How is this pill different from older combination pills?

Nextstellis uses estetrol, a native estrogen, paired with drospirenone. Many traditional combination pills use ethinyl estradiol instead. The specific estrogen and progestin can influence tolerability, bleeding patterns, and interaction profiles. Your experience may differ from prior pills. Review the Patient Information and speak with a healthcare professional about your history, goals, and any prior side effects on other methods before switching.

What should I do if I miss tablets?

The steps depend on how many active tablets you miss and when in the pack it happens. One missed active tablet is often taken as soon as remembered, then you continue as scheduled. Missing two or more active tablets usually requires a backup method for a time. If you vomit shortly after a dose, it can count as a miss. Always follow the official instructions for your pack and ask a clinician if you are unsure.

Can I use this method while breastfeeding?

Combined hormonal contraceptives may affect milk supply, especially early postpartum. Many clinicians suggest waiting until lactation is well established, and a progestin-only option may be considered first. Timing recommendations vary by region and health status. Discuss the best approach with your prescriber, who will consider your postpartum timeline and any risk factors before starting Nextstellis or another method.

Will it help with acne, cramps, or heavy periods?

Some combined pills can improve acne, cramps, or cycle regularity for certain users, but results vary. This medicine is approved for pregnancy prevention. Any cycle or skin benefits are secondary and can differ by individual and formulation. If those concerns are important to you, ask your healthcare professional about expectations and whether a different contraceptive might better target those symptoms.

Which medicines can reduce effectiveness?

Enzyme-inducing drugs can lower hormone levels and reduce contraceptive efficacy. Examples include rifampin, certain anti-seizure medicines like carbamazepine and phenytoin, and herbal products such as St. John’s wort. Some antiviral therapies can also interact. Always share a full medication and supplement list with your prescriber and pharmacist so they can review for interactions and advise on backup methods when needed.

How soon does protection return after stopping?

Ovulation can return quickly after stopping combined oral contraceptives for many users. The exact timing differs by person and recent cycle history. Some people see a period within weeks, while others take longer to reestablish a regular cycle. If you are planning pregnancy, your clinician can discuss expectations and when to follow up if cycles do not resume as expected.

Does this pill protect against sexually transmitted infections?

No. Hormonal contraceptives, including Nextstellis, do not protect against sexually transmitted infections. If protection against STIs is needed, use barrier methods such as condoms and consider regular testing per your clinician’s advice. Combining methods can help address both pregnancy prevention and infection risk, based on your circumstances and preferences.

Promotion

Nextstellis

Nextstellis® Tablets for Birth Control

Contraception

Please note: a valid prescription is required for all prescription medication.

Stock up and Save - Get 20% off when you buy 3 or more of any one product. Use code SAVE20 at checkout.

Coupon code cannot be combined with other offers. Sale applies to all products originating from Canada. Maximum allowable quantity equal to a 90 day supply per single order.

Price:

$69.99

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Nextstellis® is a combined oral contraceptive used to prevent pregnancy. This page explains how it works, safety basics, and how to check nextstellis price without insurance. We also support US delivery from Canada so you can plan refills confidently.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

What Nextstellis Is and How It Works

This medicine pairs estetrol, a native estrogen, with drospirenone, a progestin. Together, they primarily prevent ovulation. The treatment also thickens cervical mucus and alters the endometrium, which helps reduce the chance of sperm reaching an egg and implantation. Drospirenone may have anti-mineralocorticoid activity, which can modestly increase potassium in some people. Read the Patient Information and follow your prescriber’s guidance.

Who It’s For

This contraceptive is indicated for the prevention of pregnancy in females of reproductive potential. It is not for those who are pregnant. People with certain conditions should not use combined oral contraceptives, including a history of blood clots, stroke, certain heart problems, migraine with aura, breast cancer or other estrogen- or progestin-sensitive cancers, liver tumors or severe liver disease, or uncontrolled hypertension. Smoking cigarettes and being over age 35 raises serious cardiovascular risks; avoid combined pills in that setting.

Those with kidney disease, adrenal insufficiency, or who take medicines that raise potassium may require extra caution because of drospirenone. Your healthcare professional will review your medical history to determine suitability. For broader family planning options, you can also explore our Contraception resources.

