Nifedipine XR — Generic to Adalat CC®

What Nifedipine XR Is and How It Works

Nifedipine XR is a long‑acting calcium channel blocker used for high blood pressure and chronic stable angina. The extended‑release tablet provides 24‑hour control with once‑daily dosing. Many people compare Nifedipine XR price options, especially without insurance, because long‑term therapy is common.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing. We offer brand and generic medicines at Canadian prices, and you can order online or by phone during posted office hours.

Nifedipine blocks L‑type calcium channels in vascular smooth muscle. This relaxes peripheral arteries, lowers systemic vascular resistance, and reduces blood pressure. It also dilates coronary arteries, which helps prevent angina episodes. As a dihydropyridine class agent, its effect on heart rate and conduction is minimal compared with non‑dihydropyridines.

Common strengths include Nifedipine XR 30 mg and 60 mg. Mylan Nifedipine XR 30 mg is a frequent starting option. Different extended‑release technologies exist, so product‑to‑product substitution should follow prescriber guidance. Immediate‑release nifedipine is not suitable for rapid blood pressure reduction.

We also supply through licensed, vetted partner pharmacies abroad to keep a broad selection of authentic brands at accessible prices.

Dosage and Usage

• Typical initiation: 30 mg once daily. Some patients may start lower per prescriber direction.
• Titration: adjust in 7–14 day intervals based on response and tolerability.
• Maintenance range: 30–90 mg once daily. Some patients may use 120 mg if directed.
• Administration: swallow tablets whole; do not crush, chew, or split.
• Take at the same time each day, with or without food, but stay consistent.
• Avoid grapefruit or grapefruit juice due to CYP3A4 interactions.
• Do not switch between extended‑release brands without clinical guidance.
• If a dose is missed, take it when remembered unless it is near the next dose; do not double up.
• An inert tablet shell may appear in stool with some formulations; the medicine has been absorbed.

• Store your tablets at 15–30°C (59–86°F) in a dry place, away from moisture.
• Keep in the original bottle or blister until use; protect from light.
• When you travel, carry your medication in your hand luggage with the pharmacy label.
• Avoid leaving your supply in hot cars or near heaters; do not freeze.
• Use a pill organizer if needed, but keep desiccants with the original container.
• Pack extra doses for delays, and keep your prescriber’s details handy.
• Keep out of reach of children and pets.

Benefits and Savings

Nifedipine XR lowers blood pressure steadily over 24 hours and reduces angina frequency. Once‑daily dosing supports adherence. Extended‑release delivery limits rapid peaks, which can reduce flushing compared with immediate‑release forms. For many, stable blood pressure helps lower cardiovascular risk over time.

Buying from Canada can bring 60–80% savings versus typical US prices. That value can matter for patients paying a Nifedipine XR cash price or managing ongoing therapy without insurance. Multi‑month supplies and occasional bulk promotions may reduce the per‑month cost even further.

For current offers, see our Nifedipine XR coupon page.

Side Effects and Safety

• Headache or flushing
• Dizziness or lightheadedness
• Peripheral edema (ankle swelling)
• Fatigue
• Nausea or stomach discomfort
• Constipation
• Palpitations or a warm sensation
• Gingival overgrowth (with prolonged use)
• Rash

Serious reactions are uncommon but can include marked hypotension, fainting, or worsening chest pain when starting or increasing the dose, especially in severe coronary artery disease. Use caution with aortic stenosis, heart failure with reduced ejection fraction, or significant hepatic impairment. Avoid strong CYP3A4 inhibitors (e.g., clarithromycin, ketoconazole) and inducers (e.g., rifampin, carbamazepine). Limit alcohol and avoid grapefruit products.

Onset Time

Blood pressure often begins to decline within the first day, with clearer effects after several doses. The full antihypertensive response may develop over 1–2 weeks as steady‑state is reached and doses are adjusted. Angina prevention typically improves within days of consistent use and titration.

Compare With Alternatives

Amlodipine is another dihydropyridine calcium channel blocker with a long half‑life and once‑daily dosing. It offers similar blood pressure control and angina prevention, with a lower rate of flushing for some patients. Edema can occur with both agents; switching within the class is sometimes considered when side effects persist.

Diltiazem extended‑release and verapamil extended‑release are non‑dihydropyridine options. They reduce heart rate and contractility and are useful for certain arrhythmias or angina. They may not suit patients with conduction abnormalities or reduced ejection fraction. Drug‑interaction profiles differ because of additional heart‑rate effects.

Other classes for hypertension include ACE inhibitors, ARBs, thiazide diuretics, and beta blockers. Many patients benefit from combinations to reach targets while limiting dose‑related adverse effects.

Combination Therapy

• With ACE inhibitor or ARB for complementary blood pressure control.
• With a thiazide diuretic to improve diastolic and systolic reductions.
• With long‑acting nitrates or a beta blocker for stable angina, per prescriber guidance.
• Adjust doses if symptomatic hypotension occurs when combining agents.
• Review CYP3A4 interactions when adding or removing therapies.

Patient Suitability and Cost-Saving Tips

Nifedipine XR suits many adults with hypertension or chronic stable angina who need once‑daily therapy. Caution is advised in advanced aortic stenosis, recent myocardial infarction with decompensation, severe hepatic impairment, or heart failure with reduced ejection fraction. Older adults may require slower titration. Discuss pregnancy and breastfeeding considerations with a clinician.

Grapefruit products, strong CYP3A4 inhibitors, and inducers can change nifedipine levels. Simvastatin exposure can increase; a lower simvastatin dose may be advised. Monitor for dizziness, ankle swelling, or headaches during dose changes. Report persistent edema or chest discomfort promptly.

To manage Nifedipine XR cost, consider larger fills when appropriate. Reorder reminders help prevent gaps in therapy. Multi‑month supplies can reduce shipping fees and the monthly average. These strategies can be helpful when purchasing Nifedipine XR without insurance.

Authoritative Sources

Pfizer Medical Information: Procardia XL (nifedipine extended‑release)

FDA Drug Label and Approval History: Procardia XL

Health Canada Drug Product Database: Nifedipine listings

Order Nifedipine XR from Youdrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This material is for educational purposes only and does not replace professional medical advice, diagnosis, or treatment. Always speak with a qualified healthcare professional about your therapy.