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Nitrostat® Sublingual Tablets for Angina
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What Nitrostat Is and How It Works
Nitrostat® is a fast-acting sublingual nitrate used to relieve sudden chest pain from angina. It relaxes and widens coronary blood vessels, which can reduce the heart’s workload and improve blood flow. We support US delivery from Canada so you can manage refills even without insurance.
YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.
The treatment contains nitroglycerin, a vasodilator that converts to nitric oxide in vascular smooth muscle. This process triggers relaxation of veins and arteries. Relief is usually felt quickly after correct sublingual use. Always follow your prescriber’s instructions and the official label.
Who It’s For
This medicine is used for the acute relief of angina pectoris. It may also be used before activities that often bring on chest pain, as directed by a clinician. People with severe anemia, increased intracranial pressure, or known hypersensitivity to nitrates should avoid it. Those using phosphodiesterase type 5 inhibitors for erectile dysfunction must not combine them with nitrates.
Dosage and Usage
Use at the first sign of chest discomfort. Place one tablet under the tongue and allow it to dissolve completely without swallowing or chewing. Sit or rest while taking it to reduce the chance of dizziness or fainting. If pain persists after the first dose, follow the label directions and your prescriber’s plan, which may include repeat dosing at set intervals. Seek emergency care when instructed by the label or your clinician.
For prevention before exertion, take as directed by your prescriber. Do not exceed the maximum daily dosing described on the official label. Avoid alcohol while using this therapy, as it can increase blood pressure lowering effects. Stand up slowly to reduce lightheadedness.
Strengths and Forms
These tablets are designed for sublingual use only. A commonly used strength is 0.4 mg. Other strengths or package sizes may exist, but availability can vary by market and supply.
Missed Dose and Timing
This is not taken on a fixed schedule for chronic control. Use at symptom onset or before known triggers when instructed. If a dose is missed for pre-activity prevention, take it when remembered if the activity has not started and your clinician has advised pre-dosing. Do not double doses close together. Follow emergency guidance if chest pain does not improve as directed on the label.
Storage and Travel Basics
Keep tablets in the original glass container with the cap tightly closed. Protect from moisture and keep away from heat and direct light. Do not place tablets in pill organizers or plastic bags, as exposure to air can reduce potency. Store out of reach of children and pets.
For travel, carry the bottle with you, not in checked luggage. Keep the label intact and bring a copy of your prescription. If crossing borders, allow extra time for security checks. Replace any tablets that appear crumbled, discolored, or have been exposed to humidity.
Benefits
This therapy provides rapid, on-demand relief of angina symptoms when used correctly. The sublingual form is small, portable, and easy to administer without water. Using it before predictable triggers may help reduce discomfort during activities, as advised by a prescriber.
Side Effects and Safety
- Headache: common, can be throbbing, usually lessens with time
- Dizziness or lightheadedness: more likely when standing quickly
- Flushing or warmth: typically brief
- Nausea: may occur in some users
Serious effects can include severe hypotension, fainting, or worsening chest pain. Rare reactions include allergic responses such as rash or swelling. Seek immediate medical help for persistent chest pain unrelieved by labeled dosing, signs of a severe drop in blood pressure, or symptoms of an allergic reaction. Use caution when driving or operating machinery until you know how you respond.
Drug Interactions and Cautions
Do not combine with PDE-5 inhibitors (such as sildenafil, tadalafil, or vardenafil) due to the risk of profound blood pressure reduction. Avoid concurrent riociguat. Use with other blood pressure therapies requires careful monitoring by a clinician. Alcohol can enhance hypotension.
People with certain heart valve conditions, severe anemia, or recent head injury require medical guidance before use. For broader heart health topics, you may find related reading in Eliquis Side Effects and Apixaban Nursing Considerations.
What to Expect Over Time
Relief may occur quickly when tablets are used at symptom onset. Headaches are common early and may decrease with continued use. Keep tablets accessible at all times and replace the bottle by the labeled expiry date. Work with your prescriber to review triggers, activity plans, and overall heart risk reduction strategies.
Compare With Alternatives
Some patients also use other preventive cardiovascular therapies. Calcium channel blockers can help reduce angina episodes in selected cases. See Caduet® for a calcium channel blocker plus statin combination, when appropriate. Beta blockers are another option for chronic angina control in many patients; see Propranolol for an example. Your prescriber will determine the best plan.
