Nardil® (phenelzine) Tablets for Major Depressive Disorder

What Nardil® Is and How It Works

Nardil (phenelzine) is a monoamine oxidase inhibitor (MAOI) used for major depressive disorder, including atypical and treatment-resistant cases. It is supplied as oral tablets and is taken in divided doses. Many people compare Nardil price and Nardil cost when planning therapy, especially if they need Nardil without insurance.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing. We also work with vetted, licensed international partner pharmacies to source authentic brand and generic medicines at fair prices and a broad selection.

Nardil’s drug class blocks monoamine oxidase (types A and B), which slows the breakdown of serotonin, norepinephrine, and dopamine. This increases neurotransmitter levels over time and can improve mood, energy, and motivation. Clinicians may choose Nardil for people with atypical features such as hypersomnia, increased appetite, and rejection sensitivity. The active ingredient in Nardil tablets is phenelzine sulfate.

Because MAOIs carry important drug and food interactions, treatment requires a careful plan. Prescribers set dosing schedules, dietary limits on tyramine-containing foods, and washout periods with other antidepressants. If you plan to buy Nardil online, you will still need a valid Nardil prescription for safe dispensing and ongoing care.

Dosage and Usage

• Start: 15 mg three times daily (or as prescribed). Your provider may increase by 15 mg every few days.
• Typical effective dose: 60–90 mg per day in divided doses. Some patients respond to lower or higher totals.
• Maintenance: After response, doses are often reduced to the lowest effective amount, such as 15 mg two to three times daily.
• How to take: Swallow phenelzine tablets with water. You can take with or without food, but use the same approach each day.
• Missed dose: Take it when remembered unless it is near the next dose. Do not double up.
• Dietary rules: Avoid high-tyramine foods and beverages, including most aged cheeses, cured meats, soy products, yeast extracts, and some draft beers.
• Drug washout: Wait at least 14 days after stopping most antidepressants before starting Nardil. Wait 5 weeks after fluoxetine before starting an MAOI. Allow similar washouts when switching off Nardil to other agents.
• Interactions to avoid: Do not combine with SSRIs, SNRIs, bupropion, tricyclics, meperidine, tramadol, dextromethorphan, linezolid, methylene blue, sympathomimetic decongestants, or stimulant drugs unless a prescriber directs and monitors a washout.
• Alcohol: Limit or avoid alcohol due to additive sedation and blood pressure effects.
• Driving: Nardil may cause drowsiness or dizziness, especially early in treatment. Use caution with tasks requiring alertness.

• Store at 20–25 °C (68–77 °F); brief 15–30 °C (59–86 °F) excursions are acceptable.
• Keep tablets dry in the original, tightly closed container; protect from moisture and light.
• Do not store in a bathroom or glovebox. Avoid excess heat or freezing.
• When traveling, carry your Nardil medication in your hand luggage with a copy of your prescription.
• Use a pill organizer only if you can maintain dryness and labeling; keep out of reach of children and pets.

Benefits and Savings

Nardil uses include major depressive disorder that has not improved with other medicines. It can be effective for depression with atypical features, chronic anxiety components, and cases marked by hypersomnia and increased appetite. Some patients who did not respond to other drug classes recover well on phenelzine tablets.

Convenience comes from simple tablet dosing and clear dietary guidance. Many people report improved mood after dose optimization, with better energy, motivation, and daily functioning. You can compare Nardil availability, Nardil prescription requirements, and generic Nardil options to find the best fit for your plan.

Buying from Canada can lower total costs. People often see 60–80% savings versus typical U.S. prices. This can help if you are managing cash price Nardil or paying for Nardil online without insurance. Multi-month supplies may further reduce the per-month cost when allowed by your prescriber.

For promotions, see any available Nardil coupon on our site.

Side Effects and Safety

• Common: dizziness, drowsiness, insomnia, headache, dry mouth, nausea, constipation, diarrhea, tremor.
• Blood pressure effects: orthostatic hypotension (lightheadedness when standing) can occur early or with dose changes.
• Weight and appetite: weight gain can occur during long-term use.
• Sexual effects: decreased libido or difficulty with orgasm may occur.
• Swelling or fluid retention: peripheral edema can happen in some patients.

Serious effects are uncommon but require urgent care. A hypertensive crisis can occur after consuming high-tyramine foods or interacting drugs; symptoms include severe headache, chest pain, neck stiffness, palpitations, or nausea. Serotonin syndrome may happen with serotonergic combinations (agitation, fever, sweating, rigidity). Liver problems, severe blood pressure changes, mania, psychosis, and suicidal thoughts can also occur. Review your full medication list with your prescriber before starting.

Onset Time

Some people notice changes in sleep or energy within 1–2 weeks as dosing titrates. Mood and interest typically improve after 2–4 weeks. The full antidepressant effect can take 6–8 weeks, sometimes longer, depending on your dose and the duration of symptoms. Keep taking Nardil as prescribed unless your provider advises a change.

Compare With Alternatives

Escitalopram is an SSRI often chosen first due to fewer dietary limits and a low interaction burden. It is taken once daily and is available as a generic. You can review Cipralex® Lexapro or consider the generic option at Escitalopram if your prescriber recommends an SSRI.

Fluoxetine is another SSRI with a long half-life, which can ease discontinuation. It is taken once daily and has a well-known safety profile. See Fluoxetine for more details. If SSRIs or SNRIs have not worked, MAOIs like Nardil (phenelzine) remain an option when supervised by an experienced clinician.

Other choices include bupropion or venlafaxine, depending on symptom patterns and medical history. Your clinician can weigh prior responses, side effects, and interaction risks when deciding between Nardil phenelzine and these alternatives.

Combination Therapy

• Psychotherapy: Cognitive behavioral therapy or other talk therapies are often combined with medication to improve outcomes.
• Sleep and anxiety aids: Short-term benzodiazepines or sedating agents may be used cautiously; clinicians adjust doses to limit additive sedation or blood pressure changes.
• Augmentation: Because MAOIs have many interactions, pharmacologic add-ons are limited. Do not combine with serotonergic antidepressants or stimulant products without specialist oversight and appropriate washouts.
• Non-drug options: Light therapy, structured exercise, and healthy sleep routines can complement treatment.

Patient Suitability and Cost-Saving Tips

Nardil medication may suit adults with major depressive disorder who did not respond to SSRIs or SNRIs, or who have atypical features. It is not suitable for people with pheochromocytoma, a history of hypertensive crisis, severe liver disease, or those using interacting medications listed above. Elderly patients may be more sensitive to blood pressure changes.

Women who are pregnant, planning to become pregnant, or breastfeeding should discuss risks and benefits with their prescriber. People with cardiovascular disease, seizure history, or bipolar disorder need careful assessment before starting phenelzine tablets. Close follow-up helps manage dose adjustments and any side effects.

To manage costs for uninsured Nardil, compare Nardil cost across strengths and pack sizes. A 2–3 month supply may lower the monthly price when appropriate. You can set up simple reorder reminders in your account so you do not run out. Bulk promotions may apply at times, which can reduce the per-month expense.

If you are considering generic Nardil options, ask your prescriber whether phenelzine tablets are appropriate for you. We can dispense brand or generic when available and supplied by our trusted sources. Availability can change, so check Nardil availability on the product page and contact our team via chat during office hours if needed.

Authoritative Sources

FDA Prescribing Information for Nardil (phenelzine)

Health Canada Drug Product Database

Pfizer Nardil Product Information

Order Nardil® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This material is for educational purposes and does not replace advice from your healthcare professional. Always follow your prescriber’s directions for diagnosis, treatment, and monitoring.