Myfembree® Tablets for Uterine Fibroids and Endometriosis

Myfembree is a prescription combination tablet for premenopausal adults. It treats heavy menstrual bleeding from uterine fibroids and pain from endometriosis. You can order with US shipping from Canada, and compare options if paying without insurance.

What Myfembree Is and How It Works

Myfembree® medication combines three active ingredients: relugolix, estradiol, and norethindrone acetate. Relugolix is a GnRH receptor antagonist that lowers ovarian estrogen production. The added estradiol and norethindrone help reduce low-estrogen side effects while maintaining symptom control. The treatment acts on the hypothalamic-pituitary-ovarian axis to reduce bleeding and pain related to fibroids and endometriosis.

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This medicine is taken by mouth once daily, at about the same time each day. It may be used for up to 24 months, as directed by your prescriber. The product is not a contraceptive, and pregnancy must be avoided during treatment.

Who It’s For

This therapy is for premenopausal adults with heavy menstrual bleeding due to uterine fibroids or moderate to severe endometriosis pain. Prescribers use Myfembree for fibroids to help decrease heavy flow and improve quality of life. It may also reduce endometriosis-related pelvic pain, dyspareunia, and non-menstrual pelvic pain.

It is not for people who are pregnant or trying to conceive. Avoid use if you have a history of blood clots, stroke, certain heart conditions, uncontrolled high blood pressure, hormone-sensitive cancers, liver disease, undiagnosed abnormal uterine bleeding, or osteoporosis. Smoking increases clotting risks, especially if age 35 or older. Your healthcare professional will review risks and decide if this therapy fits your history.

Learn more about these conditions: Uterine Fibroids and Endometriosis. You can also browse related options in Womens Health.

Dosage and Usage

Follow the Myfembree dosage on your prescription label and the official package insert. Take one tablet by mouth once daily, with or without food, at the same time each day. Swallow tablets whole with water; do not crush or chew. If starting therapy, your prescriber may advise a start date aligned with your cycle. Use effective nonhormonal contraception during treatment and for a short period after the last dose, as advised in the prescribing information.

Your clinician may order baseline tests such as pregnancy testing and bone mineral density assessment. They may monitor blood pressure, mood, lipid profile, and symptoms at intervals. Do not change your dose or stop therapy without consulting your prescriber.

Strengths and Forms

This treatment is available as oral tablets containing relugolix 40 mg, estradiol 1 mg, and norethindrone acetate 0.5 mg in a single, fixed-dose combination. Packs commonly contain a 28-day supply in calendarized blisters. Availability may vary by supply and region.

Missed Dose and Timing

If you miss one dose, take it as soon as you remember on the same day, and then take your next dose at the regular time the following day. If you miss two or more consecutive doses, skip the missed tablets and resume with the next scheduled tablet. Breakthrough bleeding or spotting may occur after missed doses. If you are unsure how to proceed, consult the patient leaflet or your prescriber.

Storage and Travel Basics

Store tablets at room temperature in the original blister to protect from moisture. Keep the package closed and out of reach of children and pets. Do not store in a bathroom or near heat sources. When traveling, carry your medication in your hand luggage along with your prescription and a copy of the pharmacy label. Use a pill organizer only if each day’s dose remains protected and properly labeled. If traveling across time zones, maintain a consistent 24-hour dosing interval; ask your clinician or pharmacist for help adjusting timing.

Benefits

This therapy can reduce heavy menstrual bleeding related to fibroids and improve endometriosis pain. The once-daily tablet is convenient and designed to balance symptom relief with fewer low-estrogen effects. Many patients appreciate that add-back hormones may lessen hot flushes, night sweats, and bone loss risk compared with antagonist therapy alone. Your clinician will evaluate benefits against risks for your situation.

