Corgard® (nadolol) tablets for hypertension and angina

What Corgard® (nadolol) Is and How It Works

Nadolol is a nonselective beta blocker used for high blood pressure and chronic stable angina. It is the generic for Corgard® and comes as oral tablets, often 20 mg, 40 mg, and 80 mg strengths. Its long half-life supports once-daily dosing. If you compare nadolol price options before ordering, Canadian pharmacy pricing can help.

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Nadolol blocks beta-1 and beta-2 receptors. This lowers heart rate, blood pressure, and myocardial oxygen demand, and it reduces renin release from the kidneys. The result is steadier blood pressure control and fewer angina episodes during exertion. Some clinicians also use nadolol off label for migraine prevention or certain arrhythmias.

The medication nadolol is not a weight loss therapy. Like other beta blockers, it may mask symptoms of low blood sugar in people with diabetes. It has fewer central nervous system effects than lipophilic agents, which may mean less drowsiness or vivid dreams for some patients.

Dosage and Usage

• Hypertension: usual starting dose 40 mg once daily. Titrate every 1–2 weeks to 40–320 mg daily as needed and tolerated.
• Angina: typical starting dose 80 mg once daily. Increase at 1–2 week intervals up to 80–320 mg daily to control exertional chest discomfort.
• Renal impairment: reduce dose or extend dosing interval, as nadolol is renally cleared and accumulates when kidney function is reduced.
• Administration: swallow tablets with water, with or without food. Keep a consistent schedule. Many take nadolol in the morning; the best time to take nadolol is the time that can be kept daily.
• Do not stop suddenly. Taper over 1–2 weeks to lower the risk of rebound angina, hypertension, or arrhythmias.
• Missed dose: take when remembered unless it is close to the next dose; if so, skip the missed dose. Do not double up.
• Common strengths include nadolol 20 mg, nadolol 40 mg, and nadolol 80 mg. Some brands, including Corgard 40 mg, are available; scored tablets may allow splitting if labeled for it.

• Storage: store tablets at 15–25 °C (59–77 °F) in a dry place, away from moisture and direct light. Keep in the original container with the label.
• Travel: keep your medication in your carry-on. Use the original labeled bottle for airport screening. Pack extra doses for delays.
• Handling: do not leave pills in a hot car or near heaters. Avoid bathrooms where humidity is high.
• Refills: set reorder reminders so your supply does not run out. Multi-month fills can reduce per-month costs.
• Shipping: choose prompt, express delivery when planning long trips so your order arrives before departure.

Benefits and Savings

Nadolol provides once-daily blood pressure control for many patients. Its steady 24-hour effect can reduce heart rate, improve exercise tolerance in angina, and simplify routines compared with multiple daily dosing. For those sensitive to central nervous system effects, its lower lipid solubility may lessen sleep disturbance compared with propranolol.

Buying nadolol online from a Canadian pharmacy often brings 60–80% savings versus typical US prices. Price differences are most noticeable at common strengths like nadolol 20 mg and nadolol 40 mg. Multi-month supplies and occasional bulk promotions can reduce the effective monthly cost even further.

For current offers, see our nadolol discount page.

You can compare nadolol 20 mg cost, nadolol 40 mg price, and higher strengths to match your prescription and budget. Reorder reminders help keep therapy consistent, which supports stable blood pressure and angina control.

Side Effects and Safety

• Fatigue, low energy, or dizziness
• Slow heart rate (bradycardia)
• Cold hands or feet; Raynaud-like symptoms
• Gastrointestinal upset, nausea, or diarrhea
• Sleep disturbance or vivid dreams (less common with nadolol)
• Sexual dysfunction
• Mild weight changes

Serious but less common risks include severe bradycardia, heart block, worsening heart failure, bronchospasm (especially in asthma or COPD), depression, and severe hypotension. Beta blockers can mask adrenergic symptoms of hypoglycemia; the risk of hypoglycemia increases when combined with insulin or sulfonylureas. Do not stop nadolol abruptly; taper to avoid rebound angina or hypertension.

Key nadolol warnings include avoidance in severe asthma, second- or third-degree heart block without a pacemaker, sick sinus syndrome, cardiogenic shock, and untreated pheochromocytoma unless adequately alpha-blocked. Use caution in peripheral vascular disease, diabetes, thyroid disorders, and renal impairment.

Onset Time

Blood pressure improvement often starts within 1–2 weeks as the dose is titrated. Full effect may take 2–4 weeks on a stable dose. Angina frequency can decline within 1–2 weeks of reaching an effective daily dose, with continued gains as activity levels and heart rate targets improve. Off-label migraine prevention may require 4–6 weeks to assess benefit.

Compare With Alternatives

Propranolol is another nonselective beta blocker with more central nervous system penetration. It is often used for migraine prevention and performance anxiety, but it usually requires twice-daily dosing. Nadolol offers once-daily coverage and may cause fewer CNS effects for some patients.

Metoprolol is beta-1 selective and is available as immediate-release (twice daily) and extended-release (once daily) forms. It can be preferred in patients with mild reactive airway disease. There is no direct nadolol to metoprolol conversion; clinicians individualize dosing based on response and heart rate targets.

If migraine education is of interest, see What Are Migraine Headaches Are They A Type Of Epilepsy for background on migraine symptoms and triggers.

Combination Therapy

• Hypertension: combine with a thiazide diuretic (e.g., hydrochlorothiazide) or an ACE inhibitor/ARB for additive blood pressure reduction.
• Angina: pair with long-acting nitrates; add a dihydropyridine calcium channel blocker if needed. Avoid combining with verapamil or diltiazem without close monitoring due to bradycardia risk.
• Diabetes therapy: when used with insulin or sulfonylureas, monitor glucose closely and consider dose adjustments to reduce hypoglycemia risk.
• Clonidine: when discontinuing clonidine, taper nadolol first to lower rebound hypertension risk.
• Antiarrhythmics and digoxin: concurrent use can increase bradycardia or conduction block risk; monitor ECG and heart rate.

Patient Suitability and Cost-Saving Tips

Nadolol may suit adults with essential hypertension or chronic stable angina who benefit from once-daily beta blockade. It is generally not preferred in reactive airway disease with active bronchospasm. Those with marked bradycardia, heart block, or decompensated heart failure should avoid it unless directed by a cardiology team.

People with diabetes can use nadolol, but they should monitor for masked hypoglycemia symptoms. Patients with Raynaud phenomenon, peripheral vascular disease, depression, or psoriasis need individualized risk–benefit discussions. Renal impairment requires dose adjustments due to nadolol’s renal clearance.

Pregnancy and breastfeeding require clinician guidance. Beta blockers may be used when benefits outweigh risks; neonatal monitoring for bradycardia and hypoglycemia may be needed around delivery.

To lower nadolol cost, consider a 90-day supply if appropriate, which can reduce the per-month price. Use reorder reminders so there is time to refill before running out. Combining household prescriptions in one shipment can also reduce shipping fees.

Authoritative Sources

Corgard (nadolol) US Prescribing Information (FDA)

Drugs@FDA Application 018063 Overview

Health Canada Drug Product Database

Order Corgard® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This material is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s directions and your pharmacist’s guidance.