Dosage and Usage

Take one tablet by mouth each day at the same time, with or without food. Swallow with water and follow the pack order without skipping days. Many packs have 24 active tablets followed by 4 inactive tablets; bleeding often occurs during the inactive days. If starting on Day 1 of your period, effectiveness begins with the first active tablet. If using a Sunday start or switching from a different method, consult the official label for backup timing. Set reminders to maintain steady daily dosing.

If you miss pills or start late, the need for backup contraception can vary. The official Patient Information has detailed instructions for each scenario. When uncertain, use a barrier method until you can confirm the correct steps with a clinician.

For background reading on pill routines and lifestyle fit, see Birth Control Pills.

Strengths and Forms

This product is supplied as a 28-day pack with active and inactive tablets in a labeled sequence. The commonly available strength combines 14.2 mg of estetrol with 3 mg of drospirenone in each active tablet. Availability can vary by region and over time.

Missed Dose and Timing

Missing one active tablet can often be handled by taking it as soon as remembered, then taking the next tablet at the usual time. Missing two or more active tablets in a row typically requires backup contraception for a period as outlined in the Patient Information. If vomiting or severe diarrhea occurs within several hours of a dose, follow the label’s guidance as it may count as a missed tablet.

Cycle timing matters. If active tablets are missed late in the pack, you may be instructed to skip the inactive days and start a new pack right away. Check the official instructions for the exact steps. For cycle questions, you may also find Pregnant On Your Period helpful.

Storage and Travel Basics

Store tablets at room temperature in the original blister to protect from moisture and light. Keep out of reach of children and pets. When traveling, carry your current pack and a spare in your hand luggage. Keep doses on schedule across time zones by aligning to your usual clock time when practical. Bring a copy of your prescription if you will be away during a refill window.

Do not store tablets in the bathroom. If a blister is damaged or exposed to water, follow the label instructions or ask your pharmacist for next steps.

Benefits

This therapy offers a familiar once-daily schedule with a predictable monthly routine. Many users appreciate having a defined window for withdrawal bleeding. The class can also provide cycle control over time. With active and inactive days clearly labeled, adherence can be simpler for those who prefer a structured regimen.

Some people value using an estrogen that is distinct from ethinyl estradiol. Individual responses vary, so discussion with your prescriber is important when choosing the best fit.

Side Effects and Safety

Headache or migraine
Nausea or stomach discomfort
Breast tenderness
Irregular bleeding or spotting
Mood changes
Acne or changes in skin

Serious risks can include blood clots, stroke, heart attack, high blood pressure, liver problems, and gallbladder disease. Drospirenone can raise potassium; combining with certain medicines may increase that risk. Stop the tablets and seek care for symptoms such as sudden severe headache, chest pain, shortness of breath, leg swelling, or vision changes. Smoking while using combined hormonal contraceptives increases serious cardiovascular risks, especially over age 35.

Drug Interactions and Cautions

Medicines that induce enzymes can reduce contraceptive effectiveness. Examples include rifampin, carbamazepine, phenytoin, topiramate, and St. John’s wort. Certain HIV/HCV therapies can interact. Strong inhibitors may raise hormone levels. Drospirenone may increase potassium, so use caution with ACE inhibitors, ARBs, potassium-sparing diuretics like spironolactone, or supplements with high potassium. Combined pills can lower lamotrigine levels.

Tell your prescriber about all medicines, vitamins, and herbal products. Do not change doses on your own. The official label provides a full list of interactions and warnings.

What to Expect Over Time

Spotting or unscheduled bleeding may occur during the first cycles. Many people see more regular cycles with continued use. If you miss pills, irregular bleeding is more likely. Cramps can improve for some users, though experiences vary. The pills do not protect against sexually transmitted infections, so consider barrier methods if needed.

Set daily alarms and keep your pack visible to support adherence. If side effects are troublesome or persistent, contact a healthcare professional to review options.

Compare With Alternatives

Alternative options include other combined oral contraceptives, a progestin-only minipill, and the etonogestrel vaginal ring. Your prescriber can help weigh estrogen-containing versus progestin-only methods based on your health history. For ring details, see Nuvaring Benefits. You can also browse methods by condition in our Contraception section.

Pricing and Access

View current Canadian pricing with US delivery from Canada directly on this page once your selection is set. We post live availability and show typical cash-pay ranges before checkout.

Many shoppers compare estetrol drospirenone tablets price against other options to estimate value. You can also review supply choices and see if a 2- or 3-pack aligns with your budget or schedule. For broader context on options, The Contraceptive offers a helpful overview.

