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Neupro® Transdermal Patch for Parkinson’s Disease and RLS
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The Neupro Transdermal Patch is a once-daily skin patch that delivers rotigotine for continuous symptom control. It is used for Parkinson’s disease and moderate-to-severe Restless Legs Syndrome. This page explains how it works, who it suits, and how to use and store it, with US delivery from Canada. It also covers options if you pay without insurance.
What Neupro Is and How It Works
Neupro® contains rotigotine, a dopamine agonist. It stimulates dopamine receptors in the brain to help reduce movement symptoms of Parkinson’s disease and relieve uncomfortable leg sensations linked to RLS. The patch provides steady 24-hour exposure, which may help smooth day and night symptoms. It is a rotigotine transdermal system that you apply to intact, clean skin once daily.
YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.
People exploring therapy for Parkinsons Disease or Restless Legs Syndrome often value round-the-clock dosing. This medicine can be used alone or alongside other approved treatments, as directed by a clinician. It may be helpful if swallowing tablets is hard or gastrointestinal effects limit oral options.
Who It’s For
This treatment is indicated for early and advanced Parkinson’s disease, and for moderate-to-severe primary RLS. It is for adults. The Neupro patch for RLS may ease evening and nighttime leg discomfort and improve sleep quality.
Do not use it if you are allergic to rotigotine or any patch components. Avoid if you have significant adhesive allergies or active skin disease at application sites. Tell your prescriber if you have low blood pressure, heart rhythm issues, serious mental health conditions, or sleep attacks with other dopamine agonists. Discuss pregnancy or breastfeeding plans, as safety decisions are individualized.
Dosage and Usage
Apply one patch to a flat, hairless site once every 24 hours. Common sites include the abdomen, hip, flank, shoulder, or upper thigh. Rotate areas daily, avoiding the same spot for 14 days to help minimize skin reactions. Wash and dry your hands, open the pouch, and peel the liner. Place the patch on clean, dry skin with no oils, lotions, or powders. Press firmly for 30 seconds, especially around the edges.
For RLS, labels describe a low starting dosage with gradual weekly increases to a typical effective range. For Parkinson’s disease, dosing is titrated weekly to balance benefit and tolerability, with a labeled maximum for 24-hour delivery. Do not cut the patch. Avoid external heat, such as heating pads, saunas, hot tubs, or prolonged sun exposure on the patch. Heat can increase absorption and side effects.
If skin irritation occurs, use a different site each day and ensure the skin is fully dry before application. If the edges lift, press again for several seconds. If a patch falls off, apply a new one to a different site and continue your normal schedule the next day unless instructed otherwise by your prescriber.
Strengths and Forms
The patch is supplied in sealed pouches for single use, designed to deliver medicine over 24 hours. Commonly published strengths include 1 mg/24 hr, 2 mg/24 hr, 3 mg/24 hr, 4 mg/24 hr, 6 mg/24 hr, and 8 mg/24 hr. Your prescriber will choose a starting level and adjust over time.
Many adults are titrated through available strengths during initiation. Your pharmacist can assist with questions on pouches, backing layers, and removal tabs. Some patients encounter the Neupro 2 mg 24 hr patch during early titration, depending on condition and response.
Missed Dose and Timing
If you forget a dose, apply a patch as soon as you remember and continue your usual timing the next day. Do not wear two patches at the same time. If a patch detaches, put on a new one at a different site and keep your regular daily schedule. Call your clinician if you miss several days, as you may need advice on restarting.
Storage and Travel Basics
Keep patches in their original sealed pouches until use. Store at room temperature away from excess heat and direct sunlight. Do not freeze. Keep out of reach of children and pets. Do not cut or alter the patch.
For travel, pack pouches in a carry-on with prescription labels. Bring extra pouches in case of delays or damage. A doctor’s letter can help with airport security if needed. Keep patches away from hot car interiors and do not place them near heating vents during trips. Fold the used patch with sticky sides together and dispose of it safely according to local guidance. If your community has take-back options, use them.
Benefits
This therapy offers continuous 24-hour delivery, which may support steadier symptom control between doses. Once-daily application can simplify regimens and help with morning function. The patch avoids swallowing pills, which may be useful if you have dysphagia or stomach upset. Site rotation and daily routines can integrate smoothly with other medicines for Parkinson’s disease or RLS.
Side Effects and Safety
- Skin reactions: redness, itching, or irritation at the site
- Nausea or vomiting
- Dizziness or lightheadedness
- Sleepiness or fatigue
- Headache
- Insomnia or vivid dreams
- Constipation or dry mouth
Serious effects can include falling asleep suddenly, hallucinations, confusion, severe hypotension, or allergic reactions. Impulse-control symptoms such as gambling, spending, or hypersexuality can occur with dopamine agonists. Rare but notable skin reactions may require removal. For RLS, symptom augmentation may occur in some people over time. If you experience worrisome effects, contact a healthcare professional promptly. Remove the patch before MRI or cardioversion procedures to reduce burn risk.
Drug Interactions and Cautions
Tell your prescriber about all medicines and supplements. Dopamine antagonists (certain antipsychotics and metoclopramide) may reduce benefit. Sedatives, alcohol, and other central nervous system depressants can increase drowsiness. Blood pressure medicines may add to dizziness or fainting. Use caution with MAO inhibitors and other agents affecting dopamine pathways. External heat sources increase absorption and should be avoided on the patch area.
The patch contains adhesive materials and may include sulfites; people with severe sulfite sensitivity should discuss risks. Use caution if you have a history of psychosis, severe cardiovascular disease, or significant orthostatic hypotension. If you experience sleep attacks, avoid driving or operating machinery until you talk to your clinician.