Side Effects and Safety

• Common Myfembree side effects: headache, hot flushes, nausea, abdominal pain
• Mood changes or irritability
• Fatigue or sleep changes
• Breast tenderness
• Irregular bleeding or spotting
• Decreased libido
• Joint or muscle aches

Serious risks may include blood clots, stroke, heart attack, high blood pressure, liver problems, severe allergic reactions, and significant bone mineral density loss over time. Report symptoms of clotting (leg swelling, sudden chest pain, shortness of breath, vision changes, severe headache) right away. Depression or suicidal thoughts can occur; seek help if mood symptoms worsen. Use is limited to a defined duration to manage bone health risks; your prescriber may monitor bone density during treatment.

Drug Interactions and Cautions

Tell your healthcare professional about all medicines and supplements you take. Strong P-gp inhibitors or inducers may affect relugolix exposure; your clinician may advise avoiding certain combinations. St. John’s wort and some anticonvulsants can alter hormone levels. Do not use estrogen- or progestin-only contraceptives with this therapy unless your prescriber says it is appropriate; nonhormonal contraception is generally preferred. Alcohol and tobacco may increase certain risks, including blood pressure and clotting. Review the full prescribing information for detailed interaction guidance, and ask your pharmacist to check your list.

For background on related hormone therapies, see our article Zoladex Cost and our Contraceptive overview.

What to Expect Over Time

Bleeding often decreases with continued, consistent daily use. Endometriosis-related pain may ease gradually with adherence. Some low-estrogen symptoms such as hot flushes can occur, though add-back hormones are intended to lessen these effects. Your prescriber may reassess symptoms, blood pressure, mood, and bone health at intervals. If you miss doses, spotting or heavier flow can return temporarily. Keep a symptom diary to discuss progress at follow-up visits.

Compare With Alternatives

Other options may be considered if this therapy is unsuitable or unavailable. Dienogest is a progestin used in some regions for endometriosis-related pain. Combined oral contraceptives, such as Cyclen, may help regulate cycles and reduce bleeding for some patients; suitability depends on your risk profile. Your clinician can explain differences in mechanisms, side effects, and monitoring needs for each option.

Pricing and Access

You can review Myfembree cost without insurance in your account and compare fill lengths before checkout. Canadian pricing is visible after sign-in, with transparent details and no subscription requirements. Orders Ships from Canada to US to your address with tracked service. For current offers, check our Promotions page. Encrypted checkout protects your information.

Questions about coverage or cash-pay? Our team can explain how to upload your prescription and view options before you place an order.

Availability and Substitutions

Supply can vary. If your medicine is unavailable, your prescriber may suggest an appropriate alternative or a temporary substitution. People who search to Buy relugolix estradiol norethindrone acetate sometimes ask about generics; at this time, branded supply is common. Your clinician will decide if switching to another therapy is appropriate for your condition.

Patient Suitability and Cost-Saving Tips

This treatment may suit premenopausal adults needing non-surgical management of fibroid bleeding or endometriosis pain who do not have major cardiovascular, clotting, liver, or bone health contraindications. It is not appropriate in pregnancy or for people with hormone-sensitive cancers or uncontrolled hypertension. Your prescriber may also evaluate migraine with aura, lipid disorders, and smoking status.

Ways to manage costs and adherence:

• Multi-month fills: fewer refills, potential per-pack savings
• Refill reminders: help maintain steady dosing
• Blister calendar: supports on-time daily use
• Travel-ready plan: keep tablets on hand when away
• Medication list: share with your pharmacist for interaction checks

Questions to Ask Your Clinician

• Is this therapy appropriate for my bleeding pattern or pain profile?
• How will we monitor bone health and blood pressure during use?
• What nonhormonal contraception should I use while taking this?
• Which medicines or supplements should I avoid with this treatment?
• How long should I continue before we reassess benefits and risks?
• What are signs of clotting or liver problems I should watch for?
• If I miss doses, how should I get back on schedule safely?

Authoritative Sources

Manufacturer Website

FDA DailyMed

FDA Drug Database

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