Nardil® (phenelzine) tablets for depression

What Nardil® Is and How It Works

Nardil® (phenelzine) is a monoamine oxidase inhibitor (MAOI) used to treat major depressive disorder, including atypical features. It is an oral prescription medicine, usually taken in divided doses each day. Many people compare the Nardil price across pharmacies, and some look for Nardil without insurance to manage out-of-pocket costs. YouDrugstore is a licensed Canadian pharmacy based in Manitoba. Orders are reviewed by licensed pharmacists before dispensing, and you can shop brand and generic options at Canadian prices.

Phenelzine works by irreversibly inhibiting both MAO-A and MAO-B enzymes. This raises levels of serotonin, norepinephrine, and dopamine in the brain. The effect can relieve persistent low mood, improve energy, and reduce anxiety in suitable patients. Sourcing is straightforward and transparent: we partner only with licensed, vetted international pharmacies so brands are authentic, selection is broad, and pricing stays affordable.

You can order online through YouDrugstore or by phone during posted hours. Friendly customer-service chat can help with account or order questions, and our pharmacists can address medication questions before your prescription is filled.

Dosage and Usage

Follow your prescriber’s directions. Phenelzine is generally started at a low dose and increased in steps until a response is seen, then adjusted to a maintenance dose.

• Take tablets by mouth, with or without food, at the same times each day.
• Doses are often split two or three times daily to improve tolerance.
• Titration is gradual; the typical maximum is 90 mg per day.
• When stable, a lower maintenance dose may be used.

Missed dose guidance:

• If a dose is missed, take it when remembered unless it is close to the next dose.
• If it is near the next dose, skip the missed dose and resume the schedule.
• Do not double up.

Storage and travel:

• Store at 20–25°C (68–77°F) in a dry place away from light.
• Keep tablets in the original bottle with the label.
• Carry extra doses in your hand luggage when traveling.
• Use a travel pill organizer, and bring your prescription or a copy.

Benefits and Savings

Nardil® can help when other antidepressants have not worked, especially in atypical depression marked by mood reactivity, increased sleep, and increased appetite. It may also benefit social anxiety disorder under medical supervision. Some patients sustain long-term remission once stabilized.

Ordering through YouDrugstore gives access to Canadian pricing and a choice of brand or generic (phenelzine) when available. Typical savings are 60–80% versus common US retail prices. This can lower costs even for those paying without insurance.

Side Effects and Safety

Common effects tend to be mild to moderate at the start and may improve with time. Serious reactions require urgent care. This list is not complete.

• Common: dizziness, drowsiness, insomnia, dry mouth, constipation, nausea, weight changes, sweating, tremor, sexual dysfunction, edema, orthostatic hypotension.
• Less common: headache, blurred vision, restlessness, paresthesia, rash.
• Serious: hypertensive crisis (sudden severe headache, neck stiffness, chest pain, palpitations), serotonin syndrome (agitation, fever, muscle rigidity), liver problems (dark urine, jaundice), suicidal thoughts (especially in young adults), mania in bipolar disorder.

Dietary tyramine can trigger severe hypertension while on an MAOI. Avoid aged cheeses, cured meats, fermented or pickled foods, soy sauces, concentrated yeast extracts, some protein supplements, and draft beers. Many medicines interact, including SSRIs/SNRIs, other MAOIs, meperidine, tramadol, dextromethorphan, linezolid, methylene blue, and many decongestants. Washout periods are required when switching therapies.

Onset Time

Improvement often appears within 2 to 4 weeks, with full benefit by 6 to 8 weeks in some patients. Anxiety and sleep may shift earlier or later than mood. Continued use at a stable maintenance dose is typical after response. Any changes in dose or discontinuation should follow prescriber guidance with appropriate washout times.

Compare With Alternatives

Selective serotonin reuptake inhibitors (SSRIs) are common first-line options. For example, Fluoxetine and Paxil® are usually taken once daily and do not require a tyramine-restricted diet. They have fewer food interactions but can cause sexual dysfunction, GI upset, and, at times, activation or weight changes.

Escitalopram is another SSRI often chosen for tolerability. Compared with SSRIs, Nardil® may be considered after inadequate response to multiple agents, particularly in atypical or treatment-resistant depression. The trade-offs include diet restrictions and broader drug-interaction risks, but the potential for robust symptom relief in select patients.

Combination Therapy

Non-drug therapies can complement medication. Cognitive behavioral therapy, interpersonal therapy, and structured exercise programs may improve outcomes. Light therapy can be useful for seasonal patterns. Because phenelzine has extensive interactions, combinations with other psychotropics must be managed carefully. Short-term use of certain anxiolytics or sleep agents may be considered by prescribers when risks and benefits are reviewed. Always maintain required washout periods when adding or stopping serotonergic drugs.

Patient Suitability and Cost-Saving Tips

Nardil® may suit patients with major depressive disorder who have not responded to other treatments, including those with atypical features or social anxiety disorder. It is not appropriate for people with pheochromocytoma, uncontrolled hypertension, active liver disease, or those taking contraindicated medicines. Pregnancy and breastfeeding require individualized assessment. Older adults may be more sensitive to blood-pressure changes and falls.

Choosing generic phenelzine when available can lower monthly costs. Ordering a multi-month supply can reduce the per-month price, and reorder reminders help prevent gaps in therapy. For current deals and bulk options, see our Nardil coupon page. If paying out of pocket, comparing the Nardil price across strengths can identify the most economical package size. Those uninsured may also find savings by combining promotions with multi-bottle orders.

For educational reading about other therapies for anxiety and mood, you can review our article Fluoxetine For Anxiety How It Boosts Mood And Reduces Worry. To explore related conditions, browse Depression and Anxiety.

Authoritative Sources

FDA Prescribing Information (Nardil)

Health Canada Drug Product Database: phenelzine

YouDrugstore provides caring support, clear pricing, and secure checkout from Canada. Order today for prompt, express, cold-chain shipping to the US, with pharmacists reviewing prescriptions before dispensing.

Disclaimer: This content is for general information. It does not replace advice from your prescriber or pharmacist. Always follow your own healthcare professional’s directions and the patient information supplied with your medication.