Revia® (Naltrexone HCL) 50 mg Tablets for Dependence Treatment

What Revia® Is and How It Works

Naltrexone HCL is the generic medicine in Revia. It is an opioid receptor antagonist used to support treatment of alcohol use disorder and to prevent relapse in opioid dependence after detox. Many patients take the standard naltrexone hydrochloride 50mg tablet once daily. If you are comparing options, you may see this product listed as a naltrexone hcl 50mg tab. Savings are often meaningful for patients buying naltrexone hcl without insurance.

YouDrugstore is a licensed Canadian pharmacy based in Manitoba. Prescriptions are reviewed by licensed pharmacists before dispensing. We offer brand and generic medicines at Canadian prices, plus OTC health products. You can order online, and customer-service chat is available during posted hours.

Naltrexone blocks mu-opioid receptors. For alcohol use disorder, this reduces the rewarding effects of drinking and helps curb cravings. For opioid dependence, it prevents opioids from producing euphoria and respiratory depression. The oral tablet route allows daily, flexible dosing without an injection appointment.

Dosage and Usage

• Usual adult dose: 50 mg once daily for alcohol use disorder and relapse prevention after opioid detox. Alternate schedules (for example, 100 mg every other day, or 150 mg every third day) may be used under supervision.
• Opioid-free interval: Patients typically need to be opioid-free for at least 7–10 days before starting to avoid precipitated withdrawal. A naloxone challenge may be used when the history is uncertain.
• Initiation: Clinicians may start at 25 mg for the first dose to assess tolerance, then advance to 50 mg daily.
• Duration: Treatment length varies. Programs often continue for months as counseling and recovery supports progress.
• Missed dose: Take the next dose at the usual time. Do not double up.
• Food: Taking with food can reduce nausea.
• Opioid analgesics: Naltrexone blocks opioid pain medicines. Emergency analgesia may require non-opioid strategies or higher monitored doses of opioids.
• Avoid opioid-containing products (including some cough syrups and antidiarrheals) unless specifically directed by a clinician.

• Storage: Keep tablets at 20–25°C (68–77°F). Short excursions 15–30°C are acceptable.
• Moisture: Store in the original, tightly closed container. Keep desiccant in place if present.
• Light: Protect from excessive light and heat. Do not store in a car.
• Travel: Carry your medicine in hand luggage with a copy of your prescription.
• Safety: Keep out of reach of children and pets. Do not use tablets that are chipped, discolored, or expired.

Benefits and Savings

Naltrexone hydrochloride use supports abstinence goals and reduces heavy-drinking days. It has no abuse potential and does not cause physiological dependence. For people in opioid recovery who have completed detox, daily tablets can maintain receptor blockade without clinic visits for dosing.

Cost savings are a key advantage. Many customers report 60–80% lower prices versus typical U.S. pharmacy costs, especially when comparing the naltrexone hcl price across a few quantities. Multi-month supplies may lower the per-month naltrexone hcl cost, and reorder reminders help you avoid gaps in therapy. These options can be helpful if purchasing naltrexone hcl without insurance or paying a naltrexone hcl cash price.

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Side Effects and Safety

• Common: Nausea, vomiting, stomach pain, decreased appetite, diarrhea or constipation.
• Central nervous system: Headache, dizziness, fatigue, insomnia, anxiety, restlessness.
• Musculoskeletal: Joint or muscle aches.
• Dermatologic: Sweating, rash or itching.
• Liver enzymes: Mild, reversible increases can occur.

Serious effects are uncommon but need prompt attention. These include liver injury (upper right abdominal pain, dark urine, jaundice), severe allergic reactions, depression or suicidal thoughts, and precipitated withdrawal if opioids are in the system. People with acute hepatitis or liver failure should not use naltrexone. Baseline and periodic liver function tests are often obtained. Naltrexone does not cause hypoglycemia; the low blood sugar risk noted with insulin or sulfonylureas does not apply to this medicine.

Onset Time

Opioid receptor blockade starts within about one hour of a 50 mg dose, with effects lasting about 24 hours. Some opioid challenge data show partial blockade up to 48–72 hours at higher supervised dosing schedules. For alcohol use disorder, reductions in cravings can appear in the first one to two weeks and often strengthen with continued daily use plus counseling.

Weight change is not an expected effect with naltrexone alone. In obesity management, the bupropion–naltrexone combination (marketed separately) is used instead. In that setting, clinically meaningful weight loss is usually assessed by 12–16 weeks after titration.

Compare With Alternatives

Acamprosate supports abstinence in alcohol use disorder by modulating glutamate and GABA, and it is dosed three times daily. It does not block opioid receptors or treat opioid dependence.

Disulfiram deters alcohol use by causing unpleasant reactions if alcohol is consumed. It requires strict adherence and abstinence and is not used for opioid dependence.

Buprenorphine or methadone are opioid agonist therapies for opioid use disorder. They reduce withdrawal and cravings but use a different approach than an antagonist. Choice of therapy depends on clinical goals, history, and access to care.

Extended-release injectable naltrexone is administered monthly in a clinic. It can improve adherence for some patients but requires an injection visit and different handling than tablets.

Combination Therapy

• Counseling and behavioral therapies alongside naltrexone improve outcomes in alcohol use disorder.
• Mutual-support groups and recovery programs provide structure and accountability.
• For weight management, a fixed-dose combination of naltrexone hcl and bupropion hcl is used under a separate prescription.
• When combining with other CNS-active agents, clinicians monitor for additive side effects like insomnia or anxiety.
• Do not combine with opioid analgesics unless medically supervised due to reduced analgesia and withdrawal risk.

Patient Suitability and Cost-Saving Tips

Naltrexone hcl uses include alcohol use disorder and relapse prevention after opioid detox. It is not a treatment for acute opioid withdrawal and is not appropriate for people who must take opioid pain medicines. Patients with acute hepatitis, liver failure, or positive opioid screens are generally not candidates. Caution is used during pregnancy and breastfeeding.

People sometimes ask about naltrexone hcl 3mg, often called low-dose naltrexone. That regimen is not an approved dose for alcohol or opioid indications. Any off-label use should be evaluated by a prescriber.

To manage costs, consider larger fills when appropriate. Multi-pack or bulk promotions can reduce per-month pricing. Set a reminder in your account to reorder before you run out. These approaches can help if you are paying naltrexone hcl without insurance.

Authoritative Sources

FDA Prescribing Information for Revia (naltrexone HCl) tablets

Health Canada Product Monograph: Naltrexone Hydrochloride Tablets

Medication guide and professional monograph for naltrexone

Order Revia® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This content is educational and does not replace advice from your healthcare professional.