Pricing and Access
We offer Canadian pharmacy pricing for brand and therapeutic alternatives. To review availability and Nitrostat 0.4 mg price, sign in to check current options and packaging. For a broader sense of total therapy costs, see typical add-on medicines such as Pravastatin Sodium or antiplatelet agents like Persantine® if your prescriber has recommended them. Orders Ships from Canada to US with secure payment and clear invoices.
If you are looking for offers, check our Promotions page for current site-wide savings when available. For a broader estimate of Nitroglycerin 0.4 mg sublingual tablet cost, compare package sizes once your prescription is uploaded.
Availability and Substitutions
Supply can vary. If this item is unavailable, your prescriber may recommend an alternative in the same class or a different class for angina control. We also list related conditions in our Angina category and broader heart medicines under Cardiovascular.
Patient Suitability and Cost-Saving Tips
This therapy may suit adults diagnosed with angina who need rapid relief. It is not a daily maintenance pill. People with significant low blood pressure, severe anemia, or recent head trauma should discuss risks with a clinician before use.
- Multi-month planning: keep more than one bottle if advised
- Smart refills: set reminders so you never run out
- Travel backup: carry a spare bottle in a separate bag
- Package choices: review quantities that match your use pattern
- Secure checkout: encrypted checkout protects your information
Questions to Ask Your Clinician
- When should I call emergency services if pain continues?
- How many tablets can I use per episode under the label?
- Can I take it before exercise or cold-weather activity?
- Which medicines or supplements should I avoid the same day?
- How often should my overall heart plan be reviewed?
Authoritative Sources
US DailyMed: Nitrostat (nitroglycerin) Sublingual Tablets
Manufacturer: Nitrostat Product Information
Health Canada Drug Product Database: Nitroglycerin
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How should I take the first tablet during chest pain?
At the first sign of chest pain or pressure, sit or rest. Place one tablet under your tongue and let it dissolve completely. Do not chew or swallow it whole. Avoid eating or drinking until it has fully dissolved. If discomfort persists after the first dose, follow the steps on the official label and your clinician’s plan. Call emergency services if advised on the label, especially when pain continues or worsens.
Can I use it to prevent angina before activity?
Some people are instructed to use a sublingual tablet before activities known to bring on angina, such as climbing stairs or walking in cold weather. Only do this if your prescriber has advised it. Use the timing and maximum number of doses on the label. If symptoms occur despite pre-dosing, follow the labeled steps for repeat dosing and when to seek urgent care.
Which medicines must I avoid with this nitrate?
Do not combine nitrates with PDE-5 inhibitors such as sildenafil, tadalafil, or vardenafil because of the risk of severe low blood pressure. Avoid using riociguat with nitrates as well. Take care with other blood pressure therapies and alcohol, which can increase dizziness. Share a full list of your medicines and supplements with your healthcare professional so they can check for risks.
How long does relief usually take?
Relief can occur quickly when a tablet fully dissolves under the tongue. Individual response varies. Sit or lie down to reduce the chance of fainting. If pain does not improve as instructed by the label, take the next step in your action plan and seek emergency help when indicated. This therapy is for rapid relief, not long-term control of stable angina.
How should I store the tablets for best potency?
Keep tablets in the original glass container with the cap tightly closed. Protect from moisture, heat, and light. Do not transfer tablets into pill organizers or plastic bags, as exposure to air can reduce effectiveness. Carry the bottle with you so a dose is available at symptom onset, and keep it out of reach of children and pets. Replace by the expiry date.
What if I also take heart or cholesterol medicines?
Many people with coronary disease also take preventive therapies such as statins or antihypertensives. That is common, but interactions depend on the specific drug. Share all medicines with your clinician to confirm safety. For background reading on cardiovascular treatments, browse our Angina and Cardiovascular categories on the site to understand how therapies may fit together in a care plan.
Is there a generic and how is it used?
Nitroglycerin is the active ingredient in this sublingual treatment. Generic nitroglycerin products are used the same way as the brand, under the tongue at symptom onset and as directed by a prescriber. Follow the same safety rules regarding other medicines and alcohol. Use only as labeled and keep tablets in the original bottle for proper protection.
