chlorambucil) is an oral alkylating chemotherapy used for chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and certain non-Hodgkin lymphomas. It is usually taken as short daily courses or in intermittent cycles based on the treatment plan your oncology team sets. Many people compare Leukeran price options to manage long-term care costs when they buy Leukeran online, including those paying without insurance.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and licensed pharmacists review prescriptions before dispensing. We also work with licensed, vetted international partner pharmacies to supply authentic brand medicines across many conditions at affordable pricing.

Chlorambucil works by forming DNA cross-links in rapidly dividing cells. This prevents cancer cells from replicating and triggers cell death. The effect is not immediate; blood counts and lymph node size change over weeks. Leukeran tablets are typically 2 mg strength, and dosing is personalized by weight, diagnosis, and response.

Dosage and Usage

• Dosing is individualized. Common ranges include: CLL 0.1–0.2 mg/kg once daily for several weeks; Hodgkin lymphoma about 0.2 mg/kg once daily for 4–8 weeks; indolent non-Hodgkin lymphoma about 0.1 mg/kg once daily. Courses may repeat after recovery, or be given intermittently per protocol.
• Take once daily at the same time. May be taken with or without food. Swallow tablets whole; do not crush, split, or chew because this is a hazardous drug.
• Wash hands after handling tablets. Caregivers should wear disposable gloves when handling the bottle or tablets.
• Routine blood tests are required to monitor white cells, hemoglobin, and platelets. Treatment holds or dose changes are common when counts drop.
• If a dose is missed, take it when remembered unless it is close to the next dose. Do not double up. Call the clinic for specific guidance if more than one dose is missed.
• Use effective contraception during treatment and for a period after the last dose as advised by the prescriber. Do not breastfeed while on chlorambucil.
• Avoid live vaccines during therapy and until the care team says it is safe.

• Store in a refrigerator at 2–8 °C (36–46 °F). Do not freeze. Keep the bottle tightly closed, in the original container, and protected from moisture and light.
• Keep out of reach of children and pets. Return unused tablets via a pharmacy take-back program; do not flush.
• For travel, use an insulated pouch with cold packs to maintain 2–8 °C. Place the bottle in a sealed bag to avoid condensation. Do not place tablets in direct contact with ice.
• Carry your medication in your hand luggage. Do not leave it in a hot or cold car. Keep a copy of your prescription for security checkpoints.
• When your order arrives, move it to the refrigerator promptly. Save the cold packaging until you confirm the contents are cool and intact.

Benefits and Savings

Leukeran is a well-studied oral option for certain leukemias and lymphomas. It may reduce lymphocyte counts, shrink nodes, and help control symptoms. The tablet form avoids infusion visits and can be easier to schedule during multi-cycle care.

Ordering from a Canadian pharmacy can lower your Leukeran cost. Many customers report 60–80% savings versus typical US prices. This can help with a high Leukeran cash price, and it may be especially helpful for those paying without insurance. Multi-month supplies, when prescribed, can also reduce per-month costs.

Leukeran coupon information, when available, appears on our Promotions page.

Side Effects and Safety

• Low white blood cells, anemia, or low platelets (infection, fatigue, or bruising risk)
• Nausea, vomiting, poor appetite, or diarrhea
• Mouth or throat soreness
• Skin rash or itching
• Fatigue or malaise
• Elevated liver enzymes
• Fertility changes or menstrual irregularities

Serious risks include severe bone marrow suppression, serious infections, and rare severe skin reactions. Chlorambucil can cause embryo-fetal harm and may affect future fertility. Secondary malignancies have been reported with alkylating agents. Use caution with liver impairment, and monitor closely when combining with other myelosuppressive therapies. Seek urgent care for fever, bleeding, worsening shortness of breath, severe rash, or seizures.

Onset Time

Responses are gradual. Lymphocyte counts often start to fall within 1–4 weeks as dosing stabilizes. Lymph nodes may soften and decrease in size over several weeks to months. Clinicians usually assess best response after multiple cycles. Fatigue and other symptoms may improve as disease control is achieved and blood counts recover between cycles.

Compare With Alternatives

Targeted oral therapies are now common in CLL. For example, the BTK inhibitor Imbruvica® is taken daily and does not cause traditional chemotherapy-related DNA cross-linking. It can be effective in various CLL settings, though it has its own cardiovascular and bleeding risks and monitoring needs.

Anti-CD20 antibodies such as rituximab or obinutuzumab are often combined with oral agents rather than used alone. These are infusions given in clinic and are paired with premedication and observation.

Other blood cancers use different targeted drugs. Chronic myeloid leukemia is treated with tyrosine kinase inhibitors such as Tasigna®. These are not interchangeable with chlorambucil, and suitability depends on the exact diagnosis, stage, and prior therapies.

Combination Therapy

• Chlorambucil plus prednisone is a classic regimen for certain indolent lymphomas and may be used short term.
• Chlorambucil with an anti-CD20 antibody (for example, obinutuzumab) is used in some CLL protocols; infusion scheduling and premedication are required.
• When combining with other myelosuppressive agents, clinicians often reduce doses or adjust schedules to limit overlapping bone marrow suppression.
• Avoid live vaccines during combination therapy. Non-live vaccines may be timed around cycles to improve response.

Patient Suitability and Cost-Saving Tips

Leukeran may be considered for adults with CLL or indolent lymphomas where an oral alkylating agent is suitable. It is not appropriate during pregnancy or breastfeeding. People with very low blood counts, active uncontrolled infections, or severe liver disease may need different options or careful dose adjustments.

Discuss prior therapies, fertility plans, seizure history, and vaccination timing with the oncology team. Handling precautions matter at home. Keep tablets away from children and pets, and avoid crushing or cutting tablets.

To manage expenses, compare Leukeran tablets for sale from Canadian sources, and plan ahead for refills. Reorder reminders can help you avoid gaps in treatment. If your prescriber writes for multiple cycles, a longer supply can lower per-month costs through bulk promotions. These steps may ease the burden of Leukeran without insurance.

Authoritative Sources

FDA Prescribing Information for Leukeran (chlorambucil)
Health Canada Drug Product Database
Manufacturer information (GSK) for Leukeran

Order Leukeran® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This content is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s directions and local guidance.