What to Expect Over Time
Many patients start low and increase week by week to find a tolerable, effective level. Skin reactions are common early and often lessen with careful site rotation and dry, clean skin. Dizziness or nausea may improve as your body adapts. Set a daily routine for changes at the same time to support adherence. Keep regular follow-ups so your prescriber can monitor symptom control and any side effects, and adjust other Parkinson’s or sleep-related therapies if needed. Improvement for RLS may be most noticeable in the evening and overnight.
Compare With Alternatives
Some people use a dopamine agonist patch for steady coverage. Others respond well to an oral MAO-B inhibitor such as Azilect®, which can be used alone in early disease or added to levodopa later. Many patients rely on the established standard of care, Levodopa Carbidopa, for symptom control in Parkinson’s disease. Your prescriber can explain when these options are used alone or together, and how choices change as needs evolve.
Pricing and Access
Canadian retail models may offer lower list figures for some brand medicines compared to domestic options. You can order Neupro patch online with a valid prescription and have it filled at YouDrugstore with US delivery from Canada. Many people compare cash-pay totals and pharmacy service features before choosing where to fill.
Pricing varies by strength and pack size. See our product page for current figures and availability. If you use coupons, check our limited-time Promotions. This is a prescription product; prescription required and verified.
Availability and Substitutions
Neupro patch availability can change based on supply and strength. If a specific size is out of stock, your prescriber may recommend a different strength or an alternative therapy from the same class or another class. Ask before switching, as products are not interchangeable without clinical guidance.
Patient Suitability and Cost-Saving Tips
This medicine may suit adults who need continuous symptom coverage and prefer a once-daily routine. It may not suit those with severe adhesive allergies, uncontrolled hallucinations, or people who have significant reactions to dopamine agonists. Discuss goals, daily schedule, and driving or machinery needs because sleepiness can occur.
To manage costs, consider multi-month fills when appropriate, as fewer transactions may lower overall fees. Use refill reminders so you do not run short. Compare options by strength and supply. People paying out of pocket sometimes review rotigotine transdermal price across pharmacies to understand differences in posted figures and shipping policies.
Questions to Ask Your Clinician
- Starting level and increases: How will my dose be titrated?
- Skin care plan: What helps reduce redness or itching?
- Daily routine: What time should I change the patch?
- Safety: What are signs I should stop and call you?
- Driving: How do we manage daytime sleepiness risk?
- Other medicines: Which drugs could reduce benefit or raise side effects?
- Procedures: Should I remove the patch before MRI or surgery?
Authoritative Sources
Manufacturer SiteFDA DailyMed Prescribing InformationHealth Canada Drug Product Database
Ready to proceed? Place your order at YouDrugstore for prompt US delivery from Canada with temperature-controlled handling when required. This information is not a substitute for your prescriber’s advice. Always follow the official label and your clinician’s guidance.
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Where can I apply the patch, and how often should I change sites?
Apply the patch once daily to clean, dry, healthy skin on the abdomen, hip, flank, shoulder, or upper thigh. Rotate sites every day. Try not to use the same spot again for at least 14 days to reduce irritation. Avoid areas with cuts, rash, or lotions. Hair should be clipped, not shaved. Press firmly for 30 seconds, especially around the edges. If you have ongoing skin issues at application areas, let your clinician know.
Can I shower, bathe, or swim while wearing this patch?
Yes, the patch is designed to stay on during normal activities, including showering or bathing. Apply to a site that will not be rubbed by tight clothing. After swimming or heavy sweating, check the edges. If it lifts, press again for several seconds. If the patch comes off, apply a new one at a different site and continue your usual schedule. Do not reuse a detached patch, and avoid hot tubs or saunas on the patch area.
What should I avoid while using rotigotine patches?
Avoid external heat on the patch area, such as heating pads, saunas, hot tubs, and prolonged sun exposure, because heat can increase absorption. Do not cut or split the patch. Alcohol and sedatives can add to sleepiness. Dopamine antagonists, including some antipsychotics and metoclopramide, may reduce benefit. Remove the patch before MRI or cardioversion to reduce burn risk. Ask your clinician before starting new medicines or supplements.
What are common side effects, and when should I seek care?
Common effects include skin irritation, nausea, dizziness, sleepiness, headache, and insomnia. Many lessen as your body adjusts and with careful site rotation. Seek care if you experience severe rash, hallucinations, confusion, fainting, sudden sleep attacks, or strong uncontrollable urges. Contact a healthcare professional if side effects persist or interfere with daily activities. Do not stop treatment abruptly without medical guidance.
How is rotigotine used for Restless Legs Syndrome?
Rotigotine can help reduce evening and nighttime leg discomfort and urges to move in moderate-to-severe RLS. Clinicians usually start with a low dose and increase weekly to achieve benefit with tolerable effects. Apply one patch each day and rotate sites. Heat on the patch area should be avoided. If symptoms change or daytime restlessness develops, consult your prescriber about next steps.
Does the patch have to be removed before procedures or imaging?
Yes. Remove the patch before MRI or cardioversion to prevent burns or skin injury. Tell your care team you use a transdermal medicine. After the procedure, apply a new patch to a different site and continue your regular schedule. For surgery, ask your clinician for instructions about use on the day of the procedure, as plans may vary by case and type of anesthesia.
Is there a generic version of the rotigotine patch?
Availability can vary by country and time. In the United States, many patients receive brand-only supply through regular channels. Your pharmacist can check current listings and stock. If no equivalent is available locally, your prescriber may suggest other dopamine agonists or different classes for your condition. Ask about costs, supply expectations, and the plan if your strength is unavailable.

