Neulasta® Prefilled Syringe With UltraSafe Guard for Chemotherapy Support

What Neulasta® Is and How It Works

Neulasta is pegfilgrastim, a long-acting granulocyte colony-stimulating factor (G-CSF). It helps your body make more neutrophils, which fight infection. It is used to reduce the risk of infection and febrile neutropenia in people receiving chemotherapy that lowers white blood cells. It is also approved to increase survival in patients with the hematopoietic subsyndrome of acute radiation syndrome. Many customers compare Neulasta Prefilled Syr cost without insurance when planning therapy.

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The Neulasta prefilled syringe with UltraSafe Guard is given as a single subcutaneous dose once per chemotherapy cycle. Typical adult dosing is 6 mg at least 24 hours after chemotherapy, and at least 14 days before the next cycle. For acute radiation syndrome, dosing is weight-based and may be repeated one week later, as directed by the treating team.

By stimulating neutrophil production and release from bone marrow, pegfilgrastim shortens the duration of severe neutropenia. This lowers the chance of serious infections and hospitalizations. During chemotherapy, it supports planned dosing and reduces treatment interruptions. For radiation exposure, it forms part of supportive care to restore blood counts. Learn more about risks like Febrile Neutropenia and related concerns such as Radiation Sickness.

To keep prices low, we also work with licensed, vetted partner pharmacies internationally to supply authentic brands across many treatments at affordable rates.

Dosage and Usage

• For chemotherapy: most adults receive 6 mg subcutaneously once per cycle. Give at least 24 hours after cytotoxic chemotherapy and at least 14 days before the next cycle.
• For acute radiation syndrome: dosing is weight-based in adults and children, with a second dose one week later, as prescribed.
• Preferred injection sites: abdomen (avoid 2 inches around the navel), front of thighs, or outer upper arms if someone else gives the injection.
• Do not give Neulasta within 24 hours before chemotherapy or within 24 hours after chemotherapy ends.
• Missed dose: contact the prescriber for timing. If late, it is often given as soon as feasible while respecting the 14-day window before the next chemotherapy.
• Inspect the solution. It should be clear and colorless. Do not use if cloudy, discolored, or contains particles.
• Let the prefilled syringe sit at room temperature for about 30 minutes before injection. Do not warm with heat or microwave. Do not shake.
• Wash hands and clean the site with an alcohol swab. Remove the needle cap just before use. The cap may contain dry natural rubber (latex).
• Pinch the skin, insert the needle at 45–90 degrees, and inject the full contents. Do not expel the small air bubble before injection.
• After injecting, remove the needle. The UltraSafe Guard activates to cover the needle. Do not recap. Dispose in an FDA-cleared sharps container.

• Refrigerate at 2–8 °C (36–46 °F). Keep in the original carton to protect from light.
• Do not freeze. If accidentally frozen once, return to the refrigerator to thaw. Do not use if frozen more than once.
• If needed, a single room-temperature exposure up to 48 hours (20–25 °C/68–77 °F) is acceptable. After that, discard.
• Do not shake the syringe. Do not expose to heat or direct sunlight.
• For travel, use a cooler with gel packs to keep 2–8 °C. Do not place the syringe directly on ice. Pack a backup thermometer if possible.
• Keep out of reach of children. Carry a copy of your prescription and a sharps container when traveling.

Benefits and Savings

Neulasta reduces febrile neutropenia, antibiotic use, and hospital stays across chemotherapy cycles. It allows planned dose intensity, which supports treatment goals. The once-per-cycle dosing is convenient compared with daily G-CSF injections. In radiation injury, it helps restore neutrophil counts as part of comprehensive care.

Ordering from Youdrugstore can offer 60–80% savings versus typical US prices. Many patients compare Neulasta Prefilled Syr cost without insurance to plan budgets across multiple cycles. Multi-month supplies, when prescribed for several cycles, may reduce the per-month cost. You can set gentle reorder reminders so your next dose arrives on time.

For current deals, see our Neulasta Prefilled Syr coupon page.

Side Effects and Safety

• Bone pain or back pain
• Muscle or joint aches
• Headache
• Fatigue
• Nausea
• Injection site redness or tenderness
• Generalized pain or limb pain

Serious but uncommon risks include splenic rupture, acute respiratory distress syndrome, capillary leak syndrome, glomerulonephritis, aortitis, and severe allergic reactions. Sickle cell crisis has occurred in people with sickle cell disease. Report left upper abdominal or shoulder-tip pain, sudden breathing problems, swelling, or signs of anaphylaxis. Transient leukocytosis can occur and is usually not clinically significant. The needle cap contains dry natural rubber (latex), which may cause reactions in sensitive individuals.

Onset Time

Absolute neutrophil counts often begin to rise within 24 hours of dosing. Peak effects are commonly seen around days two to three after injection. Across chemotherapy cycles, Neulasta shortens the duration of severe neutropenia by several days. Fewer infection-related events are typically observed starting with the first supported cycle. Bone pain, when it happens, usually appears within a few days and is often brief.

Compare With Alternatives

Filgrastim (daily G-CSF) is an alternative given as a short-acting injection, usually for several days each cycle. It can be useful when flexible day-to-day titration is desired, but it requires more frequent dosing and clinic visits or self-injections.

Pegfilgrastim biosimilars, such as pegfilgrastim-jmdb or pegfilgrastim-cbqv, offer similar efficacy to the reference product with potential cost differences. They are generally given as the same single 6 mg dose per cycle in adults.

Neulasta On-body Injector (OBI) is a wearable device applied on chemotherapy day, programmed to deliver the dose about 27 hours later. It avoids a return visit the next day, but device placement and certain chemotherapy regimens may limit suitability.

For background on cancer treatment strategies, you may find Common Types Of Cancer What You Need To Know and Understanding Calquence Medication For Cancer Treatment helpful.

Combination Therapy

• With cytotoxic chemotherapy: give Neulasta at least 24 hours after completion. Do not administer within 24 hours before chemotherapy.
• With antibiotics: used when infections occur despite prophylaxis or for febrile neutropenia management.
• With supportive medications: analgesics for bone pain; antihistamines or corticosteroids for hypersensitivity as directed.
• Acute radiation syndrome: part of a broader care plan that may include antimicrobials, fluids, and transfusions.
• Lithium may increase neutrophil counts; clinicians may monitor more closely.

Patient Suitability and Cost-Saving Tips

Neulasta is for patients receiving myelosuppressive chemotherapy with a significant risk of febrile neutropenia, or for those treated for acute radiation syndrome. It is not for use with chemotherapy regimens intended to treat myeloid malignancies, such as acute myeloid leukemia, unless a specialist advises otherwise. Prior severe allergy to pegfilgrastim or filgrastim is a contraindication.

Use caution in people with sickle cell disease, splenic enlargement, or a history of severe allergies. Discuss pregnancy and breastfeeding with the oncology team. Pediatric dosing for radiation injury is weight-based. Pediatric cancer prophylaxis follows specialist guidance.

To save on ongoing cycles, consider a prescription for several cycles if clinically appropriate. That can enable bulk pricing and fewer shipments. You can schedule gentle reorder reminders in your account so doses do not overlap with clinic days. If paying out of pocket, many compare Neulasta Prefilled Syr cost without insurance across supply sizes to lower per-dose expense.

For more context on treatment complications, see Chemotherapy Infections and Hematopoietic Subsyndrome.

Authoritative Sources

Neulasta official patient site (Amgen)

Neulasta HCP resources and prescribing information

FDA Prescribing Information for Neulasta (pegfilgrastim)

Order Neulasta® from Youdrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This content is educational and does not replace advice from your healthcare professional.