Naltrexone® HCL Anhydrous Powder for Compounding and Therapy Support

What Naltrexone Is and How It Works

Naltrexone is an opioid receptor antagonist used for alcohol use disorder and for maintaining opioid abstinence after detoxification. Naltrexone HCL Anhydrous Powder lets your prescriber tailor capsule or liquid strengths, including low-dose preparations. Many patients compare Naltrexone HCL Anhydrous Powder price options or seek Naltrexone HCL Anhydrous Powder without insurance when choosing a compounding plan.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and our pharmacists review every prescription before dispensing.

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Mechanism: Naltrexone blocks μ-opioid receptors. This reduces the rewarding effects of alcohol and prevents opioid agonists from producing euphoria or analgesia. Form and route: this anhydrous powder is for pharmacist-compounded oral capsules or oral suspensions. Your dose, frequency, and formulation are determined by your prescriber.

Indications: alcohol use disorder (AUD) to reduce heavy drinking and relapse, and opioid use disorder (OUD) to support abstinence after detox. Some clinicians use low-dose naltrexone (LDN) off label for certain conditions; compounded powder allows precise small-dose capsules or liquids when prescribed.

Dosage and Usage

• Take exactly as prescribed. Do not self-compound unless trained. Pharmacist-prepared capsules or suspensions provide accurate dosing and safety labeling.
• Before starting, you should be opioid-free to avoid precipitated withdrawal. Many protocols require 7–10 days opioid-free; your prescriber may confirm with a test if needed.
• Common AUD/OUD oral initiation: a test dose may be used, then typical maintenance is 50 mg once daily. Some regimens use supervised higher doses on fewer days. Follow your prescriber’s plan.
• Low-dose naltrexone (LDN) is off label. Prescribed compounded strengths may start very low and increase gradually to a target dose. Timing is often once daily.
• Take with or without food. If nausea occurs, taking with food may help.
• Missed dose: take the next dose at the usual time. Do not double up.
• Avoid all opioid medications (including cough syrups and antidiarrheals with opioids). Carry a medical alert noting naltrexone use.
• Do not attempt to overcome the opioid blockade with high opioid doses. This can cause overdose and death.

Storage and Travel

• Store the powder or compounded product at 15–25°C (59–77°F). Protect from moisture and light.
• Keep the container tightly closed with desiccant if supplied. Do not store in bathrooms.
• For compounded liquids, follow the label for storage (room temperature or refrigerated) and beyond-use date.
• When you travel, keep medication in original labeled containers in your carry-on.
• Do not freeze. Keep away from children and pets.

Benefits and Savings

Compounded Naltrexone HCL Anhydrous Powder offers dosing flexibility and precise strengths. This supports individualized therapy, including standard 50 mg dosing and prescriber-directed low-dose options. In AUD, naltrexone can reduce cravings and heavy drinking days. In OUD, it blocks opioids and helps maintain abstinence after detox, when adherence is supported.

Ordering from Canada can deliver meaningful savings. Many customers see 60–80% lower costs compared with typical US prices. If you pay cash, Naltrexone HCL Anhydrous Powder without insurance can be an affordable path, and multi-month fills may reduce per-month cost.

For current offers, see our single page for promotions; some shoppers look for a Naltrexone HCL Anhydrous Powder coupon during bulk purchases.

Side Effects and Safety

• Common effects: nausea, abdominal pain, decreased appetite, headache, dizziness, fatigue, insomnia, anxiety, and constipation or diarrhea.
• Less common: joint or muscle aches, rash, irritability, increased blood pressure, increased liver enzymes.
• Serious signs (seek urgent care): severe abdominal pain, dark urine, yellowing of skin/eyes, fainting, severe vomiting, confusion, or signs of opioid withdrawal if opioids were recently used.
• Allergy symptoms: swelling of face or throat, hives, or trouble breathing.

Naltrexone can elevate liver enzymes and rarely cause dose-related hepatocellular injury. Use is not advised in acute hepatitis or liver failure. Baseline and periodic liver function tests are often performed. Starting naltrexone while physiologically dependent on opioids may trigger sudden withdrawal. After stopping naltrexone, opioid sensitivity may be increased, raising overdose risk if opioids are used.

Onset Time

Opioid blockade begins within 1–2 hours after an oral dose and lasts roughly 24 hours at 50 mg, longer at higher doses. In alcohol use disorder, reduction in craving or heavy drinking often emerges within 1–2 weeks, with continued gains over 4–8 weeks as adherence continues. For prescriber-directed low-dose naltrexone, symptom changes vary; many patients assess response over 2–8 weeks.

Compare With Alternatives

Acamprosate helps maintain abstinence in alcohol use disorder. It is taken three times daily and can be used when patients are already abstinent. It does not block opioids and has a different side-effect profile, including gastrointestinal effects.

Disulfiram creates alcohol sensitivity to discourage drinking. It requires strict alcohol avoidance, including hidden sources. It does not reduce craving and can interact with many products, so careful counseling is needed.

Extended-release naltrexone injection (monthly) provides consistent blockade without daily dosing. It requires an in-clinic injection and documented opioid-free status, similar to oral therapy, and may suit patients who prefer supervised dosing.

For opioid use disorder, buprenorphine/naloxone supports treatment through partial agonist therapy. This differs from naltrexone’s pure antagonist effect and may be preferred early in care or when blockade is not suitable.

Combination Therapy

• Combine with counseling, cognitive behavioral therapy, and mutual-support programs for best outcomes.
• For AUD, some prescribers consider acamprosate with naltrexone in selected cases.
• Address coexisting conditions such as depression or anxiety with appropriate therapies.
• If planned surgery or acute pain arises, inform clinicians early. Opioid pain control may be less effective until naltrexone is discontinued and cleared.

Patient Suitability and Cost-Saving Tips

Who may be candidates: adults with alcohol use disorder seeking to reduce heavy drinking or maintain abstinence, and adults who have completed opioid detoxification and wish to avoid relapse with opioid blockade.

Who should not use: people currently using opioids or in acute opioid withdrawal; those with acute hepatitis or liver failure; those with a positive opioid urine screen when starting therapy; and anyone with known hypersensitivity to naltrexone or formulation components. Discuss pregnancy or breastfeeding plans with your clinician.

Practical tips: set reminders to support adherence. You can use reorder reminders so you do not run out. Ask your prescriber about multi-month quantities; larger fills and bulk promotions can lower the per-month Naltrexone HCL Anhydrous Powder cost. This can help whether you pay cash or seek Naltrexone HCL Anhydrous Powder without insurance.

Authoritative Sources

FDA Prescribing Information for Naltrexone Hydrochloride Tablets

Health Canada Drug Product Database: Naltrexone Hydrochloride

Canadian Product Monograph: Revia (naltrexone) tablets

Order Naltrexone HCL Anhydrous Powder from Youdrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This content is for educational purposes only and does not replace advice from your healthcare professional.