People sometimes ask about estetrol drospirenone 3mg/14.2mg cost relative to older pills. Exact totals vary by pack size and market conditions. Check our cart to see the most up-to-date numbers, then discuss any questions with your prescriber or pharmacist. Explore seasonal offers on our Promotions page when available.

Availability and Substitutions

Supply can change based on manufacturing and distribution. If a pack is unavailable, a prescriber may recommend another combined pill or a different method based on your health needs. When stock permits, you can buy estetrol drospirenone tablets using your valid prescription. Stock notices on our site reflect current warehouse status.

We serve a wide range of women’s needs across the Womens Health category. Prescription required and verified.

Patient Suitability and Cost-Saving Tips

This pill may suit adults who want a daily oral method and can take estrogen safely. It may not be appropriate if you have the contraindications listed above, or if you prefer long-acting reversible contraception. If you and your clinician choose this method, consider a multi-month fill to reduce trips and help maintain adherence. Calendar reminders or smartphone alerts can prevent late or missed tablets.

To plan your budget, some users compare nextstellis cost with other methods and choose packs that match their routine. Keeping one spare pack can prevent gaps, if your prescription allows. For postmenopausal bone health needs unrelated to contraception, therapies such as Evenity may be discussed separately with your clinician.

Questions to Ask Your Clinician

Is this the right hormonal method for my health history?
How should I start the first pack based on my current method?
What should I do if I miss active tablets late in the pack?
Do any of my medicines or supplements interact with this pill?
What symptoms should prompt a call or visit right away?
How long should I use backup if I start mid-cycle?
Are there non-estrogen options I should consider?

Authoritative Sources

FDA DailyMed

Health Canada DPD

Manufacturer Website

Ready when you are. To get your prescription filled with US delivery from Canada, you can order next and choose prompt, express shipping with temperature-controlled handling when required. This page is informational and not a substitute for medical advice; always follow your prescriber’s directions.

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View All FAQs

How is this pill different from older combination pills?
Nextstellis uses estetrol, a native estrogen, paired with drospirenone. Many traditional combination pills use ethinyl estradiol instead. The specific estrogen and progestin can influence tolerability, bleeding patterns, and interaction profiles. Your experience may differ from prior pills. Review the Patient Information and speak with a healthcare professional about your history, goals, and any prior side effects on other methods before switching.
What should I do if I miss tablets?
The steps depend on how many active tablets you miss and when in the pack it happens. One missed active tablet is often taken as soon as remembered, then you continue as scheduled. Missing two or more active tablets usually requires a backup method for a time. If you vomit shortly after a dose, it can count as a miss. Always follow the official instructions for your pack and ask a clinician if you are unsure.
Can I use this method while breastfeeding?
Combined hormonal contraceptives may affect milk supply, especially early postpartum. Many clinicians suggest waiting until lactation is well established, and a progestin-only option may be considered first. Timing recommendations vary by region and health status. Discuss the best approach with your prescriber, who will consider your postpartum timeline and any risk factors before starting Nextstellis or another method.
Will it help with acne, cramps, or heavy periods?
Some combined pills can improve acne, cramps, or cycle regularity for certain users, but results vary. This medicine is approved for pregnancy prevention. Any cycle or skin benefits are secondary and can differ by individual and formulation. If those concerns are important to you, ask your healthcare professional about expectations and whether a different contraceptive might better target those symptoms.
Which medicines can reduce effectiveness?
Enzyme-inducing drugs can lower hormone levels and reduce contraceptive efficacy. Examples include rifampin, certain anti-seizure medicines like carbamazepine and phenytoin, and herbal products such as St. John’s wort. Some antiviral therapies can also interact. Always share a full medication and supplement list with your prescriber and pharmacist so they can review for interactions and advise on backup methods when needed.
How soon does protection return after stopping?
Ovulation can return quickly after stopping combined oral contraceptives for many users. The exact timing differs by person and recent cycle history. Some people see a period within weeks, while others take longer to reestablish a regular cycle. If you are planning pregnancy, your clinician can discuss expectations and when to follow up if cycles do not resume as expected.
Does this pill protect against sexually transmitted infections?
No. Hormonal contraceptives, including Nextstellis, do not protect against sexually transmitted infections. If protection against STIs is needed, use barrier methods such as condoms and consider regular testing per your clinician’s advice. Combining methods can help address both pregnancy prevention and infection risk, based on your circumstances and preferences.